JP6234571B2 - 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン - Google Patents
呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン Download PDFInfo
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- JP6234571B2 JP6234571B2 JP2016528882A JP2016528882A JP6234571B2 JP 6234571 B2 JP6234571 B2 JP 6234571B2 JP 2016528882 A JP2016528882 A JP 2016528882A JP 2016528882 A JP2016528882 A JP 2016528882A JP 6234571 B2 JP6234571 B2 JP 6234571B2
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- 0 C*[C@@](COP(O)(O)OP(O)(OP(O)O)=O)([C@@](C1)O)O[C@]1C1=CC[C@](C(C*)=NC=N)N1 Chemical compound C*[C@@](COP(O)(O)OP(O)(OP(O)O)=O)([C@@](C1)O)O[C@]1C1=CC[C@](C(C*)=NC=N)N1 0.000 description 27
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- ALSLAZPECLFUDO-AUUVJJABSA-N C=P(O)(OC[C@@]([C@H]([C@H]1O)O)(N)O[C@H]1c1ccc2[n]1ncnc2N)OP(O)(OP(O)(O)=O)=O Chemical compound C=P(O)(OC[C@@]([C@H]([C@H]1O)O)(N)O[C@H]1c1ccc2[n]1ncnc2N)OP(O)(OP(O)(O)=O)=O ALSLAZPECLFUDO-AUUVJJABSA-N 0.000 description 1
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- DOJWDIYNHGLSFH-GMXVVIOVSA-N CC[C@@](CO)([C@H](C1=[F])O)O[C@H]1c1ccc2[n]1ncnc2N Chemical compound CC[C@@](CO)([C@H](C1=[F])O)O[C@H]1c1ccc2[n]1ncnc2N DOJWDIYNHGLSFH-GMXVVIOVSA-N 0.000 description 1
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- GNEFAMPUFZUUCA-YFYGNXCZSA-N C[C@@](COP(O)(OP(O)(OP(O)(O)=O)=O)=O)([C@H]([C@H]1F)O)OC1c1ccc2[n]1ncnc2N Chemical compound C[C@@](COP(O)(OP(O)(OP(O)(O)=O)=O)=O)([C@H]([C@H]1F)O)OC1c1ccc2[n]1ncnc2N GNEFAMPUFZUUCA-YFYGNXCZSA-N 0.000 description 1
- BARQHHFJGICHCM-UHFFFAOYSA-N NC1NC(F)=N[n]2c(I)ccc12 Chemical compound NC1NC(F)=N[n]2c(I)ccc12 BARQHHFJGICHCM-UHFFFAOYSA-N 0.000 description 1
- KGBHBKOYCNZMKN-UHFFFAOYSA-N Nc1nc(F)n[n]2c1ccc2 Chemical compound Nc1nc(F)n[n]2c1ccc2 KGBHBKOYCNZMKN-UHFFFAOYSA-N 0.000 description 1
- PONRKWXOBUXXDV-UHFFFAOYSA-N Nc1nc(N)n[n]2c1ccc2 Chemical compound Nc1nc(N)n[n]2c1ccc2 PONRKWXOBUXXDV-UHFFFAOYSA-N 0.000 description 1
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- SMWDFEZZVXVKRB-UHFFFAOYSA-N c1ccc2ncccc2c1 Chemical compound c1ccc2ncccc2c1 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902544P | 2013-11-11 | 2013-11-11 | |
| US61/902,544 | 2013-11-11 | ||
| PCT/US2014/064412 WO2015069939A1 (en) | 2013-11-11 | 2014-11-06 | Pyrrolo [1,2,f] [1,2,4] triazines useful for treating respiratory syncitial virus infections |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017160336A Division JP6393380B2 (ja) | 2013-11-11 | 2017-08-23 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017502925A JP2017502925A (ja) | 2017-01-26 |
| JP6234571B2 true JP6234571B2 (ja) | 2017-11-22 |
Family
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Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528882A Active JP6234571B2 (ja) | 2013-11-11 | 2014-11-06 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
| JP2017160336A Active JP6393380B2 (ja) | 2013-11-11 | 2017-08-23 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
| JP2018000710A Withdrawn JP2018070658A (ja) | 2013-11-11 | 2018-01-05 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
| JP2019222179A Active JP7054394B2 (ja) | 2013-11-11 | 2019-12-09 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2020193294A Active JP7247155B2 (ja) | 2013-11-11 | 2020-11-20 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2022063956A Withdrawn JP2022088661A (ja) | 2013-11-11 | 2022-04-07 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2024006714A Withdrawn JP2024041986A (ja) | 2013-11-11 | 2024-01-19 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017160336A Active JP6393380B2 (ja) | 2013-11-11 | 2017-08-23 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
| JP2018000710A Withdrawn JP2018070658A (ja) | 2013-11-11 | 2018-01-05 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２，ｆ］［１，２，４］トリアジン |
| JP2019222179A Active JP7054394B2 (ja) | 2013-11-11 | 2019-12-09 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2020193294A Active JP7247155B2 (ja) | 2013-11-11 | 2020-11-20 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2022063956A Withdrawn JP2022088661A (ja) | 2013-11-11 | 2022-04-07 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
| JP2024006714A Withdrawn JP2024041986A (ja) | 2013-11-11 | 2024-01-19 | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン |
Country Status (36)
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| DK2480559T3 (da) | 2009-09-21 | 2013-08-05 | Gilead Sciences Inc | Fremgangsmåder og mellemprodukter til fremstillingen af 1'-cyano-carbanukleosid-analoger |
| MA34470B1 (fr) | 2010-07-22 | 2013-08-01 | Gilead Sciences Inc | Procédés et composés pour traiter des infections à virus paramyxoviridae |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| WO2015143712A1 (en) * | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
| TWI678369B (zh) | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
| PE20170698A1 (es) | 2014-09-26 | 2017-06-05 | Riboscience Llc | Derivados de nucleosidos sustituidos con 4'-vinilo como inhibidores de la replicacion del arn del virus respiratorio sincitial |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| CN118286245A (zh) | 2014-12-26 | 2024-07-05 | 埃莫里大学 | N4-羟基胞苷和衍生物及与其相关的抗病毒用途 |
| MX394858B (es) | 2015-09-16 | 2025-03-24 | Gilead Sciences Inc | Compuestos de formula i para usarse en el tratamiento de infecciones por virus arenaviridae y coronaviridae |
| RU2720811C2 (ru) * | 2015-09-23 | 2020-05-13 | Мерк Шарп И Доум Лимитед | 4'-замещенные нуклеозидные ингибиторы обратной транскриптазы и их получение |
| AU2017231824B2 (en) | 2016-03-09 | 2021-07-01 | Alios Biopharma, Inc. | Acyclic antivirals |
| CA3056072C (en) * | 2017-03-14 | 2022-08-23 | Gilead Sciences, Inc. | Methods of treating feline coronavirus infections |
| KR20190141747A (ko) | 2017-05-01 | 2019-12-24 | 길리애드 사이언시즈, 인코포레이티드 | (S)-2-에틸부틸 2-(((S)-(((2R,3S,4R,5R)-5-(4-아미노피롤로[2,1-f] [1,2,4]트리아진-7-일)-5-시아노-3,4-디히드록시테트라히드로푸란-2-일)메톡시)(페녹시) 포스포릴)아미노)프로파노에이트의 결정질 형태 |
| EP4512475A3 (en) | 2017-07-11 | 2025-05-14 | Gilead Sciences, Inc. | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| AU2018332540B2 (en) | 2017-09-18 | 2023-10-05 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| CN109748921B (zh) * | 2017-11-03 | 2022-03-22 | 中国科学院上海药物研究所 | N-叔丁氧羰基保护的杂环类化合物、其制备方法及其用于制备c-核苷类似物的方法 |
| RS66222B1 (sr) | 2017-12-07 | 2024-12-31 | Univ Emory | N4-hidroksicitidin i derivati i antivirusne upotrebe povezane sa njim |
| US11040975B2 (en) | 2017-12-08 | 2021-06-22 | Merck Sharp & Dohme Corp. | Carbocyclic nucleoside reverse transcriptase inhibitors |
| CN108787177B (zh) * | 2018-08-07 | 2024-03-15 | 中南大学 | 淤浆法制备黄原酸盐的方法及系统 |
| US12234255B2 (en) | 2019-05-14 | 2025-02-25 | Regents Of The University Of Michigan | Methods for glycosylation |
| AU2021214911A1 (en) | 2020-01-27 | 2022-07-21 | Gilead Sciences, Inc. | Methods for treating SARS CoV-2 infections |
| TWI775313B (zh) * | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI883391B (zh) | 2020-02-18 | 2025-05-11 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AU2021224588B2 (en) * | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI791193B (zh) * | 2020-02-18 | 2023-02-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| CN111187269A (zh) * | 2020-02-27 | 2020-05-22 | 江苏阿尔法药业有限公司 | 一种瑞德西韦中间体的合成方法 |
| CN113336758B (zh) * | 2020-03-03 | 2022-08-19 | 北京桦冠医药科技有限公司 | 化合物7-碘吡咯并[2，1-f][1，2，4]三嗪-4-胺的一种新合成方法 |
| CN111233870A (zh) * | 2020-03-11 | 2020-06-05 | 中国科学技术大学 | 用于快速制备瑞德西韦药物中间体的方法 |
| KR20220153619A (ko) | 2020-03-12 | 2022-11-18 | 길리애드 사이언시즈, 인코포레이티드 | 1'-시아노 뉴클레오사이드의 제조 방법 |
| WO2021207049A1 (en) | 2020-04-06 | 2021-10-14 | Gilead Sciences, Inc. | Inhalation formulations of 1'-cyano substituted carbanucleoside analogs |
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