JP6337021B2 - Uv硬化可能な無溶媒抗菌性組成物 - Google Patents
Uv硬化可能な無溶媒抗菌性組成物 Download PDFInfo
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- JP6337021B2 JP6337021B2 JP2015558062A JP2015558062A JP6337021B2 JP 6337021 B2 JP6337021 B2 JP 6337021B2 JP 2015558062 A JP2015558062 A JP 2015558062A JP 2015558062 A JP2015558062 A JP 2015558062A JP 6337021 B2 JP6337021 B2 JP 6337021B2
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- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Plant Pathology (AREA)
- Paints Or Removers (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
本発明の範囲内のクロルヘキシジンジアセテート(CHA)を含むUV硬化可能なコーティング組成物で被覆されたニードルレスコネクターを、2種の市販のニードルレスコネクターとともに、有効性について試験した。2種の市販のニードルレスコネクターの一方は、銀をベースとする抗菌配合物を有し、他方はCHAを含浸したセプタムを有する。
抗菌剤の溶出速度は、良好に規定され、かつ被覆厚さ、被覆面積および抗菌剤濃度を制御することにより制御することができる。本実施例では、ルアー装置内の溶出したクロルヘキシジンジアセテートの濃度を、被覆厚さ(単位:ミル、すなわち0.001インチ(25.4μm))、被覆高さ(coating height)(単位:インチ(25.4mm))、およびクロルヘキシジンジアセテートの濃度(単位:%(質量/質量))の関数としてプロットした。ルアー装置は、高さ1インチ(25.4mm)の円筒形内部体積を有し、かつ、多くのニードルレスコネクターの内部体積の範囲内である、0.12mlの内部体積を有した。溶出したCHA濃度は、7日間のプレコンディショニング後の装置に関するものである。表皮ブドウ球菌(Staphylococcus epidermidis)の最小発育阻止濃度が2μg/mlであることから、コーティング配合物および被覆面積を設計して、長期の使用時間にわたって適切な有効性を維持することは容易である。これらの試験結果を図2に示す。
レオロジー調整剤を用いることなしに、粗大CHAの相分離時間に対する微細CHAの相分離時間の比較を実施した。2種の抗菌性コーティング懸濁物を調製した。メスシリンダー中のそれぞれの懸濁物100mLを、相分離に関して監視した。それぞれの懸濁物は、アクリレートをベースとするUV硬化可能なコーティング溶液中に10%(w/w)のCHAを含有した。17μmの平均粒度を有する粗大CHAを10%含む、比較対照懸濁物サンプルを提供した。同様に、6μmの平均粒度を有する微細CHA(Medichem, Spain)を10%含む、試験懸濁物サンプルを提供した。平均粒度は、画像をベースとするパーティクルカウンターによって測定される粒度分布から決定した。
Claims (19)
- オリゴマー、モノマーおよび光開始剤を含む粘着剤と、
6μm以上15μm未満の粒度を有する不溶性抗菌剤と
を含み、前記不溶性抗菌剤がクロルヘキシジン化合物、ポリマーに結合した抗菌性ペプチド、アルキルピリジニウムヨージド、ソルビン酸、アレキシジン二塩酸塩、オクテニジン二塩酸塩、リファンピシン、トリクロサンおよびそれらの組み合わせからなる群から選択されることを特徴とする抗菌性紫外(UV)硬化可能なコーティング組成物。 - 前記粒度が6μm以上10μm未満であることを特徴とする請求項1に記載の抗菌性UV硬化可能なコーティング組成物。
- 前記不溶性抗菌剤が、クロルヘキシジンジアセテートであることを特徴とする請求項1に記載の抗菌性UV硬化可能なコーティング組成物。
- 前記不溶性抗菌剤の濃度が、100質量部の前記抗菌性UV硬化可能なコーティング組成物中、0.5質量部から50質量部であることを特徴とする請求項1に記載の抗菌性UV硬化可能なコーティング組成物。
- 前記不溶性抗菌剤の濃度が、100質量部の前記抗菌性UV硬化可能なコーティング組成物中、2質量部から14質量部であることを特徴とする請求項1に記載の抗菌性UV硬化可能なコーティング組成物。
- 前記不溶性抗菌剤の濃度が、100質量部の前記抗菌性UV硬化可能なコーティング組成物中、8.9質量部未満であることを特徴とする請求項1に記載の抗菌性UV硬化可能なコーティング組成物。
- 5センチポアズから500センチポアズまでの粘度をさらに有することを特徴とする請求項1に記載の抗菌性UV硬化可能なコーティング組成物。
- 前記オリゴマーが、アクリル化された脂肪族ウレタン、アクリル化された芳香族ウレタン、アクリル化されたポリエステル、不飽和ポリエステル、アクリル化されたポリエーテルおよびアクリル化されたアクリル樹脂からなる群から選択されることを特徴とする請求項1に記載の抗菌性UV硬化可能なコーティング組成物。
- アクリル化された官能基は、単官能、二官能、三官能、四官能、五官能および六官能アクリレートからなる群から選択されることを特徴とする請求項8に記載の抗菌性UV硬化可能なコーティング組成物。
- 前記モノマーが、2−エチルヘキシルアクリレート、イソオクチルアクリレート、イソボルニルアクリレート、1,6−ヘキサンジオールジアクリレート、ジエチレングリコールジアクリレート、トリエチレングリコールジアクリレート、ペンタエリトリトールテトラアクリレート、ペンタエリトリトールトリアクリレート、ジメトキシフェニルアセトフェノンヘキシルメチルアクリレート、および1,6−ヘキサンジオールメタクリレートからなる群から選択されることを特徴とする請求項1に記載の抗菌性UV硬化可能なコーティング組成物。
- 前記光開始剤が、ベンゾインエーテル、アセトフェノン類、ベンゾイルオキシム、アシルホスフィンオキシド、およびミヒラーズケトン、チオキサントン、アントログイオノン、ベンゾフェノン、メチルジエタノールアミン、および2−N−ブトキシエチル−4−(ジメチルアミノ)ベンゾエートからなる群から選択されることを特徴とする請求項1に記載の抗菌性UV硬化可能なコーティング組成物。
- オリゴマー、モノマーおよび光開始剤を含む粘着剤と、
6μm以上15μm未満の粒度を有する不溶性抗菌剤と
を含み、前記不溶性抗菌剤は、アルデヒド、アニリド、ビグアニド、ビスフェノール、および第4級アンモニウム化合物からなる群から選択されることを特徴とする抗菌性UV硬化可能なコーティング組成物。 - UV硬化可能なコーティング組成物であって、
(a)粘着剤であって、
100質量部のUV硬化可能なコーティング組成物中、10質量部から90質量部までのオリゴマーであって、前記オリゴマーは、アクリル化された脂肪族ウレタン、アクリル化された芳香族ウレタン、アクリル化されたポリエステル、不飽和ポリエステル、アクリル化されたポリエーテル、およびアクリル化されたアクリル樹脂からなる群から選択されるオリゴマーと、
100質量部のUV硬化可能なコーティング組成物中、5質量部から90質量部までのモノマーであって、前記モノマーは、2−エチルヘキシルアクリレート、イソオクチルアクリレート、イソボルニルアクリレート、1,6−ヘキサンジオールジアクリレート、ジエチレングリコールジアクリレート、トリエチレングリコールジアクリレート、ペンタエリトリトールテトラアクリレート、ペンタエリトリトールトリアクリレート、ジメトキシフェニルアセトフェノンヘキシルメチルアクリレート、および1,6−ヘキサンジオールメタクリレートからなる群から選択されるモノマーと、
100質量部のUV硬化可能なコーティング組成物中、1質量部から10質量部までの光開始剤であって、前記光開始剤は、1種または複数種のベンゾインエーテル、アセトフェノン、ベンゾイルオキシム、アシルホスフィンオキシド、およびミヒラーズケトン、チオキサントン、アントログイオノン、ベンゾフェノン、メチルジエタノールアミン、および2−N−ブトキシエチル−4−(ジメチルアミノ)ベンゾエートからなる群から選択される光開始剤と
を有する粘着剤と、
(b)6μm以上15μm未満の粒度を有し、100質量部のUV硬化可能なコーティング組成物中0.5質量部から50質量部までの濃度で提供される不溶性抗菌剤であって、前記不溶性抗菌剤は、アルデヒド、アニリド、ビグアニド、ビスフェノール、および第4級アンモニウム化合物からなる群から選択される不溶性抗菌剤と
を含むことを特徴とするUV硬化可能なコーティング組成物。 - 前記粒度が6μm以上10μm未満であることを特徴とする請求項13に記載のUV硬化可能なコーティング組成物。
- 5センチポアズから500センチポアズまでの粘度をさらに有することを特徴とする請求項13に記載のUV硬化可能なコーティング組成物。
- オリゴマー、モノマー、および光開始剤を有するUV硬化可能な組成物と、
6μm以上15μm未満の粒度を有し、クロルヘキシジンジアセテート、ポリマーに結合した抗菌性ペプチド、アルキルピリジニウムヨージド、ソルビン酸、およびそれらの組み合わせからなる群から選択される不溶性抗菌剤と
を含むことを特徴とする抗菌性コーティング組成物。 - 前記不溶性抗菌剤が、クロルヘキシジンジアセテートであることを特徴とする請求項16に記載の抗菌性コーティング組成物。
- 前記粒度が6μm以上10μm未満であることを特徴とする請求項16に記載の抗菌性コーティング組成物。
- 5センチポアズから500センチポアズまでの粘度をさらに有することを特徴とする請求項16に記載の抗菌性コーティング組成物。
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