JP6204830B2 - 間葉系幹細胞エキソソームに関連する方法および組成物 - Google Patents
間葉系幹細胞エキソソームに関連する方法および組成物 Download PDFInfo
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- JP6204830B2 JP6204830B2 JP2013557912A JP2013557912A JP6204830B2 JP 6204830 B2 JP6204830 B2 JP 6204830B2 JP 2013557912 A JP2013557912 A JP 2013557912A JP 2013557912 A JP2013557912 A JP 2013557912A JP 6204830 B2 JP6204830 B2 JP 6204830B2
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Pulmonology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451981P | 2011-03-11 | 2011-03-11 | |
| US61/451,981 | 2011-03-11 | ||
| PCT/US2012/028524 WO2012125471A1 (en) | 2011-03-11 | 2012-03-09 | Methods and compositions relating to mesenchymal stem cell exosomes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017168158A Division JP6524162B2 (ja) | 2011-03-11 | 2017-09-01 | 間葉系幹細胞エキソソームに関連する方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507482A JP2014507482A (ja) | 2014-03-27 |
| JP2014507482A5 JP2014507482A5 (enExample) | 2016-09-01 |
| JP6204830B2 true JP6204830B2 (ja) | 2017-09-27 |
Family
ID=45852770
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557912A Active JP6204830B2 (ja) | 2011-03-11 | 2012-03-09 | 間葉系幹細胞エキソソームに関連する方法および組成物 |
| JP2017168158A Active JP6524162B2 (ja) | 2011-03-11 | 2017-09-01 | 間葉系幹細胞エキソソームに関連する方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017168158A Active JP6524162B2 (ja) | 2011-03-11 | 2017-09-01 | 間葉系幹細胞エキソソームに関連する方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9901600B2 (enExample) |
| EP (1) | EP2683389B1 (enExample) |
| JP (2) | JP6204830B2 (enExample) |
| KR (2) | KR102063069B1 (enExample) |
| CN (2) | CN109432126B (enExample) |
| CA (1) | CA2829586C (enExample) |
| ES (1) | ES2629502T3 (enExample) |
| WO (1) | WO2012125471A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018030845A (ja) * | 2011-03-11 | 2018-03-01 | チルドレンズ メディカル センター コーポレーション | 間葉系幹細胞エキソソームに関連する方法および組成物 |
Families Citing this family (93)
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| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| ITRM20110403A1 (it) * | 2011-07-28 | 2013-01-29 | Ospedale Pediatrico Bambino Gesu | Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori. |
| US9427450B2 (en) | 2012-01-31 | 2016-08-30 | Xon Cells, Inc. | Therapeutic immune modulation by stem cell secreted exosomes |
| GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
| US9828603B2 (en) | 2012-08-13 | 2017-11-28 | Cedars Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| CN103865873B (zh) * | 2012-12-12 | 2017-04-05 | 中国医学科学院基础医学研究所 | 亚全能干细胞分泌的外来体及其应用 |
| EP2931373B1 (en) * | 2012-12-12 | 2019-08-21 | Mesoblast, Inc. | Methods of treating or preventing respiratory conditions |
| EP2971162B1 (en) * | 2013-03-15 | 2019-05-08 | Board Of Regents, The University Of Texas System | Mirna biogenesis in exosomes for diagnosis and therapy |
| EP3003290B1 (en) | 2013-06-05 | 2021-03-10 | AgeX Therapeutics, Inc. | Compositions for use in the treatment of wounds in mammalian species |
| US20160199413A1 (en) * | 2013-08-01 | 2016-07-14 | Isletone Ab | Mscs in the treatment of inflammatory pulmonary diseases |
| GB201317887D0 (en) | 2013-10-09 | 2013-11-20 | Reneuron Ltd | Product |
| CN104694466A (zh) * | 2013-12-06 | 2015-06-10 | 山西医科大学 | 间充质干细胞来源的胞外体制备及在急性肺损伤中的应用 |
| JP6343671B2 (ja) * | 2013-12-12 | 2018-06-13 | サムスン ライフ パブリック ウェルフェア ファウンデーション | トロンビンを利用した幹細胞由来のエキソソームの生成促進方法 |
| US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
| US9919011B2 (en) | 2014-03-18 | 2018-03-20 | Samsung Life Public Welfare Foundation | Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome |
| WO2015179227A1 (en) * | 2014-05-18 | 2015-11-26 | Children's Medical Center Corporation | Methods and compositions relating to exosomes |
| US20170112879A1 (en) * | 2014-06-09 | 2017-04-27 | University Of Washington | Methods of protection against ischemia reperfusion injury |
| SG11201610844PA (en) * | 2014-06-30 | 2017-01-27 | Tigenix S A U | Mesenchymal stromal cells for treating sepsis |
| US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
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| US11357799B2 (en) | 2014-10-03 | 2022-06-14 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| WO2016057560A1 (en) * | 2014-10-06 | 2016-04-14 | Cedars-Sinai Medical Center | Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells |
| AU2015343845B2 (en) * | 2014-11-07 | 2018-11-08 | Exostemtech Co., Ltd. | Composition for differentiation induction of adipocyte containing stem cell-derived exosome, regeneration of adipose tissue, and skin whitening or wrinkle improvement |
| WO2016072821A1 (ko) * | 2014-11-07 | 2016-05-12 | 한양대학교 에리카산학협력단 | 줄기세포 유래 엑소좀을 함유하는 지방세포 분화유도, 지방조직 재생, 피부 미백 또는 주름개선용 조성물 |
| EP3227434A4 (en) * | 2014-12-03 | 2018-07-11 | Capricor, Inc. | Processes for producing exosomes in reduced oxygen culture conditions |
| CN104560877B (zh) * | 2014-12-18 | 2017-07-28 | 福州市传染病医院 | 一种快速分离细胞外吐小体的方法 |
| CA2972226A1 (en) * | 2014-12-24 | 2016-06-30 | Ube Industries, Ltd. | Cell culture supernatant fluid derived from lung tissue |
| US10342830B2 (en) | 2015-01-05 | 2019-07-09 | Gary M. Petrucci | Methods and materials for treating lung disorders |
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| US20180325830A1 (en) | 2017-05-09 | 2018-11-15 | Vivex Biomedical, Inc. | Coated biological composition |
| US11160904B2 (en) * | 2017-05-09 | 2021-11-02 | Vivex Biologies Group, Inc. | Biological composition in a protectant shroud and methods |
| KR101566450B1 (ko) * | 2015-04-03 | 2015-11-05 | (유)스템메디케어 | 중간엽 줄기세포에서 단백질의 대량 생산 방법 |
| MX2017013852A (es) | 2015-04-28 | 2019-04-15 | Texas A & M Univ Sys | Produccion escalable de vesiculas extracelulares estandarizadas, preparaciones de vesiculas extracelular y usos de estos. |
| WO2016201220A1 (en) * | 2015-06-10 | 2016-12-15 | Children's National Medical Center | Adipocyte-derived exosomes, and compositions, kits, and methods of using the same for detection and screening |
| CA2988585A1 (en) * | 2015-06-10 | 2016-12-15 | Raghu Kalluri | Use of exosomes for the treatment of disease |
| WO2016197196A1 (en) * | 2015-06-12 | 2016-12-15 | Prince Henry's Institute Of Medical Research Trading As The Hudson Institute Of Medical Research | A method of treatment |
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| SMT202300249T1 (it) * | 2015-07-31 | 2023-09-06 | Exotropin Llc | Composizione di esosomi e procedimenti per la loro preparazione e per il loro uso per la regolazione ed il condizionamento di pelle e capelli |
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| KR101843634B1 (ko) * | 2016-04-15 | 2018-03-30 | 사회복지법인 삼성생명공익재단 | 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물 |
| US11351200B2 (en) | 2016-06-03 | 2022-06-07 | Cedars-Sinai Medical Center | CDC-derived exosomes for treatment of ventricular tachyarrythmias |
| US10946047B2 (en) * | 2016-06-17 | 2021-03-16 | United Therapeutics Corporation | Extracellular vesicles with enhanced potency |
| CA3027970A1 (en) * | 2016-06-17 | 2017-12-21 | United Therapeutics Corporation | Extracellular vesicles with enhanced potency |
| EP3494979B1 (en) * | 2016-08-03 | 2025-07-09 | Yabuki, Hiroshi | Alleviation and treatment of ischemia reperfusion-induced lung injury using pluripotent stem cells |
| WO2018025973A1 (ja) | 2016-08-03 | 2018-02-08 | 国立大学法人名古屋大学 | 多能性幹細胞による慢性肺疾患の改善及び治療 |
| WO2018026203A1 (ko) * | 2016-08-05 | 2018-02-08 | 한양대학교 에리카산학협력단 | 지방 유래 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 폐 섬유증 예방 또는 치료용 조성물 |
| EP3515459A4 (en) | 2016-09-20 | 2020-08-05 | Cedars-Sinai Medical Center | CELLS DERIVED FROM CARDIOSPHERES AND THEIR EXTRACELLULAR VESICLES TO DELAY OR REVERSE AGING AND AGE-RELATED DISORDERS |
| EP3525801A1 (en) * | 2016-10-13 | 2019-08-21 | VBC Holdings LLC | Medical uses of exosomes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2018030845A (ja) * | 2011-03-11 | 2018-03-01 | チルドレンズ メディカル センター コーポレーション | 間葉系幹細胞エキソソームに関連する方法および組成物 |
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| CN103648509B (zh) | 2019-02-22 |
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| CN109432126A (zh) | 2019-03-08 |
| EP2683389B1 (en) | 2017-05-03 |
| US20140065240A1 (en) | 2014-03-06 |
| CN103648509A (zh) | 2014-03-19 |
| KR102063069B1 (ko) | 2020-01-08 |
| CA2829586C (en) | 2021-03-02 |
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