|
US2803586A
(en)
|
1953-06-29 |
1957-08-20 |
Abbott Lab |
ph control in production of fumagillin
|
|
GB8500209D0
(en)
|
1985-01-04 |
1985-02-13 |
Ceskoslovenska Akademie Ved |
Synthetic polymeric drugs
|
|
SE8702550D0
(sv)
|
1987-06-18 |
1987-06-18 |
Anders Grubb |
Cysteinproteashemmare
|
|
US5166172A
(en)
|
1988-09-01 |
1992-11-24 |
Takeda Chemical Industries, Ltd. |
Fumagillol derivatives and pharmaceutical compositions thereof
|
|
US4997878A
(en)
|
1988-12-29 |
1991-03-05 |
Exxon Research And Engineering Company |
Hydrophobically associating polymers containing dimethyl acrylamide functionality
|
|
US5258453A
(en)
|
1992-01-21 |
1993-11-02 |
University Of Utah |
Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
|
|
GB9320781D0
(en)
|
1993-10-08 |
1993-12-01 |
Erba Carlo Spa |
Polymer-bound camptothecin derivatives
|
|
US20030220233A1
(en)
|
1994-01-24 |
2003-11-27 |
Neorx Corporation |
Radiolabeled annexins
|
|
TW409058B
(en)
|
1996-06-06 |
2000-10-21 |
Daiichi Seiyaku Co |
Method for preparation of a drug complex
|
|
TW527183B
(en)
|
1996-06-06 |
2003-04-11 |
Daiichi Seiyaku Co |
Drug complex
|
|
US6759509B1
(en)
|
1996-11-05 |
2004-07-06 |
Bristol-Myers Squibb Company |
Branched peptide linkers
|
|
WO1999011272A1
(en)
|
1997-09-02 |
1999-03-11 |
Johns Hopkins University School Of Medicine |
Vitamin d3 analog loaded polymer formulations for cancer and neurodegenerative disorders
|
|
US6306819B1
(en)
|
1997-10-31 |
2001-10-23 |
Massachusetts Institute Of Technology |
Method for regulating size of vascularized normal tissue
|
|
CO5021134A1
(es)
*
|
1998-05-01 |
2001-03-27 |
Abbott Lab |
Inhibidores beta-aminoacidos substituidos de aminopeptida- sa-2 metionina
|
|
US6242494B1
(en)
|
1998-05-01 |
2001-06-05 |
Abbott Laboratories |
Substituted β-amino acid inhibitors of methionine aminopeptidase-2
|
|
WO1999057098A2
(en)
|
1998-05-01 |
1999-11-11 |
Abbott Laboratories |
Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
|
|
KR100357542B1
(ko)
|
1998-05-15 |
2002-10-18 |
주식회사종근당 |
푸마질롤 유도체 및 그 제조방법
|
|
EA003398B1
(ru)
|
1998-05-22 |
2003-04-24 |
Дайити Фармасьютикал Ко., Лтд. |
Лекарственный комплекс c полимерным носителем
|
|
US6464850B1
(en)
|
1998-07-31 |
2002-10-15 |
Biowhittaker Molecular Applications, Inc. |
Method for producing hydrophilic monomers and uses thereof
|
|
CN1191093C
(zh)
|
1998-10-30 |
2005-03-02 |
第一制药株式会社 |
Dds化合物及其测定方法
|
|
AU7025600A
(en)
|
1999-09-08 |
2001-04-10 |
School Of Pharmacy, University Of London, The |
Uniform molecular weight polymers
|
|
US6811788B2
(en)
|
2000-01-19 |
2004-11-02 |
Baofa Yu |
Combinations and methods for treating neoplasms
|
|
US20020002152A1
(en)
|
2000-04-14 |
2002-01-03 |
Craig Richard A. |
Hydrazide and alkoxyamide angiogenesis inhibitors
|
|
US20070161570A1
(en)
|
2000-11-01 |
2007-07-12 |
Praecis Pharmaceuticals, Inc. |
Methionine aminopeptidase-2 inhibitors and methods of use thereof
|
|
US6548477B1
(en)
|
2000-11-01 |
2003-04-15 |
Praecis Pharmaceuticals Inc. |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
|
|
EP1243276A1
(en)
|
2001-03-23 |
2002-09-25 |
Franciscus Marinus Hendrikus De Groot |
Elongated and multiple spacers containing activatible prodrugs
|
|
US7091186B2
(en)
|
2001-09-24 |
2006-08-15 |
Seattle Genetics, Inc. |
p-Amidobenzylethers in drug delivery agents
|
|
DE60233420D1
(de)
|
2001-09-27 |
2009-10-01 |
Equispharm Co Ltd |
Fumagillolderivate und verfahren zu deren herstellung
|
|
EP1483579A4
(en)
|
2002-02-15 |
2006-07-12 |
Merckle Gmbh |
CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, PROCESS FOR THEIR MANUFACTURE AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF
|
|
EP1494662B1
(en)
|
2002-04-11 |
2012-11-28 |
Children's Medical Center Corporation |
Tnp-470-hpma-methacrylic acid copolymer conjugates and use thereof
|
|
US20040001801A1
(en)
|
2002-05-23 |
2004-01-01 |
Corvas International, Inc. |
Conjugates activated by cell surface proteases and therapeutic uses thereof
|
|
US7030262B2
(en)
|
2002-08-06 |
2006-04-18 |
Abbott Laboratories |
3-Amino-2-hydroxyalkanoic acids and their prodrugs
|
|
US20040116348A1
(en)
|
2002-09-23 |
2004-06-17 |
Ying Chau |
Polymer-linker-drug conjugates for targeted drug delivery
|
|
US7491718B2
(en)
|
2002-10-08 |
2009-02-17 |
Abbott Laboratories |
Sulfonamides having antiangiogenic and anticancer activity
|
|
US20040228831A1
(en)
|
2003-05-15 |
2004-11-18 |
Belinka Benjamin A. |
Polymeric conjugates for tissue activated drug delivery
|
|
CN102989009B
(zh)
*
|
2003-12-31 |
2015-06-03 |
宾夕法尼亚州研究基金会 |
预测并克服对卵巢癌化疗的抗性的方法及预测结肠癌发生的方法
|
|
US20070287680A1
(en)
|
2004-05-10 |
2007-12-13 |
University Of Utah Research Foundation |
Combined Active and Passive Targeting of Biologically Active Agents
|
|
US7214664B2
(en)
|
2004-12-03 |
2007-05-08 |
The Curators Of The University Of Missouri |
Peptidyl prodrugs that resist P-glycoprotein mediated drug efflux
|
|
US20080248030A1
(en)
|
2005-02-02 |
2008-10-09 |
Children's Medical Center Corporation |
Method of Treating Angiogenic Diseases
|
|
US7629315B2
(en)
|
2005-03-09 |
2009-12-08 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Compositions for blocking the inhibitory effect of human CRP on human leptin
|
|
WO2006124711A1
(en)
|
2005-05-16 |
2006-11-23 |
The Board Of Trustees Of The University Of Illinois |
Composition and method for providing localized delivery of a therapeutic agent
|
|
WO2011053822A2
(en)
|
2009-11-01 |
2011-05-05 |
The Brigham And Women's Hospital, Inc. |
Notch inhibition in the treatment and prevention of obesity and metabolic syndrome
|
|
JP2010531896A
(ja)
|
2007-06-26 |
2010-09-30 |
チルドレンズ メディカル センター コーポレーション |
治療的投与のためのＭｅｔＡＰ−２阻害剤ポリマーソーム
|
|
WO2009036108A1
(en)
|
2007-09-13 |
2009-03-19 |
Children's Medical Center Corporation |
Methods and compositions for inhibiting vascular leakage
|
|
US20090104210A1
(en)
|
2007-10-17 |
2009-04-23 |
Tota Michael R |
Peptide compounds for treating obesity and insulin resistance
|
|
US7732491B2
(en)
*
|
2007-11-12 |
2010-06-08 |
Bipar Sciences, Inc. |
Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
|
|
EP2217244A4
(en)
*
|
2007-11-12 |
2011-08-31 |
Bipar Sciences Inc |
TREATMENT OF NUTRITIONAL CANCER AND EGG CANCER WITH A PARP INHIBITOR ALONE OR IN COMBINATION WITH ANTITUMOROUS MEDICINES
|
|
BRPI0820229A2
(pt)
|
2007-11-28 |
2017-05-09 |
A Stevenson Cheri |
conjugados de análogos de fumagilina biodegradáveis biocompatíveis
|
|
EP2231147A2
(en)
|
2007-12-13 |
2010-09-29 |
Novartis AG |
Combinations of therapeutic agents for treating cancer
|
|
US8586019B2
(en)
|
2008-05-22 |
2013-11-19 |
Ramot At Tel-Aviv University Ltd. |
Conjugates of polymers having a therapeutically active agent and an angiogenesis targeting moiety attached thereto and uses thereof in the treatment of angiogenesis related diseases
|
|
DE102008027574A1
(de)
|
2008-06-10 |
2009-12-17 |
Merck Patent Gmbh |
Neue Pyrrolidinderivate als MetAP-2 Inhibitoren
|
|
US20120004162A1
(en)
|
2008-12-04 |
2012-01-05 |
Vath James E |
Methods of Treating an Overweight or Obese Subject
|
|
US8642650B2
(en)
|
2008-12-04 |
2014-02-04 |
Zafgen, Inc. |
Methods of treating an overweight or obese subject
|
|
TWI373345B
(en)
|
2009-02-19 |
2012-10-01 |
Academia Sinica |
Breast cancer-targeting peptides and use thereof
|
|
JP5827239B2
(ja)
*
|
2010-01-08 |
2015-12-02 |
ザフゲン，インコーポレイテッド |
フマギロール型化合物並びにその製造方法及び使用方法
|
|
US20130266578A1
(en)
|
2010-04-07 |
2013-10-10 |
Thomas E. Hughes |
Methods of treating an overweight subject
|
|
US9895449B2
(en)
|
2010-05-25 |
2018-02-20 |
Syndevrx, Inc. |
Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof
|
|
WO2011150022A2
(en)
*
|
2010-05-25 |
2011-12-01 |
Syndevrx, Inc. |
Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof
|
|
US20130137831A1
(en)
|
2010-05-25 |
2013-05-30 |
John S. Petersen |
Optimized drug conjugates
|
|
PH12013500934A1
(en)
|
2010-11-09 |
2022-10-24 |
Zafgen Inc |
Crystalline solids of a metap-2 inhibitor and methods of making and using same
|
|
RS54648B1
(sr)
|
2010-11-12 |
2016-08-31 |
Pharma Mar S.A. |
Kombinovana terapija sa antitumorskim alkaloidom
|
|
KR101875988B1
(ko)
|
2011-03-08 |
2018-07-06 |
자프겐 인크. |
옥사스피로[2.5]옥탄 유도체 및 유사체
|
|
CA2908993C
(en)
*
|
2013-04-10 |
2023-05-23 |
Syndevrx, Inc. |
Metap2 inhibitors and methods of treating obesity
|
|
CN105828822B
(zh)
|
2013-08-14 |
2019-10-18 |
诺华股份有限公司 |
用于治疗癌症的组合疗法
|
|
ES2893749T3
(es)
|
2015-12-10 |
2022-02-10 |
Syndevrx Inc |
Derivados de fumagilol y polimorfos de los mismos
|
|
CA3239447A1
(en)
|
2016-01-11 |
2017-07-20 |
Syndevrx, Inc. |
Treatment for tumors driven by metabolic dysfunction
|
|
JP7187035B2
(ja)
|
2016-08-03 |
2022-12-12 |
アールイーエムディー バイオセラピューティクス，インコーポレイテッド |
癌を治療するためのグルカゴン受容体アンタゴニストとｐｉ３ｋ経路阻害剤との組み合わせ
|
|
JP2022512826A
(ja)
*
|
2018-10-26 |
2022-02-07 |
シンデブルックス，インコーポレイティド |
ＭｅｔＡＰ２阻害剤のバイオマーカーとその応用
|