IN2015DN03928A - - Google Patents

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Publication number
IN2015DN03928A
IN2015DN03928A IN3928DEN2015A IN2015DN03928A IN 2015DN03928 A IN2015DN03928 A IN 2015DN03928A IN 3928DEN2015 A IN3928DEN2015 A IN 3928DEN2015A IN 2015DN03928 A IN2015DN03928 A IN 2015DN03928A
Authority
IN
India
Prior art keywords
compound
formula
mek
inhibitor
disclosed
Prior art date
Application number
Inventor
Sriram Naganathan
Nathan Guz
Matthew Pfeiffer
C Gregory Sowell
Tracy Bostick
Jason Yang
Amit Srivastava
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of IN2015DN03928A publication Critical patent/IN2015DN03928A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.
IN3928DEN2015 2012-10-12 2013-10-14 IN2015DN03928A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261713104P 2012-10-12 2012-10-12
PCT/US2013/064866 WO2014059422A1 (en) 2012-10-12 2013-10-14 Novel process for making compounds for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
IN2015DN03928A true IN2015DN03928A (en) 2015-10-02

Family

ID=49474740

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3928DEN2015 IN2015DN03928A (en) 2012-10-12 2013-10-14

Country Status (31)

Country Link
US (4) US9771347B2 (en)
EP (1) EP2909188B1 (en)
JP (2) JP6300042B2 (en)
KR (1) KR102204520B1 (en)
CN (2) CN104837826B (en)
AU (1) AU2013328929B2 (en)
BR (1) BR112015008113B1 (en)
CA (1) CA2889466C (en)
CL (1) CL2015000926A1 (en)
CR (2) CR20200237A (en)
EA (1) EA030613B1 (en)
ES (1) ES2671502T3 (en)
GE (1) GEP201706690B (en)
HK (1) HK1213567A1 (en)
HR (1) HRP20180670T1 (en)
IL (1) IL238116B (en)
IN (1) IN2015DN03928A (en)
MA (1) MA38085B1 (en)
MX (2) MX372708B (en)
MY (1) MY186549A (en)
NZ (1) NZ706723A (en)
PE (3) PE20191818A1 (en)
PH (1) PH12015500785B1 (en)
PL (1) PL2909188T3 (en)
SA (1) SA515360271B1 (en)
SG (1) SG11201502795VA (en)
SI (1) SI2909188T1 (en)
TR (1) TR201807861T4 (en)
UA (1) UA115455C2 (en)
WO (1) WO2014059422A1 (en)
ZA (1) ZA201502349B (en)

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KR20230165795A (en) 2021-04-06 2023-12-05 제넨테크, 인크. Combination therapy with belvarafenib and cobimetinib or belvarafenib, cobimetinib, and atezolizumab

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Also Published As

Publication number Publication date
ES2671502T3 (en) 2018-06-06
JP6300042B2 (en) 2018-03-28
AU2013328929A1 (en) 2015-04-30
TR201807861T4 (en) 2018-06-21
KR20150067339A (en) 2015-06-17
CN108948043A (en) 2018-12-07
US9771347B2 (en) 2017-09-26
CN104837826B (en) 2018-07-27
UA115455C2 (en) 2017-11-10
SA515360271B1 (en) 2016-05-19
PH12015500785A1 (en) 2015-06-15
PH12015500785B1 (en) 2015-06-15
JP2015533175A (en) 2015-11-19
MA38085B1 (en) 2018-11-30
US20190185447A1 (en) 2019-06-20
MA38085A1 (en) 2018-08-31
ZA201502349B (en) 2019-12-18
US11414396B2 (en) 2022-08-16
CN108948043B (en) 2021-05-04
CA2889466A1 (en) 2014-04-17
BR112015008113B1 (en) 2022-05-24
MX372708B (en) 2020-05-29
SI2909188T1 (en) 2018-07-31
PE20151494A1 (en) 2015-11-06
IL238116B (en) 2018-06-28
CR20150245A (en) 2015-11-19
WO2014059422A1 (en) 2014-04-17
BR112015008113A2 (en) 2017-07-04
HRP20180670T1 (en) 2018-07-13
NZ706723A (en) 2018-07-27
PE20200387A1 (en) 2020-02-24
PL2909188T3 (en) 2018-08-31
KR102204520B1 (en) 2021-01-20
HK1213878A1 (en) 2016-07-15
CA2889466C (en) 2021-09-14
US10793541B2 (en) 2020-10-06
JP2018052973A (en) 2018-04-05
EP2909188B1 (en) 2018-03-07
MX2020005533A (en) 2020-10-12
EA030613B1 (en) 2018-08-31
EP2909188A1 (en) 2015-08-26
GEP201706690B (en) 2017-06-26
US10239858B2 (en) 2019-03-26
CN104837826A (en) 2015-08-12
PE20191818A1 (en) 2019-12-27
CL2015000926A1 (en) 2015-08-28
SG11201502795VA (en) 2015-05-28
EA201590700A1 (en) 2015-09-30
US20200392104A1 (en) 2020-12-17
HK1213567A1 (en) 2016-07-08
US20170349569A1 (en) 2017-12-07
AU2013328929B2 (en) 2018-01-04
CR20200237A (en) 2020-07-26
US20150210668A1 (en) 2015-07-30
MX2015004660A (en) 2015-08-07
MY186549A (en) 2021-07-26

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