JP6300042B2 - 癌の処置に使用するための化合物の製造方法 - Google Patents

癌の処置に使用するための化合物の製造方法 Download PDF

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Publication number
JP6300042B2
JP6300042B2 JP2015536988A JP2015536988A JP6300042B2 JP 6300042 B2 JP6300042 B2 JP 6300042B2 JP 2015536988 A JP2015536988 A JP 2015536988A JP 2015536988 A JP2015536988 A JP 2015536988A JP 6300042 B2 JP6300042 B2 JP 6300042B2
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compound
formula
group
preparation
alkyl
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Japanese (ja)
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JP2015533175A (ja
Inventor
スリラム ナガナサン，
スリラム ナガナサン，
ネイサン グズ，
ネイサン グズ，
マシュー ファイファー，
マシュー ファイファー，
シー． グレゴリー ソウェル，
シー． グレゴリー ソウェル，
トレイシー ボスティック，
トレイシー ボスティック，
ジェイソン ヤン，
ジェイソン ヤン，
アミット スリバスタバ，
アミット スリバスタバ，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2015536988A 2012-10-12 2013-10-14 癌の処置に使用するための化合物の製造方法 Active JP6300042B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261713104P 2012-10-12 2012-10-12
US61/713,104 2012-10-12
PCT/US2013/064866 WO2014059422A1 (en) 2012-10-12 2013-10-14 Novel process for making compounds for use in the treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017234208A Division JP2018052973A (ja) 2012-10-12 2017-12-06 癌の処置に使用するための化合物の製造方法

Publications (2)

Publication Number Publication Date
JP2015533175A JP2015533175A (ja) 2015-11-19
JP6300042B2 true JP6300042B2 (ja) 2018-03-28

Family

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JP2015536988A Active JP6300042B2 (ja) 2012-10-12 2013-10-14 癌の処置に使用するための化合物の製造方法
JP2017234208A Withdrawn JP2018052973A (ja) 2012-10-12 2017-12-06 癌の処置に使用するための化合物の製造方法

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JP2017234208A Withdrawn JP2018052973A (ja) 2012-10-12 2017-12-06 癌の処置に使用するための化合物の製造方法

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US (4) US9771347B2 (enExample)
EP (1) EP2909188B1 (enExample)
JP (2) JP6300042B2 (enExample)
KR (1) KR102204520B1 (enExample)
CN (2) CN108948043B (enExample)
AU (1) AU2013328929B2 (enExample)
BR (1) BR112015008113B1 (enExample)
CA (1) CA2889466C (enExample)
CL (1) CL2015000926A1 (enExample)
CR (2) CR20200237A (enExample)
EA (1) EA030613B1 (enExample)
ES (1) ES2671502T3 (enExample)
GE (1) GEP201706690B (enExample)
HK (1) HK1213567A1 (enExample)
HR (1) HRP20180670T1 (enExample)
IL (1) IL238116B (enExample)
IN (1) IN2015DN03928A (enExample)
MA (1) MA38085B1 (enExample)
MX (2) MX372708B (enExample)
MY (1) MY186549A (enExample)
NZ (1) NZ706723A (enExample)
PE (3) PE20151494A1 (enExample)
PH (1) PH12015500785B1 (enExample)
PL (1) PL2909188T3 (enExample)
SA (1) SA515360271B1 (enExample)
SG (1) SG11201502795VA (enExample)
SI (1) SI2909188T1 (enExample)
TR (1) TR201807861T4 (enExample)
UA (1) UA115455C2 (enExample)
WO (1) WO2014059422A1 (enExample)
ZA (1) ZA201502349B (enExample)

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CN105330643B (zh) * 2015-12-09 2017-12-05 苏州明锐医药科技有限公司 卡比替尼的制备方法
CN106045969B (zh) * 2016-05-27 2019-04-12 湖南欧亚药业有限公司 一种卡比替尼的合成方法
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WO2020187674A1 (en) 2019-03-15 2020-09-24 Sandoz Ag Crystalline (s)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl][3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl]methanone hemisuccinate
KR20230156731A (ko) 2021-03-09 2023-11-14 제넨테크, 인크. 뇌암 치료에 이용하기 위한 벨바라페닙
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Publication number Publication date
US20200392104A1 (en) 2020-12-17
MX2020005533A (es) 2020-10-12
CR20200237A (es) 2020-07-26
US9771347B2 (en) 2017-09-26
CA2889466C (en) 2021-09-14
CN108948043A (zh) 2018-12-07
EP2909188B1 (en) 2018-03-07
US11414396B2 (en) 2022-08-16
BR112015008113B1 (pt) 2022-05-24
MY186549A (en) 2021-07-26
SI2909188T1 (en) 2018-07-31
SA515360271B1 (ar) 2016-05-19
US10793541B2 (en) 2020-10-06
GEP201706690B (en) 2017-06-26
ES2671502T3 (es) 2018-06-06
CA2889466A1 (en) 2014-04-17
MX372708B (es) 2020-05-29
PH12015500785A1 (en) 2015-06-15
IL238116B (en) 2018-06-28
IN2015DN03928A (enExample) 2015-10-02
US20150210668A1 (en) 2015-07-30
MX2015004660A (es) 2015-08-07
KR102204520B1 (ko) 2021-01-20
MA38085A1 (fr) 2018-08-31
JP2015533175A (ja) 2015-11-19
SG11201502795VA (en) 2015-05-28
HK1213567A1 (zh) 2016-07-08
EP2909188A1 (en) 2015-08-26
AU2013328929A1 (en) 2015-04-30
MA38085B1 (fr) 2018-11-30
US20190185447A1 (en) 2019-06-20
HRP20180670T1 (hr) 2018-07-13
KR20150067339A (ko) 2015-06-17
JP2018052973A (ja) 2018-04-05
BR112015008113A2 (pt) 2017-07-04
CN104837826B (zh) 2018-07-27
ZA201502349B (en) 2019-12-18
US20170349569A1 (en) 2017-12-07
PE20191818A1 (es) 2019-12-27
US10239858B2 (en) 2019-03-26
WO2014059422A1 (en) 2014-04-17
EA030613B1 (ru) 2018-08-31
HK1213878A1 (en) 2016-07-15
PH12015500785B1 (en) 2015-06-15
CR20150245A (es) 2015-11-19
UA115455C2 (uk) 2017-11-10
PL2909188T3 (pl) 2018-08-31
PE20200387A1 (es) 2020-02-24
EA201590700A1 (ru) 2015-09-30
CL2015000926A1 (es) 2015-08-28
NZ706723A (en) 2018-07-27
CN104837826A (zh) 2015-08-12
PE20151494A1 (es) 2015-11-06
TR201807861T4 (tr) 2018-06-21
AU2013328929B2 (en) 2018-01-04
CN108948043B (zh) 2021-05-04

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