MX2018008321A - Tratamiento de tumores ocasionados por disfuncion metabolica. - Google Patents

Tratamiento de tumores ocasionados por disfuncion metabolica.

Info

Publication number
MX2018008321A
MX2018008321A MX2018008321A MX2018008321A MX2018008321A MX 2018008321 A MX2018008321 A MX 2018008321A MX 2018008321 A MX2018008321 A MX 2018008321A MX 2018008321 A MX2018008321 A MX 2018008321A MX 2018008321 A MX2018008321 A MX 2018008321A
Authority
MX
Mexico
Prior art keywords
treatment
metabolic dysfunction
tumors driven
driven
present disclosure
Prior art date
Application number
MX2018008321A
Other languages
English (en)
Inventor
Shanahan James
Cornelius Peter
Original Assignee
Syndevrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syndevrx Inc filed Critical Syndevrx Inc
Publication of MX2018008321A publication Critical patent/MX2018008321A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente descripción se refiere a inhibidores de MetAp2 modificados o conjugados con polímeros. La presente descripción también se refiere a métodos para tratar enfermedades y trastornos ocasionados metabólicamente, tales como ciertos cánceres.
MX2018008321A 2016-01-11 2017-01-11 Tratamiento de tumores ocasionados por disfuncion metabolica. MX2018008321A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662277293P 2016-01-11 2016-01-11
US201662393929P 2016-09-13 2016-09-13
US201662395446P 2016-09-16 2016-09-16
PCT/US2017/012968 WO2017123603A1 (en) 2016-01-11 2017-01-11 Treatment for tumors driven by metabolic dysfunction

Publications (1)

Publication Number Publication Date
MX2018008321A true MX2018008321A (es) 2018-09-21

Family

ID=57882196

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018008321A MX2018008321A (es) 2016-01-11 2017-01-11 Tratamiento de tumores ocasionados por disfuncion metabolica.
MX2023002076A MX2023002076A (es) 2016-01-11 2018-07-04 Conjugado de polimero util para tratar tumores ocasionados por disfuncion metabolica.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023002076A MX2023002076A (es) 2016-01-11 2018-07-04 Conjugado de polimero util para tratar tumores ocasionados por disfuncion metabolica.

Country Status (9)

Country Link
US (3) US10646463B2 (es)
EP (1) EP3402529A1 (es)
JP (2) JP7022066B2 (es)
KR (1) KR20180100663A (es)
CN (2) CN114225045A (es)
AU (2) AU2017206718B2 (es)
CA (1) CA3008960A1 (es)
MX (2) MX2018008321A (es)
WO (1) WO2017123603A1 (es)

Families Citing this family (10)

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WO2011150022A2 (en) 2010-05-25 2011-12-01 Syndevrx, Inc. Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof
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WO2014169026A1 (en) 2013-04-10 2014-10-16 Syndevrx, Inc. Metap2 inhibitors and methods of treating obesity
KR20180093995A (ko) 2015-12-10 2018-08-22 신데브알엑스, 인크. 푸마길롤 유도체 및 그의 다형체
CN114225045A (zh) 2016-01-11 2022-03-25 辛德弗雷克斯公司 代谢功能障碍引起的肿瘤的治疗
AU2017273857B2 (en) 2016-06-01 2021-08-19 Athira Pharma, Inc. Compounds
CN107670048B (zh) * 2017-08-30 2019-04-26 南京明臻医药科技有限公司 具有协同抗癌活性的中间体药物和聚乙二醇偶联协同抗癌药物、及其制备方法和应用
WO2020087077A1 (en) * 2018-10-26 2020-04-30 Syndevrx,Inc. Biomarkers of metap2 inhibitors and applications thereof
CN112915210A (zh) * 2019-12-06 2021-06-08 重庆阿普格雷生物科技有限公司 一种聚乙二醇偶联药物、其制备方法及应用
WO2024036274A1 (en) * 2022-08-10 2024-02-15 Syndevrx, Inc. Metap2 inhibitors for the treatment of pulmonary fibrosis

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Also Published As

Publication number Publication date
JP2019501206A (ja) 2019-01-17
US10646463B2 (en) 2020-05-12
JP7022066B2 (ja) 2022-02-17
EP3402529A1 (en) 2018-11-21
AU2021286420B2 (en) 2024-03-14
AU2017206718A1 (en) 2018-07-05
CA3008960A1 (en) 2017-07-20
CN114225045A (zh) 2022-03-25
US20170196830A1 (en) 2017-07-13
JP2022048388A (ja) 2022-03-25
KR20180100663A (ko) 2018-09-11
AU2017206718B2 (en) 2021-09-30
US11273142B2 (en) 2022-03-15
AU2021286420A1 (en) 2022-01-20
MX2023002076A (es) 2023-03-17
CN108697807A (zh) 2018-10-23
WO2017123603A1 (en) 2017-07-20
CN108697807B (zh) 2021-11-26
US20220280470A1 (en) 2022-09-08
US20210077452A1 (en) 2021-03-18

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