DE60138832D1 - Expression xenogener (menschlicher) immunglobuline in geklonten, transgenen rindern - Google Patents

Expression xenogener (menschlicher) immunglobuline in geklonten, transgenen rindern

Info

Publication number
DE60138832D1
DE60138832D1 DE60138832T DE60138832T DE60138832D1 DE 60138832 D1 DE60138832 D1 DE 60138832D1 DE 60138832 T DE60138832 T DE 60138832T DE 60138832 T DE60138832 T DE 60138832T DE 60138832 D1 DE60138832 D1 DE 60138832D1
Authority
DE
Germany
Prior art keywords
expression
antibodies
immunoglobuline
xenogenic
cloned
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60138832T
Other languages
English (en)
Inventor
James M Robl
Richard A Goldsby
Stacy E Ferguson
Yoshimi Kuroiwa
Kazuma Tomizuka
Isao Ishida
Barbara A Osborne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Co Ltd
Original Assignee
Kyowa Hakko Kirin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kirin Co Ltd filed Critical Kyowa Hakko Kirin Co Ltd
Application granted granted Critical
Publication of DE60138832D1 publication Critical patent/DE60138832D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0273—Cloned animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knockout animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
DE60138832T 2000-11-17 2001-11-16 Expression xenogener (menschlicher) immunglobuline in geklonten, transgenen rindern Expired - Lifetime DE60138832D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71418500A 2000-11-17 2000-11-17
US25645800P 2000-12-20 2000-12-20
US31162501P 2001-08-09 2001-08-09
PCT/US2001/043128 WO2002070648A2 (en) 2000-11-17 2001-11-16 Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates

Publications (1)

Publication Number Publication Date
DE60138832D1 true DE60138832D1 (de) 2009-07-09

Family

ID=27400960

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60144305T Expired - Lifetime DE60144305D1 (de) 2000-11-17 2001-11-16 Expression von xenogenen (humanen) Immunglobulinen in klonierten, transgenen Huftieren
DE60138832T Expired - Lifetime DE60138832D1 (de) 2000-11-17 2001-11-16 Expression xenogener (menschlicher) immunglobuline in geklonten, transgenen rindern

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60144305T Expired - Lifetime DE60144305D1 (de) 2000-11-17 2001-11-16 Expression von xenogenen (humanen) Immunglobulinen in klonierten, transgenen Huftieren

Country Status (11)

Country Link
EP (2) EP1343880B1 (de)
JP (2) JP3797974B2 (de)
KR (2) KR100882030B1 (de)
CN (1) CN1486365B (de)
AT (2) ATE432343T1 (de)
AU (2) AU2001297523B2 (de)
CA (1) CA2428053C (de)
DE (2) DE60144305D1 (de)
MX (1) MXPA03004313A (de)
NZ (1) NZ525664A (de)
WO (1) WO2002070648A2 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0110029D0 (en) 2001-04-24 2001-06-13 Grosveld Frank Transgenic animal
KR20050000558A (ko) * 2002-05-17 2005-01-05 헤마테크, 엘엘씨 인간 항체를 제조할 수 있는 트랜스제닉 유제동물
EP1559782B1 (de) * 2002-10-04 2016-12-21 Kyowa Hakko Kirin Co., Ltd. Hac-vektor (human artificial chromosome - künstliches menschliches chromosom)
NZ539459A (en) * 2002-11-08 2009-02-28 Kirin Pharma Kk Transgenic ungulates having reduced prion protein activity and uses thereof
JP2007528721A (ja) 2003-08-14 2007-10-18 ダイアックス コーポレイション エンドセリアーゼ−２リガンド
JP2007507510A (ja) * 2003-09-30 2007-03-29 スターンベルド バイオテクノロジー ノース アメリカ， インコーポレイテッド トランスジェニック哺乳動物の乳汁中に外因性タンパク質を産生するためのプロセスおよびそれからタンパク質を精製するためのプロセス
NZ550106A (en) 2004-04-22 2009-06-26 Kyowa Hakko Kirin Co Ltd Transgenic animals and uses thereof
US20080026457A1 (en) 2004-10-22 2008-01-31 Kevin Wells Ungulates with genetically modified immune systems
CA3079874C (en) * 2004-10-22 2023-01-03 Revivicor, Inc. Ungulates with genetically modified immune systems
WO2006117910A1 (ja) 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. 抗血小板膜糖蛋白質ⅵモノクローナル抗体
EP2348827B1 (de) 2008-10-27 2015-07-01 Revivicor, Inc. Immunsupprimierte huftiere
CN112680475A (zh) * 2008-12-18 2021-04-20 伊拉兹马斯大学鹿特丹医学中心 表达人源化抗体的非人转基因动物及其用途
US9445581B2 (en) 2012-03-28 2016-09-20 Kymab Limited Animal models and therapeutic molecules
US20120204278A1 (en) 2009-07-08 2012-08-09 Kymab Limited Animal models and therapeutic molecules
EP2564695B1 (de) 2009-07-08 2015-04-15 Kymab Limited Tiermodelle und therapeutische Moleküle
US20120233715A1 (en) 2009-11-17 2012-09-13 Kyowa Hakko Kirin Co., Ltd Human artificial chromosome vector
WO2013041844A2 (en) 2011-09-19 2013-03-28 Kymab Limited Antibodies, variable domains & chains tailored for human use
EP2759551B1 (de) 2011-09-21 2019-05-22 Fujirebio Inc. Antikörper die an einen affinitätskomplex binden der 25oh-vitamin d2 oder d3 und einen dagegen gerichteten antikörper enthält
WO2013045916A1 (en) 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
US9253965B2 (en) 2012-03-28 2016-02-09 Kymab Limited Animal models and therapeutic molecules
KR102280111B1 (ko) 2011-12-22 2021-07-21 에프. 호프만-라 로슈 아게 발현 벡터 구성, 신규한 생산 세포 생성 방법 및 폴리펩티드의 재조합 생산을 위한 그의 용도
US10251377B2 (en) 2012-03-28 2019-04-09 Kymab Limited Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
IN2015DN01700A (de) * 2012-08-03 2015-05-22 Sab Llc
US9788534B2 (en) 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
US9783618B2 (en) 2013-05-01 2017-10-10 Kymab Limited Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
US11707056B2 (en) 2013-05-02 2023-07-25 Kymab Limited Animals, repertoires and methods
US9783593B2 (en) 2013-05-02 2017-10-10 Kymab Limited Antibodies, variable domains and chains tailored for human use
DE112014004537T5 (de) 2013-10-01 2016-07-21 Kymab Limited Tiermodelle und therapeutische Moleküle
US9888673B2 (en) 2014-12-10 2018-02-13 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
KR20190017985A (ko) * 2016-06-14 2019-02-20 리전츠 오브 더 유니버스티 오브 미네소타 질환을 치료하기 위한 유전적으로 변형된 세포, 조직, 및 장기
US20190254264A1 (en) 2016-10-31 2019-08-22 National University Corporation Tottori University Human antibody-producing non-human animal and method for preparing human antibodies using same

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
ES2246502T3 (es) 1990-08-29 2006-02-16 Genpharm International, Inc. Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5789650A (en) * 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5625126A (en) * 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
ATE381614T1 (de) * 1992-07-24 2008-01-15 Amgen Fremont Inc Bildung von xenogenen antikörpern
EP1621627A3 (de) 1993-03-16 2006-06-07 The Austin Research Institute Verwendung von Schwein gal-g(a)(1,3) Galaktosyltransferase für xenogene Therapien
WO1995016670A1 (en) 1993-12-16 1995-06-22 The Procter & Gamble Company Process for making sulfonated fatty acid alkyl ester surfactant
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
US5639940A (en) * 1994-03-03 1997-06-17 Pharmaceutical Proteins Ltd. Production of fibrinogen in transgenic animals
ES2304786T3 (es) 1995-04-27 2008-10-16 Amgen Fremont Inc. Anticuerpos anti-il-8 humanos, derivados a partir de xenoratones inmunizados.
US5683993A (en) 1995-06-22 1997-11-04 Ciba Vision Corporation Compositions and methods for stabilizing polymers
AU718138B2 (en) 1995-08-29 2000-04-06 Kyowa Hakko Kirin Co., Ltd. Chimeric animal and method for constructing the same
JP3030092B2 (ja) 1995-08-29 2000-04-10 麒麟麦酒株式会社 キメラ動物およびその作製法
DK1500329T3 (da) 1996-12-03 2012-07-09 Amgen Fremont Inc Humane antistoffer, der specifikt binder TNF-alfa
TWI255853B (en) 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
AU1777301A (en) * 1999-11-19 2001-05-30 Hematech, Llc Production of ungulates, preferably bovines that produce human immunoglobulins
US6721750B1 (en) 2001-07-03 2004-04-13 Bellsouth Intellectual Property Corporation System and method for broadband capacity tracking

Also Published As

Publication number Publication date
JP2005504507A (ja) 2005-02-17
AU2001297523B2 (en) 2007-01-18
AU2007201700A1 (en) 2007-05-10
KR100882030B1 (ko) 2009-02-09
ATE503012T1 (de) 2011-04-15
KR20080005616A (ko) 2008-01-14
KR20030059260A (ko) 2003-07-07
KR100882029B1 (ko) 2009-02-09
ATE432343T1 (de) 2009-06-15
WO2002070648A3 (en) 2003-02-13
EP2042594B1 (de) 2011-03-23
EP2042594A1 (de) 2009-04-01
JP3797974B2 (ja) 2006-07-19
CA2428053A1 (en) 2002-09-12
JP2005224250A (ja) 2005-08-25
WO2002070648A2 (en) 2002-09-12
DE60144305D1 (de) 2011-05-05
EP1343880A2 (de) 2003-09-17
CN1486365B (zh) 2010-05-12
EP1343880B1 (de) 2009-05-27
NZ525664A (en) 2008-08-29
MXPA03004313A (es) 2007-02-27
CA2428053C (en) 2012-08-21
CN1486365A (zh) 2004-03-31
EP1343880A4 (de) 2005-03-16

Similar Documents

Publication Publication Date Title
DE60138832D1 (de) Expression xenogener (menschlicher) immunglobuline in geklonten, transgenen rindern
DK0854917T3 (da) Transgene ikke-humane dyr, som kan producere heterologe antistoffer
ATE378403T1 (de) Transchromosomale transgen-nagetiere zur herstellung von humänen antikörpern
DE60126249D1 (de) Heterologe expression von neisseria proteine
DK1212422T3 (da) Humane CTLA-4-antistoffer og anvendelserne deraf
CY1109149T1 (el) Anti-il-12 αντισωματα, συνθεσεις, μεθοδοι και χρησεις
ATE344323T1 (de) Transgene mäuse, die den menschliche immunoglobulinlambdalokus exprimieren
DE60040012D1 (de) Rekombinantes gelatin in impstoffen
NI200200128A (es) "anticuerpos para cd40"
DK1492869T3 (da) Transplantataccept-inducerende celler af monocytisk oprindelse, deres fremstilling og anvendelse
HK1089480A1 (en) Human artificial chromosome containing human antibody lambda light chain and non-human animal containing the human artificial chromosome capable of genetic transmission
EA200300464A1 (ru) ГУМАНИЗИРОВАННОЕ АНТИТЕЛО ПРОТИВ РЕЦЕПТОРА ЛИМФОТОКСИНА-β (ВАРИАНТЫ), КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ИЛИ СНИЖЕНИЯ РИСКА РАЗВИТИЯ, ТЯЖЕСТИ ИЛИ ПОСЛЕДСТВИЙ НЕОПЛАЗИИ У ЧЕЛОВЕКА, ВЫДЕЛЕННАЯ НУКЛЕИНОВАЯ КИСЛОТА (ВАРИАНТЫ), КЛЕТКА КЛЕТОЧНОЙ ЛИНИИ
ATE400289T1 (de) Verwendung vom vaskulären endothelialen wachstumsfaktor 2 (vegf-2)
DE60116115D1 (de) Nacht-leuchtende Wegwerfwindel
IL165088A0 (en) Transgenic ungulates capable of human antibody production
DE60023451D1 (de) Aus nicht-menschlichen transgenen tieren gewonnene menschliche polyklonale antikörper
DK1274464T3 (da) Sammensætninger og fremgangsmåder til regulering af proteinekspression i tarm
BR0014527A (pt) Proteìnas de fusão produzidas transgenicamente
DE60037397D1 (de) Expression von ausgeschiedenem, menschlichem alpha-fetoprotein in transgenen tieren
DE60121324D1 (de) Tiermodel für neurodegenerative erkrankungen
DE69842239D1 (de) Zusammenfuegung von prokollagen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition