ES2743619T3 - Pirrolo[1,2-f][1,2,4]triazinas útiles para tratar infecciones por virus respiratorio sincitial - Google Patents
Pirrolo[1,2-f][1,2,4]triazinas útiles para tratar infecciones por virus respiratorio sincitial Download PDFInfo
- Publication number
- ES2743619T3 ES2743619T3 ES14806123T ES14806123T ES2743619T3 ES 2743619 T3 ES2743619 T3 ES 2743619T3 ES 14806123 T ES14806123 T ES 14806123T ES 14806123 T ES14806123 T ES 14806123T ES 2743619 T3 ES2743619 T3 ES 2743619T3
- Authority
- ES
- Spain
- Prior art keywords
- acn
- mmol
- pharmaceutically acceptable
- acceptable salt
- added
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 *[C@]([C@](C1N2N=C(*)N=C(*)C2=CC1)OC1=C)C1=* Chemical compound *[C@]([C@](C1N2N=C(*)N=C(*)C2=CC1)OC1=C)C1=* 0.000 description 16
- OCDDESQBNXICKO-IENPIDJESA-N C=C([C@H](C1)O)OC1c1ccc(c(N)n2)[n]1nc2F Chemical compound C=C([C@H](C1)O)OC1c1ccc(c(N)n2)[n]1nc2F OCDDESQBNXICKO-IENPIDJESA-N 0.000 description 1
- BJRHEXOMZCHTJY-CMCBDOJDSA-N C=C[C@@](COCc1ccccc1)([C@H]([C@H]1OCc2ccccc2)OCc2ccccc2)OC1(c1ccc2[n]1ncnc2N)O Chemical compound C=C[C@@](COCc1ccccc1)([C@H]([C@H]1OCc2ccccc2)OCc2ccccc2)OC1(c1ccc2[n]1ncnc2N)O BJRHEXOMZCHTJY-CMCBDOJDSA-N 0.000 description 1
- MAVMDSQKUALENT-UQJYGFKOSA-N C=C[C@@](COCc1ccccc1)([C@H]([C@H]1OCc2ccccc2)OCc2ccccc2)O[C@H]1c1ccc2[n]1ncnc2N Chemical compound C=C[C@@](COCc1ccccc1)([C@H]([C@H]1OCc2ccccc2)OCc2ccccc2)O[C@H]1c1ccc2[n]1ncnc2N MAVMDSQKUALENT-UQJYGFKOSA-N 0.000 description 1
- XRFRFUIFTPCZPD-ZOCYIJKUSA-N CC(C)(O[C@H](C1)O[C@H](C2OC(C)(C)OC2)C1=O)[O]=C Chemical compound CC(C)(O[C@H](C1)O[C@H](C2OC(C)(C)OC2)C1=O)[O]=C XRFRFUIFTPCZPD-ZOCYIJKUSA-N 0.000 description 1
- KIBKUPNDXSPYDB-ASKATJPDSA-N CCOCC(C([C@H](C1)OC)=[O][C@@H]1OC(C)(C)O)OCC Chemical compound CCOCC(C([C@H](C1)OC)=[O][C@@H]1OC(C)(C)O)OCC KIBKUPNDXSPYDB-ASKATJPDSA-N 0.000 description 1
- MDLCXCFFNSWYNV-UHFFFAOYSA-N Nc1nc(F)n[n]2c(Br)ccc12 Chemical compound Nc1nc(F)n[n]2c(Br)ccc12 MDLCXCFFNSWYNV-UHFFFAOYSA-N 0.000 description 1
- OILZYXIVWCELJK-HYZFPXJKSA-N Nc1nc(F)n[n]2c1ccc2C([C@@H]1F)(O)O[C@H]([C@@H]2OCc3ccccc3)[C@@]12OCc1ccccc1 Chemical compound Nc1nc(F)n[n]2c1ccc2C([C@@H]1F)(O)O[C@H]([C@@H]2OCc3ccccc3)[C@@]12OCc1ccccc1 OILZYXIVWCELJK-HYZFPXJKSA-N 0.000 description 1
- MBCIEGCLTKDAMB-YVAXUJRWSA-N Nc1nc(F)n[n]2c1ccc2C([C@@H]1F)O[C@H](C2I)[C@@]12O Chemical compound Nc1nc(F)n[n]2c1ccc2C([C@@H]1F)O[C@H](C2I)[C@@]12O MBCIEGCLTKDAMB-YVAXUJRWSA-N 0.000 description 1
- ZEBGLCLVPCOXIV-UHFFFAOYSA-N Nc1ncn[n]2c(I)ccc12 Chemical compound Nc1ncn[n]2c(I)ccc12 ZEBGLCLVPCOXIV-UHFFFAOYSA-N 0.000 description 1
- VSPXQZSDPSOPRO-UHFFFAOYSA-N Nc1ncn[n]2c1ccc2 Chemical compound Nc1ncn[n]2c1ccc2 VSPXQZSDPSOPRO-UHFFFAOYSA-N 0.000 description 1
- IUZKJOQVNFFRJT-ZTCOLXNVSA-N Nc1ncn[n]2c1ccc2[C@@H]1O[C@H](COCc2ccccc2)C[C@H]1OCc1ccccc1 Chemical compound Nc1ncn[n]2c1ccc2[C@@H]1O[C@H](COCc2ccccc2)C[C@H]1OCc1ccccc1 IUZKJOQVNFFRJT-ZTCOLXNVSA-N 0.000 description 1
- MMSMPGBZUHVLAD-ADVPSNOWSA-N O=C([C@@H]1F)O[C@H](C2OCc3ccccc3)[C@@]12OCc1ccccc1 Chemical compound O=C([C@@H]1F)O[C@H](C2OCc3ccccc3)[C@@]12OCc1ccccc1 MMSMPGBZUHVLAD-ADVPSNOWSA-N 0.000 description 1
- ZZUMZLPNUGZXOY-QGZVFWFLSA-N O[C@H](COCc1ccccc1)[IH]COCc1ccccc1 Chemical compound O[C@H](COCc1ccccc1)[IH]COCc1ccccc1 ZZUMZLPNUGZXOY-QGZVFWFLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902544P | 2013-11-11 | 2013-11-11 | |
| PCT/US2014/064412 WO2015069939A1 (en) | 2013-11-11 | 2014-11-06 | Pyrrolo [1,2,f] [1,2,4] triazines useful for treating respiratory syncitial virus infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2743619T3 true ES2743619T3 (es) | 2020-02-20 |
Family
ID=52003049
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14806123T Active ES2743619T3 (es) | 2013-11-11 | 2014-11-06 | Pirrolo[1,2-f][1,2,4]triazinas útiles para tratar infecciones por virus respiratorio sincitial |
| ES18209267T Active ES2926155T3 (es) | 2013-11-11 | 2014-11-06 | Pirrolo[1,2-f][1,2,4]triazinas útiles para tratar infecciones por virus respiratorio sincitial |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18209267T Active ES2926155T3 (es) | 2013-11-11 | 2014-11-06 | Pirrolo[1,2-f][1,2,4]triazinas útiles para tratar infecciones por virus respiratorio sincitial |
Country Status (36)
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ599404A (en) | 2009-09-21 | 2014-02-28 | Gilead Sciences Inc | Processes and intermediates for the preparation of 1’-substituted carba-nucleoside analogs |
| PT2595980E (pt) | 2010-07-22 | 2014-11-27 | Gilead Sciences Inc | Métodos e compostos para tratar infeções pelo vírus da família paramyxoviridae |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| WO2015143712A1 (en) * | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
| TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
| SG10201810361TA (en) | 2014-09-26 | 2018-12-28 | Riboscience Llc | 4'-vinyl substituted nucleoside derivatives as inhibitors of respiratory syncytial virus rna replication |
| TWI698444B (zh) * | 2014-10-29 | 2020-07-11 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| WO2016106050A1 (en) | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| DK3349758T3 (da) | 2015-09-16 | 2022-06-13 | Gilead Sciences Inc | Fremgangsmåder til behandling af arenaviridae-virusinfektioner |
| JP6768796B2 (ja) * | 2015-09-23 | 2020-10-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ４’−置換ヌクレオシド逆転写酵素阻害剤及びその調製 |
| US10745427B2 (en) | 2016-03-09 | 2020-08-18 | Janssen Biopharma, Inc. | Acyclic antivirals |
| CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
| EP4219513A1 (en) | 2017-05-01 | 2023-08-02 | Gilead Sciences, Inc. | Crystalline form of (s)-2-ethylbutyl 2-(((s)-(((2r,3s,4r,5r)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| CN111093627B (zh) | 2017-07-11 | 2024-03-08 | 吉利德科学公司 | 用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物 |
| WO2019053696A1 (en) * | 2017-09-18 | 2019-03-21 | Alios Biopharma, Inc. | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF |
| CN109748921B (zh) * | 2017-11-03 | 2022-03-22 | 中国科学院上海药物研究所 | N-叔丁氧羰基保护的杂环类化合物、其制备方法及其用于制备c-核苷类似物的方法 |
| RU2020116571A (ru) | 2017-12-07 | 2021-11-22 | Эмори Юниверсити | N4-гидроксицитидин и производные и связанные с этим противовирусные применения |
| US11040975B2 (en) | 2017-12-08 | 2021-06-22 | Merck Sharp & Dohme Corp. | Carbocyclic nucleoside reverse transcriptase inhibitors |
| CN108787177B (zh) * | 2018-08-07 | 2024-03-15 | 中南大学 | 淤浆法制备黄原酸盐的方法及系统 |
| WO2020232194A1 (en) * | 2019-05-14 | 2020-11-19 | The Regents Of The University Of Michigan | Methods for glycosylation |
| KR20220132608A (ko) | 2020-01-27 | 2022-09-30 | 길리애드 사이언시즈, 인코포레이티드 | SARS CoV-2 감염증을 치료하기 위한 방법 |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI791193B (zh) * | 2020-02-18 | 2023-02-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| KR20250133471A (ko) | 2020-02-18 | 2025-09-05 | 길리애드 사이언시즈, 인코포레이티드 | 항바이러스 화합물 |
| TWI775313B (zh) * | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| CN111187269A (zh) * | 2020-02-27 | 2020-05-22 | 江苏阿尔法药业有限公司 | 一种瑞德西韦中间体的合成方法 |
| CN113336758B (zh) * | 2020-03-03 | 2022-08-19 | 北京桦冠医药科技有限公司 | 化合物7-碘吡咯并[2，1-f][1，2，4]三嗪-4-胺的一种新合成方法 |
| CN111233870A (zh) * | 2020-03-11 | 2020-06-05 | 中国科学技术大学 | 用于快速制备瑞德西韦药物中间体的方法 |
| TWI785528B (zh) | 2020-03-12 | 2022-12-01 | 美商基利科學股份有限公司 | 1’-氰基核苷之製備方法 |
| JP7482250B2 (ja) | 2020-04-06 | 2024-05-13 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノ置換カルバヌクレオシド類似体の吸入製剤 |
| CN112778310B (zh) | 2020-04-20 | 2025-05-30 | 中国科学院上海药物研究所 | 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用 |
| CN113527303B (zh) * | 2020-04-21 | 2022-06-10 | 浙江工业大学 | 一种瑞德西韦母核中间体的制备工艺 |
| CN111440176B (zh) * | 2020-04-28 | 2022-04-26 | 江苏大学 | 金属配合物促进的瑞德西韦中间体的合成方法 |
| EP4157272B1 (en) | 2020-05-29 | 2025-07-02 | Gilead Sciences, Inc. | Remdesivir for the treatment of viral infections |
| CN111620903A (zh) * | 2020-06-17 | 2020-09-04 | 安徽贝克联合制药有限公司 | C-核苷类似物以及用于合成瑞德西韦合成的含腈c-核苷类化合物的制备方法及其应用 |
| IL299202A (en) | 2020-06-24 | 2023-02-01 | Gilead Sciences Inc | 1'-cyano nucleoside analogs and uses thereof |
| CN111732618A (zh) * | 2020-07-03 | 2020-10-02 | 镇江巨杰新材料技术研发中心(有限合伙) | 瑞德西韦关键片段的合成方法 |
| CN111793101B (zh) | 2020-07-17 | 2022-09-30 | 四川大学 | C-核苷化合物的合成方法 |
| LT4192839T (lt) | 2020-08-06 | 2025-11-25 | Remdesiviro tarpiniai junginiai | |
| JP7559223B2 (ja) | 2020-08-24 | 2024-10-01 | ギリアード サイエンシーズ， インコーポレイテッド | リン脂質化合物及びその使用 |
| US11926645B2 (en) | 2020-08-27 | 2024-03-12 | Gilead Sciences, Inc. | Compounds and methods for treatment of viral infections |
| TWI925033B (zh) * | 2020-10-16 | 2026-05-11 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| CN113880846B (zh) * | 2020-12-31 | 2022-10-14 | 山东诚汇双达药业有限公司 | 一种7-碘吡咯并[2,1-f][1,2,4]三嗪-4-胺的制备方法 |
| AU2022256476B2 (en) | 2021-04-16 | 2025-06-05 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
| CA3228162A1 (en) * | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| IL310854A (en) | 2021-08-20 | 2024-04-01 | Shionogi & Co | Nucleoside compounds and their drug derivatives possessing viral growth inhibitory activity |
| KR20240154647A (ko) | 2022-03-02 | 2024-10-25 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스성 감염 치료를 위한 화합물 및 방법 |
| US20230382940A1 (en) * | 2022-03-03 | 2023-11-30 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| CN118843629A (zh) | 2022-03-03 | 2024-10-25 | 吉利德科学公司 | 抗病毒化合物及其制备和使用方法 |
| EP4547665A1 (en) | 2022-06-30 | 2025-05-07 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| WO2024173458A1 (en) | 2023-02-16 | 2024-08-22 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| WO2025049699A1 (en) | 2023-08-31 | 2025-03-06 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| US20250084088A1 (en) | 2023-08-31 | 2025-03-13 | Gilead Sciences, Inc. | Antiviral compounds and methods of making and using the same |
| KR20260079626A (ko) | 2023-09-28 | 2026-06-02 | 길리애드 사이언시즈, 인코포레이티드 | 바이러스성 감염 치료를 위한 화합물 및 방법 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3361306A (en) | 1966-03-31 | 1968-01-02 | Merck & Co Inc | Aerosol unit dispensing uniform amounts of a medically active ingredient |
| US3565070A (en) | 1969-02-28 | 1971-02-23 | Riker Laboratories Inc | Inhalation actuable aerosol dispenser |
| FR2224175B1 (enExample) | 1973-04-04 | 1978-04-14 | Isf Spa | |
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| IT1017153B (it) | 1974-07-15 | 1977-07-20 | Isf Spa | Apparecchio per inalazioni |
| SE438261B (sv) | 1981-07-08 | 1985-04-15 | Draco Ab | Anvendning i dosinhalator av ett perforerat membran |
| US4805811A (en) | 1985-03-29 | 1989-02-21 | Aktiebolaget Draco | Dosage device |
| SE448277B (sv) | 1985-04-12 | 1987-02-09 | Draco Ab | Indikeringsanordning vid en doseringsanordning for lekemedel |
| IT1228459B (it) | 1989-02-23 | 1991-06-19 | Phidea S R L | Inalatore con svuotamento regolare e completo della capsula. |
| US4955371A (en) | 1989-05-08 | 1990-09-11 | Transtech Scientific, Inc. | Disposable inhalation activated, aerosol device for pulmonary medicine |
| ES2141108T3 (es) | 1991-07-02 | 2000-03-16 | Inhale Inc | Metodo y dispositivo para proporcionar medicamentos en aerosol. |
| US5261538A (en) | 1992-04-21 | 1993-11-16 | Glaxo Inc. | Aerosol testing method |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US5388572A (en) | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
| US5522385A (en) | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
| US5622163A (en) | 1994-11-29 | 1997-04-22 | Iep Group, Inc. | Counter for fluid dispensers |
| US5544647A (en) | 1994-11-29 | 1996-08-13 | Iep Group, Inc. | Metered dose inhalator |
| US6116234A (en) | 1999-02-01 | 2000-09-12 | Iep Pharmaceutical Devices Inc. | Metered dose inhaler agitator |
| KR20090089922A (ko) * | 2000-10-18 | 2009-08-24 | 파마셋 인코포레이티드 | 바이러스 감염 및 비정상적인 세포 증식의 치료를 위한 변형된 뉴클레오시드 |
| GB0114286D0 (en) | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
| AU2002330154A1 (en) | 2001-09-28 | 2003-04-07 | Centre National De La Recherche Scientifique | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
| WO2005020885A2 (en) | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
| AR046959A1 (es) * | 2003-12-18 | 2006-01-04 | Tibotec Pharm Ltd | Morfolinilo que contiene bencimidazoles como inhibidores de la replicacion del virus sincitial respiratorio |
| NZ598927A (en) * | 2007-01-12 | 2013-09-27 | Biocryst Pharm Inc | Antiviral nucleoside analogs |
| DK2155758T3 (da) * | 2007-05-10 | 2012-11-05 | Biocryst Pharm Inc | Tetrahydrofuro[3,4-d]dioxolanforbindelser til anvendelse i behandlingen af virusinfektioner og cancer |
| ATE515861T1 (de) | 2007-07-25 | 2011-07-15 | Nokia Siemens Networks Oy | Verfahren zur adressierung von ethernetströmen mit strukturierter gpon-gem-port-id |
| PL2280973T3 (pl) | 2008-04-23 | 2013-05-31 | Gilead Sciences Inc | Analogi karba-nukleozydowe do leczenia przeciwwirusowego |
| EP2313102A2 (en) | 2008-07-03 | 2011-04-27 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| NZ599404A (en) | 2009-09-21 | 2014-02-28 | Gilead Sciences Inc | Processes and intermediates for the preparation of 1’-substituted carba-nucleoside analogs |
| DK2480552T3 (en) | 2009-09-21 | 2017-02-20 | Gilead Sciences Inc | 2 'FLUOROUS-SUBSTITUTED CARBA NUCLEOSIDE ANALYSIS FOR ANTIVIRAL TREATMENT |
| US8455451B2 (en) * | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| TW201201815A (en) | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
| EA025311B1 (ru) * | 2010-07-19 | 2016-12-30 | Гайлид Сайэнсиз, Инк. | Способы получения диастереомерно чистых фосфорамидатных пролекарств |
| PT2595980E (pt) * | 2010-07-22 | 2014-11-27 | Gilead Sciences Inc | Métodos e compostos para tratar infeções pelo vírus da família paramyxoviridae |
| TW201305185A (zh) | 2010-09-13 | 2013-02-01 | 吉李德科學股份有限公司 | 用於抗病毒治療之２’－氟取代之碳－核苷類似物 |
| SG188223A1 (en) * | 2010-09-20 | 2013-04-30 | Gilead Sciences Inc | 2' -fluoro substituted carba-nucleoside analogs for antiviral treatment |
| TW201306841A (zh) | 2010-12-20 | 2013-02-16 | Gilead Sciences Inc | 治療ｃ型肝炎病毒（ｈｃｖ）之方法 |
| EP2697242B1 (en) | 2011-04-13 | 2018-10-03 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| US20130143835A1 (en) * | 2011-12-05 | 2013-06-06 | Medivir Ab | HCV Polymerase Inhibitors |
| KR102072041B1 (ko) * | 2011-12-22 | 2020-01-31 | 앨리오스 바이오파마 인크. | 치환된 뉴클레오사이드, 뉴클레오타이드 및 그의 유사체 |
| NZ629996A (en) * | 2012-03-13 | 2016-10-28 | Gilead Sciences Inc | 2’- substituted carba-nucleoside analogs for antiviral treatment |
| ES2674980T3 (es) | 2012-10-08 | 2018-07-05 | Idenix Pharmaceuticals Llc | Análogos de 2'-cloro nucleósidos para infección por VHC |
| AR094537A1 (es) | 2013-11-07 | 2015-08-12 | Bristol Myers Squibb Co | COMPUESTOS DE PIRIDILO SUSTITUIDOS CON ALQUILAMIDA ÚTILES COMO MODULADORES DE LAS RESPUESTAS DE IL-12, IL-23 Y/O IFNa |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
-
2014
- 2014-06-11 UA UAA201606308A patent/UA119050C2/uk unknown
- 2014-11-06 ES ES14806123T patent/ES2743619T3/es active Active
- 2014-11-06 WO PCT/US2014/064412 patent/WO2015069939A1/en not_active Ceased
- 2014-11-06 DK DK18209267.6T patent/DK3505173T3/da active
- 2014-11-06 SI SI201431284T patent/SI3068405T1/sl unknown
- 2014-11-06 PL PL14806123T patent/PL3068405T3/pl unknown
- 2014-11-06 MD MDA20160063A patent/MD4596C1/ro not_active IP Right Cessation
- 2014-11-06 AP AP2016009186A patent/AP2016009186A0/en unknown
- 2014-11-06 SG SG11201603427XA patent/SG11201603427XA/en unknown
- 2014-11-06 PT PT182092676T patent/PT3505173T/pt unknown
- 2014-11-06 CN CN201910045494.8A patent/CN110003215B/zh active Active
- 2014-11-06 MY MYPI2016701599A patent/MY182986A/en unknown
- 2014-11-06 AU AU2014346665A patent/AU2014346665A1/en not_active Abandoned
- 2014-11-06 TR TR2019/10961T patent/TR201910961T4/tr unknown
- 2014-11-06 US US14/534,715 patent/US9388208B2/en active Active
- 2014-11-06 SI SI201431978T patent/SI3505173T1/sl unknown
- 2014-11-06 MX MX2016006066A patent/MX376186B/es active IP Right Grant
- 2014-11-06 BR BR112016010261-4A patent/BR112016010261B1/pt active IP Right Grant
- 2014-11-06 KR KR1020217011476A patent/KR102355881B1/ko active Active
- 2014-11-06 KR KR1020187014999A patent/KR102113705B1/ko active Active
- 2014-11-06 CN CN202111444706.3A patent/CN114085243B/zh active Active
- 2014-11-06 DK DK14806123.7T patent/DK3068405T3/da active
- 2014-11-06 CN CN201480072871.2A patent/CN105899216B/zh active Active
- 2014-11-06 EA EA201792639A patent/EA039734B1/ru unknown
- 2014-11-06 PT PT14806123T patent/PT3068405T/pt unknown
- 2014-11-06 EP EP18209267.6A patent/EP3505173B1/en active Active
- 2014-11-06 HR HRP20191303TT patent/HRP20191303T1/hr unknown
- 2014-11-06 MY MYPI2021000404A patent/MY197933A/en unknown
- 2014-11-06 JP JP2016528882A patent/JP6234571B2/ja active Active
- 2014-11-06 HU HUE14806123A patent/HUE044960T2/hu unknown
- 2014-11-06 EP EP14806123.7A patent/EP3068405B1/en active Active
- 2014-11-06 KR KR1020207013948A patent/KR102243724B1/ko active Active
- 2014-11-06 HR HRP20220920TT patent/HRP20220920T1/hr unknown
- 2014-11-06 HU HUE18209267A patent/HUE059683T2/hu unknown
- 2014-11-06 NZ NZ719592A patent/NZ719592A/en unknown
- 2014-11-06 EA EA201690978A patent/EA029712B1/ru unknown
- 2014-11-06 EP EP22182880.9A patent/EP4122932A1/en active Pending
- 2014-11-06 KR KR1020167015220A patent/KR101864973B1/ko active Active
- 2014-11-06 PE PE2016000605A patent/PE20160670A1/es unknown
- 2014-11-06 PL PL18209267.6T patent/PL3505173T3/pl unknown
- 2014-11-06 LT LTEP14806123.7T patent/LT3068405T/lt unknown
- 2014-11-06 CA CA2928674A patent/CA2928674C/en active Active
- 2014-11-06 ES ES18209267T patent/ES2926155T3/es active Active
- 2014-11-06 LT LTEP18209267.6T patent/LT3505173T/lt unknown
-
2016
- 2016-04-27 IL IL245324A patent/IL245324B/en active IP Right Grant
- 2016-05-09 DO DO2016000107A patent/DOP2016000107A/es unknown
- 2016-05-09 MX MX2020010628A patent/MX2020010628A/es unknown
- 2016-05-10 PH PH12016500867A patent/PH12016500867A1/en unknown
- 2016-05-10 ZA ZA2016/03123A patent/ZA201603123B/en unknown
- 2016-05-11 CU CUP2016000065A patent/CU20160065A7/es unknown
- 2016-05-11 CL CL2016001120A patent/CL2016001120A1/es unknown
- 2016-05-11 GT GT201600086A patent/GT201600086A/es unknown
- 2016-05-11 CR CR20160220A patent/CR20160220A/es unknown
- 2016-06-14 US US15/182,529 patent/US9701682B2/en active Active
-
2017
- 2017-05-31 US US15/610,104 patent/US10059716B2/en active Active
- 2017-08-23 JP JP2017160336A patent/JP6393380B2/ja active Active
- 2017-09-18 AU AU2017232039A patent/AU2017232039C1/en active Active
-
2018
- 2018-01-05 JP JP2018000710A patent/JP2018070658A/ja not_active Withdrawn
- 2018-07-25 US US16/045,371 patent/US10377761B2/en active Active
-
2019
- 2019-06-21 AU AU2019204381A patent/AU2019204381B2/en active Active
- 2019-07-30 CY CY20191100814T patent/CY1121948T1/el unknown
- 2019-12-09 JP JP2019222179A patent/JP7054394B2/ja active Active
-
2020
- 2020-11-20 JP JP2020193294A patent/JP7247155B2/ja active Active
-
2021
- 2021-03-11 AU AU2021201554A patent/AU2021201554B2/en active Active
-
2022
- 2022-04-07 JP JP2022063956A patent/JP2022088661A/ja not_active Withdrawn
- 2022-09-16 CY CY20221100621T patent/CY1125559T1/el unknown
-
2023
- 2023-04-26 AU AU2023202506A patent/AU2023202506B2/en active Active
-
2024
- 2024-01-19 JP JP2024006714A patent/JP2024041986A/ja not_active Withdrawn
- 2024-08-30 US US18/821,476 patent/US20250236623A1/en active Pending
-
2025
- 2025-11-07 JP JP2025188200A patent/JP2026027391A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7247155B2 (ja) | 呼吸器合胞体ウイルス感染を処置するのに有用なピロロ［１，２－ｆ］［１，２，４］トリアジン | |
| HK40085014A (en) | Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections | |
| HK40010164A (en) | Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections | |
| HK40010164B (en) | Pyrrolo[1,2-f][1,2,4]triazines useful for treating respiratory syncitial virus infections | |
| HK1227722B (en) | Pyrrolo [1,2,f][1,2,4]triazines useful for treating respiratory syncitial virus infections | |
| HK1227722A1 (en) | Pyrrolo [1,2,f][1,2,4]triazines useful for treating respiratory syncitial virus infections | |
| OA19704A (en) | Pyrrolo[1,2-f][1,2,4]Triazines useful for treating respiratory syncitial virus infections |