JP6226869B2 - 酵素法 - Google Patents
酵素法 Download PDFInfo
- Publication number
- JP6226869B2 JP6226869B2 JP2014536328A JP2014536328A JP6226869B2 JP 6226869 B2 JP6226869 B2 JP 6226869B2 JP 2014536328 A JP2014536328 A JP 2014536328A JP 2014536328 A JP2014536328 A JP 2014536328A JP 6226869 B2 JP6226869 B2 JP 6226869B2
- Authority
- JP
- Japan
- Prior art keywords
- pore
- target polynucleotide
- helicase
- seq
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/50—Other enzymatic activities
- C12Q2521/513—Winding/unwinding enzyme, e.g. helicase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/631—Detection means characterised by use of a special device being a biochannel or pore
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161549998P | 2011-10-21 | 2011-10-21 | |
| US61/549,998 | 2011-10-21 | ||
| US201261599244P | 2012-02-15 | 2012-02-15 | |
| US61/599,244 | 2012-02-15 | ||
| PCT/GB2012/052579 WO2013057495A2 (en) | 2011-10-21 | 2012-10-18 | Enzyme method |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014534812A JP2014534812A (ja) | 2014-12-25 |
| JP2014534812A5 JP2014534812A5 (enExample) | 2015-12-10 |
| JP6226869B2 true JP6226869B2 (ja) | 2017-11-08 |
Family
ID=47073477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014536328A Active JP6226869B2 (ja) | 2011-10-21 | 2012-10-18 | 酵素法 |
Country Status (9)
| Country | Link |
|---|---|
| US (5) | US9758823B2 (enExample) |
| EP (2) | EP2987870B1 (enExample) |
| JP (1) | JP6226869B2 (enExample) |
| KR (1) | KR20140090633A (enExample) |
| CN (1) | CN104039979B (enExample) |
| AU (1) | AU2012324639B2 (enExample) |
| BR (1) | BR112014009579B1 (enExample) |
| CA (1) | CA2852812A1 (enExample) |
| WO (1) | WO2013057495A2 (enExample) |
Families Citing this family (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2126588A1 (en) | 2007-02-20 | 2009-12-02 | Oxford Nanopore Technologies Limited | Formation of lipid bilayers |
| GB0724736D0 (en) | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
| EP3686602A1 (en) | 2008-09-22 | 2020-07-29 | University of Washington | Msp nanopores and related methods |
| CA2750879C (en) | 2009-01-30 | 2018-05-22 | Oxford Nanopore Technologies Limited | Adaptors for nucleic acid constructs in transmembrane sequencing |
| EP2715343B1 (en) | 2011-05-27 | 2019-10-02 | Oxford Nanopore Technologies Limited | Coupling method |
| US9957560B2 (en) | 2011-07-25 | 2018-05-01 | Oxford Nanopore Technologies Ltd. | Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores |
| CN104066850B (zh) | 2011-09-23 | 2017-11-10 | 牛津楠路珀尔科技有限公司 | 包含聚合物单元的聚合物的分析 |
| WO2013057495A2 (en) | 2011-10-21 | 2013-04-25 | Oxford Nanopore Technologies Limited | Enzyme method |
| AU2012360244B2 (en) | 2011-12-29 | 2018-08-23 | Oxford Nanopore Technologies Limited | Enzyme method |
| US9617591B2 (en) | 2011-12-29 | 2017-04-11 | Oxford Nanopore Technologies Ltd. | Method for characterising a polynucleotide by using a XPD helicase |
| GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
| IN2014DN06796A (enExample) | 2012-02-15 | 2015-05-22 | Oxford Nanopore Tech Ltd | |
| JP6226888B2 (ja) | 2012-02-16 | 2017-11-08 | オックスフォード ナノポール テクノロジーズ リミテッド | ポリマーの測定の解析 |
| CN112646019B (zh) | 2012-04-10 | 2022-08-16 | 牛津纳米孔科技公开有限公司 | 突变胞溶素孔 |
| AU2013291763B2 (en) * | 2012-07-19 | 2019-06-20 | Oxford Nanopore Technologies Limited | Modified helicases |
| AU2013291765C1 (en) | 2012-07-19 | 2019-08-08 | Oxford Nanopore Technologies Limited | Enzyme construct |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| US9551023B2 (en) | 2012-09-14 | 2017-01-24 | Oxford Nanopore Technologies Ltd. | Sample preparation method |
| GB201313121D0 (en) | 2013-07-23 | 2013-09-04 | Oxford Nanopore Tech Ltd | Array of volumes of polar medium |
| WO2014072703A1 (en) | 2012-11-06 | 2014-05-15 | Oxford Nanopore Technologies Limited | Quadruplex method |
| GB201222928D0 (en) | 2012-12-19 | 2013-01-30 | Oxford Nanopore Tech Ltd | Analysis of a polynucleotide |
| BR112015021788B1 (pt) | 2013-03-08 | 2023-02-28 | Oxford Nanopore Technologies Plc | Métodos para mover uma ou mais helicases imobilizadas, para controlar o movimento de um polinucleotídeo alvo, para caracterizar um polinucleotídeo alvo e para controlar o carregamento de uma ou mais helicases em um polinucleotídeo alvo, uso de um poro de transmembrana e de um potencial aplicado e de um ou mais espaçadores, complexo, e, kit |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| GB201318465D0 (en) | 2013-10-18 | 2013-12-04 | Oxford Nanopore Tech Ltd | Method |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| US9766248B2 (en) * | 2013-05-23 | 2017-09-19 | Arizona Board of Regents of behalf of Arizona State University | Chemistry, systems and methods of translocation of a polymer through a nanopore |
| GB201406151D0 (en) * | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| CN118256603A (zh) | 2013-10-18 | 2024-06-28 | 牛津纳米孔科技公开有限公司 | 经修饰的酶 |
| FI3556869T3 (fi) * | 2013-11-26 | 2023-09-28 | Illumina Inc | Koostumuksia ja menetelmiä polynukleotidien sekvensointiin |
| GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
| AU2015208919B9 (en) | 2014-01-22 | 2021-04-01 | Oxford Nanopore Technologies Limited | Method for attaching one or more polynucleotide binding proteins to a target polynucleotide |
| WO2015126494A1 (en) | 2014-02-19 | 2015-08-27 | University Of Washington | Nanopore-based analysis of protein characteristics |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| CN106460061B (zh) | 2014-04-04 | 2020-03-06 | 牛津纳米孔技术公司 | 在双链核酸分子的两端使用纳米孔和锚分子来表征所述双链核酸的方法 |
| WO2015166275A1 (en) | 2014-05-02 | 2015-11-05 | Oxford Nanopore Technologies Limited | Mutant pores |
| GB201417712D0 (en) * | 2014-10-07 | 2014-11-19 | Oxford Nanopore Tech Ltd | Method |
| WO2015187670A2 (en) * | 2014-06-03 | 2015-12-10 | Illumina, Inc. | Compositions, systems, and methods for detecting events using tethers anchored to or adjacent to nanopores |
| GB201411285D0 (en) | 2014-06-25 | 2014-08-06 | Prosser Joseph | Sequencer |
| ES2984002T3 (es) | 2014-07-31 | 2024-10-28 | Illumina Inc | Secuenciación de ácido nucleico con sensores de nanoporos híbridos |
| KR20170042794A (ko) | 2014-09-01 | 2017-04-19 | 브이아이비 브이지더블유 | 돌연변이체 csgg 포어 |
| US10266885B2 (en) | 2014-10-07 | 2019-04-23 | Oxford Nanopore Technologies Ltd. | Mutant pores |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| EP3971300B1 (en) | 2014-10-16 | 2024-06-05 | Oxford Nanopore Technologies plc | Sorting of polymers |
| GB201418512D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Electrical device with detachable components |
| JP6824881B2 (ja) * | 2014-10-17 | 2021-02-03 | オックスフォード ナノポール テクノロジーズ リミテッド | ナノ細孔ｒｎａを特徴付けるための方法 |
| GB201418469D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
| ES2891085T3 (es) | 2015-01-30 | 2022-01-26 | Harvard College | Obtención de imágenes sin microscopio |
| CN107533045B (zh) | 2015-02-05 | 2020-10-09 | 哈佛大学校长及研究员协会 | 包括流体通道的纳米孔感测器 |
| GB201502809D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Mutant pore |
| GB201502810D0 (en) | 2015-02-19 | 2015-04-08 | Oxford Nanopore Tech Ltd | Method |
| US11169138B2 (en) | 2015-04-14 | 2021-11-09 | Katholieke Universiteit Leuven | Nanopores with internal protein adaptors |
| GB201508003D0 (en) | 2015-05-11 | 2015-06-24 | Oxford Nanopore Tech Ltd | Apparatus and methods for measuring an electrical current |
| GB201508669D0 (en) | 2015-05-20 | 2015-07-01 | Oxford Nanopore Tech Ltd | Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown |
| AU2016270887C1 (en) | 2015-06-03 | 2025-01-16 | Illumina, Inc. | Compositions, systems, and methods for sequencing polynucleotides using tethers anchored to polymerases adjacent to nanopores |
| CN109072295B (zh) | 2015-12-08 | 2022-05-31 | 鲁汶大学研究与发展中心 | 修饰的纳米孔，包含其的组合物及其应用 |
| JP7085999B2 (ja) | 2016-02-17 | 2022-06-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 分子プログラミングツール |
| WO2017149316A1 (en) | 2016-03-02 | 2017-09-08 | Oxford Nanopore Technologies Limited | Mutant pore |
| CN118326018B (zh) | 2016-04-06 | 2025-11-07 | 牛津纳米孔科技公开有限公司 | 突变体孔 |
| GB201609221D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| US12215384B2 (en) | 2016-05-25 | 2025-02-04 | Oxford Nanopore Technologies Plc | Methods of characterising target polynucleotides |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
| WO2018057502A2 (en) | 2016-09-20 | 2018-03-29 | President And Fellows Harvard College | Molecular verification systems |
| GB201616590D0 (en) | 2016-09-29 | 2016-11-16 | Oxford Nanopore Technologies Limited | Method |
| GB201619930D0 (en) | 2016-11-24 | 2017-01-11 | Oxford Nanopore Tech | Apparatus and methods for controlling insertion of a membrane channel into a membrane |
| GB201620450D0 (en) | 2016-12-01 | 2017-01-18 | Oxford Nanopore Tech Ltd | Method |
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| US11999948B2 (en) * | 2017-05-04 | 2024-06-04 | The Regents Of The University Of California | Methods of producing size-selected nucleic acid libraries and compositions and kits for practicing same |
| GB201707140D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Method |
| GB201707122D0 (en) | 2017-05-04 | 2017-06-21 | Oxford Nanopore Tech Ltd | Pore |
| EP3646025B1 (en) * | 2017-06-29 | 2021-08-04 | President and Fellows of Harvard College | Deterministic stepping of polymers through a nanopore |
| AU2018294660B2 (en) | 2017-06-30 | 2022-05-19 | Oxford Nanopore Technologies Plc | Novel protein pores |
| GB2568895B (en) | 2017-11-29 | 2021-10-27 | Oxford Nanopore Tech Ltd | Microfluidic device |
| GB2569977A (en) | 2018-01-05 | 2019-07-10 | Oxford Nanopore Tech Ltd | Method |
| US11981956B2 (en) | 2018-01-26 | 2024-05-14 | President And Fellows Of Harvard College | Proximity detection methods and compositions |
| GB201801768D0 (en) | 2018-02-02 | 2018-03-21 | Oxford Nanopore Tech Ltd | Synthesis method |
| WO2019183359A1 (en) | 2018-03-22 | 2019-09-26 | President And Fellows Of Harvard College | Methods and compositions for molecular authentication |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| GB201808556D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| GB201808554D0 (en) | 2018-05-24 | 2018-07-11 | Oxford Nanopore Tech Ltd | Method |
| GB201809323D0 (en) | 2018-06-06 | 2018-07-25 | Oxford Nanopore Tech Ltd | Method |
| US20220162692A1 (en) | 2018-07-30 | 2022-05-26 | Oxford University Innovation Limited | Assemblies |
| JP2020031557A (ja) * | 2018-08-28 | 2020-03-05 | 株式会社日立ハイテクノロジーズ | 生体分子分析装置 |
| CN112805393A (zh) * | 2018-09-28 | 2021-05-14 | 北京齐碳科技有限公司 | 一种解旋酶及其应用 |
| WO2020084705A1 (ja) * | 2018-10-24 | 2020-04-30 | 株式会社日立ハイテク | 生体ポリマ分析デバイス及びそれを用いた分析装置、並びに分析方法 |
| EP3650558A1 (en) * | 2018-11-07 | 2020-05-13 | Siemens Healthcare GmbH | Liquid sample workflow for nanopore sequencing |
| GB201821155D0 (en) | 2018-12-21 | 2019-02-06 | Oxford Nanopore Tech Ltd | Method |
| EP3938779B1 (en) | 2019-03-12 | 2025-07-30 | Oxford Nanopore Technologies plc | Nanopore sensing device and method |
| GB201907246D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| GB201907244D0 (en) | 2019-05-22 | 2019-07-03 | Oxford Nanopore Tech Ltd | Method |
| US11926819B2 (en) | 2019-05-28 | 2024-03-12 | The Regents Of The University Of California | Methods of adding polymers to ribonucleic acids |
| EP4003382A4 (en) * | 2019-07-31 | 2023-10-11 | Axbio Inc. | Systems and methods for assessing a target molecule |
| EP4036106A4 (en) | 2019-09-29 | 2024-01-17 | Qitan Technology Ltd., Beijing | MNEP MONOMER VARIANT AND THEIR USE |
| WO2021056599A1 (zh) | 2019-09-29 | 2021-04-01 | 北京齐碳科技有限公司 | 一种Mnep单体变体及其应用 |
| GB201917060D0 (en) | 2019-11-22 | 2020-01-08 | Oxford Nanopore Tech Ltd | Method |
| EP4671766A2 (en) | 2019-12-02 | 2025-12-31 | Oxford Nanopore Technologies PLC | METHOD FOR CHARACTERIZING A TARGET POLYPEPTIDE USING A NANOPORE |
| GB201917742D0 (en) | 2019-12-04 | 2020-01-15 | Oxford Nanopore Tech Ltd | Method |
| WO2021124468A1 (ja) * | 2019-12-18 | 2021-06-24 | 株式会社日立ハイテク | 分子複合体、および生体ポリマ分析方法 |
| NL2024579B1 (en) * | 2019-12-24 | 2021-09-06 | Univ Delft Tech | Protein and peptide fingerprinting and sequencing by nanopore translocation of peptide-oligonucleotide complexes |
| GB202004944D0 (en) | 2020-04-03 | 2020-05-20 | King S College London | Method |
| CN115667542A (zh) | 2020-06-10 | 2023-01-31 | 豪夫迈·罗氏有限公司 | 用于膜中自限性蛋白质孔插入的法拉第系统和方法 |
| US20230295712A1 (en) | 2020-06-18 | 2023-09-21 | Oxford Nanopore Technologies Plc | A method of selectively characterising a polynucleotide using a detector |
| GB202009349D0 (en) | 2020-06-18 | 2020-08-05 | Oxford Nanopore Tech Ltd | Method |
| WO2021255476A2 (en) | 2020-06-18 | 2021-12-23 | Oxford Nanopore Technologies Limited | Method |
| CN113930406B (zh) | 2021-12-17 | 2022-04-08 | 北京齐碳科技有限公司 | 一种Pif1-like解旋酶及其应用 |
| BR112022014144A2 (pt) | 2020-06-19 | 2022-12-27 | Qitan Tech Ltd Beijing | Helicase do tipo pif1, constructo, ácido nucleico, vetor de expressão, célula hospedeira, método para controlar o movimento de um polinucleotídeo, método de caracterização de um polinucleotídeo alvo, produto para caracterizar um polinucleotídeo alvo e uso da helicase do tipo pif1 |
| EP4675256A2 (en) | 2020-07-17 | 2026-01-07 | Oxford Nanopore Technologies PLC | Nanopore sensing device |
| US20230266268A1 (en) | 2020-07-22 | 2023-08-24 | Oxford Nanopore Technologies Inc. | Solid state nanopore formation |
| GB202015993D0 (en) | 2020-10-08 | 2020-11-25 | Oxford Nanopore Tech Ltd | Method |
| CN116601297A (zh) * | 2020-12-14 | 2023-08-15 | 北京齐碳科技有限公司 | 一种经修饰的解旋酶及其应用 |
| EP4299746A4 (en) | 2021-04-06 | 2024-06-19 | Qitan Technology Ltd., Chengdu | Modified prp43 helicase and use thereof |
| US20240240248A1 (en) | 2021-05-19 | 2024-07-18 | Oxford Nanopore Technologies Plc | Methods for complement strand sequencing |
| GB202107192D0 (en) | 2021-05-19 | 2021-06-30 | Oxford Nanopore Tech Ltd | Method |
| GB202107354D0 (en) | 2021-05-24 | 2021-07-07 | Oxford Nanopore Tech Ltd | Method |
| GB202112235D0 (en) | 2021-08-26 | 2021-10-13 | Oxford Nanopore Tech Ltd | Nanopore |
| GB202118906D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| GB202118908D0 (en) | 2021-12-23 | 2022-02-09 | Oxford Nanopore Tech Ltd | Method |
| GB202205617D0 (en) | 2022-04-14 | 2022-06-01 | Oxford Nanopore Tech Plc | Novel modified protein pores and enzymes |
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| CN119213145A (zh) * | 2022-05-27 | 2024-12-27 | 深圳华大生命科学研究院 | 一种维持纳米孔测序速度的方法 |
| CA3262948A1 (en) | 2022-08-09 | 2024-02-15 | The Regents Of The University Of California | NEW PORE-FORMING MONOMERS AND PORES |
| GB202211602D0 (en) | 2022-08-09 | 2022-09-21 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| GB202211607D0 (en) | 2022-08-09 | 2022-09-21 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| EP4608850A2 (en) | 2022-10-28 | 2025-09-03 | Oxford Nanopore Technologies PLC | Pore monomers and pores |
| GB202216162D0 (en) | 2022-10-31 | 2022-12-14 | Oxford Nanopore Tech Plc | Method |
| GB202216905D0 (en) | 2022-11-11 | 2022-12-28 | Oxford Nanopore Tech Plc | Novel pore monomers and pores |
| CN120359304A (zh) * | 2022-12-16 | 2025-07-22 | 深圳华大生命科学研究院 | 纳米孔测序方法和试剂盒 |
| GB202304324D0 (en) | 2023-03-24 | 2023-05-10 | Oxford Nanopore Tech Plc | Method and kits |
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