JP6251678B2 - Ｃｄ２７ｌ抗原結合タンパク質 - Google Patents

Ｃｄ２７ｌ抗原結合タンパク質 Download PDF

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JP6251678B2
JP6251678B2 JP2014531981A JP2014531981A JP6251678B2 JP 6251678 B2 JP6251678 B2 JP 6251678B2 JP 2014531981 A JP2014531981 A JP 2014531981A JP 2014531981 A JP2014531981 A JP 2014531981A JP 6251678 B2 JP6251678 B2 JP 6251678B2
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amino acid
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JP2015501134A5 (enExample
JP2015501134A (ja
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デラニー，ジョン・エム
ファンスロー，ウィリアム・クリスチャン・ザ・サード
キング，チャドウィック・テレンス
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
JP2014531981A 2011-09-22 2012-09-20 Ｃｄ２７ｌ抗原結合タンパク質 Active JP6251678B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161538024P 2011-09-22 2011-09-22
US61/538,024 2011-09-22
PCT/US2012/056429 WO2013043933A2 (en) 2011-09-22 2012-09-20 Cd27l antigen binding proteins

Related Child Applications (1)

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JP2017145168A Division JP2018021031A (ja) 2011-09-22 2017-07-27 Ｃｄ２７ｌ抗原結合タンパク質

Publications (3)

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JP2015501134A JP2015501134A (ja) 2015-01-15
JP2015501134A5 JP2015501134A5 (enExample) 2015-11-12
JP6251678B2 true JP6251678B2 (ja) 2017-12-20

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JP2014531981A Active JP6251678B2 (ja) 2011-09-22 2012-09-20 Ｃｄ２７ｌ抗原結合タンパク質
JP2017145168A Pending JP2018021031A (ja) 2011-09-22 2017-07-27 Ｃｄ２７ｌ抗原結合タンパク質

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US (3) US8987422B2 (enExample)
EP (1) EP2758437B1 (enExample)
JP (2) JP6251678B2 (enExample)
KR (1) KR102007055B1 (enExample)
CN (1) CN104136461B (enExample)
AP (1) AP2014007588A0 (enExample)
AR (1) AR093186A1 (enExample)
AU (2) AU2012312274B2 (enExample)
BR (1) BR112014006822B1 (enExample)
CA (1) CA2849318C (enExample)
CL (2) CL2014000699A1 (enExample)
CO (1) CO7020862A2 (enExample)
CR (1) CR20140169A (enExample)
EA (2) EA027900B1 (enExample)
ES (1) ES2806146T3 (enExample)
IL (1) IL231603B (enExample)
JO (1) JO3625B1 (enExample)
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MY (1) MY173865A (enExample)
PE (1) PE20141151A1 (enExample)
PH (1) PH12014500666B1 (enExample)
SG (2) SG11201400859SA (enExample)
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TW (2) TWI646109B (enExample)
UA (1) UA118332C2 (enExample)
UY (1) UY34343A (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018021031A (ja) * 2011-09-22 2018-02-08 アムジエン・インコーポレーテツド Ｃｄ２７ｌ抗原結合タンパク質

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BR112013021562B1 (pt) 2011-03-16 2023-01-10 Argenx Bvba Anticorpos para cd70
TWI679019B (zh) * 2013-04-29 2019-12-11 法商賽諾菲公司 抗ｉｌ－４／抗ｉｌ－１３之雙特異性抗體調配物
US20170101466A1 (en) * 2014-06-03 2017-04-13 Masahisa Handa Anti-blys antibodies
US10391168B1 (en) 2014-08-22 2019-08-27 University Of Bern Anti-CD70 combination therapy
MA40539A (fr) 2014-09-02 2016-03-10 Immunogen Inc Procédés de formulation de compositions de conjugués anticorps-médicaments
US20160208018A1 (en) 2015-01-16 2016-07-21 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for ror1
TWI717375B (zh) * 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Ｃｄ７０及ｃｄ３抗體構築體
MX390630B (es) 2016-01-25 2025-03-21 Regeneron Pharma Derivados de maitansinoide, conjugados de los mismos y metodos de uso.
JP7029401B2 (ja) 2016-02-02 2022-03-03 フレッド ハッチンソン キャンサー リサーチ センター 抗ｒｏｒ１抗体およびその使用
JOP20190055A1 (ar) 2016-09-26 2019-03-24 Merck Sharp & Dohme أجسام مضادة ضد cd27
EP3583129B1 (en) * 2017-02-14 2021-11-03 Kite Pharma, Inc. Cd70 binding molecules and methods of use thereof
GB201800649D0 (en) 2018-01-16 2018-02-28 Argenx Bvba CD70 Combination Therapy
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