JP6204830B2 - 間葉系幹細胞エキソソームに関連する方法および組成物 - Google Patents

間葉系幹細胞エキソソームに関連する方法および組成物 Download PDF

Info

Publication number
JP6204830B2
JP6204830B2 JP2013557912A JP2013557912A JP6204830B2 JP 6204830 B2 JP6204830 B2 JP 6204830B2 JP 2013557912 A JP2013557912 A JP 2013557912A JP 2013557912 A JP2013557912 A JP 2013557912A JP 6204830 B2 JP6204830 B2 JP 6204830B2
Authority
JP
Japan
Prior art keywords
msc
exosomes
lung
hypoxia
mex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013557912A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014507482A (ja
JP2014507482A5 (enExample
Inventor
ミツィアリス,エス.,アレクサンダー
リー,チャンジン
コーレンバナス,ステラ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Original Assignee
Boston Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital filed Critical Boston Childrens Hospital
Publication of JP2014507482A publication Critical patent/JP2014507482A/ja
Publication of JP2014507482A5 publication Critical patent/JP2014507482A5/ja
Application granted granted Critical
Publication of JP6204830B2 publication Critical patent/JP6204830B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42Respiratory system, e.g. lungs, bronchi or lung cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0082Lung surfactant, artificial mucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • A61P33/12Schistosomicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
JP2013557912A 2011-03-11 2012-03-09 間葉系幹細胞エキソソームに関連する方法および組成物 Active JP6204830B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161451981P 2011-03-11 2011-03-11
US61/451,981 2011-03-11
PCT/US2012/028524 WO2012125471A1 (en) 2011-03-11 2012-03-09 Methods and compositions relating to mesenchymal stem cell exosomes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017168158A Division JP6524162B2 (ja) 2011-03-11 2017-09-01 間葉系幹細胞エキソソームに関連する方法および組成物

Publications (3)

Publication Number Publication Date
JP2014507482A JP2014507482A (ja) 2014-03-27
JP2014507482A5 JP2014507482A5 (enExample) 2016-09-01
JP6204830B2 true JP6204830B2 (ja) 2017-09-27

Family

ID=45852770

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013557912A Active JP6204830B2 (ja) 2011-03-11 2012-03-09 間葉系幹細胞エキソソームに関連する方法および組成物
JP2017168158A Active JP6524162B2 (ja) 2011-03-11 2017-09-01 間葉系幹細胞エキソソームに関連する方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2017168158A Active JP6524162B2 (ja) 2011-03-11 2017-09-01 間葉系幹細胞エキソソームに関連する方法および組成物

Country Status (8)

Country Link
US (3) US9901600B2 (enExample)
EP (1) EP2683389B1 (enExample)
JP (2) JP6204830B2 (enExample)
KR (2) KR101947699B1 (enExample)
CN (2) CN109432126B (enExample)
CA (1) CA2829586C (enExample)
ES (1) ES2629502T3 (enExample)
WO (1) WO2012125471A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018030845A (ja) * 2011-03-11 2018-03-01 チルドレンズ メディカル センター コーポレーション 間葉系幹細胞エキソソームに関連する方法および組成物

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
ITRM20110403A1 (it) 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
US9427450B2 (en) * 2012-01-31 2016-08-30 Xon Cells, Inc. Therapeutic immune modulation by stem cell secreted exosomes
GB201202319D0 (en) 2012-02-10 2012-03-28 Orbsen Therapeutics Ltd Stromal stem cells
EP3563859B1 (en) 2012-08-13 2021-10-13 Cedars-Sinai Medical Center Cardiosphere-derived exosomes for tissue regeneration
CN103865873B (zh) * 2012-12-12 2017-04-05 中国医学科学院基础医学研究所 亚全能干细胞分泌的外来体及其应用
CN115919901A (zh) * 2012-12-12 2023-04-07 麦瑟布莱斯特公司 治疗或预防呼吸病症的方法
AU2014239309B2 (en) * 2013-03-15 2020-03-05 Beth Israel Deaconess Medical Center, Inc. miRNA biogenesis in exosomes for diagnosis and therapy
WO2014197421A1 (en) 2013-06-05 2014-12-11 Biotime, Inc. Compositions and methods for induced tissue regeneration in mammalian species
EP3027738B1 (en) * 2013-08-01 2022-03-02 Swedish StromaBio AB Mscs in the treatment of inflammatory pulmonary diseases
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
CN104694466A (zh) * 2013-12-06 2015-06-10 山西医科大学 间充质干细胞来源的胞外体制备及在急性肺损伤中的应用
KR101643825B1 (ko) * 2013-12-12 2016-07-29 사회복지법인 삼성생명공익재단 트롬빈을 이용한 줄기세포 유래 엑소좀의 생성 촉진 방법
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
WO2015142061A1 (ko) 2014-03-18 2015-09-24 사회복지법인 삼성생명공익재단 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌 염증성 질환의 치료용 조성물
JP6773563B2 (ja) * 2014-05-18 2020-10-21 ザ チルドレンズ メディカル センター コーポレーション エキソソームに関連する方法および組成物
US20170112879A1 (en) * 2014-06-09 2017-04-27 University Of Washington Methods of protection against ischemia reperfusion injury
AU2015283662B2 (en) * 2014-06-30 2020-09-24 Takeda Pharmaceutical Company Limited Mesenchymal stromal cells for treating sepsis
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
US10918669B2 (en) 2014-07-25 2021-02-16 Recellerate, Inc. Methods of treating exercise-induced pulmonary hemorrhage
AU2015327812B2 (en) 2014-10-03 2021-04-15 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
WO2016057560A1 (en) * 2014-10-06 2016-04-14 Cedars-Sinai Medical Center Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
CN118161444A (zh) 2014-11-07 2024-06-11 胞外体干细胞株式会社 用于成脂分化诱导、脂肪组织再生、皮肤美白或改善皱纹的包含干细胞来源外泌体的组合物
WO2016072821A1 (ko) * 2014-11-07 2016-05-12 한양대학교 에리카산학협력단 줄기세포 유래 엑소좀을 함유하는 지방세포 분화유도, 지방조직 재생, 피부 미백 또는 주름개선용 조성물
EP3226875B1 (en) * 2014-12-03 2020-05-27 Capricor, Inc. Processes for producing stable exosome formulations
CN104560877B (zh) * 2014-12-18 2017-07-28 福州市传染病医院 一种快速分离细胞外吐小体的方法
EP3239292A4 (en) * 2014-12-24 2018-09-05 Ube Industries, Ltd. Cell culture supernatant fluid derived from lung tissue
WO2016111899A1 (en) 2015-01-05 2016-07-14 Petrucci Gary M Methods and materials for treating lung disorders
US9687511B2 (en) * 2015-03-06 2017-06-27 Vivex Biomedical, Inc. Acellular biologic composition and method of manufacture
US11160904B2 (en) * 2017-05-09 2021-11-02 Vivex Biologies Group, Inc. Biological composition in a protectant shroud and methods
US20180325830A1 (en) 2017-05-09 2018-11-15 Vivex Biomedical, Inc. Coated biological composition
KR101566450B1 (ko) * 2015-04-03 2015-11-05 (유)스템메디케어 중간엽 줄기세포에서 단백질의 대량 생산 방법
WO2016176500A1 (en) * 2015-04-28 2016-11-03 The Texas A&M University System Scalable production of standardized extracellular vesicles, extracellular vesicle preparations and uses thereof
EA201890006A1 (ru) 2015-06-10 2018-05-31 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем Применение экзосом для лечения болезни
US11320441B2 (en) 2015-06-10 2022-05-03 Children's National Medical Center Adipocyte-derived exosomes, and compositions, kits, and methods of using the same for detection and screening
KR102782722B1 (ko) * 2015-06-12 2025-03-18 허드슨 인스티튜트 오브 메디컬 리서치 치료 방법
US11077147B2 (en) * 2015-07-20 2021-08-03 Vivex Biologics Group, Inc. Acellular biologic composition and method of manufacture
PL3328397T3 (pl) * 2015-07-31 2023-10-16 Exotropin, Llc Kompozycje egzosomów oraz sposoby ich wytwarzania i stosowania do regulowania i kondycjonowania skóry i włosów
AU2016366158B2 (en) 2015-12-07 2023-02-23 Agex Therapeutics, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells
US11253551B2 (en) 2016-01-11 2022-02-22 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
US11918687B2 (en) * 2016-01-15 2024-03-05 Orbsen Therapeutics Limited SDC-2 exosome compositions and methods of isolation and use
CN109414340B (zh) 2016-01-29 2021-09-10 帕格尼亚医疗公司 用于肺递送的干细胞或干细胞衍生物的雾化
KR101843634B1 (ko) 2016-04-15 2018-03-30 사회복지법인 삼성생명공익재단 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
US10946047B2 (en) * 2016-06-17 2021-03-16 United Therapeutics Corporation Extracellular vesicles with enhanced potency
EP3471827A1 (en) * 2016-06-17 2019-04-24 United Therapeutics Corporation Extracellular vesicles with enhanced potency
SG10202101160RA (en) * 2016-08-03 2021-03-30 Hiroshi Yabuki Alleviation and treatment of ischemia reperfusion-induced lung injury using pluripotent stem cells
WO2018025973A1 (ja) * 2016-08-03 2018-02-08 国立大学法人名古屋大学 多能性幹細胞による慢性肺疾患の改善及び治療
JP6882450B2 (ja) * 2016-08-05 2021-06-02 株式会社エキソステムテックExostemtech Co.,Ltd. 脂肪由来幹細胞から抽出されたエキソソームを有効成分として含む肺線維症の予防または治療用の組成物
WO2018057542A1 (en) 2016-09-20 2018-03-29 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
CN110072534A (zh) * 2016-10-13 2019-07-30 Vbc控股有限责任公司 外泌体的医学应用
US20200046779A1 (en) * 2016-10-13 2020-02-13 Vbc Holdings Llc Anti-inflammatory exosomes from inflamed cells or tissues
US11963984B2 (en) * 2017-02-28 2024-04-23 Université De Lorraine Mesenchymal stem cells obtained from Wharton's jelly for the treatment of sepsis
WO2018187686A1 (en) * 2017-04-07 2018-10-11 StemoniX Inc. Method of manufacturing and purifying exosomes from non-terminally differentiated cells
AU2018255346B2 (en) 2017-04-19 2024-05-02 Capricor, Inc. Methods and compositions for treating skeletal muscular dystrophy
US11692172B2 (en) * 2017-06-26 2023-07-04 Mackay Memorial Hosptal Formulation comprising extracellular vesicles, method for producing the same, and uses thereof
WO2019010373A1 (en) 2017-07-06 2019-01-10 Children's National Medical Center Exosomes and methods of use thereof
KR20190011213A (ko) * 2017-07-24 2019-02-01 한양대학교 에리카산학협력단 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 골다공증 예방 또는 치료용 조성물
WO2019035880A1 (en) 2017-08-15 2019-02-21 Children's Medical Center Corporation EXOSOMES OF PURIFIED MESENCHYMAL STEM CELLS AND USES THEREOF
US11471559B2 (en) * 2017-11-20 2022-10-18 Vivex Biologics Group, Inc. Bioenergetic bone
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
WO2019152549A1 (en) 2018-02-05 2019-08-08 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and y-rnas
CA3098514A1 (en) 2018-04-30 2019-11-14 Children's Medical Center Corporation Mesenchymal stromal cell exosomes and uses thereof
US12031976B2 (en) 2018-05-04 2024-07-09 Samsung Life Public Welfare Foundation Screening method for therapeutic substance for preventing or treating bronchopulmonary dysplasia (BPD)
CA3101971A1 (en) * 2018-05-30 2019-12-05 Direct Biologics Llc A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use
US20210113625A1 (en) * 2018-06-11 2021-04-22 Health And Biotech France (H & B France) Extracellular vesicles derived from mesenchymal stem cells
EP3813858B1 (en) * 2018-06-29 2023-11-01 North Carolina State University Therapeutic lung repair by inhalation of lung spheroid exosomes
KR20210060441A (ko) * 2018-07-24 2021-05-26 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 세포외 소포의 형질전환과 연관된 조성물 및 방법
AU2019316742B2 (en) 2018-08-10 2024-11-14 Omnispirant Limited Extracellular vesicles for inhalation
US20220016175A1 (en) * 2018-11-15 2022-01-20 Washington University Stem cell-derived extracellular vesicles and methods of use thereof
JP2022522357A (ja) * 2019-02-28 2022-04-18 メラクリス セラピューティクス リミテッド ライアビリティ カンパニー 羊水由来の細胞外小胞及び創傷治癒のためのその使用
JP7372518B2 (ja) * 2019-06-27 2023-11-01 国立大学法人山口大学 骨髄由来間葉系幹細胞の培養方法
CA3146433A1 (en) 2019-07-18 2021-01-21 Direct Biologics Llc Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
EP4006144A4 (en) * 2019-07-31 2023-04-05 Shanghai Santeja H & M Tech. Development Inc THERAPEUTIC MEDICINE FOR FIBROSIS, INFLAMMATION AND/OR AGE-RELATED DISEASES
US20210052641A1 (en) * 2019-08-23 2021-02-25 United Therapeutics Corporation Pre-conditioned extracellular vesicles and methods of production
CN110777113B (zh) * 2019-09-10 2021-09-24 中山大学 一种用于日本血吸虫感染治疗的间质干细胞处理方法
KR20220131902A (ko) * 2019-12-04 2022-09-29 유나이티드 쎄러퓨틱스 코포레이션 세포외 소포 및 이의 용도
CN113384597A (zh) * 2020-03-13 2021-09-14 西比曼生物科技(上海)有限公司 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用
CN111346110A (zh) * 2020-03-17 2020-06-30 遵义医学院附属医院 间充质干细胞上清液在制备治疗肺细胞损伤制剂中的应用
WO2021216903A1 (en) * 2020-04-22 2021-10-28 Kenneth Allen Pettine Methods and compositions for treating inflammatory conditions associated with infectious disease
AU2021306640A1 (en) * 2020-07-09 2023-02-09 Exo Biologics Sa Process for the manufacturing of protein-associated extracellular vesicles
EP4178591A1 (en) 2020-07-09 2023-05-17 Exo Biologics Sa Extracellular vesicles and compositions thereof
EP4181935A1 (en) * 2020-07-20 2023-05-24 Brainstorm Cell Therapeutics Ltd. Methods and compositions for treating lung conditions
CN112007049A (zh) * 2020-09-21 2020-12-01 济南磐升生物技术有限公司 一种用于治疗膝骨关节炎的干细胞外泌体组合物
CN112043686A (zh) * 2020-09-21 2020-12-08 沈阳三禾生物科技有限公司 脐带间充质干细胞外泌体雾化液在制备治疗哮喘产品中的应用
EP3995130A1 (en) * 2020-11-06 2022-05-11 JunctuCell Biomed Manufacturing GmbH A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections
US20230414730A1 (en) * 2020-11-06 2023-12-28 Aatec Medical Gmbh A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections
US20230405050A1 (en) * 2020-11-26 2023-12-21 Samsung Life Public Welfare Foundation Composition for treating infectious diseases, comprising exosomes derived from thrombin-treated stem cells
USD1046870S1 (en) 2020-12-08 2024-10-15 Samsung Electronics Co., Ltd. Accessory panel for television receiver
CN112675203A (zh) * 2021-02-08 2021-04-20 瑞太生物科技(沈阳)有限公司 一种细胞来源的外泌体在制备治疗哮喘和/或肺纤维化生物制剂中的应用
WO2023044443A1 (en) 2021-09-16 2023-03-23 Life Technologies Corporation Cell expansion methods and compositions for use therein
EP4501338A1 (en) 2022-03-28 2025-02-05 Hiroko Science Inc. Pharmaceutical composition containing mir-140 and method for producing same
CN115725499B (zh) * 2022-08-15 2025-08-15 哈尔滨医科大学 一种人脐带间充质干细胞膜仿生纳米囊泡的制备方法和应用
CN116897887A (zh) * 2023-07-31 2023-10-20 湖南中医药大学 一种病毒性哮喘动物模型的构建方法
US12502407B2 (en) 2024-04-25 2025-12-23 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles
WO2025250774A1 (en) * 2024-05-31 2025-12-04 Leksum LLC Extracellular vesicles for therapy

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
FR2766205B1 (fr) * 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
US20030221199A1 (en) * 1998-10-20 2003-11-27 Whitsett Jeffrey A. Surfactant protein D for the prevention and diagnosis of pulmonary emphysema
US20040214783A1 (en) * 2002-05-08 2004-10-28 Terman David S. Compositions and methods for treatment of neoplastic disease
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
US8337815B2 (en) 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
US20060286089A1 (en) 2005-04-08 2006-12-21 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
CN101341245A (zh) 2005-09-02 2009-01-07 新加坡科技研究局 获取祖细胞系的方法
US9029146B2 (en) 2005-09-02 2015-05-12 Agency For Science, Technology And Research Mesenchymal stem cell conditioned medium
WO2007124594A1 (en) * 2006-04-27 2007-11-08 Cell Therapy Technologies, Inc. Et Al. Stem cells for treating lung diseases
DK2578081T3 (en) * 2006-10-11 2016-06-27 Massachusetts Gen Hospital Compositions, methods and devices for the treatment of liver disease
SI2254586T1 (sl) 2008-02-22 2015-07-31 Agency For Science, Technology And Research (A*Star) Delci mezenhimske matične celice
SG10201403202XA (en) 2009-07-23 2014-08-28 Agency Science Tech & Res Pre-natal mesenchymal stem cells
CN102858997B (zh) * 2009-11-02 2014-06-18 新加坡科技研究局 用于监测细胞状态和用于永生间充质干细胞的方法
KR101189655B1 (ko) 2010-06-30 2012-10-11 성균관대학교산학협력단 줄기세포 배양액을 포함하는 폐질환 치료용 조성물
CN101890050B (zh) * 2010-07-14 2012-07-04 江苏大学 脐带间质干细胞来源膜性囊泡及其应用
WO2012020308A2 (en) 2010-08-13 2012-02-16 The University Court Of The University Of Glasgow Cellular and molecular therapies
WO2012115885A1 (en) 2011-02-22 2012-08-30 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers
ES2629502T3 (es) * 2011-03-11 2017-08-10 Children's Medical Center Corporation Métodos y composiciones relacionados con exosomas de células madre mesenquimales
EP2833893B1 (en) 2012-04-03 2018-08-29 Reneuron Limited Stem cell microparticles
JP6773563B2 (ja) 2014-05-18 2020-10-21 ザ チルドレンズ メディカル センター コーポレーション エキソソームに関連する方法および組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018030845A (ja) * 2011-03-11 2018-03-01 チルドレンズ メディカル センター コーポレーション 間葉系幹細胞エキソソームに関連する方法および組成物

Also Published As

Publication number Publication date
US20140065240A1 (en) 2014-03-06
WO2012125471A1 (en) 2012-09-20
JP2014507482A (ja) 2014-03-27
ES2629502T3 (es) 2017-08-10
CA2829586C (en) 2021-03-02
KR101947699B1 (ko) 2019-02-14
US20180221412A1 (en) 2018-08-09
KR20140024310A (ko) 2014-02-28
US20220096560A1 (en) 2022-03-31
US9901600B2 (en) 2018-02-27
CN103648509A (zh) 2014-03-19
CA2829586A1 (en) 2012-09-20
WO2012125471A9 (en) 2012-11-08
EP2683389B1 (en) 2017-05-03
JP6524162B2 (ja) 2019-06-05
JP2018030845A (ja) 2018-03-01
CN103648509B (zh) 2019-02-22
EP2683389A1 (en) 2014-01-15
KR102063069B1 (ko) 2020-01-08
KR20190018536A (ko) 2019-02-22
CN109432126A (zh) 2019-03-08
CN109432126B (zh) 2022-06-14

Similar Documents

Publication Publication Date Title
JP6204830B2 (ja) 間葉系幹細胞エキソソームに関連する方法および組成物
US11759481B2 (en) Methods and compositions relating to exosomes
JP2024120900A (ja) 精製された間葉系幹細胞エキソソームおよびその使用
CN115066491A (zh) 细胞外囊泡及其用途
Bisaccia Study of the mechanism of action of extracellular vesicles derived from umbilical cord stromal cells in a rat model of bronchopulmonary dysplasia: focus on oxidative stress and fibrosis processes.

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150309

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150309

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160104

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160401

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20160603

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160704

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20160704

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161202

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170302

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170501

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170602

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20170703

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170802

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20170901

R150 Certificate of patent or registration of utility model

Ref document number: 6204830

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250