JP6195561B2 - 外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体 - Google Patents

外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体 Download PDF

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JP6195561B2
JP6195561B2 JP2014514097A JP2014514097A JP6195561B2 JP 6195561 B2 JP6195561 B2 JP 6195561B2 JP 2014514097 A JP2014514097 A JP 2014514097A JP 2014514097 A JP2014514097 A JP 2014514097A JP 6195561 B2 JP6195561 B2 JP 6195561B2
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artesunate
treatment
reperfusion
hemorrhagic shock
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JP2014517001A (ja
JP2014517001A5 (https=
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ティーマーマン,クリストフ
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クイーン マリー ユニバーシティ オブ ロンドン
クイーン マリー ユニバーシティ オブ ロンドン
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Priority claimed from GBGB1109845.6A external-priority patent/GB201109845D0/en
Priority claimed from GBGB1109846.4A external-priority patent/GB201109846D0/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2014514097A 2011-06-10 2012-06-08 外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体 Expired - Fee Related JP6195561B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1109847.2 2011-06-10
GBGB1109847.2A GB201109847D0 (en) 2011-06-10 2011-06-10 Artemisinin and its derivatives for use in the treatment of myocardial infarction and coronary heart disease
GB1109846.4 2011-06-10
GBGB1109845.6A GB201109845D0 (en) 2011-06-10 2011-06-10 Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions
GBGB1109846.4A GB201109846D0 (en) 2011-06-10 2011-06-10 Artemisinin and its derivatives for use in medicine
GB1109845.6 2011-06-10
PCT/EP2012/060929 WO2012168450A1 (en) 2011-06-10 2012-06-08 Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions

Publications (3)

Publication Number Publication Date
JP2014517001A JP2014517001A (ja) 2014-07-17
JP2014517001A5 JP2014517001A5 (https=) 2015-07-23
JP6195561B2 true JP6195561B2 (ja) 2017-09-13

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JP2014514097A Expired - Fee Related JP6195561B2 (ja) 2011-06-10 2012-06-08 外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体

Country Status (5)

Country Link
US (2) US9623005B2 (https=)
EP (2) EP3269371A1 (https=)
JP (1) JP6195561B2 (https=)
ES (1) ES2643182T3 (https=)
WO (1) WO2012168450A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6195561B2 (ja) 2011-06-10 2017-09-13 クイーン マリー ユニバーシティ オブ ロンドン 外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体
US9603831B2 (en) 2012-12-12 2017-03-28 Queen Mary & Westfield College, University Of London Artemisinin and its derivatives for use in the treatment of kidney disease
CN104721874B (zh) * 2014-12-23 2017-09-22 重庆联佰博超医疗器械有限公司 一种多糖止血粉及其制备方法、应用
CN104523679A (zh) * 2015-01-09 2015-04-22 中国人民解放军第三军医大学第一附属医院 青蒿琥酯在制备治疗、预防中枢神经损伤药物中的应用
CN105147666A (zh) * 2015-09-09 2015-12-16 云南大学 一种治疗和缓解神经变性疾病的化合物
CN105963244A (zh) 2016-01-15 2016-09-28 赵鸣 注射用青蒿琥酯制剂及其应用
ES2651717B1 (es) * 2016-07-26 2018-11-16 Lara OLLER DUQUE Solución acuosa cristaloide isotónica
KR20190067155A (ko) 2016-08-02 2019-06-14 유나이티 헬스 토론토 대뇌내 출혈 및 뇌 미세출혈의 발생률을 감소시키는 소분자 치료 화합물
CN107793427A (zh) * 2016-08-30 2018-03-13 天津太平洋制药有限公司 一种青蒿琥酯的制备方法
WO2019104247A1 (en) 2017-11-21 2019-05-31 Ming Zhao Artemisinin-derived trimers and tetramers and their use thereof
CN109364061A (zh) * 2018-10-30 2019-02-22 澳门大学 蒿甲醚在防治脑卒中的应用
CN109364064A (zh) * 2018-10-30 2019-02-22 澳门大学 青蒿素在防治脑卒中的应用
US11478200B2 (en) * 2018-12-12 2022-10-25 Covidien Lp Blood pressure and autoregulation monitoring
CN111235098B (zh) * 2020-01-17 2022-06-28 康妍葆(北京)干细胞科技有限公司 青蒿素在制备培养干细胞的产品中的应用、培养基及培养方法
EP4015623A1 (en) * 2020-12-17 2022-06-22 Universite De Montpellier Pre-treatment of msc with ppar beta/delta agonist for treatment of ischemia-reperfusion injury
US20240122987A1 (en) * 2022-10-14 2024-04-18 The Government Of The United States, As Represented By The Secretary Of The Army Prolyl hydroxylase domain inhibitor treatment to improve survivability of hemorrhagic shock

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CN1814601A (zh) 2005-02-04 2006-08-09 中国科学院上海药物研究所 具有免疫抑制作用的青蒿素衍生物及药物组合物
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JP6195561B2 (ja) 2011-06-10 2017-09-13 クイーン マリー ユニバーシティ オブ ロンドン 外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体
US9603831B2 (en) * 2012-12-12 2017-03-28 Queen Mary & Westfield College, University Of London Artemisinin and its derivatives for use in the treatment of kidney disease

Also Published As

Publication number Publication date
US9949948B2 (en) 2018-04-24
JP2014517001A (ja) 2014-07-17
ES2643182T3 (es) 2017-11-21
US20150297558A1 (en) 2015-10-22
EP2717879B1 (en) 2017-08-16
EP2717879A1 (en) 2014-04-16
WO2012168450A1 (en) 2012-12-13
US9623005B2 (en) 2017-04-18
EP3269371A1 (en) 2018-01-17
US20170182000A1 (en) 2017-06-29

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