JP2013518912A5 - - Google Patents
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- Publication number
- JP2013518912A5 JP2013518912A5 JP2012552152A JP2012552152A JP2013518912A5 JP 2013518912 A5 JP2013518912 A5 JP 2013518912A5 JP 2012552152 A JP2012552152 A JP 2012552152A JP 2012552152 A JP2012552152 A JP 2012552152A JP 2013518912 A5 JP2013518912 A5 JP 2013518912A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- drug conjugate
- fragment
- antibody drug
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000611 antibody drug conjugate Substances 0.000 claims 33
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 33
- 239000012634 fragment Substances 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 239000000427 antigen Substances 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- MFRNYXJJRJQHNW-DEMKXPNLSA-N (2s)-2-[[(2r,3r)-3-methoxy-3-[(2s)-1-[(3r,4s,5s)-3-methoxy-5-methyl-4-[methyl-[(2s)-3-methyl-2-[[(2s)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 MFRNYXJJRJQHNW-DEMKXPNLSA-N 0.000 claims 11
- 108010059074 monomethylauristatin F Proteins 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 241000124008 Mammalia Species 0.000 claims 5
- 230000001268 conjugating effect Effects 0.000 claims 5
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 4
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 206010038389 Renal cancer Diseases 0.000 claims 4
- 201000010982 kidney cancer Diseases 0.000 claims 4
- 201000007270 liver cancer Diseases 0.000 claims 4
- 208000014018 liver neoplasm Diseases 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 229940127089 cytotoxic agent Drugs 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000004614 tumor growth Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000000562 conjugate Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30248910P | 2010-02-08 | 2010-02-08 | |
| US61/302,489 | 2010-02-08 | ||
| PCT/US2011/024055 WO2011097627A1 (en) | 2010-02-08 | 2011-02-08 | Antibody drug conjugates (adc) that bind to 161p2f10b proteins |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016223674A Division JP6529478B2 (ja) | 2010-02-08 | 2016-11-17 | １６１ｐ２ｆ１０ｂタンパク質に結合する抗体薬物コンジュゲート（ａｄｃ） |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518912A JP2013518912A (ja) | 2013-05-23 |
| JP2013518912A5 true JP2013518912A5 (https=) | 2014-11-13 |
| JP6046494B2 JP6046494B2 (ja) | 2016-12-14 |
Family
ID=44355840
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552152A Active JP6046494B2 (ja) | 2010-02-08 | 2011-02-08 | １６１ｐ２ｆ１０ｂタンパク質に結合する抗体薬物コンジュゲート（ａｄｃ） |
| JP2016223674A Active JP6529478B2 (ja) | 2010-02-08 | 2016-11-17 | １６１ｐ２ｆ１０ｂタンパク質に結合する抗体薬物コンジュゲート（ａｄｃ） |
| JP2019091063A Pending JP2019131616A (ja) | 2010-02-08 | 2019-05-14 | １６１ｐ２ｆ１０ｂタンパク質に結合する抗体薬物コンジュゲート（ａｄｃ） |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016223674A Active JP6529478B2 (ja) | 2010-02-08 | 2016-11-17 | １６１ｐ２ｆ１０ｂタンパク質に結合する抗体薬物コンジュゲート（ａｄｃ） |
| JP2019091063A Pending JP2019131616A (ja) | 2010-02-08 | 2019-05-14 | １６１ｐ２ｆ１０ｂタンパク質に結合する抗体薬物コンジュゲート（ａｄｃ） |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8609092B2 (https=) |
| EP (2) | EP3395361A1 (https=) |
| JP (3) | JP6046494B2 (https=) |
| KR (1) | KR101510413B1 (https=) |
| CN (2) | CN102844045A (https=) |
| AU (3) | AU2011213609B2 (https=) |
| BR (1) | BR112012019780A2 (https=) |
| CA (1) | CA2789230C (https=) |
| EA (1) | EA201201120A1 (https=) |
| ES (1) | ES2668645T3 (https=) |
| IL (1) | IL221205A (https=) |
| MX (1) | MX2012008884A (https=) |
| PH (1) | PH12012501545B1 (https=) |
| TW (1) | TWI504410B (https=) |
| UA (1) | UA115517C2 (https=) |
| WO (1) | WO2011097627A1 (https=) |
Families Citing this family (28)
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| CN102844045A (zh) * | 2010-02-08 | 2012-12-26 | 艾更斯司股份有限公司 | 结合于161p2f10b蛋白的抗体药物偶联物(adc) |
| US20130116404A1 (en) | 2011-11-08 | 2013-05-09 | Case Western Reserve University | Targeted non-invasive imaging probes of egfr expressing cells |
| AU2013229786B2 (en) | 2012-03-08 | 2017-06-22 | Halozyme, Inc. | Conditionally active anti-epidermal growth factor receptor antibodies and methods of use thereof |
| CN104640572B (zh) | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物，偶联方法，及其用途 |
| TWI606063B (zh) * | 2012-08-23 | 2017-11-21 | 艾澤西公司 | 結合至１５８ｐ１ｄ７蛋白之抗體藥物結合物（ａｄｃ） |
| JP6282745B2 (ja) | 2013-09-12 | 2018-02-21 | ハロザイム インコーポレイテッド | 修飾抗上皮成長因子受容体抗体およびその使用法 |
| AU2014337317A1 (en) | 2013-10-15 | 2016-09-15 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| NZ758049A (en) | 2013-10-15 | 2024-03-22 | Seagen Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| RU2016122041A (ru) * | 2013-11-06 | 2017-12-11 | ЭББВИ СТЕМСЕНТРКС ЭлЭлСи | Новые анти-клаудин антитела и способы их применения |
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| CN109843919A (zh) | 2016-03-25 | 2019-06-04 | 西雅图基因公司 | 用于制备聚乙二醇化的药物-接头及其中间体的方法 |
| US20200338210A1 (en) * | 2016-12-22 | 2020-10-29 | Ardeagen Corporation | Anti-ror1 antibody and conjugates thereof |
| KR102648564B1 (ko) | 2017-03-24 | 2024-03-19 | 씨젠 인크. | 글루쿠로니드 약물-링커의 제조 공정 및 그 중간물 |
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| MA51184A (fr) | 2017-12-15 | 2020-10-21 | Juno Therapeutics Inc | Molécules de liaison à l'anti-cct5 et procédés d'utilisation associés |
| CN119241554A (zh) | 2017-12-15 | 2025-01-03 | 四川科伦博泰生物医药股份有限公司 | 生物活性物偶联物及其制备方法和用途 |
| WO2019183633A1 (en) | 2018-03-23 | 2019-09-26 | Case Western Reserve Univeristy | Psma targeted conjugate compounds and uses thereof |
| IL326284A (en) | 2018-09-24 | 2026-04-01 | Janssen Biotech Inc | A safe and effective method for treating ulcerative colitis with an anti-IL12/IL23 antibody |
| JP7689074B2 (ja) | 2019-01-15 | 2025-06-05 | ヤンセン バイオテツク，インコーポレーテツド | 若年性特発性関節炎の治療のための抗ｔｎｆ抗体、組成物、及び方法 |
| US20220073603A1 (en) | 2020-07-30 | 2022-03-10 | Janssen Biotech, Inc. | Method of Treating Psoriasis in Pediatric Subjects with Anti-IL12/IL23 Antibody |
| AU2021386367A1 (en) | 2020-11-24 | 2023-06-22 | Les Laboratoires Servier | Bcl-xl inhibitor antibody-drug conjugates and methods of use thereof |
| US20250332265A1 (en) | 2021-11-09 | 2025-10-30 | Case Western Reserve University | Psma targeted conjugate compounds and uses thereof |
| US20260061065A1 (en) | 2022-05-20 | 2026-03-05 | Novartis Ag | Antibody drug conjugates |
| US20250387504A1 (en) | 2022-05-20 | 2025-12-25 | Novartis Ag | Antibody-drug conjugates of antineoplastic compounds and methods of use thereof |
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| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| BRPI0509274A (pt) | 2004-03-26 | 2007-09-04 | Pfizer Prod Inc | usos de anticorpos anti-ctla-4 |
| US7691962B2 (en) | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| CN101500590A (zh) * | 2005-03-31 | 2009-08-05 | 阿根西斯公司 | 与161p2f10b蛋白结合的抗体和相关分子 |
| RU2413735C2 (ru) * | 2005-03-31 | 2011-03-10 | Эдженсис, Инк. | Антитела и родственные молекулы, связывающиеся с белками 161p2f10b |
| US8350009B2 (en) * | 2005-03-31 | 2013-01-08 | Agensys, Inc. | Antibodies and related molecules that bind to 161P2F10B proteins |
| DK1912677T3 (da) | 2005-06-20 | 2014-01-13 | Psma Dev Company L L C | PSMA-antistof-lægemiddel-konjugater |
| EP1928912A4 (en) * | 2005-09-07 | 2010-02-24 | Medimmune Inc | EPH ANTI-RECEPTOR ANTIBODIES CONJUGATED TO TOXINS |
| MX2009008430A (es) * | 2007-02-09 | 2009-10-28 | Genentech Inc | Anticuerpos anti-robo4 y sus usos. |
| EA020696B1 (ru) * | 2007-10-12 | 2015-01-30 | Сиэтл Дженетикс, Инк. | Способ лечения лимфомы ходжкина с использованием комбинации гемцитабина и конъюгата антитела против cd30 с ауристатином |
| DK2211904T3 (en) * | 2007-10-19 | 2016-10-24 | Seattle Genetics Inc | Cd19-binding agents and uses thereof |
| CN102844045A (zh) * | 2010-02-08 | 2012-12-26 | 艾更斯司股份有限公司 | 结合于161p2f10b蛋白的抗体药物偶联物(adc) |
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2011
- 2011-02-08 CN CN201180008612XA patent/CN102844045A/zh active Pending
- 2011-02-08 EP EP18162821.5A patent/EP3395361A1/en not_active Withdrawn
- 2011-02-08 MX MX2012008884A patent/MX2012008884A/es active IP Right Grant
- 2011-02-08 AU AU2011213609A patent/AU2011213609B2/en active Active
- 2011-02-08 WO PCT/US2011/024055 patent/WO2011097627A1/en not_active Ceased
- 2011-02-08 TW TW100104156A patent/TWI504410B/zh active
- 2011-02-08 CA CA2789230A patent/CA2789230C/en active Active
- 2011-02-08 JP JP2012552152A patent/JP6046494B2/ja active Active
- 2011-02-08 KR KR1020127023540A patent/KR101510413B1/ko active Active
- 2011-02-08 BR BR112012019780-0A patent/BR112012019780A2/pt not_active Application Discontinuation
- 2011-02-08 EP EP11740529.0A patent/EP2533804B1/en active Active
- 2011-02-08 PH PH1/2012/501545A patent/PH12012501545B1/en unknown
- 2011-02-08 EA EA201201120A patent/EA201201120A1/ru unknown
- 2011-02-08 CN CN201610972361.1A patent/CN106975082A/zh active Pending
- 2011-02-08 US US13/022,905 patent/US8609092B2/en active Active
- 2011-02-08 UA UAA201210247A patent/UA115517C2/uk unknown
- 2011-02-08 ES ES11740529T patent/ES2668645T3/es active Active
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2012
- 2012-07-31 IL IL221205A patent/IL221205A/en active IP Right Grant
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2013
- 2013-12-13 US US14/106,444 patent/US9308278B2/en active Active
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2016
- 2016-03-15 US US15/071,146 patent/US20160256563A1/en not_active Abandoned
- 2016-11-17 JP JP2016223674A patent/JP6529478B2/ja active Active
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2017
- 2017-01-30 AU AU2017200600A patent/AU2017200600B2/en active Active
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2018
- 2018-11-29 AU AU2018271337A patent/AU2018271337A1/en not_active Abandoned
- 2018-12-11 US US16/216,841 patent/US20190328898A1/en not_active Abandoned
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2019
- 2019-05-14 JP JP2019091063A patent/JP2019131616A/ja active Pending
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