JP6349256B2 - ウイルス感染の治療のためのプリン誘導体 - Google Patents

ウイルス感染の治療のためのプリン誘導体 Download PDF

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JP6349256B2
JP6349256B2 JP2014540449A JP2014540449A JP6349256B2 JP 6349256 B2 JP6349256 B2 JP 6349256B2 JP 2014540449 A JP2014540449 A JP 2014540449A JP 2014540449 A JP2014540449 A JP 2014540449A JP 6349256 B2 JP6349256 B2 JP 6349256B2
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mmol
alkyl
mixture
stirred
compound
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JP2014534231A (ja
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ボンファナティ，ジャン−フランソワ
マーク モーリス ドゥブレ，フレデリック
マーク モーリス ドゥブレ，フレデリック
エンブレッツ，ベルナー
ミシェル クロード フォルタン，ジェローム
ミシェル クロード フォルタン，ジェローム
ゴワン，ダイビッド クレグ エムシー
ゴワン，ダイビッド クレグ エムシー
ミューラー，フィリッペ
ジャン−マリー ベルナルド ラボイソン，ピエール
ジャン−マリー ベルナルド ラボイソン，ピエール
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ヤンセン・サイエンシズ・アイルランド・ユーシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014540449A 2011-11-09 2012-11-08 ウイルス感染の治療のためのプリン誘導体 Active JP6349256B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11188511 2011-11-09
EP11188511.7 2011-11-09
PCT/EP2012/072090 WO2013068438A1 (en) 2011-11-09 2012-11-08 Purine derivatives for the treatment of viral infections

Publications (2)

Publication Number Publication Date
JP2014534231A JP2014534231A (ja) 2014-12-18
JP6349256B2 true JP6349256B2 (ja) 2018-06-27

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JP2014540449A Active JP6349256B2 (ja) 2011-11-09 2012-11-08 ウイルス感染の治療のためのプリン誘導体

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US (4) US9556176B2 (show.php)
EP (1) EP2776439B1 (show.php)
JP (1) JP6349256B2 (show.php)
KR (1) KR102025276B1 (show.php)
CN (2) CN104066733A (show.php)
AU (1) AU2012334127B2 (show.php)
BR (2) BR122019020718B1 (show.php)
CA (1) CA2850448C (show.php)
CL (1) CL2014001205A1 (show.php)
CY (1) CY1121452T1 (show.php)
DK (1) DK2776439T3 (show.php)
EA (2) EA033830B1 (show.php)
ES (1) ES2690082T3 (show.php)
HR (1) HRP20181497T1 (show.php)
HU (1) HUE040541T2 (show.php)
IL (1) IL232046A (show.php)
IN (1) IN2014MN00862A (show.php)
LT (1) LT2776439T (show.php)
MX (1) MX347596B (show.php)
MY (1) MY173422A (show.php)
PH (1) PH12014501045B1 (show.php)
PL (1) PL2776439T3 (show.php)
PT (1) PT2776439T (show.php)
RS (1) RS57851B1 (show.php)
SG (1) SG11201401244TA (show.php)
SI (1) SI2776439T1 (show.php)
SM (1) SMT201800514T1 (show.php)
UA (1) UA116083C2 (show.php)
WO (1) WO2013068438A1 (show.php)

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