JP6387086B2 - 新規ソマトスタチン受容体亜型4(sstr4)作動薬 - Google Patents
新規ソマトスタチン受容体亜型4(sstr4)作動薬 Download PDFInfo
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- JP6387086B2 JP6387086B2 JP2016513359A JP2016513359A JP6387086B2 JP 6387086 B2 JP6387086 B2 JP 6387086B2 JP 2016513359 A JP2016513359 A JP 2016513359A JP 2016513359 A JP2016513359 A JP 2016513359A JP 6387086 B2 JP6387086 B2 JP 6387086B2
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- 0 C*C(C)(*)NC([C@]1[C@@]2[C@]1CN(*)C2)=O Chemical compound C*C(C)(*)NC([C@]1[C@@]2[C@]1CN(*)C2)=O 0.000 description 1
- BKIKNNIHPPZMBG-UHFFFAOYSA-N CC(C)(C(NCc1ncncc1)=O)NC(OCc1ccccc1)=O Chemical compound CC(C)(C(NCc1ncncc1)=O)NC(OCc1ccccc1)=O BKIKNNIHPPZMBG-UHFFFAOYSA-N 0.000 description 1
- YVWLKWYISKFPEJ-UHFFFAOYSA-N CC(C)(C(O)=O)c1n[o]c2c1cccc2 Chemical compound CC(C)(C(O)=O)c1n[o]c2c1cccc2 YVWLKWYISKFPEJ-UHFFFAOYSA-N 0.000 description 1
- KXYUCHYTEPOFKD-JHIQODARSA-N CC(C)(C)OC(N(C[C@H]12)CC1[C@H]2C(NC(C)(C)c1n[nH]c2c(C(F)(F)F)cccc12)=O)=O Chemical compound CC(C)(C)OC(N(C[C@H]12)CC1[C@H]2C(NC(C)(C)c1n[nH]c2c(C(F)(F)F)cccc12)=O)=O KXYUCHYTEPOFKD-JHIQODARSA-N 0.000 description 1
- IGDFPMOKEBBAHK-QLPKVWCKSA-N CC(C)(C)OC(N(C[C@H]12)C[C@@H]1[C@H]2C(NC(C)(C)c1c(C)nc2[n]1cccc2)=O)=O Chemical compound CC(C)(C)OC(N(C[C@H]12)C[C@@H]1[C@H]2C(NC(C)(C)c1c(C)nc2[n]1cccc2)=O)=O IGDFPMOKEBBAHK-QLPKVWCKSA-N 0.000 description 1
- QVESQRFZUMXKBE-FICVDOATSA-N CC(C)(C)OC(N(C[C@H]12)C[C@@H]1[C@H]2C(NC(C)(C)c1nnc2[n]1cccc2C)=O)=O Chemical compound CC(C)(C)OC(N(C[C@H]12)C[C@@H]1[C@H]2C(NC(C)(C)c1nnc2[n]1cccc2C)=O)=O QVESQRFZUMXKBE-FICVDOATSA-N 0.000 description 1
- HWQMZDLNMTXZLI-UHFFFAOYSA-N CC(C)(CCc1ncccc1C(F)(F)F)N Chemical compound CC(C)(CCc1ncccc1C(F)(F)F)N HWQMZDLNMTXZLI-UHFFFAOYSA-N 0.000 description 1
- BDNJUGSFFTVBLW-UHFFFAOYSA-N CC(C)(COc(c(C)c1)ncc1F)N Chemical compound CC(C)(COc(c(C)c1)ncc1F)N BDNJUGSFFTVBLW-UHFFFAOYSA-N 0.000 description 1
- VPRVQLWPUQEZBW-FOLVSLTJSA-N CC(C)(COc(c1c2cccc1)cnc2Cl)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O Chemical compound CC(C)(COc(c1c2cccc1)cnc2Cl)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O VPRVQLWPUQEZBW-FOLVSLTJSA-N 0.000 description 1
- UVQOAIKFJAHEPD-IWIIMEHWSA-N CC(C)(COc1c(C(F)(F)F)ccnc1)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O Chemical compound CC(C)(COc1c(C(F)(F)F)ccnc1)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O UVQOAIKFJAHEPD-IWIIMEHWSA-N 0.000 description 1
- UMDPIRYSPFJXOV-SSGZVVCFSA-N CC(C)(COc1c(C)cccc1)NC([C@@H]1[C@@H]2[C@H]1CN(C)C2)O Chemical compound CC(C)(COc1c(C)cccc1)NC([C@@H]1[C@@H]2[C@H]1CN(C)C2)O UMDPIRYSPFJXOV-SSGZVVCFSA-N 0.000 description 1
- RUCBXBGWWWYZDZ-FICVDOATSA-N CC(C)(COc1c(C2CC2)cccn1)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O Chemical compound CC(C)(COc1c(C2CC2)cccn1)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O RUCBXBGWWWYZDZ-FICVDOATSA-N 0.000 description 1
- FPHQHULGJFFCLZ-UHFFFAOYSA-N CC(C)(COc1ccccc1F)[N+]([O-])=O Chemical compound CC(C)(COc1ccccc1F)[N+]([O-])=O FPHQHULGJFFCLZ-UHFFFAOYSA-N 0.000 description 1
- JNZSKKKRJYZYAA-UHFFFAOYSA-N CC(C)(COc1nnccc1C)NC(C1C2C1CNC2)=O Chemical compound CC(C)(COc1nnccc1C)NC(C1C2C1CNC2)=O JNZSKKKRJYZYAA-UHFFFAOYSA-N 0.000 description 1
- JMLKTWMDMDGNQX-IWIIMEHWSA-N CC(C)(c([nH]c1c2)nc1ccc2Cl)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O Chemical compound CC(C)(c([nH]c1c2)nc1ccc2Cl)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O JMLKTWMDMDGNQX-IWIIMEHWSA-N 0.000 description 1
- LYLHALCVDIWLTO-ONXXMXGDSA-N CC(C)(c(cc1)c[n]2c1ncc2)NC(C1[C@@H]2[C@H]1CNC2)=O Chemical compound CC(C)(c(cc1)c[n]2c1ncc2)NC(C1[C@@H]2[C@H]1CNC2)=O LYLHALCVDIWLTO-ONXXMXGDSA-N 0.000 description 1
- WDYRPVHKYSFTPL-UHFFFAOYSA-N CC(C)(c1c(cccc2)c2ncn1)NC(C1C2(C)C1CNC2)=O Chemical compound CC(C)(c1c(cccc2)c2ncn1)NC(C1C2(C)C1CNC2)=O WDYRPVHKYSFTPL-UHFFFAOYSA-N 0.000 description 1
- ALLAHEPCHBRBAQ-UHFFFAOYSA-N CC(C)(c1c(ccnc2)c2ccc1)NC(C1C2C1CNC2)=O Chemical compound CC(C)(c1c(ccnc2)c2ccc1)NC(C1C2C1CNC2)=O ALLAHEPCHBRBAQ-UHFFFAOYSA-N 0.000 description 1
- WAFNGLHVCXJFKD-UHFFFAOYSA-N CC(C)(c1cc2ncc[n]2cc1)NC(C1C2C1CNC2)=O Chemical compound CC(C)(c1cc2ncc[n]2cc1)NC(C1C2C1CNC2)=O WAFNGLHVCXJFKD-UHFFFAOYSA-N 0.000 description 1
- ORXLKEOBMQETFX-UHFFFAOYSA-N CC(C)(c1cncc2c1cccc2)NC(C1C2C1CNC2)=O Chemical compound CC(C)(c1cncc2c1cccc2)NC(C1C2C1CNC2)=O ORXLKEOBMQETFX-UHFFFAOYSA-N 0.000 description 1
- BSWSUJIEKZHADN-UHFFFAOYSA-N CC(C)(c1n[nH]c2c(C)cccc12)NC(C1C2(C)C1CNC2)=O Chemical compound CC(C)(c1n[nH]c2c(C)cccc12)NC(C1C2(C)C1CNC2)=O BSWSUJIEKZHADN-UHFFFAOYSA-N 0.000 description 1
- DEWGUMCLXFSVQC-UHFFFAOYSA-N CC(C)(c1n[o]c2c1cccc2C)NC(C1C2C1CNC2)=O Chemical compound CC(C)(c1n[o]c2c1cccc2C)NC(C1C2C1CNC2)=O DEWGUMCLXFSVQC-UHFFFAOYSA-N 0.000 description 1
- WNWXLHSKHQGJRW-YIOYIWSBSA-N CC(C)(c1ncnc2c1cccc2C)NC([C@@H]1C2[C@H]1CNC2)=O Chemical compound CC(C)(c1ncnc2c1cccc2C)NC([C@@H]1C2[C@H]1CNC2)=O WNWXLHSKHQGJRW-YIOYIWSBSA-N 0.000 description 1
- XIFKMRFYKUCGFA-UHFFFAOYSA-N CC(C)(c1nnc2[n]1cccc2C)N Chemical compound CC(C)(c1nnc2[n]1cccc2C)N XIFKMRFYKUCGFA-UHFFFAOYSA-N 0.000 description 1
- JYTVMQSGYSVKOE-JYBDTMGZSA-N CC(COc1c(C)cccc1)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O Chemical compound CC(COc1c(C)cccc1)NC([C@@H]1[C@@H]2[C@H]1CNC2)=O JYTVMQSGYSVKOE-JYBDTMGZSA-N 0.000 description 1
- CVVDMUYJTWFLAW-UHFFFAOYSA-N CC(c1cnc2[n]1nccc2)=O Chemical compound CC(c1cnc2[n]1nccc2)=O CVVDMUYJTWFLAW-UHFFFAOYSA-N 0.000 description 1
- PVROETJHCUDAFG-UHFFFAOYSA-N C[n]1nc(C(N)=O)c2ccccc12 Chemical compound C[n]1nc(C(N)=O)c2ccccc12 PVROETJHCUDAFG-UHFFFAOYSA-N 0.000 description 1
- JAORERSHXBOUHR-UHFFFAOYSA-N Cc1cc2cnccc2c(C#N)n1 Chemical compound Cc1cc2cnccc2c(C#N)n1 JAORERSHXBOUHR-UHFFFAOYSA-N 0.000 description 1
- LAGDDNBYYCFVNJ-UHFFFAOYSA-N Cc1ccc[n]2c(C#N)ccc12 Chemical compound Cc1ccc[n]2c(C#N)ccc12 LAGDDNBYYCFVNJ-UHFFFAOYSA-N 0.000 description 1
- PQLZCOPDSVJING-JLRAQOTISA-N O=C([C@@H]1[C@@H]2[C@H]1CNC2)NC1(COCC1)c1nc(ccc(Cl)c2)c2[nH]1 Chemical compound O=C([C@@H]1[C@@H]2[C@H]1CNC2)NC1(COCC1)c1nc(ccc(Cl)c2)c2[nH]1 PQLZCOPDSVJING-JLRAQOTISA-N 0.000 description 1
- SMWDFEZZVXVKRB-UHFFFAOYSA-N c(cc1)cc2c1nccc2 Chemical compound c(cc1)cc2c1nccc2 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 1
- JMANUKZDKDKBJP-UHFFFAOYSA-N c(nc1)c2[n]1cccc2 Chemical compound c(nc1)c2[n]1cccc2 JMANUKZDKDKBJP-UHFFFAOYSA-N 0.000 description 1
- DVUBDHRTVYLIPA-UHFFFAOYSA-N c1c(cccc2)[n]2nc1 Chemical compound c1c(cccc2)[n]2nc1 DVUBDHRTVYLIPA-UHFFFAOYSA-N 0.000 description 1
- HOBCFUWDNJPFHB-UHFFFAOYSA-N c1c[n](cccc2)c2c1 Chemical compound c1c[n](cccc2)c2c1 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 description 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N c1ccc(cnnc2)c2c1 Chemical compound c1ccc(cnnc2)c2c1 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 description 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N c1ccc2ncncc2c1 Chemical compound c1ccc2ncncc2c1 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N c1ccccc1 Chemical compound c1ccccc1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- LTHXZJUAGBTZSE-UHFFFAOYSA-N c1cnc2[n]1c(-c1c(ccnc3)c3ncc1)ccc2-c1cncc2c1cccc2 Chemical compound c1cnc2[n]1c(-c1c(ccnc3)c3ncc1)ccc2-c1cncc2c1cccc2 LTHXZJUAGBTZSE-UHFFFAOYSA-N 0.000 description 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N c1n[nH]c2c1cccc2 Chemical compound c1n[nH]c2c1cccc2 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 1
- KTZQTRPPVKQPFO-UHFFFAOYSA-N c1n[o]c2ccccc12 Chemical compound c1n[o]c2ccccc12 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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| EP3397631B1 (en) | 2015-12-29 | 2021-04-07 | Pfizer Inc | Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors |
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| CN112423759A (zh) | 2018-03-30 | 2021-02-26 | 因赛特公司 | 使用jak抑制剂治疗化脓性汗腺炎 |
| US11668295B2 (en) | 2018-12-28 | 2023-06-06 | Avent, Inc. | Pump head for a peristaltic pump |
| CN112979655A (zh) | 2019-12-16 | 2021-06-18 | 上海赛默罗生物科技有限公司 | 三唑并哒嗪类衍生物、其制备方法、药物组合物和用途 |
| AR121682A1 (es) * | 2020-03-31 | 2022-06-29 | Takeda Pharmaceuticals Co | Derivados de n-(heterociclil y heterociclilalquil)-3-bencilpiridin-2-amina como agonistas de sstr4 |
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| KR20230015333A (ko) * | 2020-05-21 | 2023-01-31 | 광저우 페르미온 테크놀로지 씨오., 엘티디. | 융합된 고리 화합물, 이의 제조 방법, 이의 약제학적 조성물 및 용도 |
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| JP2023537670A (ja) | 2020-07-28 | 2023-09-05 | シージェン インコーポレイテッド | ポリペプチドを生産するための方法及びシステム |
| WO2022125670A1 (en) | 2020-12-08 | 2022-06-16 | Incyte Corporation | Jak1 pathway inhibitors for the treatment of vitiligo |
| DK4333840T3 (da) | 2021-05-03 | 2025-11-24 | Incyte Corp | Jak1-vejinhibitorer til behandling af prurigo nodularis |
| AR127055A1 (es) * | 2021-09-14 | 2023-12-13 | Lilly Co Eli | Sales agonistas de sstr4 |
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| US6355613B1 (en) | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| US6057338A (en) | 1997-04-04 | 2000-05-02 | Merck & Co., Inc. | Somatostatin agonists |
| US6063796A (en) | 1997-04-04 | 2000-05-16 | Merck & Co., Inc. | Somatostatin agonists |
| US20100004339A1 (en) | 2003-10-06 | 2010-01-07 | Oy Juvantia Pharma Ltd. | Somatostatin Receptor 1 and/or 4 Selective Agonists and Antagonists |
| FI20031454A0 (fi) | 2003-10-06 | 2003-10-06 | Juvantia Pharma Ltd Oy | Selektiivisiä somatostatiinireseptori 1 ja/tai 4 -agonisteja ja -antagonisteja |
| CA2542279C (en) * | 2003-10-14 | 2011-08-09 | Pfizer Products Inc. | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors |
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| WO2010059922A1 (en) | 2008-11-21 | 2010-05-27 | Ligand Pharmaceuticals Incorporated | Pyrrolidine carboxamide compounds |
| US8835472B2 (en) | 2010-09-02 | 2014-09-16 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical compositions and uses thereof |
| US20140005165A1 (en) * | 2011-03-17 | 2014-01-02 | Anilkumar G. Nair | Substituted 3-azabicyclo[3.1.0]hexane derivatives useful as ccr2 antagonists |
| CN102675290B (zh) * | 2011-03-18 | 2014-11-12 | 山东亨利医药科技有限责任公司 | 含有并环的二氢吡唑类化合物 |
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