ATE511348T1 - Transgenes modell für morbus alzheimer - Google Patents
Transgenes modell für morbus alzheimerInfo
- Publication number
- ATE511348T1 ATE511348T1 AT05722229T AT05722229T ATE511348T1 AT E511348 T1 ATE511348 T1 AT E511348T1 AT 05722229 T AT05722229 T AT 05722229T AT 05722229 T AT05722229 T AT 05722229T AT E511348 T1 ATE511348 T1 AT E511348T1
- Authority
- AT
- Austria
- Prior art keywords
- alzheimer
- disease
- transgene
- transgenic
- transgenic model
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 5
- 238000012301 transgenic model Methods 0.000 title 1
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 abstract 2
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 abstract 2
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 abstract 2
- 108700019146 Transgenes Proteins 0.000 abstract 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 230000009261 transgenic effect Effects 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000008506 pathogenesis Effects 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Eye Examination Apparatus (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400707A SE0400707D0 (sv) | 2004-03-22 | 2004-03-22 | Transgenic animal model |
| PCT/SE2005/000383 WO2005089539A1 (en) | 2004-03-22 | 2005-03-17 | Transgenic model for alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE511348T1 true ATE511348T1 (de) | 2011-06-15 |
Family
ID=32067463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05722229T ATE511348T1 (de) | 2004-03-22 | 2005-03-17 | Transgenes modell für morbus alzheimer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7709695B1 (de) |
| EP (1) | EP1729569B1 (de) |
| JP (1) | JP4914343B2 (de) |
| AT (1) | ATE511348T1 (de) |
| AU (1) | AU2005224992B2 (de) |
| CA (1) | CA2560551A1 (de) |
| DK (1) | DK1729569T3 (de) |
| ES (1) | ES2367310T3 (de) |
| SE (1) | SE0400707D0 (de) |
| WO (1) | WO2005089539A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001268005A1 (en) | 2000-07-07 | 2002-01-21 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| BRPI0709050B1 (pt) | 2006-03-23 | 2018-12-26 | Bioarctic Neuroscience Ab | anticorpo ou fragmento do mesmo, composição, métodos para detectar protofibrilas ab in vitro, e, uso do anticorpo |
| CN102065881B (zh) | 2008-04-14 | 2014-03-12 | 埃尔奇诺瓦公司 | 稳定的淀粉样beta单体和寡聚体 |
| KR101634244B1 (ko) * | 2014-06-19 | 2016-06-29 | 한경대학교 산학협력단 | Talen을 이용하여 grk5 넉아웃 마우스를 제조하는 방법 |
| SI3166970T1 (sl) | 2014-07-10 | 2021-09-30 | Bioarctic Ab | Izboljšana A-beta protofibril vezavna protitelesa |
| WO2016085876A1 (en) | 2014-11-25 | 2016-06-02 | The Broad Institute Inc. | Clonal haematopoiesis |
| EP3626832B1 (de) | 2014-11-25 | 2024-06-12 | The Brigham and Women's Hospital, Inc. | Verfahren zur identifizierung einer person mit einer prädisposition für eine kardiometabolische krankheit oder eine davon betroffene person |
| CN114269925A (zh) * | 2020-02-28 | 2022-04-01 | 尔知渃米斯股份有限公司 | Apoe4 rna特异性反式剪接核酶及其用途 |
| CN113957095A (zh) * | 2021-10-22 | 2022-01-21 | 江苏集萃药康生物科技股份有限公司 | 一种用于构建阿尔兹海默症动物模型的构建方法及其核酸组合物和应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0620849T3 (da) | 1992-01-07 | 2003-10-20 | Elan Pharm Inc | Transgene dyremodeller for Alzheimer's sygdom |
| US5604102A (en) | 1992-04-15 | 1997-02-18 | Athena Neurosciences, Inc. | Methods of screening for β-amyloid peptide production inhibitors |
| US5455169A (en) | 1992-06-04 | 1995-10-03 | Alzheimer's Institute Of America, Inc. | Nucleic acids for diagnosing and modeling Alzheimer's disease |
| US5449604A (en) | 1992-10-21 | 1995-09-12 | University Of Washington | Chromosome 14 and familial Alzheimers disease genetic markers and assays |
| DE69426571T2 (de) | 1993-10-27 | 2001-08-09 | Elan Pharm Inc | TRANSGENE TIERE, DIE APP Allele mit der schwedischen Mutation beherbergen |
| US5877399A (en) | 1994-01-27 | 1999-03-02 | Johns Hopkins University | Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease |
| JPH07238035A (ja) * | 1994-02-28 | 1995-09-12 | Kyowa Hakko Kogyo Co Ltd | βアミロイド蛋白質分解剤 |
| US5777194A (en) | 1995-04-26 | 1998-07-07 | Cephalon, Inc. | Gene-targeted mice with humanized Aβ sequence and Swedish FAD mutation |
| US5986054A (en) | 1995-04-28 | 1999-11-16 | The Hospital For Sick Children, Hsc Research And Development Limited Partnership | Genetic sequences and proteins related to alzheimer's disease |
| US6717031B2 (en) | 1995-06-07 | 2004-04-06 | Kate Dora Games | Method for selecting a transgenic mouse model of alzheimer's disease |
| ES2307300T3 (es) | 1996-07-24 | 2008-11-16 | Novartis Ag | Modelo animal transgenico para la enfermedad de alzheimer. |
| US5898094A (en) | 1996-10-21 | 1999-04-27 | University Of South Florida | Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes |
| US20030131364A1 (en) | 1999-04-27 | 2003-07-10 | Karen Duff | Method for producing transgenic animal models with modulated phenotype and animals produced therefrom |
| AU2001268005A1 (en) | 2000-07-07 | 2002-01-21 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| US7196163B2 (en) * | 2001-05-22 | 2007-03-27 | Merk & Co., Inc. | Assays using amyloid precursor proteins with modified β-secretase cleavage sites to monitor β-secretase activity |
| WO2002102412A2 (en) * | 2001-06-18 | 2002-12-27 | Mcgill University | Selective inhibition of intracellular amyloid-beta neurotoxicity in human neurons |
| AU2003285151A1 (en) * | 2002-11-04 | 2004-06-07 | Bioarctic Neuroscience Ab | Methods for the identification of agents that modulate the structure and processing of beta-amyloid precursor protein |
| US20040255341A1 (en) * | 2003-10-21 | 2004-12-16 | Envivo Pharmaceuticals, Inc. | Transgenic flies expressing Abeta42-Arctic |
-
2004
- 2004-03-22 SE SE0400707A patent/SE0400707D0/xx unknown
-
2005
- 2005-03-17 ES ES05722229T patent/ES2367310T3/es not_active Expired - Lifetime
- 2005-03-17 EP EP05722229A patent/EP1729569B1/de not_active Expired - Lifetime
- 2005-03-17 JP JP2007504909A patent/JP4914343B2/ja not_active Expired - Fee Related
- 2005-03-17 CA CA002560551A patent/CA2560551A1/en not_active Abandoned
- 2005-03-17 AT AT05722229T patent/ATE511348T1/de active
- 2005-03-17 US US10/593,639 patent/US7709695B1/en not_active Expired - Fee Related
- 2005-03-17 AU AU2005224992A patent/AU2005224992B2/en not_active Ceased
- 2005-03-17 WO PCT/SE2005/000383 patent/WO2005089539A1/en not_active Ceased
- 2005-03-17 DK DK05722229.1T patent/DK1729569T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1729569B1 (de) | 2011-06-01 |
| JP2007530035A (ja) | 2007-11-01 |
| AU2005224992B2 (en) | 2010-05-06 |
| WO2005089539A1 (en) | 2005-09-29 |
| AU2005224992A1 (en) | 2005-09-29 |
| ES2367310T3 (es) | 2011-11-02 |
| CA2560551A1 (en) | 2005-09-29 |
| DK1729569T3 (da) | 2011-09-19 |
| EP1729569A1 (de) | 2006-12-13 |
| US7709695B1 (en) | 2010-05-04 |
| JP4914343B2 (ja) | 2012-04-11 |
| SE0400707D0 (sv) | 2004-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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