MA38085B1 - Nouveau procédé pour la production de composés à utiliser dans le traitement du cancer - Google Patents
Nouveau procédé pour la production de composés à utiliser dans le traitement du cancerInfo
- Publication number
- MA38085B1 MA38085B1 MA38085A MA38085A MA38085B1 MA 38085 B1 MA38085 B1 MA 38085B1 MA 38085 A MA38085 A MA 38085A MA 38085 A MA38085 A MA 38085A MA 38085 B1 MA38085 B1 MA 38085B1
- Authority
- MA
- Morocco
- Prior art keywords
- production
- cancer
- compounds
- treatment
- new process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
L'invention concerne un procédé pour la production d'un composé de formule i. Ledit composé de formule i est un inhibiteur de mek et peut ainsi être utilisé pour traiter le cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261713104P | 2012-10-12 | 2012-10-12 | |
PCT/US2013/064866 WO2014059422A1 (fr) | 2012-10-12 | 2013-10-14 | Nouveau procédé pour la production de composés à utiliser dans le traitement du cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
MA38085A1 MA38085A1 (fr) | 2018-08-31 |
MA38085B1 true MA38085B1 (fr) | 2018-11-30 |
Family
ID=49474740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38085A MA38085B1 (fr) | 2012-10-12 | 2013-10-14 | Nouveau procédé pour la production de composés à utiliser dans le traitement du cancer |
Country Status (31)
Country | Link |
---|---|
US (4) | US9771347B2 (fr) |
EP (1) | EP2909188B1 (fr) |
JP (2) | JP6300042B2 (fr) |
KR (1) | KR102204520B1 (fr) |
CN (2) | CN108948043B (fr) |
AU (1) | AU2013328929B2 (fr) |
BR (1) | BR112015008113B1 (fr) |
CA (1) | CA2889466C (fr) |
CL (1) | CL2015000926A1 (fr) |
CR (2) | CR20200237A (fr) |
EA (1) | EA030613B1 (fr) |
ES (1) | ES2671502T3 (fr) |
GE (1) | GEP201706690B (fr) |
HK (2) | HK1213567A1 (fr) |
HR (1) | HRP20180670T1 (fr) |
IL (1) | IL238116B (fr) |
IN (1) | IN2015DN03928A (fr) |
MA (1) | MA38085B1 (fr) |
MX (2) | MX2015004660A (fr) |
MY (1) | MY186549A (fr) |
NZ (1) | NZ706723A (fr) |
PE (3) | PE20151494A1 (fr) |
PH (1) | PH12015500785A1 (fr) |
PL (1) | PL2909188T3 (fr) |
SA (1) | SA515360271B1 (fr) |
SG (1) | SG11201502795VA (fr) |
SI (1) | SI2909188T1 (fr) |
TR (1) | TR201807861T4 (fr) |
UA (1) | UA115455C2 (fr) |
WO (1) | WO2014059422A1 (fr) |
ZA (1) | ZA201502349B (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY186549A (en) | 2012-10-12 | 2021-07-26 | Exelixis Inc | Novel process for making compounds for use in the treatment of cancer |
US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
HRP20240045T1 (hr) | 2015-06-30 | 2024-03-29 | Genentech, Inc. | Tablete s trenutnim oslobađanjem koje sadrže lijek i postupci za proizvodnju tableta |
AR105483A1 (es) | 2015-06-30 | 2017-10-11 | Exelixis Inc | Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona |
CN105330643B (zh) * | 2015-12-09 | 2017-12-05 | 苏州明锐医药科技有限公司 | 卡比替尼的制备方法 |
CN106045969B (zh) * | 2016-05-27 | 2019-04-12 | 湖南欧亚药业有限公司 | 一种卡比替尼的合成方法 |
EP3496752B1 (fr) | 2016-08-12 | 2022-05-18 | Genentech, Inc. | Polythérapie avec un inhibiteur de mek, un inhibiteur de l'axe pd-1 et un inhibiteur de vegf |
JP2019534251A (ja) | 2016-09-29 | 2019-11-28 | ジェネンテック, インコーポレイテッド | Mek阻害剤、pd−1軸阻害剤、及びタキサンを用いた併用療法 |
WO2020187674A1 (fr) | 2019-03-15 | 2020-09-24 | Sandoz Ag | Hémisuccinate de (s)-[3,4-difluoro-2-(2-fluoro-4-iodophénylamino)phényl][3-hydroxy-3-(pipéridin-2-yl) azétidin-1-yl]méthanone cristallin |
KR20230156731A (ko) | 2021-03-09 | 2023-11-14 | 제넨테크, 인크. | 뇌암 치료에 이용하기 위한 벨바라페닙 |
JP2024514112A (ja) | 2021-04-06 | 2024-03-28 | ジェネンテック, インコーポレイテッド | ベルバラフェニブおよびコビメチニブを用いた併用療法、またはベルバラフェニブ、コビメチニブおよびアテゾリズマブを用いた併用療法 |
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US1915473A (en) * | 1930-12-31 | 1933-06-27 | Raney Murray | Method of preparing catalytic material |
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US5155110A (en) | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
CA2186947A1 (fr) | 1994-04-01 | 1995-10-12 | Kazuo Ueda | Derive d'oxime et bactericide le contenant en tant qu'ingredient actif |
AU6966696A (en) | 1995-10-05 | 1997-04-28 | Warner-Lambert Company | Method for treating and preventing inflammation and atherosclerosis |
WO1998037881A1 (fr) | 1997-02-28 | 1998-09-03 | Warner Lambert Company | Methode de traitement ou de prevention du choc septique par administration d'un inhibiteur mek |
WO1999001426A1 (fr) | 1997-07-01 | 1999-01-14 | Warner-Lambert Company | Derives d'acide benzhydroxamique phenylamino 4-bromo ou 4-iodo et utilisation de ces derniers en tant qu'inhibiteurs de mek |
DE69836378T2 (de) * | 1997-07-01 | 2007-10-11 | Warner-Lambert Co. Llc | Benzoesäure- und Benzamid-Derivate von Anthranilsäure und ihre Anwendung als MEK-Inhibitoren |
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CA2403017A1 (fr) | 2000-03-15 | 2001-09-20 | Warner-Lambert Company | Diarylamines a substitution 5-amide, utilises en tant qu'inhibiteur de kinases erk mitogenes mek |
AR033517A1 (es) | 2000-04-08 | 2003-12-26 | Astrazeneca Ab | Derivados de piperidina, proceso para su preparacion y uso de estos derivados en la fabricacion de medicamentos |
SI1301472T1 (sl) | 2000-07-19 | 2014-05-30 | Warner-Lambert Company Llc | Oksigenirani estri 4-jodo fenilamino benzihidroksamskih kislin |
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DE10141266A1 (de) | 2001-08-21 | 2003-03-06 | Syntec Ges Fuer Chemie Und Tec | Elektrolumineszierende Derivate der 2,5-Diamino-terephthalsäure und deren Verwendung in organischen Leuchtdioden |
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ATE384058T1 (de) | 2003-12-08 | 2008-02-15 | Hoffmann La Roche | Thiazolderivate |
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KR101318012B1 (ko) * | 2004-10-20 | 2013-10-14 | 메르크 세로노 에스.에이. | 3-아릴아미노 피리딘 유도체 |
WO2006061712A2 (fr) | 2004-12-10 | 2006-06-15 | Pfizer Inc. | Utilisation d'inhibiteurs de mek dans le traitement d'une croissance cellulaire anormale |
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EA019983B1 (ru) * | 2005-10-07 | 2014-07-30 | Экселиксис, Инк. | Ингибиторы mek и способы их применения |
AU2007284562B2 (en) | 2006-08-16 | 2013-05-02 | Exelixis, Inc. | Using PI3K and MEK modulators in treatments of cancer |
WO2008076415A1 (fr) | 2006-12-14 | 2008-06-26 | Exelixis, Inc. | Procédés d'utilisation d'inhibiteurs de mek |
MY186549A (en) | 2012-10-12 | 2021-07-26 | Exelixis Inc | Novel process for making compounds for use in the treatment of cancer |
ES2702891T3 (es) | 2014-02-07 | 2019-03-06 | Sumitomo Chemical Co | Método para producir (R)-1,1,3-Trimetil-4-aminoindano |
AR105483A1 (es) | 2015-06-30 | 2017-10-11 | Exelixis Inc | Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona |
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2013
- 2013-10-14 MY MYPI2015000897A patent/MY186549A/en unknown
- 2013-10-14 KR KR1020157012066A patent/KR102204520B1/ko active IP Right Grant
- 2013-10-14 CA CA2889466A patent/CA2889466C/fr active Active
- 2013-10-14 CR CR20200237A patent/CR20200237A/es unknown
- 2013-10-14 EP EP13780303.7A patent/EP2909188B1/fr active Active
- 2013-10-14 WO PCT/US2013/064866 patent/WO2014059422A1/fr active Application Filing
- 2013-10-14 UA UAA201504532A patent/UA115455C2/uk unknown
- 2013-10-14 PE PE2015000485A patent/PE20151494A1/es active IP Right Grant
- 2013-10-14 JP JP2015536988A patent/JP6300042B2/ja active Active
- 2013-10-14 EA EA201590700A patent/EA030613B1/ru not_active IP Right Cessation
- 2013-10-14 IN IN3928DEN2015 patent/IN2015DN03928A/en unknown
- 2013-10-14 PL PL13780303T patent/PL2909188T3/pl unknown
- 2013-10-14 SG SG11201502795VA patent/SG11201502795VA/en unknown
- 2013-10-14 GE GEAP201313824A patent/GEP201706690B/en unknown
- 2013-10-14 NZ NZ706723A patent/NZ706723A/en unknown
- 2013-10-14 CN CN201810758236.XA patent/CN108948043B/zh active Active
- 2013-10-14 TR TR2018/07861T patent/TR201807861T4/tr unknown
- 2013-10-14 PE PE2019002024A patent/PE20191818A1/es unknown
- 2013-10-14 AU AU2013328929A patent/AU2013328929B2/en active Active
- 2013-10-14 SI SI201331045T patent/SI2909188T1/en unknown
- 2013-10-14 ES ES13780303.7T patent/ES2671502T3/es active Active
- 2013-10-14 MX MX2015004660A patent/MX2015004660A/es active IP Right Grant
- 2013-10-14 MA MA38085A patent/MA38085B1/fr unknown
- 2013-10-14 CN CN201380064338.7A patent/CN104837826B/zh active Active
- 2013-10-14 BR BR112015008113-4A patent/BR112015008113B1/pt active IP Right Grant
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2015
- 2015-04-02 IL IL238116A patent/IL238116B/en active IP Right Grant
- 2015-04-08 ZA ZA2015/02349A patent/ZA201502349B/en unknown
- 2015-04-08 PH PH12015500785A patent/PH12015500785A1/en unknown
- 2015-04-10 MX MX2020005533A patent/MX2020005533A/es unknown
- 2015-04-12 SA SA515360271A patent/SA515360271B1/ar unknown
- 2015-04-13 US US14/684,826 patent/US9771347B2/en active Active
- 2015-04-13 CL CL2015000926A patent/CL2015000926A1/es unknown
- 2015-05-11 CR CR20150245A patent/CR20150245A/es unknown
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2016
- 2016-02-12 HK HK16101572.6A patent/HK1213567A1/zh unknown
- 2016-02-18 HK HK16101725.2A patent/HK1213878A1/zh unknown
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2017
- 2017-08-25 US US15/686,333 patent/US10239858B2/en active Active
- 2017-12-06 JP JP2017234208A patent/JP2018052973A/ja not_active Withdrawn
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2018
- 2018-04-26 HR HRP20180670TT patent/HRP20180670T1/hr unknown
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2019
- 2019-02-08 US US16/271,215 patent/US10793541B2/en active Active
- 2019-08-08 PE PE2019001563A patent/PE20200387A1/es unknown
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2020
- 2020-08-26 US US17/003,570 patent/US11414396B2/en active Active
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