DE60121324D1 - Tiermodel für neurodegenerative erkrankungen - Google Patents

Tiermodel für neurodegenerative erkrankungen

Info

Publication number
DE60121324D1
DE60121324D1 DE60121324T DE60121324T DE60121324D1 DE 60121324 D1 DE60121324 D1 DE 60121324D1 DE 60121324 T DE60121324 T DE 60121324T DE 60121324 T DE60121324 T DE 60121324T DE 60121324 D1 DE60121324 D1 DE 60121324D1
Authority
DE
Germany
Prior art keywords
animal model
neurodegenerative diseases
model
3beta
gsk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60121324T
Other languages
English (en)
Other versions
DE60121324T2 (de
Inventor
Felix Hernandez Perez
Grado Jesus Avila De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Autonoma de Madrid
Original Assignee
Consejo Superior de Investigaciones Cientificas CSIC
Universidad Autonoma de Madrid
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior de Investigaciones Cientificas CSIC, Universidad Autonoma de Madrid filed Critical Consejo Superior de Investigaciones Cientificas CSIC
Publication of DE60121324D1 publication Critical patent/DE60121324D1/de
Application granted granted Critical
Publication of DE60121324T2 publication Critical patent/DE60121324T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Catching Or Destruction (AREA)
  • Housing For Livestock And Birds (AREA)
  • Toys (AREA)
  • Endoscopes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
DE60121324T 2000-05-18 2001-05-18 Tiermodel für neurodegenerative erkrankungen Expired - Lifetime DE60121324T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0012056.8A GB0012056D0 (en) 2000-05-18 2000-05-18 Model for neurodegenerative disease
GB0012056 2000-05-18
PCT/GB2001/002218 WO2001088109A2 (en) 2000-05-18 2001-05-18 Model for neurodegenerative disease

Publications (2)

Publication Number Publication Date
DE60121324D1 true DE60121324D1 (de) 2006-08-17
DE60121324T2 DE60121324T2 (de) 2007-07-05

Family

ID=9891881

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60121324T Expired - Lifetime DE60121324T2 (de) 2000-05-18 2001-05-18 Tiermodel für neurodegenerative erkrankungen

Country Status (17)

Country Link
US (1) US7265259B2 (de)
EP (1) EP1280404B1 (de)
JP (2) JP2003533227A (de)
KR (1) KR100764889B1 (de)
CN (1) CN100352927C (de)
AT (1) ATE332078T1 (de)
AU (2) AU2001262482B2 (de)
CA (1) CA2409075A1 (de)
CY (1) CY1105641T1 (de)
DE (1) DE60121324T2 (de)
DK (1) DK1280404T3 (de)
ES (1) ES2267773T3 (de)
GB (1) GB0012056D0 (de)
IL (2) IL152844A0 (de)
MX (1) MXPA02011391A (de)
PT (1) PT1280404E (de)
WO (1) WO2001088109A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2294931C2 (ru) * 2000-05-11 2007-03-10 Консехо Супериор Инвестигасионес Сьентификас Гетероциклические ингибиторы гликоген-синтазы киназы gsk-3
KR101040757B1 (ko) * 2008-04-11 2011-06-10 임재주 안전모
EP3224380A1 (de) 2014-11-25 2017-10-04 The Broad Institute Inc. Klonale hämatopoese
US11168369B2 (en) 2014-11-25 2021-11-09 The Brigham And Women's Hospital, Inc. Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2923279B1 (de) * 1979-06-08 1980-11-20 Kali Chemie Pharma Gmbh Verfahren zur Herstellung von Pankreatin-Pellets
GB9316727D0 (en) * 1993-08-12 1993-09-29 Inst Of Psychiatry Models of alzheimers's disease
AU718473B2 (en) * 1996-07-24 2000-04-13 Novartis Ag Transgenic animal model for alzheimer disease
NZ515956A (en) * 1999-07-02 2004-04-30 Janssen Pharmaceutica Nv Transgenic animals as models for neurodegenerative disease

Also Published As

Publication number Publication date
PT1280404E (pt) 2006-11-30
EP1280404A2 (de) 2003-02-05
MXPA02011391A (es) 2004-08-12
CN100352927C (zh) 2007-12-05
JP2003533227A (ja) 2003-11-11
US7265259B2 (en) 2007-09-04
WO2001088109A8 (en) 2002-09-26
AU2001262482B2 (en) 2006-06-08
CY1105641T1 (el) 2010-12-22
AU6248201A (en) 2001-11-26
IL152844A (en) 2008-11-26
DK1280404T3 (da) 2006-10-30
KR20030027892A (ko) 2003-04-07
ATE332078T1 (de) 2006-07-15
EP1280404B1 (de) 2006-07-05
US20030177510A1 (en) 2003-09-18
IL152844A0 (en) 2003-06-24
ES2267773T3 (es) 2007-03-16
WO2001088109A2 (en) 2001-11-22
GB0012056D0 (en) 2000-07-12
KR100764889B1 (ko) 2007-10-09
DE60121324T2 (de) 2007-07-05
JP2012085653A (ja) 2012-05-10
CN1443038A (zh) 2003-09-17
WO2001088109A3 (en) 2002-07-04
CA2409075A1 (en) 2001-11-22

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Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: PEREZ, FELIX HERNANDEZ, E-28006 MADRID, ES

Inventor name: DE GRADO, JESUS AVILA, E-28006 MADRID, ES

Inventor name: LOZANO, JOSE JAVIER LUCAS, MADRID, ES

8381 Inventor (new situation)

Inventor name: PEREZ, FELIX HERNANDEZ, E-28006 MADRID, ES

Inventor name: DE GRADO, JESUS AVILA, E-28006 MADRID, ES

Inventor name: LOZANO, JOSE JAVIER LUCAS, MADRID, ES

8364 No opposition during term of opposition