ATE310567T1 - Chemotheriapie mit einem antimitotischen mittel und einem mek inhibitor - Google Patents

Chemotheriapie mit einem antimitotischen mittel und einem mek inhibitor

Info

Publication number
ATE310567T1
ATE310567T1 AT99966523T AT99966523T ATE310567T1 AT E310567 T1 ATE310567 T1 AT E310567T1 AT 99966523 T AT99966523 T AT 99966523T AT 99966523 T AT99966523 T AT 99966523T AT E310567 T1 ATE310567 T1 AT E310567T1
Authority
AT
Austria
Prior art keywords
chemotherapy
mek inhibitor
antimitotic agent
antimitotic
agent
Prior art date
Application number
AT99966523T
Other languages
English (en)
Inventor
Richard Carleton Gowan
Judith Sebolt-Leopold
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE310567T1 publication Critical patent/ATE310567T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT99966523T 1998-12-22 1999-12-21 Chemotheriapie mit einem antimitotischen mittel und einem mek inhibitor ATE310567T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11329198P 1998-12-22 1998-12-22
US16478899P 1999-11-10 1999-11-10
PCT/US1999/030485 WO2000037141A1 (en) 1998-12-22 1999-12-21 Combination chemotherapy

Publications (1)

Publication Number Publication Date
ATE310567T1 true ATE310567T1 (de) 2005-12-15

Family

ID=26810891

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99966523T ATE310567T1 (de) 1998-12-22 1999-12-21 Chemotheriapie mit einem antimitotischen mittel und einem mek inhibitor

Country Status (31)

Country Link
EP (1) EP1140291B1 (de)
JP (1) JP2002532570A (de)
KR (1) KR20010099877A (de)
CN (1) CN1333698A (de)
AP (1) AP2001002175A0 (de)
AT (1) ATE310567T1 (de)
AU (1) AU2203900A (de)
BG (1) BG105715A (de)
BR (1) BR9916839A (de)
CA (1) CA2352326A1 (de)
CZ (1) CZ20012139A3 (de)
DE (1) DE69928568T2 (de)
EA (1) EA200100687A1 (de)
EE (1) EE200100339A (de)
ES (1) ES2253928T3 (de)
GE (1) GEP20043172B (de)
HK (1) HK1042057A1 (de)
HR (1) HRP20010473A2 (de)
HU (1) HUP0104844A3 (de)
ID (1) ID30250A (de)
IL (1) IL143939A0 (de)
IS (1) IS5969A (de)
MA (1) MA26768A1 (de)
NO (1) NO20013099L (de)
NZ (1) NZ512859A (de)
OA (1) OA11733A (de)
PL (1) PL348326A1 (de)
SK (1) SK8712001A3 (de)
TR (1) TR200101871T2 (de)
WO (1) WO2000037141A1 (de)
YU (1) YU45401A (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010068738A1 (en) 2008-12-10 2010-06-17 Dana-Farber Cancer Institute, Inc. Mek mutations conferring resistance to mek inhibitors
WO2011106298A1 (en) 2010-02-25 2011-09-01 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
US11078540B2 (en) 2010-03-09 2021-08-03 Dana-Farber Cancer Institute, Inc. Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001273498B2 (en) 2000-07-19 2006-08-24 Warner-Lambert Company Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
EP1365796A2 (de) 2000-09-01 2003-12-03 Van Andel Institute Hemmung des mitogenaktivierten proteinkinase (mapk)-weges: eine selektive therapeutische strategie gegen melanome
EP1377312A4 (de) * 2001-03-22 2004-10-06 Andel Inst Van Anthrax-letalfaktor hemmt tumorwachstum und angiogenese
IL149462A0 (en) 2001-05-09 2002-11-10 Warner Lambert Co Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
CZ20022216A3 (cs) * 2001-07-02 2003-05-14 Warner-Lambert Company Kombinační chemoterapie
AU2004279721A1 (en) * 2003-10-08 2005-04-21 Teijin Pharma Limited Process for producing aminopyrrolidine derivative and intermediate compound
EP1682495A1 (de) 2003-10-21 2006-07-26 Warner-Lambert Company LLC Polymorphe form von n-[(r)-2,3-dihydroxypropoxy]-3,4-difluor-2-(2-fluor-4-iodophenylamino)benzamid
US7956191B2 (en) * 2004-10-20 2011-06-07 Merck Serono Sa 3-arylamino pyridine derivatives
CN1807413B (zh) * 2005-09-28 2010-05-05 中国医学科学院医药生物技术研究所 咔唑磺酰胺衍生物及其制备方法
EA019983B1 (ru) 2005-10-07 2014-07-30 Экселиксис, Инк. Ингибиторы mek и способы их применения
EP1790342A1 (de) 2005-11-11 2007-05-30 Zentaris GmbH Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
AU2006313701B2 (en) 2005-11-11 2012-05-31 Aeterna Zentaris Gmbh Novel pyridopyrazines and their use as modulators of kinases
CA2671982C (en) 2006-12-14 2016-01-26 Exelixis, Inc. Methods of using mek inhibitors
CN103301096B (zh) * 2012-03-14 2015-05-06 中国中化股份有限公司 取代二苯胺类化合物作为制备抗肿瘤药物的应用
US20150141470A1 (en) 2012-05-08 2015-05-21 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
SI2909188T1 (en) 2012-10-12 2018-07-31 Exelixis, Inc. A novel process for the manufacture of compounds for use in the treatment of cancer
WO2014133071A1 (ja) * 2013-02-27 2014-09-04 第一三共株式会社 Ｍａｐｋシグナル伝達経路を阻害する化合物に対する応答性を予測する方法
CN105384754B (zh) * 2014-09-02 2018-04-20 上海科州药物研发有限公司 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途
CN111909053B (zh) * 2020-08-06 2022-12-06 湖北省生物农药工程研究中心 基于二芳胺单元的酰胺类衍生物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112248A0 (en) * 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
WO1997032604A1 (en) * 1996-03-07 1997-09-12 Novartis Ag Antiproliferative combinations, containing raf-targeted oligonucleotides and chemotherapeutic compounds
US6251943B1 (en) * 1997-02-28 2001-06-26 Warner-Lambert Company Method of treating or preventing septic shock by administering a MEK inhibitor
AU6580598A (en) * 1997-03-21 1998-10-20 Board Of Regents, The University Of Texas System (noey2) gene compositions and methods of use
US6002008A (en) * 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US5959097A (en) * 1998-11-20 1999-09-28 Isis Pharmaceuticals, Inc. Antisense modulation of MEK2 expression

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010068738A1 (en) 2008-12-10 2010-06-17 Dana-Farber Cancer Institute, Inc. Mek mutations conferring resistance to mek inhibitors
WO2011106298A1 (en) 2010-02-25 2011-09-01 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
US11078540B2 (en) 2010-03-09 2021-08-03 Dana-Farber Cancer Institute, Inc. Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy

Also Published As

Publication number Publication date
OA11733A (en) 2005-05-12
MA26768A1 (fr) 2004-12-20
NO20013099D0 (no) 2001-06-21
AP2001002175A0 (en) 2001-06-21
HK1042057A1 (zh) 2002-08-02
CA2352326A1 (en) 2000-06-29
GEP20043172B (en) 2004-02-25
HUP0104844A2 (en) 2002-06-29
IS5969A (is) 2001-06-14
WO2000037141A9 (en) 2000-12-07
DE69928568T2 (de) 2006-07-27
BG105715A (en) 2002-04-30
HUP0104844A3 (en) 2003-05-28
AU2203900A (en) 2000-07-12
JP2002532570A (ja) 2002-10-02
EE200100339A (et) 2002-10-15
SK8712001A3 (en) 2002-02-05
EP1140291A1 (de) 2001-10-10
KR20010099877A (ko) 2001-11-09
ID30250A (id) 2001-11-15
EP1140291B1 (de) 2005-11-23
BR9916839A (pt) 2001-10-09
TR200101871T2 (tr) 2001-10-22
CN1333698A (zh) 2002-01-30
IL143939A0 (en) 2002-04-21
ES2253928T3 (es) 2006-06-01
NO20013099L (no) 2001-08-20
CZ20012139A3 (cs) 2002-01-16
YU45401A (sh) 2004-07-15
WO2000037141A1 (en) 2000-06-29
NZ512859A (en) 2004-06-25
DE69928568D1 (de) 2005-12-29
PL348326A1 (en) 2002-05-20
EA200100687A1 (ru) 2001-12-24
HRP20010473A2 (en) 2002-08-31

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