ATE503012T1 - Expression von xenogenen (humanen) immunglobulinen in klonierten, transgenen huftieren - Google Patents
Expression von xenogenen (humanen) immunglobulinen in klonierten, transgenen huftierenInfo
- Publication number
- ATE503012T1 ATE503012T1 AT08016978T AT08016978T ATE503012T1 AT E503012 T1 ATE503012 T1 AT E503012T1 AT 08016978 T AT08016978 T AT 08016978T AT 08016978 T AT08016978 T AT 08016978T AT E503012 T1 ATE503012 T1 AT E503012T1
- Authority
- AT
- Austria
- Prior art keywords
- expression
- transgenic
- antibodies
- ungarees
- immunlobulins
- Prior art date
Links
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 230000002779 inactivation Effects 0.000 abstract 3
- 241000283690 Bos taurus Species 0.000 abstract 2
- 210000004507 artificial chromosome Anatomy 0.000 abstract 1
- 238000012239 gene modification Methods 0.000 abstract 1
- 230000005017 genetic modification Effects 0.000 abstract 1
- 235000013617 genetically modified food Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0273—Cloned vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71418500A | 2000-11-17 | 2000-11-17 | |
US25645800P | 2000-12-20 | 2000-12-20 | |
US31162501P | 2001-08-09 | 2001-08-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE503012T1 true ATE503012T1 (de) | 2011-04-15 |
Family
ID=27400960
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08016978T ATE503012T1 (de) | 2000-11-17 | 2001-11-16 | Expression von xenogenen (humanen) immunglobulinen in klonierten, transgenen huftieren |
AT01273248T ATE432343T1 (de) | 2000-11-17 | 2001-11-16 | Expression xenogener (menschlicher) immunglobuline in geklonten, transgenen rindern |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01273248T ATE432343T1 (de) | 2000-11-17 | 2001-11-16 | Expression xenogener (menschlicher) immunglobuline in geklonten, transgenen rindern |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP1343880B1 (de) |
JP (2) | JP3797974B2 (de) |
KR (2) | KR100882029B1 (de) |
CN (1) | CN1486365B (de) |
AT (2) | ATE503012T1 (de) |
AU (2) | AU2001297523B2 (de) |
CA (1) | CA2428053C (de) |
DE (2) | DE60144305D1 (de) |
MX (1) | MXPA03004313A (de) |
NZ (1) | NZ525664A (de) |
WO (1) | WO2002070648A2 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
CN1668187A (zh) * | 2002-05-17 | 2005-09-14 | 赫马技术有限公司 | 能够产生人抗体的转基因有蹄动物 |
JPWO2004031385A1 (ja) | 2002-10-04 | 2006-02-02 | 麒麟麦酒株式会社 | ヒト人工染色体(hac)ベクター |
BR0315300A (pt) * | 2002-11-08 | 2005-08-30 | Hematech Llc | Ungulados transgênicos tendo atividade de proteìna priÈnica reduzida e seus usos |
EP1660537A2 (de) | 2003-08-14 | 2006-05-31 | Dyax Corp. | Endotheliase-2-liganden |
CA2540667A1 (en) * | 2003-09-30 | 2005-04-14 | Sterrenbeld Biotechnologie North America, Inc. | A process for producing exogenous protein in the milk of trangenic mammals and a process for purifying proteins therefrom |
US7420099B2 (en) * | 2004-04-22 | 2008-09-02 | Kirin Holdings Kabushiki Kaisha | Transgenic animals and uses thereof |
ES2679282T3 (es) * | 2004-10-22 | 2018-08-23 | Revivicor Inc. | Porcinos transgénicos que carecen de cadena ligera de inmunoglobulina endógena |
US20080026457A1 (en) | 2004-10-22 | 2008-01-31 | Kevin Wells | Ungulates with genetically modified immune systems |
US20090041783A1 (en) | 2005-04-28 | 2009-02-12 | Mochida Pharmaceutical Co., Ltd. | Anti-platelet membrane glycoprotein vi monoclonal antibody |
ES2548377T3 (es) | 2008-10-27 | 2015-10-16 | Revivicor, Inc. | Ungulados inmunodeprimidos |
CN112715482B (zh) * | 2008-12-18 | 2022-11-11 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
PL2564695T3 (pl) | 2009-07-08 | 2015-10-30 | Kymab Ltd | Modele zwierzęce i cząsteczki terapeutyczne |
CN102803488A (zh) | 2009-11-17 | 2012-11-28 | 协和发酵麒麟株式会社 | 人类人工染色体载体 |
CA2846322A1 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
IN2014CN02113A (de) | 2011-09-21 | 2015-05-29 | Fujirebio Kk | |
EP2761008A1 (de) | 2011-09-26 | 2014-08-06 | Kymab Limited | Chimäre surrogatleichtketten (slc) mit humanem vpreb |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
JP2015502165A (ja) | 2011-12-22 | 2015-01-22 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 発現ベクター構成、新規の産生細胞生成法、およびポリペプチドの組換え産生のためのそれらの使用 |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
EP2880055B1 (de) * | 2012-08-03 | 2017-06-28 | Sab, Llc | Komplexes chromosom-engineering zur produktion von menschlichen antikörpern in transgenen tieren |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
CA2925723A1 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
WO2016094679A1 (en) | 2014-12-10 | 2016-06-16 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
AU2017285224B2 (en) * | 2016-06-14 | 2023-05-18 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
AU2017348743C1 (en) | 2016-10-31 | 2022-03-03 | National University Corporation Tottori University | Human antibody–producing non-human animal and method for preparing human antibodies using same |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
EP0814159B1 (de) | 1990-08-29 | 2005-07-27 | GenPharm International, Inc. | Transgene Mäuse fähig zur Produktion heterologer Antikörper |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5789650A (en) * | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
JPH07509137A (ja) * | 1992-07-24 | 1995-10-12 | セル ジェネシス,インク. | 異種抗体の生産 |
JP4038236B2 (ja) | 1993-03-16 | 2008-01-23 | オースチン・リサーチ・インスティテュート | 異種移植治療におけるブタGa1α(1,3)ガラクトシルトランスフェラーゼの使用 |
CN1054840C (zh) | 1993-12-16 | 2000-07-26 | 普罗格特-甘布尔公司 | 制备磺化脂肪酸烷酯表面活性剂的方法 |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US5639940A (en) * | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
US5683993A (en) | 1995-06-22 | 1997-11-04 | Ciba Vision Corporation | Compositions and methods for stabilizing polymers |
JP3030092B2 (ja) | 1995-08-29 | 2000-04-10 | 麒麟麦酒株式会社 | キメラ動物およびその作製法 |
WO1997007671A1 (fr) | 1995-08-29 | 1997-03-06 | Kirin Beer Kabushiki Kaisha | Animal chimerique et procede de constitution |
EP0942968B1 (de) | 1996-12-03 | 2008-02-27 | Amgen Fremont Inc. | Vollkommen humane Antikörper die EGFR binden |
TWI255853B (en) | 1998-08-21 | 2006-06-01 | Kirin Brewery | Method for modifying chromosomes |
AU1777301A (en) * | 1999-11-19 | 2001-05-30 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
US6721750B1 (en) | 2001-07-03 | 2004-04-13 | Bellsouth Intellectual Property Corporation | System and method for broadband capacity tracking |
-
2001
- 2001-11-16 MX MXPA03004313A patent/MXPA03004313A/es not_active Application Discontinuation
- 2001-11-16 JP JP2002570676A patent/JP3797974B2/ja not_active Expired - Fee Related
- 2001-11-16 KR KR1020037006659A patent/KR100882029B1/ko active IP Right Grant
- 2001-11-16 DE DE60144305T patent/DE60144305D1/de not_active Expired - Lifetime
- 2001-11-16 CN CN018220762A patent/CN1486365B/zh not_active Expired - Lifetime
- 2001-11-16 AT AT08016978T patent/ATE503012T1/de not_active IP Right Cessation
- 2001-11-16 AT AT01273248T patent/ATE432343T1/de not_active IP Right Cessation
- 2001-11-16 EP EP01273248A patent/EP1343880B1/de not_active Expired - Lifetime
- 2001-11-16 EP EP08016978A patent/EP2042594B1/de not_active Expired - Lifetime
- 2001-11-16 DE DE60138832T patent/DE60138832D1/de not_active Expired - Lifetime
- 2001-11-16 AU AU2001297523A patent/AU2001297523B2/en not_active Expired
- 2001-11-16 NZ NZ525664A patent/NZ525664A/en not_active IP Right Cessation
- 2001-11-16 CA CA2428053A patent/CA2428053C/en not_active Expired - Lifetime
- 2001-11-16 KR KR1020077030804A patent/KR100882030B1/ko active IP Right Grant
- 2001-11-16 WO PCT/US2001/043128 patent/WO2002070648A2/en active Application Filing
-
2005
- 2005-05-09 JP JP2005136675A patent/JP2005224250A/ja active Pending
-
2007
- 2007-04-17 AU AU2007201700A patent/AU2007201700A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA03004313A (es) | 2007-02-27 |
WO2002070648A3 (en) | 2003-02-13 |
EP1343880A4 (de) | 2005-03-16 |
CA2428053A1 (en) | 2002-09-12 |
JP2005224250A (ja) | 2005-08-25 |
EP2042594A1 (de) | 2009-04-01 |
NZ525664A (en) | 2008-08-29 |
KR100882030B1 (ko) | 2009-02-09 |
EP1343880A2 (de) | 2003-09-17 |
CN1486365B (zh) | 2010-05-12 |
KR20080005616A (ko) | 2008-01-14 |
WO2002070648A2 (en) | 2002-09-12 |
KR20030059260A (ko) | 2003-07-07 |
CN1486365A (zh) | 2004-03-31 |
AU2001297523B2 (en) | 2007-01-18 |
EP1343880B1 (de) | 2009-05-27 |
AU2007201700A1 (en) | 2007-05-10 |
EP2042594B1 (de) | 2011-03-23 |
CA2428053C (en) | 2012-08-21 |
ATE432343T1 (de) | 2009-06-15 |
DE60138832D1 (de) | 2009-07-09 |
DE60144305D1 (de) | 2011-05-05 |
JP2005504507A (ja) | 2005-02-17 |
KR100882029B1 (ko) | 2009-02-09 |
JP3797974B2 (ja) | 2006-07-19 |
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