JP6195561B2 - 外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体 - Google Patents

外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体 Download PDF

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Publication number
JP6195561B2
JP6195561B2 JP2014514097A JP2014514097A JP6195561B2 JP 6195561 B2 JP6195561 B2 JP 6195561B2 JP 2014514097 A JP2014514097 A JP 2014514097A JP 2014514097 A JP2014514097 A JP 2014514097A JP 6195561 B2 JP6195561 B2 JP 6195561B2
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artesunate
treatment
reperfusion
hemorrhagic shock
group
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JP2014517001A5 (enExample
JP2014517001A (ja
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ティーマーマン,クリストフ
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クイーン マリー ユニバーシティ オブ ロンドン
クイーン マリー ユニバーシティ オブ ロンドン
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Priority claimed from GBGB1109846.4A external-priority patent/GB201109846D0/en
Priority claimed from GBGB1109847.2A external-priority patent/GB201109847D0/en
Application filed by クイーン マリー ユニバーシティ オブ ロンドン, クイーン マリー ユニバーシティ オブ ロンドン filed Critical クイーン マリー ユニバーシティ オブ ロンドン
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014514097A 2011-06-10 2012-06-08 外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体 Expired - Fee Related JP6195561B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1109845.6A GB201109845D0 (en) 2011-06-10 2011-06-10 Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions
GB1109846.4 2011-06-10
GBGB1109846.4A GB201109846D0 (en) 2011-06-10 2011-06-10 Artemisinin and its derivatives for use in medicine
GB1109847.2 2011-06-10
GB1109845.6 2011-06-10
GBGB1109847.2A GB201109847D0 (en) 2011-06-10 2011-06-10 Artemisinin and its derivatives for use in the treatment of myocardial infarction and coronary heart disease
PCT/EP2012/060929 WO2012168450A1 (en) 2011-06-10 2012-06-08 Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions

Publications (3)

Publication Number Publication Date
JP2014517001A JP2014517001A (ja) 2014-07-17
JP2014517001A5 JP2014517001A5 (enExample) 2015-07-23
JP6195561B2 true JP6195561B2 (ja) 2017-09-13

Family

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JP2014514097A Expired - Fee Related JP6195561B2 (ja) 2011-06-10 2012-06-08 外傷出血および関連症状の治療における使用のための、アルテミシニンおよびその誘導体

Country Status (5)

Country Link
US (2) US9623005B2 (enExample)
EP (2) EP3269371A1 (enExample)
JP (1) JP6195561B2 (enExample)
ES (1) ES2643182T3 (enExample)
WO (1) WO2012168450A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3269371A1 (en) * 2011-06-10 2018-01-17 Queen Mary University of London Artemisinin and its derivatives for use in the treatment of myocardial infarction or coronary heart disease
US9603831B2 (en) 2012-12-12 2017-03-28 Queen Mary & Westfield College, University Of London Artemisinin and its derivatives for use in the treatment of kidney disease
CN104721874B (zh) * 2014-12-23 2017-09-22 重庆联佰博超医疗器械有限公司 一种多糖止血粉及其制备方法、应用
CN104523679A (zh) * 2015-01-09 2015-04-22 中国人民解放军第三军医大学第一附属医院 青蒿琥酯在制备治疗、预防中枢神经损伤药物中的应用
CN105147666A (zh) * 2015-09-09 2015-12-16 云南大学 一种治疗和缓解神经变性疾病的化合物
CN105963244A (zh) 2016-01-15 2016-09-28 赵鸣 注射用青蒿琥酯制剂及其应用
ES2651717B1 (es) * 2016-07-26 2018-11-16 Lara OLLER DUQUE Solución acuosa cristaloide isotónica
KR20190067155A (ko) * 2016-08-02 2019-06-14 유나이티 헬스 토론토 대뇌내 출혈 및 뇌 미세출혈의 발생률을 감소시키는 소분자 치료 화합물
CN107793427A (zh) * 2016-08-30 2018-03-13 天津太平洋制药有限公司 一种青蒿琥酯的制备方法
EP3713566A4 (en) 2017-11-21 2021-07-14 Ming Zhao TRIMERS AND TRETRAMERS OF ARTEMISININ AND THEIR USES
CN109364064A (zh) * 2018-10-30 2019-02-22 澳门大学 青蒿素在防治脑卒中的应用
CN109364061A (zh) * 2018-10-30 2019-02-22 澳门大学 蒿甲醚在防治脑卒中的应用
US11478200B2 (en) * 2018-12-12 2022-10-25 Covidien Lp Blood pressure and autoregulation monitoring
CN111235098B (zh) * 2020-01-17 2022-06-28 康妍葆(北京)干细胞科技有限公司 青蒿素在制备培养干细胞的产品中的应用、培养基及培养方法
EP4015623A1 (en) * 2020-12-17 2022-06-22 Universite De Montpellier Pre-treatment of msc with ppar beta/delta agonist for treatment of ischemia-reperfusion injury
US20240122987A1 (en) * 2022-10-14 2024-04-18 The Government Of The United States, As Represented By The Secretary Of The Army Prolyl hydroxylase domain inhibitor treatment to improve survivability of hemorrhagic shock

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AU4922499A (en) 1998-07-14 2000-02-07 Hong Kong University Of Science & Technology, The Trioxane derivatives
US7417156B2 (en) 2002-09-27 2008-08-26 Johns Hopkins University Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers
EP1838301B1 (de) 2004-12-28 2015-01-28 Mestex AG Verwendung von resiniferatoxin (rtx) für die herstellung eines mittels zur behandlung von schmerzen
CN1814601A (zh) 2005-02-04 2006-08-09 中国科学院上海药物研究所 具有免疫抑制作用的青蒿素衍生物及药物组合物
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US20100137246A1 (en) 2008-12-02 2010-06-03 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Anti-inflammatory compositions and methods
SG174483A1 (en) 2009-03-24 2011-10-28 Univ Singapore Use of artemisinin derivatives for the treatment of asthma and chronic obstructive pulmonary disease (copd)
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EP3269371A1 (en) 2011-06-10 2018-01-17 Queen Mary University of London Artemisinin and its derivatives for use in the treatment of myocardial infarction or coronary heart disease
US9603831B2 (en) * 2012-12-12 2017-03-28 Queen Mary & Westfield College, University Of London Artemisinin and its derivatives for use in the treatment of kidney disease

Also Published As

Publication number Publication date
ES2643182T3 (es) 2017-11-21
WO2012168450A1 (en) 2012-12-13
JP2014517001A (ja) 2014-07-17
US20170182000A1 (en) 2017-06-29
EP2717879A1 (en) 2014-04-16
US9949948B2 (en) 2018-04-24
US20150297558A1 (en) 2015-10-22
US9623005B2 (en) 2017-04-18
EP3269371A1 (en) 2018-01-17
EP2717879B1 (en) 2017-08-16

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