JP6147769B2 - アミノスルホン化合物の調製のための不斉合成方法 - Google Patents

アミノスルホン化合物の調製のための不斉合成方法 Download PDF

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JP6147769B2
JP6147769B2 JP2014557883A JP2014557883A JP6147769B2 JP 6147769 B2 JP6147769 B2 JP 6147769B2 JP 2014557883 A JP2014557883 A JP 2014557883A JP 2014557883 A JP2014557883 A JP 2014557883A JP 6147769 B2 JP6147769 B2 JP 6147769B2
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formula
isotopologue
metal catalyst
chiral
mol
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JP2015507023A (ja
JP2015507023A5 (enExample
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ジェイ．コノリ テレンス
ジェイ．コノリ テレンス
エル．ルチェルマン アレクアンデル
エル．ルチェルマン アレクアンデル
ダブリュー．レオング ウイリアム
ダブリュー．レオング ウイリアム
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Celgene Corp
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Celgene Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2014557883A 2012-02-21 2013-02-21 アミノスルホン化合物の調製のための不斉合成方法 Active JP6147769B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261601480P 2012-02-21 2012-02-21
US61/601,480 2012-02-21
US201261648521P 2012-05-17 2012-05-17
US61/648,521 2012-05-17
PCT/US2013/027010 WO2013126495A2 (en) 2012-02-21 2013-02-21 Asymmetric synthetic processes for the preparation of aminosulfone compounds

Publications (3)

Publication Number Publication Date
JP2015507023A JP2015507023A (ja) 2015-03-05
JP2015507023A5 JP2015507023A5 (enExample) 2016-04-07
JP6147769B2 true JP6147769B2 (ja) 2017-06-14

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JP2014557883A Active JP6147769B2 (ja) 2012-02-21 2013-02-21 アミノスルホン化合物の調製のための不斉合成方法

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US (1) US9126906B2 (enExample)
EP (1) EP2817289B1 (enExample)
JP (1) JP6147769B2 (enExample)
ES (1) ES2613850T3 (enExample)
WO (1) WO2013126495A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR090100A1 (es) 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US8981117B2 (en) 2012-09-14 2015-03-17 Celgene Corporation Processes for the preparation of isoindole compounds and isotopologues thereof
EP2949645A1 (en) 2014-05-28 2015-12-02 LEK Pharmaceuticals d.d. Processes for the preparation of ß-aminosulfone compounds
CN105622380B (zh) * 2014-10-29 2020-06-30 南京安源生物医药科技有限公司 一种阿普斯特的制备方法及其中间体
CN104447443B (zh) * 2014-12-05 2016-07-27 新发药业有限公司 一种阿普斯特及其中间体的制备方法
CN104761474B (zh) * 2015-03-11 2016-11-30 中山奕安泰医药科技有限公司 一种阿普斯特手性胺中间体的合成方法
EP3280701B1 (en) 2015-04-09 2019-10-16 Zentiva K.S. A method of chiral resolution of the key intermediate of the synthesis of apremilast and its use for the preparation of pure apremilast
CN104803897A (zh) * 2015-04-23 2015-07-29 中山奕安泰医药科技有限公司 一种阿普斯特中间体的合成工艺
WO2016189486A1 (en) * 2015-05-26 2016-12-01 Lupin Limited An improved process for preparation of apremilast and novel polymorphs thereof
CZ2015383A3 (cs) 2015-06-05 2016-12-14 Zentiva, K.S. Způsob přípravy klíčového intermediátu apremilastu, využívající enzymatické štěpení racemických aminů
EP3106457A1 (en) 2015-06-15 2016-12-21 LEK Pharmaceuticals d.d. A novel synthetic pathway towards apremilast
EP3144393A1 (en) 2015-09-18 2017-03-22 LEK Pharmaceuticals d.d. A synthetic pathway towards apremilast
WO2017059040A1 (en) 2015-09-29 2017-04-06 Pliva Hrvatska D.O.O. Processes for the preparation of apremilast and intermediates thereof
CN105218428A (zh) * 2015-10-20 2016-01-06 南京美嘉宁逸医药研究开发有限公司 一种高手性纯度的阿普斯特的制备方法
CN105461602B (zh) * 2015-11-27 2018-01-02 东华大学 手性S或R‑3‑乙氧基‑4‑甲氧基‑α‑[(甲磺酰基)甲基]苯甲醇的制备方法
CN105330586B (zh) * 2015-11-27 2017-12-22 东华大学 一种阿普斯特的制备方法
US10774041B2 (en) 2016-04-15 2020-09-15 Davuluri Ramamohan Rao Process for the preparation of apremilast
IT201600083132A1 (it) * 2016-08-05 2018-02-05 Dipharma Francis Srl Procedimento per la preparazione di un inibitore della fosfodiesterasi 4
EP3606908B1 (en) 2017-04-04 2020-06-17 Quimica Sintetica, S.A. Resolution of racemic beta-aminosulfone compounds
EP3421455B1 (en) * 2017-06-29 2019-03-27 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of chiral 3-amino-piperidins, useful intermediates for the preparation of tofacitinib
CN112645854B (zh) * 2020-12-23 2023-04-07 中山奕安泰医药科技有限公司 阿普斯特类中间体的精制方法
CN115894310A (zh) * 2021-08-13 2023-04-04 江苏正大清江制药有限公司 阿普斯特手性胺中间体新的制备方法
CN115850129B (zh) * 2023-02-28 2023-05-16 凯莱英生命科学技术(天津)有限公司 （s）-1-(3-乙氧基-4-甲氧基苯基)-2-（甲磺酰基）乙胺的制备方法
CN118834155B (zh) * 2024-06-21 2025-08-12 江苏知原药业股份有限公司 阿普米司特的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205978A1 (es) * 1972-11-15 1976-06-23 Sarl Una bandeja de embalaje apilable
US5250731A (en) * 1992-03-17 1993-10-05 E. I. Du Pont De Nemours And Company Preparation of optically active hydrazines and amines
EA001207B1 (ru) 1996-03-22 2000-12-25 Дюпон Фармасьютикалз Компани Способ получения r-альфа-пропил-пиперониламина и его аналогов, промежуточные продукты, используемые в этом способе
WO1997047633A1 (en) * 1996-06-14 1997-12-18 The Penn State Research Foundation Asymmetric synthesis catalyzed by transition metal complexes with cyclic chiral phosphine ligands
US6121184A (en) * 1997-07-29 2000-09-19 E. I. Du Pont De Nemours And Company Supported bis(phosphorus) ligands
DE19741399A1 (de) * 1997-09-19 1999-03-25 Bayer Ag Tetrahydrochinoline
WO1999015481A1 (en) * 1997-09-24 1999-04-01 Darwin Discovery Limited Asymmetric hydrogenation
CN102076634A (zh) 2008-06-27 2011-05-25 默克弗罗斯特加拿大有限公司 手性胺的合成
HRP20130356T1 (en) * 2008-09-10 2013-05-31 Celgene Corporation Processes for the preparation of aminosulfone compounds
AU2010246749B8 (en) 2009-05-14 2014-03-20 Ganzhou Hemay Pharmaceutical Co., Ltd Thiophene derivatives
US20110040091A1 (en) * 2009-08-13 2011-02-17 Stephan Bachmann Process for the preparation of (r)-2-phenyl propionic acid derivatives
AR090100A1 (es) * 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US8981117B2 (en) * 2012-09-14 2015-03-17 Celgene Corporation Processes for the preparation of isoindole compounds and isotopologues thereof

Also Published As

Publication number Publication date
JP2015507023A (ja) 2015-03-05
EP2817289A2 (en) 2014-12-31
EP2817289B1 (en) 2016-12-21
US20130217919A1 (en) 2013-08-22
WO2013126495A3 (en) 2013-10-31
WO2013126495A2 (en) 2013-08-29
ES2613850T3 (es) 2017-05-26
US9126906B2 (en) 2015-09-08

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