JP6324315B2 - グルココルチコイド受容体の活性を示すグルカゴンスーパーファミリーのペプチド - Google Patents
グルココルチコイド受容体の活性を示すグルカゴンスーパーファミリーのペプチド Download PDFInfo
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- JP6324315B2 JP6324315B2 JP2014542489A JP2014542489A JP6324315B2 JP 6324315 B2 JP6324315 B2 JP 6324315B2 JP 2014542489 A JP2014542489 A JP 2014542489A JP 2014542489 A JP2014542489 A JP 2014542489A JP 6324315 B2 JP6324315 B2 JP 6324315B2
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- Prior art keywords
- glucagon
- amino acid
- glp
- peptide
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
Landscapes
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- Obesity (AREA)
- Endocrinology (AREA)
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Applications Claiming Priority (3)
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| PCT/US2012/065492 WO2013074910A1 (en) | 2011-11-17 | 2012-11-16 | Glucagon superfamily peptides exhibiting glucocorticoid receptor activity |
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-
2012
- 2012-11-16 JP JP2014542489A patent/JP6324315B2/ja active Active
- 2012-11-16 CN CN201280049164.2A patent/CN103957927B/zh not_active Expired - Fee Related
- 2012-11-16 RU RU2014117678/04A patent/RU2014117678A/ru not_active Application Discontinuation
- 2012-11-16 WO PCT/US2012/065492 patent/WO2013074910A1/en not_active Ceased
- 2012-11-16 HK HK14112265.7A patent/HK1198810A1/xx unknown
- 2012-11-16 BR BR112014007124A patent/BR112014007124A2/pt unknown
- 2012-11-16 EP EP12849285.7A patent/EP2780031B1/en not_active Not-in-force
- 2012-11-16 KR KR20147012192A patent/KR20140097151A/ko not_active Withdrawn
- 2012-11-16 ES ES12849285.7T patent/ES2672880T3/es active Active
- 2012-11-16 MX MX2014003579A patent/MX2014003579A/es unknown
- 2012-11-16 US US13/679,121 patent/US8859491B2/en not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| MX2014003579A (es) | 2015-04-10 |
| BR112014007124A2 (pt) | 2017-06-13 |
| CN103957927B (zh) | 2016-11-09 |
| EP2780031A1 (en) | 2014-09-24 |
| JP2015504431A (ja) | 2015-02-12 |
| EP2780031A4 (en) | 2015-08-05 |
| US20130157934A1 (en) | 2013-06-20 |
| ES2672880T3 (es) | 2018-06-18 |
| WO2013074910A1 (en) | 2013-05-23 |
| RU2014117678A (ru) | 2015-12-27 |
| CA2847246A1 (en) | 2013-05-23 |
| HK1198810A1 (en) | 2015-06-12 |
| KR20140097151A (ko) | 2014-08-06 |
| EP2780031B1 (en) | 2018-03-07 |
| CN103957927A (zh) | 2014-07-30 |
| US8859491B2 (en) | 2014-10-14 |
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