JP6387019B2 - ジケトピペラジンおよびジケトピペラジン含有組成物を生産するための方法 - Google Patents

ジケトピペラジンおよびジケトピペラジン含有組成物を生産するための方法 Download PDF

Info

Publication number
JP6387019B2
JP6387019B2 JP2015556207A JP2015556207A JP6387019B2 JP 6387019 B2 JP6387019 B2 JP 6387019B2 JP 2015556207 A JP2015556207 A JP 2015556207A JP 2015556207 A JP2015556207 A JP 2015556207A JP 6387019 B2 JP6387019 B2 JP 6387019B2
Authority
JP
Japan
Prior art keywords
albumin
dkp
stream
hsa
dpp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2015556207A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016511238A (ja
JP2016511238A5 (enExample
Inventor
バー−オー、デイビッド
Original Assignee
アンピオ ファーマシューティカルズ，インコーポレイテッド
アンピオ ファーマシューティカルズ，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アンピオ ファーマシューティカルズ，インコーポレイテッド, アンピオ ファーマシューティカルズ，インコーポレイテッド filed Critical アンピオ ファーマシューティカルズ，インコーポレイテッド
Publication of JP2016511238A publication Critical patent/JP2016511238A/ja
Publication of JP2016511238A5 publication Critical patent/JP2016511238A5/ja
Application granted granted Critical
Publication of JP6387019B2 publication Critical patent/JP6387019B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A61K38/385—Serum albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biomedical Technology (AREA)
JP2015556207A 2013-02-01 2014-02-03 ジケトピペラジンおよびジケトピペラジン含有組成物を生産するための方法 Expired - Fee Related JP6387019B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361759922P 2013-02-01 2013-02-01
US61/759,922 2013-02-01
PCT/US2014/014478 WO2014121210A1 (en) 2013-02-01 2014-02-03 Methods for producing diketopiperazines and compositions containing diketopiperazines

Publications (3)

Publication Number Publication Date
JP2016511238A JP2016511238A (ja) 2016-04-14
JP2016511238A5 JP2016511238A5 (enExample) 2017-03-09
JP6387019B2 true JP6387019B2 (ja) 2018-09-05

Family

ID=51263032

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015556207A Expired - Fee Related JP6387019B2 (ja) 2013-02-01 2014-02-03 ジケトピペラジンおよびジケトピペラジン含有組成物を生産するための方法

Country Status (15)

Country Link
US (1) US20150366932A1 (enExample)
EP (1) EP2950811A4 (enExample)
JP (1) JP6387019B2 (enExample)
KR (1) KR20150114984A (enExample)
CN (1) CN105188737A (enExample)
AU (1) AU2014212095B2 (enExample)
BR (1) BR112015017958A2 (enExample)
CA (1) CA2900050A1 (enExample)
EA (1) EA030414B1 (enExample)
HK (1) HK1214772A1 (enExample)
IL (1) IL240125A0 (enExample)
MX (1) MX2015009908A (enExample)
PH (1) PH12015501705A1 (enExample)
SG (2) SG11201505715RA (enExample)
WO (1) WO2014121210A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5048201B2 (ja) 2000-08-04 2012-10-17 ディーエムアイ バイオサイエンシズ インコーポレイテッド ジケトピペラジン類の使用方法とジケトピペラジン類を含む組成物
CN102210852B (zh) 2003-05-15 2016-10-19 安皮奥制药股份有限公司 T-细胞介导的疾病的治疗
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
PH12014500685B1 (en) 2011-10-10 2018-10-03 Ampio Pharmaceuticals Inc Treatment of degenerative joint disease
JP2014530063A (ja) 2011-10-10 2014-11-17 アンピオ ファーマシューティカルズ，インコーポレイテッド 免疫寛容が高められた埋込み型医療用デバイス、ならびに製造方法および埋込み方法
HK1198812A1 (en) 2011-10-28 2015-06-12 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
CA2906864A1 (en) 2013-03-15 2014-09-18 Ampio Pharmaceuticals, Inc. Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
EP4066836A1 (en) 2014-08-18 2022-10-05 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES
US10426796B2 (en) * 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US20210016273A1 (en) * 2019-07-19 2021-01-21 University Of Utah Research Foundation Rapid sperm separation based on sperm morphology and motility
US20230074374A1 (en) * 2020-02-16 2023-03-09 PUR Biologics, Inc Methods of manufacturing extracellular matrix using aspartyl alanyl diketopiperazine (da-dkp)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE765030A (fr) * 1970-04-02 1971-08-16 Snam Progetti Composes contenant un noyau de dicetopiperazine et leur procedede fabrication
US5561115A (en) * 1994-08-10 1996-10-01 Bayer Corporation Low temperature albumin fractionation using sodium caprylate as a partitioning agent
US5811241A (en) * 1995-09-13 1998-09-22 Cortech, Inc. Method for preparing and identifying N-substitued 1,4-piperazines and N-substituted 1,4-piperazinediones
JP2000005569A (ja) * 1998-06-24 2000-01-11 Asahi Chem Ind Co Ltd 直列多段濾過法
JP5048201B2 (ja) * 2000-08-04 2012-10-17 ディーエムアイ バイオサイエンシズ インコーポレイテッド ジケトピペラジン類の使用方法とジケトピペラジン類を含む組成物
CN1791420A (zh) * 2003-05-15 2006-06-21 Dmi生物科学公司 T－细胞介导的疾病的治疗
CN102210852B (zh) * 2003-05-15 2016-10-19 安皮奥制药股份有限公司 T-细胞介导的疾病的治疗
US7790039B2 (en) * 2003-11-24 2010-09-07 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for stem cell enrichment
US20050197496A1 (en) * 2004-03-04 2005-09-08 Gtc Biotherapeutics, Inc. Methods of protein fractionation using high performance tangential flow filtration
JP4970260B2 (ja) * 2004-08-20 2012-07-04 プロメティック バイオサイエンシズ，リミテッド 親和性クロマトグラフィーによるタンパク質の逐次的単離および精製スキーム
AU2010311332B2 (en) * 2009-10-30 2015-04-23 Albumedix Ltd. Albumin variants
WO2012174472A1 (en) * 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
PH12014500685B1 (en) * 2011-10-10 2018-10-03 Ampio Pharmaceuticals Inc Treatment of degenerative joint disease
JP2014530063A (ja) * 2011-10-10 2014-11-17 アンピオ ファーマシューティカルズ，インコーポレイテッド 免疫寛容が高められた埋込み型医療用デバイス、ならびに製造方法および埋込み方法
HK1198812A1 (en) * 2011-10-28 2015-06-12 Ampio Pharmaceuticals, Inc. Treatment of rhinitis

Also Published As

Publication number Publication date
EP2950811A1 (en) 2015-12-09
US20150366932A1 (en) 2015-12-24
AU2014212095A1 (en) 2015-09-10
EP2950811A4 (en) 2016-06-08
MX2015009908A (es) 2015-09-24
IL240125A0 (en) 2015-09-24
CA2900050A1 (en) 2014-08-07
JP2016511238A (ja) 2016-04-14
SG11201505715RA (en) 2015-08-28
WO2014121210A1 (en) 2014-08-07
AU2014212095B2 (en) 2018-07-26
EA201500783A1 (ru) 2016-05-31
BR112015017958A2 (pt) 2017-07-11
KR20150114984A (ko) 2015-10-13
SG10201706213RA (en) 2017-09-28
CN105188737A (zh) 2015-12-23
HK1214772A1 (zh) 2016-08-05
PH12015501705A1 (en) 2015-10-12
EA030414B1 (ru) 2018-08-31

Similar Documents

Publication Publication Date Title
JP2016511238A (ja) ジケトピペラジンおよびジケトピペラジン含有組成物を生産するための方法
CN103347530B (zh) 糖尿病的治疗或预防剂
CN118203658A (zh) 一种重组抗Claudin18.2全人源单克隆抗体注射液制剂及制备方法
RS57292B1 (sr) Ace2 polipeptid
JP5366161B2 (ja) Ｔｎｆアンタゴニスト及びそれを有効成分とするｔｎｆ阻害剤
Koroleva et al. Semax as a universal drug for therapy and research
Wright et al. The brain hepatocyte growth Factor/c-Met receptor system: A new target for the treatment of Alzheimer's disease
JP2012184251A (ja) 尿細管間質性線維症または進行性腎不全を処置するための機能性ｈ因子の使用
BRPI1012647B1 (pt) Método para purificar um hormônio folículo-estimulante recombinante ou uma variante de hormônio folículo-estimulante recombinante
JP7606966B2 (ja) ミトコンドリア病を標的とするアナログ
US10744179B2 (en) Method for treatment of inflammatory skin disorders with inhibitors of IL-36 proteolytic processing
CN102321168B (zh) 新型血小板生成素拟肽复性和纯化方法
JPH10505076A (ja) 炎症反応の抑制のためのインシュリン様成長因子ｉおよびｉｉの使用
CN112409450B (zh) TIGIT-IgV的亲和剂及其应用
JP2001518450A (ja) 一酸化窒素生成の調節方法
JP4278028B2 (ja) 炎症性サイトカイン産生抑制活性を有するペプチド
JP2916947B2 (ja) Ｃｐｂ―ｉの安定化方法及び製剤組成物
KR101721733B1 (ko) 혈관신생촉진용 펩타이드 및 이의 용도
WO2018118979A1 (en) Methods of administering hepcidin
US20250304655A1 (en) Expression System for Producing a Recombinant Haptoglobin (Hp) Beta Chain
JP2916948B2 (ja) Ｃｐｂ―ｉの安定化方法及びこの製剤組成物
KR20200038309A (ko) 폰 빌레브란트 인자의 바이러스 여과 방법
JPH05178756A (ja) 肝疾患の予防・治療薬
RU2289423C1 (ru) Пептид, обладающий антикоагулянтной, фибриндеполимеризационной, антитромботической и фибринолитической активностями
JPH0482898A (ja) 新規なペプチド及びアンジオテンシン変換酵素阻害剤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170202

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170202

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171003

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171228

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180330

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180717

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180810

R150 Certificate of patent or registration of utility model

Ref document number: 6387019

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees