JP6336435B2 - 動物モデルおよび治療用分子 - Google Patents

動物モデルおよび治療用分子 Download PDF

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JP6336435B2
JP6336435B2 JP2015502439A JP2015502439A JP6336435B2 JP 6336435 B2 JP6336435 B2 JP 6336435B2 JP 2015502439 A JP2015502439 A JP 2015502439A JP 2015502439 A JP2015502439 A JP 2015502439A JP 6336435 B2 JP6336435 B2 JP 6336435B2
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human
mouse
endogenous
cell
light chain
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JP2015512634A (ja
JP2015512634A5 (OSRAM
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アラン・ブラッドリー
イー−チャン・リー
キ・リアン
ウェイ・ワン
ドミニク・スペンスベルガー
フイ・リウ
ジャスパー・クルブ
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カイマブ・リミテッド
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
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    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/00—Modified animals
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/35—Valency
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2015502439A 2012-03-28 2013-03-18 動物モデルおよび治療用分子 Active JP6336435B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13/433,084 US9445581B2 (en) 2012-03-28 2012-03-28 Animal models and therapeutic molecules
US13/433,084 2012-03-28
US13/434,361 US9253965B2 (en) 2012-03-28 2012-03-29 Animal models and therapeutic molecules
US13/434,361 2012-03-29
PCT/GB2013/050682 WO2013144566A2 (en) 2012-03-28 2013-03-18 Animal models and therapeutic molecules

Related Child Applications (1)

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JP2018088749A Division JP2018119012A (ja) 2012-03-28 2018-05-02 動物モデルおよび治療用分子

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JP2015512634A JP2015512634A (ja) 2015-04-30
JP2015512634A5 JP2015512634A5 (OSRAM) 2016-05-19
JP6336435B2 true JP6336435B2 (ja) 2018-06-06

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JP2018088749A Pending JP2018119012A (ja) 2012-03-28 2018-05-02 動物モデルおよび治療用分子
JP2020129123A Pending JP2020176140A (ja) 2012-03-28 2020-07-30 動物モデルおよび治療用分子
JP2022177513A Active JP7475415B2 (ja) 2012-03-28 2022-11-04 動物モデルおよび治療用分子

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JP2020129123A Pending JP2020176140A (ja) 2012-03-28 2020-07-30 動物モデルおよび治療用分子
JP2022177513A Active JP7475415B2 (ja) 2012-03-28 2022-11-04 動物モデルおよび治療用分子

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US (7) US9253965B2 (OSRAM)
EP (3) EP2785845A2 (OSRAM)
JP (4) JP6336435B2 (OSRAM)
CN (1) CN104334732B (OSRAM)
AU (1) AU2013239501B2 (OSRAM)
CA (1) CA2867530A1 (OSRAM)
DK (1) DK2831244T3 (OSRAM)
ES (1) ES2979344T3 (OSRAM)
IN (1) IN2014MN01879A (OSRAM)
NZ (1) NZ629202A (OSRAM)
SG (1) SG11201405058WA (OSRAM)
WO (2) WO2013061098A2 (OSRAM)

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