CN1486365A - 异种(人类)免疫球蛋白在克隆转基因有蹄类动物中的表达 - Google Patents
异种(人类)免疫球蛋白在克隆转基因有蹄类动物中的表达 Download PDFInfo
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
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Abstract
Description
克隆ID | 转移受体编号 | 40天时妊娠(%) |
8-1-OC | 5 | 4(80) |
10-1-C | 6 | 4(67) |
5-3-C | 5 | 3(60) |
总计 | 16 | 11(69) |
HAC | 细胞克隆 | 受体/胎儿编号 | NT日期 | 回收日期 | 胎儿年龄 | HAC保留H L | |
ΔΔ | 4-12 | 5580 | 2/14 | 4/13 | 58 | + | + |
ΔΔ | 2-14 | 5848 | 2/15 | 4/13 | 57 | - | - |
ΔΔ | 4-12 | 5868A | 2/14 | 6/13 | 119 | + | + |
ΔΔ | 4-12 | 5868B | 2/14 | 6/13 | 119 | + | + |
ΔΔ | 4-12 | 5542A | 2/14 | 5/16 | 91 | + | + |
ΔΔ | 4-12 | 5542B | 2/14 | 5/16 | 91 | + | + |
ΔΔ | 4-12 | 5174 | 2/14 | 5/16 | 91(异常) | nd | nd |
ΔΔ | 4-12 | 6097 | 2/14 | 遗体 | 160(7/24) | nd | nd |
Δ | 4-8 | 6032 | 1/31 | 3/30 | 58 | + | + |
Δ | 2-13 | 5983 | 2/2 | 3/30 | 56 | - | - |
Δ | 4-2 | 5968 | 2/2 | 3/30 | 56 | + | + |
Δ | 2-22 | 6045 | 2/2 | 3/30 | 56 | + | + |
Δ | 4-8 | 5846 | 1/31 | 4/20 | 79 | - | - |
Δ | 2-13 | 6053 | 2/2 | 4/27 | 84 | + | - |
Δ | 4-2 | 5996 | 2/1 | 4/20 | 77 | + | - |
克隆ID | 转移受体编号 | 40天时妊娠(%) |
2-1 | 08 | 03(38) |
4-2 | 10 | 00(00) |
4-1 | 05 | 00(00) |
4-1 | 03 | 01(33) |
2-1 | 02 | 01(50) |
总计 | 28 | 05(18) |
Claims (158)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71418500A | 2000-11-17 | 2000-11-17 | |
US09/714,185 | 2000-11-17 | ||
US25645800P | 2000-12-20 | 2000-12-20 | |
US60/256,458 | 2000-12-20 | ||
US31162501P | 2001-08-09 | 2001-08-09 | |
US60/311,625 | 2001-08-09 | ||
PCT/US2001/043128 WO2002070648A2 (en) | 2000-11-17 | 2001-11-16 | Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1486365A true CN1486365A (zh) | 2004-03-31 |
CN1486365B CN1486365B (zh) | 2010-05-12 |
Family
ID=27400960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN018220762A Expired - Lifetime CN1486365B (zh) | 2000-11-17 | 2001-11-16 | 异种(人类)免疫球蛋白在克隆转基因有蹄类动物中的表达 |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP2042594B1 (zh) |
JP (2) | JP3797974B2 (zh) |
KR (2) | KR100882029B1 (zh) |
CN (1) | CN1486365B (zh) |
AT (2) | ATE432343T1 (zh) |
AU (2) | AU2001297523B2 (zh) |
CA (1) | CA2428053C (zh) |
DE (2) | DE60138832D1 (zh) |
MX (1) | MXPA03004313A (zh) |
NZ (1) | NZ525664A (zh) |
WO (1) | WO2002070648A2 (zh) |
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CN109640645A (zh) * | 2016-06-14 | 2019-04-16 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
CN112715482A (zh) * | 2008-12-18 | 2021-04-30 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
US10993419B2 (en) | 2014-12-10 | 2021-05-04 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
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GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
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US20060185025A1 (en) | 2002-10-04 | 2006-08-17 | Kirin Beer Kabushiki Kaisha | Human artificial chromosome (hac) vector |
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JP2007533328A (ja) * | 2004-04-22 | 2007-11-22 | キリンホールディングス株式会社 | トランスジェニック動物及びその用途 |
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US20090041783A1 (en) | 2005-04-28 | 2009-02-12 | Mochida Pharmaceutical Co., Ltd. | Anti-platelet membrane glycoprotein vi monoclonal antibody |
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-
2001
- 2001-11-16 KR KR1020037006659A patent/KR100882029B1/ko active IP Right Grant
- 2001-11-16 WO PCT/US2001/043128 patent/WO2002070648A2/en active Application Filing
- 2001-11-16 KR KR1020077030804A patent/KR100882030B1/ko active IP Right Grant
- 2001-11-16 AT AT01273248T patent/ATE432343T1/de not_active IP Right Cessation
- 2001-11-16 NZ NZ525664A patent/NZ525664A/en not_active IP Right Cessation
- 2001-11-16 AU AU2001297523A patent/AU2001297523B2/en not_active Expired
- 2001-11-16 EP EP08016978A patent/EP2042594B1/en not_active Expired - Lifetime
- 2001-11-16 DE DE60138832T patent/DE60138832D1/de not_active Expired - Lifetime
- 2001-11-16 EP EP01273248A patent/EP1343880B1/en not_active Expired - Lifetime
- 2001-11-16 AT AT08016978T patent/ATE503012T1/de not_active IP Right Cessation
- 2001-11-16 DE DE60144305T patent/DE60144305D1/de not_active Expired - Lifetime
- 2001-11-16 JP JP2002570676A patent/JP3797974B2/ja not_active Expired - Fee Related
- 2001-11-16 CA CA2428053A patent/CA2428053C/en not_active Expired - Lifetime
- 2001-11-16 MX MXPA03004313A patent/MXPA03004313A/es not_active Application Discontinuation
- 2001-11-16 CN CN018220762A patent/CN1486365B/zh not_active Expired - Lifetime
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- 2005-05-09 JP JP2005136675A patent/JP2005224250A/ja active Pending
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Cited By (5)
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CN112715482A (zh) * | 2008-12-18 | 2021-04-30 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
CN107881196A (zh) * | 2011-12-22 | 2018-04-06 | 弗·哈夫曼-拉罗切有限公司 | 表达载体组织、新的生产用细胞产生方法及其在重组产生多肽中的用途 |
US10993419B2 (en) | 2014-12-10 | 2021-05-04 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
CN109640645A (zh) * | 2016-06-14 | 2019-04-16 | 明尼苏达大学董事会 | 用于治疗疾病的遗传修饰的细胞、组织和器官 |
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Also Published As
Publication number | Publication date |
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NZ525664A (en) | 2008-08-29 |
EP1343880B1 (en) | 2009-05-27 |
EP2042594B1 (en) | 2011-03-23 |
AU2007201700A1 (en) | 2007-05-10 |
WO2002070648A3 (en) | 2003-02-13 |
JP3797974B2 (ja) | 2006-07-19 |
CA2428053C (en) | 2012-08-21 |
KR20030059260A (ko) | 2003-07-07 |
DE60144305D1 (de) | 2011-05-05 |
EP1343880A4 (en) | 2005-03-16 |
CN1486365B (zh) | 2010-05-12 |
EP1343880A2 (en) | 2003-09-17 |
WO2002070648A2 (en) | 2002-09-12 |
ATE503012T1 (de) | 2011-04-15 |
CA2428053A1 (en) | 2002-09-12 |
ATE432343T1 (de) | 2009-06-15 |
EP2042594A1 (en) | 2009-04-01 |
AU2001297523B2 (en) | 2007-01-18 |
DE60138832D1 (de) | 2009-07-09 |
JP2005504507A (ja) | 2005-02-17 |
KR100882029B1 (ko) | 2009-02-09 |
KR100882030B1 (ko) | 2009-02-09 |
JP2005224250A (ja) | 2005-08-25 |
KR20080005616A (ko) | 2008-01-14 |
MXPA03004313A (es) | 2007-02-27 |
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