JP6141929B2 - アントシアニジンを含む組成物及び使用方法 - Google Patents
アントシアニジンを含む組成物及び使用方法 Download PDFInfo
- Publication number
- JP6141929B2 JP6141929B2 JP2015182146A JP2015182146A JP6141929B2 JP 6141929 B2 JP6141929 B2 JP 6141929B2 JP 2015182146 A JP2015182146 A JP 2015182146A JP 2015182146 A JP2015182146 A JP 2015182146A JP 6141929 B2 JP6141929 B2 JP 6141929B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- delphinidin
- anthocyanidins
- weight
- cyanidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims description 291
- 229930014669 anthocyanidin Natural products 0.000 title claims description 198
- 235000008758 anthocyanidins Nutrition 0.000 title claims description 198
- NWKFECICNXDNOQ-UHFFFAOYSA-N flavylium Chemical compound C1=CC=CC=C1C1=CC=C(C=CC=C2)C2=[O+]1 NWKFECICNXDNOQ-UHFFFAOYSA-N 0.000 title claims description 134
- 238000000034 method Methods 0.000 title claims description 51
- 235000007242 delphinidin Nutrition 0.000 claims description 205
- GCPYCNBGGPHOBD-UHFFFAOYSA-N Delphinidin Natural products OC1=Cc2c(O)cc(O)cc2OC1=C3C=C(O)C(=O)C(=C3)O GCPYCNBGGPHOBD-UHFFFAOYSA-N 0.000 claims description 173
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims description 64
- 229930002877 anthocyanin Natural products 0.000 claims description 64
- 235000010208 anthocyanin Nutrition 0.000 claims description 64
- 239000004410 anthocyanin Substances 0.000 claims description 64
- 150000004636 anthocyanins Chemical class 0.000 claims description 60
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 claims description 58
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 claims description 58
- 239000000284 extract Substances 0.000 claims description 55
- VEVZSMAEJFVWIL-UHFFFAOYSA-O cyanidin cation Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC=C(O)C(O)=C1 VEVZSMAEJFVWIL-UHFFFAOYSA-O 0.000 claims description 53
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 34
- 241000282414 Homo sapiens Species 0.000 claims description 31
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 31
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 31
- 241000196324 Embryophyta Species 0.000 claims description 28
- 235000007336 cyanidin Nutrition 0.000 claims description 27
- 230000004054 inflammatory process Effects 0.000 claims description 23
- 235000000346 sugar Nutrition 0.000 claims description 23
- 206010061218 Inflammation Diseases 0.000 claims description 22
- 206010012601 diabetes mellitus Diseases 0.000 claims description 21
- 241001465754 Metazoa Species 0.000 claims description 18
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 17
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 17
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 17
- 235000005875 quercetin Nutrition 0.000 claims description 17
- 229960001285 quercetin Drugs 0.000 claims description 17
- 230000036737 immune function Effects 0.000 claims description 15
- 210000000987 immune system Anatomy 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 14
- 238000000605 extraction Methods 0.000 claims description 13
- 208000015181 infectious disease Diseases 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 13
- 208000024891 symptom Diseases 0.000 claims description 12
- 208000011580 syndromic disease Diseases 0.000 claims description 11
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 claims description 9
- 206010028980 Neoplasm Diseases 0.000 claims description 9
- YTMNONATNXDQJF-UBNZBFALSA-N chrysanthemin Chemical compound [Cl-].O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 YTMNONATNXDQJF-UBNZBFALSA-N 0.000 claims description 8
- 244000144972 livestock Species 0.000 claims description 8
- 241000988895 Aristotelia chilensis Species 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- GXPTVXHTZZVLMQ-GCGJSEPQSA-N myrtillin Natural products O[C@H]1O[C@@H](OCC2=C(OC3=CC(=O)C=C(O)C3=C2)c4cc(O)c(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O GXPTVXHTZZVLMQ-GCGJSEPQSA-N 0.000 claims description 7
- CWVRJTMFETXNAD-GMZLATJGSA-N 5-Caffeoyl quinic acid Natural products O[C@H]1C[C@](O)(C[C@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-GMZLATJGSA-N 0.000 claims description 6
- 208000030507 AIDS Diseases 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- GVRNTWSGBWPJGS-YSDSKTICSA-N 4-[2-[(1r,4as,5r,6r,8as)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-2h-furan-5-one Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)CC1=CCOC1=O GVRNTWSGBWPJGS-YSDSKTICSA-N 0.000 claims description 5
- YGCYRQKJYWQXHG-RDNQFMDVSA-N 4-[2-[(1r,4as,5r,8as)-5,8a-dimethyl-2-methylidene-5-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-2h-furan-5-one Chemical compound C([C@@]1(C)[C@H]2CCC(=C)[C@@H](CCC=3C(OCC=3)=O)[C@]2(C)CCC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YGCYRQKJYWQXHG-RDNQFMDVSA-N 0.000 claims description 5
- MEEPUSVTMHGIPC-UHFFFAOYSA-N deoxyandrographiside Natural products OC1CCC2(C)C(CCC=3C(OCC=3)=O)C(=C)CCC2C1(C)COC1OC(CO)C(O)C(O)C1O MEEPUSVTMHGIPC-UHFFFAOYSA-N 0.000 claims description 5
- GVRNTWSGBWPJGS-UHFFFAOYSA-N deoxyandrographolide Natural products C=C1CCC2C(C)(CO)C(O)CCC2(C)C1CCC1=CCOC1=O GVRNTWSGBWPJGS-UHFFFAOYSA-N 0.000 claims description 5
- BBGWVUQBIGGVLS-UHFFFAOYSA-N neoandrographolide Natural products CC1(COC2OC(CO)C(O)C(O)C2O)C(O)CCC3(C)C(CCC4=C(O)COC4=O)C(=C)CCC13 BBGWVUQBIGGVLS-UHFFFAOYSA-N 0.000 claims description 5
- YGCYRQKJYWQXHG-UHFFFAOYSA-N neoandrographoside Natural products C1CCC2(C)C(CCC=3C(OCC=3)=O)C(=C)CCC2C1(C)COC1OC(CO)C(O)C(O)C1O YGCYRQKJYWQXHG-UHFFFAOYSA-N 0.000 claims description 5
- 239000002561 chemical irritant Substances 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 239000003053 toxin Substances 0.000 claims description 4
- 231100000765 toxin Toxicity 0.000 claims description 4
- 230000008736 traumatic injury Effects 0.000 claims description 4
- 241000746375 Andrographis Species 0.000 claims description 3
- 208000035143 Bacterial infection Diseases 0.000 claims description 3
- 208000036142 Viral infection Diseases 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 3
- RDFLLVCQYHQOBU-ZOTFFYTFSA-O cyanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=[O+]C1=CC(O)=C2)C=3C=C(O)C(O)=CC=3)=CC1=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 RDFLLVCQYHQOBU-ZOTFFYTFSA-O 0.000 claims description 3
- 230000009385 viral infection Effects 0.000 claims description 3
- JKHRCGUTYDNCLE-UHFFFAOYSA-O delphinidin Chemical compound [O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC(O)=C(O)C(O)=C1 JKHRCGUTYDNCLE-UHFFFAOYSA-O 0.000 claims 3
- BWHXEGJOYVNGQH-XOBUMVIESA-N (2s,3r,4s,5r)-2-[(2s,3r,4s,5s,6r)-2-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromenylium-3-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;chloride Chemical compound [Cl-].O([C@@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)CO1)O)O)CO)C1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 BWHXEGJOYVNGQH-XOBUMVIESA-N 0.000 claims 2
- RKWHWFONKJEUEF-GQUPQBGVSA-O Cyanidin 3-O-glucoside Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 RKWHWFONKJEUEF-GQUPQBGVSA-O 0.000 claims 2
- OIZFQAFWYYKPMR-PEVLUNPASA-N Delphinidin 3-O-glucoside Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)C=1[C-](c2cc(O)c(O)c(O)c2)[O+]c2c(c(O)cc(O)c2)C=1 OIZFQAFWYYKPMR-PEVLUNPASA-N 0.000 claims 2
- XENHPQQLDPAYIJ-PEVLUNPASA-O delphinidin 3-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC(O)=C(O)C(O)=C1 XENHPQQLDPAYIJ-PEVLUNPASA-O 0.000 claims 2
- XCTGXGVGJYACEI-LCENJUANSA-O delphinidin 3-O-beta-D-glucoside-5-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=[O+]C1=CC(O)=C2)C=3C=C(O)C(O)=C(O)C=3)=CC1=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 XCTGXGVGJYACEI-LCENJUANSA-O 0.000 claims 2
- 230000003113 alkalizing effect Effects 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- CWVRJTMFETXNAD-NXLLHMKUSA-N trans-5-O-caffeoyl-D-quinic acid Chemical compound O[C@H]1[C@H](O)C[C@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-NXLLHMKUSA-N 0.000 claims 1
- FFNDMZIBVDSQFI-UHFFFAOYSA-N delphinidin chloride Chemical compound [Cl-].[O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC(O)=C(O)C(O)=C1 FFNDMZIBVDSQFI-UHFFFAOYSA-N 0.000 description 169
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 74
- 210000001744 T-lymphocyte Anatomy 0.000 description 49
- 210000004027 cell Anatomy 0.000 description 43
- 150000001875 compounds Chemical class 0.000 description 35
- 239000011575 calcium Substances 0.000 description 30
- 230000000694 effects Effects 0.000 description 30
- 238000011282 treatment Methods 0.000 description 30
- 150000003839 salts Chemical class 0.000 description 25
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 23
- 229910052791 calcium Inorganic materials 0.000 description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 23
- 239000000243 solution Substances 0.000 description 22
- XPRZIORDEVHURQ-UHFFFAOYSA-N n-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide Chemical compound N1=NSC(C(=O)NC=2C=CC(=CC=2)N2C(=CC(=N2)C(F)(F)F)C(F)(F)F)=C1C XPRZIORDEVHURQ-UHFFFAOYSA-N 0.000 description 21
- 102000010907 Cyclooxygenase 2 Human genes 0.000 description 20
- 108010037462 Cyclooxygenase 2 Proteins 0.000 description 20
- 230000004073 interleukin-2 production Effects 0.000 description 19
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical class O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 18
- 229920002770 condensed tannin Polymers 0.000 description 17
- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 17
- -1 delphinidin glycoside Chemical class 0.000 description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- 235000013399 edible fruits Nutrition 0.000 description 15
- OWNRRUFOJXFKCU-UHFFFAOYSA-N Bromadiolone Chemical compound C=1C=C(C=2C=CC(Br)=CC=2)C=CC=1C(O)CC(C=1C(OC2=CC=CC=C2C=1O)=O)C1=CC=CC=C1 OWNRRUFOJXFKCU-UHFFFAOYSA-N 0.000 description 14
- 102000000588 Interleukin-2 Human genes 0.000 description 13
- 108010002350 Interleukin-2 Proteins 0.000 description 13
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- 239000002253 acid Substances 0.000 description 13
- 230000004913 activation Effects 0.000 description 13
- 230000003185 calcium uptake Effects 0.000 description 13
- 238000009472 formulation Methods 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 13
- 210000004369 blood Anatomy 0.000 description 12
- 239000008280 blood Substances 0.000 description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- 239000000969 carrier Substances 0.000 description 11
- ZJWIIMLSNZOCBP-BTTVDUMLSA-N delphinidin-3-glucoside Chemical compound [Cl-].O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC(O)=C(O)C(O)=C1 ZJWIIMLSNZOCBP-BTTVDUMLSA-N 0.000 description 11
- 244000078534 Vaccinium myrtillus Species 0.000 description 10
- 230000037396 body weight Effects 0.000 description 10
- 208000035475 disorder Diseases 0.000 description 10
- 239000003651 drinking water Substances 0.000 description 10
- 235000020188 drinking water Nutrition 0.000 description 10
- 239000002609 medium Substances 0.000 description 10
- 241000700159 Rattus Species 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000002775 capsule Substances 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 235000013305 food Nutrition 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 239000003981 vehicle Substances 0.000 description 9
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 8
- 208000008589 Obesity Diseases 0.000 description 8
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 8
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 8
- 235000012511 Vaccinium Nutrition 0.000 description 8
- 241000736767 Vaccinium Species 0.000 description 8
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 8
- 230000007423 decrease Effects 0.000 description 8
- 239000008108 microcrystalline cellulose Substances 0.000 description 8
- 229940016286 microcrystalline cellulose Drugs 0.000 description 8
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 8
- 235000020824 obesity Nutrition 0.000 description 8
- 239000000546 pharmaceutical excipient Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 8
- 244000118350 Andrographis paniculata Species 0.000 description 7
- 108060001084 Luciferase Proteins 0.000 description 7
- 239000005089 Luciferase Substances 0.000 description 7
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 7
- 235000021028 berry Nutrition 0.000 description 7
- 239000007903 gelatin capsule Substances 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- 102000004196 processed proteins & peptides Human genes 0.000 description 7
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- ZQMDJECDLYTUCE-LCENJUANSA-N Delphinidin-3,5-diglucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=C(O)C=2)OC2=CC(=O)C=C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)C2=C1 ZQMDJECDLYTUCE-LCENJUANSA-N 0.000 description 6
- 239000012981 Hank's balanced salt solution Substances 0.000 description 6
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 241000209149 Zea Species 0.000 description 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
- RKWHWFONKJEUEF-WVXKDWSHSA-O cyanidin 3-O-beta-D-galactoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 RKWHWFONKJEUEF-WVXKDWSHSA-O 0.000 description 6
- 231100000673 dose–response relationship Toxicity 0.000 description 6
- 230000005284 excitation Effects 0.000 description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 239000008101 lactose Substances 0.000 description 6
- CCQDWIRWKWIUKK-QKYBYQKWSA-O petunidin 3-O-beta-D-glucoside Chemical compound OC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1 CCQDWIRWKWIUKK-QKYBYQKWSA-O 0.000 description 6
- 229920001184 polypeptide Polymers 0.000 description 6
- 235000013824 polyphenols Nutrition 0.000 description 6
- 229920005989 resin Polymers 0.000 description 6
- 239000011347 resin Substances 0.000 description 6
- 230000000630 rising effect Effects 0.000 description 6
- 239000000377 silicon dioxide Substances 0.000 description 6
- 235000012239 silicon dioxide Nutrition 0.000 description 6
- 229960001866 silicon dioxide Drugs 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 5
- 241000208829 Sambucus Species 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 150000007513 acids Chemical class 0.000 description 5
- 229910002091 carbon monoxide Inorganic materials 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 235000005911 diet Nutrition 0.000 description 5
- 230000037213 diet Effects 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 235000008995 european elder Nutrition 0.000 description 5
- 235000008524 evening primrose extract Nutrition 0.000 description 5
- VPSRLGDRGCKUTK-UHFFFAOYSA-N fura-2-acetoxymethyl ester Chemical compound CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=C(C)C=C1OCCOC(C(=C1)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)=CC2=C1OC(C=1OC(=CN=1)C(=O)OCOC(C)=O)=C2 VPSRLGDRGCKUTK-UHFFFAOYSA-N 0.000 description 5
- 230000036039 immunity Effects 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 239000000419 plant extract Substances 0.000 description 5
- 150000008442 polyphenolic compounds Chemical class 0.000 description 5
- 229920005990 polystyrene resin Polymers 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 241001340020 Aristotelia <moth> Species 0.000 description 4
- 241001444063 Aronia Species 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 102000008070 Interferon-gamma Human genes 0.000 description 4
- 108010074328 Interferon-gamma Proteins 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 4
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 102000014384 Type C Phospholipases Human genes 0.000 description 4
- 108010079194 Type C Phospholipases Proteins 0.000 description 4
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 150000001412 amines Chemical class 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 235000021014 blueberries Nutrition 0.000 description 4
- 235000010980 cellulose Nutrition 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 235000008504 concentrate Nutrition 0.000 description 4
- 235000005822 corn Nutrition 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 235000018927 edible plant Nutrition 0.000 description 4
- 239000010475 evening primrose oil Substances 0.000 description 4
- 229940089020 evening primrose oil Drugs 0.000 description 4
- 229940075507 glyceryl monostearate Drugs 0.000 description 4
- 229930182470 glycoside Natural products 0.000 description 4
- 238000003119 immunoblot Methods 0.000 description 4
- 230000001506 immunosuppresive effect Effects 0.000 description 4
- 229960003130 interferon gamma Drugs 0.000 description 4
- 230000003834 intracellular effect Effects 0.000 description 4
- 230000001404 mediated effect Effects 0.000 description 4
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 4
- 231100000252 nontoxic Toxicity 0.000 description 4
- 230000003000 nontoxic effect Effects 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 238000003672 processing method Methods 0.000 description 4
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 239000008347 soybean phospholipid Substances 0.000 description 4
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 4
- 229960001052 streptozocin Drugs 0.000 description 4
- 150000008163 sugars Chemical class 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- 239000013598 vector Substances 0.000 description 4
- 239000008158 vegetable oil Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- FXWDXPVECLXGRZ-XIGYXKQDSA-N (2S,3R,4S,5S)-2-[5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromenylium-3-yl]oxyoxane-3,4,5-triol chloride Chemical compound [Cl-].COC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@@H](O)CO2)O)=C1 FXWDXPVECLXGRZ-XIGYXKQDSA-N 0.000 description 3
- UFUFUUOWFABDAK-JTEBGWLPSA-N (2S,3R,4S,5S,6R)-2-[3-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-2-(3,4-dihydroxyphenyl)-7-hydroxychromenylium-5-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol chloride Chemical compound [Cl-].OC[C@H]1O[C@@H](Oc2cc(O)cc3[o+]c(c(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)cc23)-c2ccc(O)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O UFUFUUOWFABDAK-JTEBGWLPSA-N 0.000 description 3
- ZJWIIMLSNZOCBP-KGDMUXNNSA-N (2s,3r,4s,5r,6r)-2-[5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chromenylium-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;chloride Chemical compound [Cl-].O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC(O)=C(O)C(O)=C1 ZJWIIMLSNZOCBP-KGDMUXNNSA-N 0.000 description 3
- YDIKCZBMBPOGFT-DIONPBRTSA-N (2s,3r,4s,5s,6r)-2-[5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromenylium-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;chloride Chemical compound [Cl-].COC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1 YDIKCZBMBPOGFT-DIONPBRTSA-N 0.000 description 3
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 3
- 108010085238 Actins Proteins 0.000 description 3
- 102000007469 Actins Human genes 0.000 description 3
- 241000272525 Anas platyrhynchos Species 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 241001107116 Castanospermum australe Species 0.000 description 3
- ORTBMTXABUAMJS-VGEDXCMYSA-N Cyanidin 3-arabinoside Chemical compound [Cl-].O[C@H]1[C@H](O)[C@H](O)CO[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 ORTBMTXABUAMJS-VGEDXCMYSA-N 0.000 description 3
- KUCVMQMKRICXJC-FBVAEJEDSA-O Cyanidin 3-arabinoside Natural products O([C@H]1[C@@H](O)[C@@H](O)[C@H](O)CO1)c1c(-c2cc(O)c(O)cc2)[o+]c2c(c(O)cc(O)c2)c1 KUCVMQMKRICXJC-FBVAEJEDSA-O 0.000 description 3
- OLBLWNPOURNBCY-QFEPKXLGSA-O Cyanidin 3-sambubioside-5-glucoside Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1Oc1c(-c2cc(O)c(O)cc2)[o+]c2c(c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)cc(O)c2)c1)[C@@H]1[C@@H](O)[C@@H](O)[C@@H](O)CO1 OLBLWNPOURNBCY-QFEPKXLGSA-O 0.000 description 3
- XCTGXGVGJYACEI-BYNFETKLSA-O Delphin Natural products O([C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@H](CO)O1)c1c(-c2cc(O)c(O)c(O)c2)[o+]c2c(c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)cc(O)c2)c1 XCTGXGVGJYACEI-BYNFETKLSA-O 0.000 description 3
- WIEYMFHXYNRELM-ZNWBIBPKSA-O Delphinidin 3-arabinoside Chemical compound O[C@H]1[C@H](O)[C@H](CO)O[C@H]1OC1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC(O)=C(O)C(O)=C1 WIEYMFHXYNRELM-ZNWBIBPKSA-O 0.000 description 3
- TWYYVOVDSNRIJM-VVFVXFQUSA-O Delphinidin 3-sambubioside Natural products O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1Oc1c(-c2cc(O)c(O)c(O)c2)[o+]c2c(c(O)cc(O)c2)c1)[C@@H]1[C@@H](O)[C@@H](O)[C@@H](O)CO1 TWYYVOVDSNRIJM-VVFVXFQUSA-O 0.000 description 3
- 238000008157 ELISA kit Methods 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 206010022489 Insulin Resistance Diseases 0.000 description 3
- ZWAAFZOEMBEAAF-KIFKTBRXSA-O Malvidin 3-arabinoside Natural products O(C)c1c(O)c(OC)cc(-c2c(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)CO3)cc3c(O)cc(O)cc3[o+]2)c1 ZWAAFZOEMBEAAF-KIFKTBRXSA-O 0.000 description 3
- YDIKCZBMBPOGFT-PWUSVEHZSA-N Malvidin 3-galactoside Chemical compound [Cl-].COC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)=C1 YDIKCZBMBPOGFT-PWUSVEHZSA-N 0.000 description 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
- 108010008211 N-Formylmethionine Leucyl-Phenylalanine Proteins 0.000 description 3
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 3
- 102000000536 PPAR gamma Human genes 0.000 description 3
- 108010016731 PPAR gamma Proteins 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- ZZWPMFROUHHAKY-SXFAUFNYSA-O Peonidin 3-O-beta-D-galactopyranoside Natural products O(C)c1c(O)ccc(-c2c(O[C@H]3[C@@H](O)[C@H](O)[C@@H](O)[C@H](CO)O3)cc3c(O)cc(O)cc3[o+]2)c1 ZZWPMFROUHHAKY-SXFAUFNYSA-O 0.000 description 3
- VDTNZDSOEFSAIZ-HVOKISQTSA-N Peonidin 3-O-galactoside Chemical compound [Cl-].C1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)=C1 VDTNZDSOEFSAIZ-HVOKISQTSA-N 0.000 description 3
- ZTQGIZPDDMLVHP-KFTCICMSSA-N Peonidin 3-arabinoside Chemical compound [Cl-].C1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@@H](O)CO2)O)=C1 ZTQGIZPDDMLVHP-KFTCICMSSA-N 0.000 description 3
- KRUPPTWQKIEURV-WBHLOVLFSA-O Peonidin 3-arabinoside Natural products O(C)c1c(O)ccc(-c2c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)CO3)cc3c(O)cc(O)cc3[o+]2)c1 KRUPPTWQKIEURV-WBHLOVLFSA-O 0.000 description 3
- CCQDWIRWKWIUKK-XJESJRCUSA-O Petunidin 3-O-beta-D-galactopyranoside Natural products OC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)=C1 CCQDWIRWKWIUKK-XJESJRCUSA-O 0.000 description 3
- CCQDWIRWKWIUKK-UHFFFAOYSA-O Petunidin 3-galactoside Chemical compound OC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)OC2C(C(O)C(O)C(CO)O2)O)=C1 CCQDWIRWKWIUKK-UHFFFAOYSA-O 0.000 description 3
- 241000286209 Phasianidae Species 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000012979 RPMI medium Substances 0.000 description 3
- 235000011483 Ribes Nutrition 0.000 description 3
- 241000220483 Ribes Species 0.000 description 3
- 240000001890 Ribes hudsonianum Species 0.000 description 3
- 235000016954 Ribes hudsonianum Nutrition 0.000 description 3
- 235000001466 Ribes nigrum Nutrition 0.000 description 3
- 241001092459 Rubus Species 0.000 description 3
- 244000235659 Rubus idaeus Species 0.000 description 3
- 241000282887 Suidae Species 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 3
- 240000001717 Vaccinium macrocarpon Species 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 239000010775 animal oil Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 235000021279 black bean Nutrition 0.000 description 3
- 235000021029 blackberry Nutrition 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- PRQROPMIIGLWRP-BZSNNMDCSA-N chemotactic peptide Chemical compound CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 PRQROPMIIGLWRP-BZSNNMDCSA-N 0.000 description 3
- 235000013330 chicken meat Nutrition 0.000 description 3
- CWVRJTMFETXNAD-JUHZACGLSA-M chlorogenate Chemical class O[C@@H]1[C@H](O)C[C@@](O)(C([O-])=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-M 0.000 description 3
- 229940074393 chlorogenic acid Drugs 0.000 description 3
- 235000001368 chlorogenic acid Nutrition 0.000 description 3
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 3
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 3
- ZPPQIOUITZSYAO-AOBOYTTNSA-O cyanidin 3-O-beta-D-sambubioside Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)CO1)O)O)CO)C1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC=C(O)C(O)=C1 ZPPQIOUITZSYAO-AOBOYTTNSA-O 0.000 description 3
- AYVZVUMKUBCNQZ-UHFFFAOYSA-N delphinidin 3,5-diglucoside Natural products OCC(O)C(O)C(O)C(O)COC1=C(Oc2cc(O)cc(OCC(O)C(O)C(O)C(O)CO)c2C1)c3cc(O)c(O)c(O)c3 AYVZVUMKUBCNQZ-UHFFFAOYSA-N 0.000 description 3
- TWYYVOVDSNRIJM-AFAGGVQESA-O delphinidin 3-O-beta-D-sambubioside Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)CO1)O)O)CO)C1=CC2=C(O)C=C(O)C=C2[O+]=C1C1=CC(O)=C(O)C(O)=C1 TWYYVOVDSNRIJM-AFAGGVQESA-O 0.000 description 3
- 239000003085 diluting agent Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 235000021323 fish oil Nutrition 0.000 description 3
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 3
- 230000003345 hyperglycaemic effect Effects 0.000 description 3
- 230000003308 immunostimulating effect Effects 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- ZZWPMFROUHHAKY-OUUKCGNVSA-O peonidin 3-O-beta-D-glucoside Chemical compound C1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1 ZZWPMFROUHHAKY-OUUKCGNVSA-O 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000000069 prophylactic effect Effects 0.000 description 3
- 238000011552 rat model Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 210000000614 rib Anatomy 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 3
- 108700012359 toxins Proteins 0.000 description 3
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- UZOVYGYOLBIAJR-UHFFFAOYSA-N 4-isocyanato-4'-methyldiphenylmethane Chemical compound C1=CC(C)=CC=C1CC1=CC=C(N=C=O)C=C1 UZOVYGYOLBIAJR-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- 235000003840 Amygdalus nana Nutrition 0.000 description 2
- 244000296825 Amygdalus nana Species 0.000 description 2
- 235000007425 Aronia melanocarpa Nutrition 0.000 description 2
- 240000005662 Aronia melanocarpa Species 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241000271566 Aves Species 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- PHEDXBVPIONUQT-UHFFFAOYSA-N Cocarcinogen A1 Natural products CCCCCCCCCCCCCC(=O)OC1C(C)C2(O)C3C=C(C)C(=O)C3(O)CC(CO)=CC2C2C1(OC(C)=O)C2(C)C PHEDXBVPIONUQT-UHFFFAOYSA-N 0.000 description 2
- SVKUZBZQDMYGEP-WOIHUOTDSA-O Delphinidin 3-sambubioside-5-glucoside Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](CO)O[C@H]1Oc1c(-c2cc(O)c(O)c(O)c2)[o+]c2c(c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)cc(O)c2)c1)[C@@H]1[C@H](O)[C@H](O)[C@H](O)CO1 SVKUZBZQDMYGEP-WOIHUOTDSA-O 0.000 description 2
- SVKUZBZQDMYGEP-AHKATGCTSA-O Delphinidin 5-O-beta-D-glucoside 3-O-beta-D-sambubioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C1=C2)=CC(O)=CC1=[O+]C(C=1C=C(O)C(O)=C(O)C=1)=C2O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)CO2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 SVKUZBZQDMYGEP-AHKATGCTSA-O 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 206010062016 Immunosuppression Diseases 0.000 description 2
- 102000015696 Interleukins Human genes 0.000 description 2
- 108010063738 Interleukins Proteins 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 description 2
- 235000016357 Mirtillo rosso Nutrition 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
- 102000003945 NF-kappa B Human genes 0.000 description 2
- 108010057466 NF-kappa B Proteins 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 235000010582 Pisum sativum Nutrition 0.000 description 2
- 240000004713 Pisum sativum Species 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 2
- 235000011432 Prunus Nutrition 0.000 description 2
- 241001290151 Prunus avium subsp. avium Species 0.000 description 2
- 235000002357 Ribes grossularia Nutrition 0.000 description 2
- 244000171263 Ribes grossularia Species 0.000 description 2
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 description 2
- 235000017848 Rubus fruticosus Nutrition 0.000 description 2
- 235000011034 Rubus glaucus Nutrition 0.000 description 2
- 235000009122 Rubus idaeus Nutrition 0.000 description 2
- 235000018735 Sambucus canadensis Nutrition 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 229940126530 T cell activator Drugs 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 2
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 2
- 235000017606 Vaccinium vitis idaea Nutrition 0.000 description 2
- 244000077923 Vaccinium vitis idaea Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 235000003650 acai Nutrition 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 2
- 150000001342 alkaline earth metals Chemical class 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 239000006286 aqueous extract Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 235000007123 blue elder Nutrition 0.000 description 2
- 230000020411 cell activation Effects 0.000 description 2
- 230000007969 cellular immunity Effects 0.000 description 2
- 235000012182 cereal bars Nutrition 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 235000019693 cherries Nutrition 0.000 description 2
- 229960004926 chlorobutanol Drugs 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 235000004634 cranberry Nutrition 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 2
- 229960001259 diclofenac Drugs 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 238000010864 dual luciferase reporter gene assay Methods 0.000 description 2
- 235000007124 elderberry Nutrition 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 229960001438 immunostimulant agent Drugs 0.000 description 2
- 239000003022 immunostimulating agent Substances 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 229940124589 immunosuppressive drug Drugs 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 229940047122 interleukins Drugs 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 description 2
- PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 239000011976 maleic acid Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000009245 menopause Effects 0.000 description 2
- 208000030159 metabolic disease Diseases 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000006408 oxalic acid Nutrition 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 230000034190 positive regulation of NF-kappaB transcription factor activity Effects 0.000 description 2
- 229940069328 povidone Drugs 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229920002414 procyanidin Polymers 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000014774 prunus Nutrition 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- YEENEYXBHNNNGV-XEHWZWQGSA-M sodium;3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodobenzoate;(2r,3r,4s,5s,6r)-2-[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound [Na+].CC(=O)N(C)C1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I.O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 YEENEYXBHNNNGV-XEHWZWQGSA-M 0.000 description 2
- 239000011877 solvent mixture Substances 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical compound CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 1
- AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 description 1
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- VFWCMGCRMGJXDK-UHFFFAOYSA-N 1-chlorobutane Chemical compound CCCCCl VFWCMGCRMGJXDK-UHFFFAOYSA-N 0.000 description 1
- VUQPJRPDRDVQMN-UHFFFAOYSA-N 1-chlorooctadecane Chemical compound CCCCCCCCCCCCCCCCCCCl VUQPJRPDRDVQMN-UHFFFAOYSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- GVRNTWSGBWPJGS-DSJDWBEOSA-N 14-deoxyandrographolide Natural products O=C1C(CC[C@@H]2C(=C)CC[C@@H]3[C@@](CO)(C)[C@H](O)CC[C@]23C)=CCO1 GVRNTWSGBWPJGS-DSJDWBEOSA-N 0.000 description 1
- VHRUMKCAEVRUBK-GODQJPCRSA-N 15-deoxy-Delta(12,14)-prostaglandin J2 Chemical compound CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O VHRUMKCAEVRUBK-GODQJPCRSA-N 0.000 description 1
- VCNKUCWWHVTTBY-UHFFFAOYSA-N 18alpha-Oleanane Natural products C1CCC(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C)(C)CC5C4CCC3C21C VCNKUCWWHVTTBY-UHFFFAOYSA-N 0.000 description 1
- 229940080296 2-naphthalenesulfonate Drugs 0.000 description 1
- WMPPDTMATNBGJN-UHFFFAOYSA-N 2-phenylethylbromide Chemical compound BrCCC1=CC=CC=C1 WMPPDTMATNBGJN-UHFFFAOYSA-N 0.000 description 1
- XMIIGOLPHOKFCH-UHFFFAOYSA-M 3-phenylpropionate Chemical compound [O-]C(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-M 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 244000003416 Asparagus officinalis Species 0.000 description 1
- 235000005340 Asparagus officinalis Nutrition 0.000 description 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 description 1
- 241000271935 Bitis Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 244000178937 Brassica oleracea var. capitata Species 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- 229940122739 Calcineurin inhibitor Drugs 0.000 description 1
- 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 description 1
- 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 description 1
- 108090000312 Calcium Channels Proteins 0.000 description 1
- 102000003922 Calcium Channels Human genes 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 description 1
- 241000371652 Curvularia clavata Species 0.000 description 1
- RDFLLVCQYHQOBU-GPGGJFNDSA-O Cyanin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@H](CO)O1)c1c(-c2cc(O)c(O)cc2)[o+]c2c(c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O3)cc(O)c2)c1 RDFLLVCQYHQOBU-GPGGJFNDSA-O 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- CITFYDYEWQIEPX-UHFFFAOYSA-N Flavanol Natural products O1C2=CC(OCC=C(C)C)=CC(O)=C2C(=O)C(O)C1C1=CC=C(O)C=C1 CITFYDYEWQIEPX-UHFFFAOYSA-N 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000573199 Homo sapiens Protein PML Proteins 0.000 description 1
- 208000013016 Hypoglycemia Diseases 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 241000208204 Linum Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 240000005561 Musa balbisiana Species 0.000 description 1
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000004496 Oenothera biennis Nutrition 0.000 description 1
- 240000008916 Oenothera biennis Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229920002230 Pectic acid Polymers 0.000 description 1
- 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 description 1
- 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 description 1
- 229940124034 Phospholipase C inhibitor Drugs 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 description 1
- 108010052090 Renilla Luciferases Proteins 0.000 description 1
- 235000016911 Ribes sativum Nutrition 0.000 description 1
- 235000002355 Ribes spicatum Nutrition 0.000 description 1
- 244000281209 Ribes triste Species 0.000 description 1
- 235000016897 Ribes triste Nutrition 0.000 description 1
- 244000111388 Rubus occidentalis Species 0.000 description 1
- 235000003942 Rubus occidentalis Nutrition 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 235000002597 Solanum melongena Nutrition 0.000 description 1
- 244000061458 Solanum melongena Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 206010054094 Tumour necrosis Diseases 0.000 description 1
- 244000177965 Vaccinium lamarckii Species 0.000 description 1
- 235000013473 Vaccinium lamarckii Nutrition 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 235000004282 Vitis labrusca Nutrition 0.000 description 1
- 244000070384 Vitis labrusca Species 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 230000011759 adipose tissue development Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 150000001453 anthocyanidins Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 230000037007 arousal Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 235000021015 bananas Nutrition 0.000 description 1
- 150000007514 bases Chemical class 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- 229940092714 benzenesulfonic acid Drugs 0.000 description 1
- 229940050390 benzoate Drugs 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- XMIIGOLPHOKFCH-UHFFFAOYSA-N beta-phenylpropanoic acid Natural products OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
- 239000007894 caplet Substances 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 229940001468 citrate Drugs 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000021019 cranberries Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 150000008050 dialkyl sulfates Chemical class 0.000 description 1
- LMEDOLJKVASKTP-UHFFFAOYSA-N dibutyl sulfate Chemical group CCCCOS(=O)(=O)OCCCC LMEDOLJKVASKTP-UHFFFAOYSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- GAFRWLVTHPVQGK-UHFFFAOYSA-N dipentyl sulfate Chemical compound CCCCCOS(=O)(=O)OCCCCC GAFRWLVTHPVQGK-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- WBZKQQHYRPRKNJ-UHFFFAOYSA-L disulfite Chemical compound [O-]S(=O)S([O-])(=O)=O WBZKQQHYRPRKNJ-UHFFFAOYSA-L 0.000 description 1
- 229930004069 diterpene Natural products 0.000 description 1
- 125000000567 diterpene group Chemical group 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940045761 evening primrose extract Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229940013317 fish oils Drugs 0.000 description 1
- 150000002206 flavan-3-ols Chemical class 0.000 description 1
- 235000011987 flavanols Nutrition 0.000 description 1
- 229930002879 flavonoid pigment Natural products 0.000 description 1
- 150000004638 flavonoid pigments Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000012458 free base Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 235000015810 grayleaf red raspberry Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 description 1
- 102000054896 human PML Human genes 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- SIOMFBXUIJKTMF-UHFFFAOYSA-N hypoglauterpenic acid Natural products C1CC(O)C(C)(C)C2=CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C SIOMFBXUIJKTMF-UHFFFAOYSA-N 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000007913 intrathecal administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000003670 luciferase enzyme activity assay Methods 0.000 description 1
- 238000003468 luciferase reporter gene assay Methods 0.000 description 1
- 150000002680 magnesium Chemical class 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 102000006240 membrane receptors Human genes 0.000 description 1
- 108020004084 membrane receptors Proteins 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 description 1
- KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 210000005170 neoplastic cell Anatomy 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 1
- 239000000346 nonvolatile oil Substances 0.000 description 1
- BPAWXSVOAOLSRP-UHFFFAOYSA-N oleanane Natural products CCCCCCCCCCCCCCCC(=O)OC1CCC2(C)C(CCC3(C)C2CC=C4C5CC(C)(C)CCC5(C)C(O)CC34C)C1(C)C BPAWXSVOAOLSRP-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 229960003742 phenol Drugs 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000003371 phospholipase C inhibitor Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000008832 photodamage Effects 0.000 description 1
- 230000000243 photosynthetic effect Effects 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229960005095 pioglitazone Drugs 0.000 description 1
- 229950010765 pivalate Drugs 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002952 polymeric resin Substances 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 239000006254 rheological additive Substances 0.000 description 1
- 229960004586 rosiglitazone Drugs 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical class OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- OOTXFYSZXCPMPG-BMYLZFHVSA-N ursane Chemical group C1CCC(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C)[C@H](C)[C@H]5[C@H]4CC[C@@H]3[C@]21C OOTXFYSZXCPMPG-BMYLZFHVSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Child & Adolescent Psychology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
Description
他は、アントシアニジン類についての使用を提案している。例えば、アントシアニジン類及びアントシアニジン誘導体は、感染された細胞における抗ウィルス効果、及び新形成細胞における抗腫瘍効果を示すことが提案されている(PCT/NO97/00100号(WO97/41137号)を参照のこと)。アントシアニンに富んでいる抽出物がまた、障害性代謝症候群の処理のために開示されている(アメリカ特許公開番号2009/0176718号を参照のこと)。
本発明の組成物がカフェオイルキネート誘導体を含む場合、それはクロロゲネート又はクロロゲン酸であり得る。
本発明の1又は複数の態様の詳細は、添付図面及び下記の記載に示される。本発明の他の特徴、目的及び利点は、前記の記載及び図面、及び請求項から明らかであろう。
免疫抑制は例えば、癌又は後天性免疫欠損症候群を有する対象において存在する。
正しい細胞免疫(インターフェロンγ、いくつかのインターロイキン類)応答の欠失が、多くの生命−脅威の障害に包含されるキー特徴である。
免疫抑制は例えば、癌又は後天性免疫欠損症候群を有する対象において存在する。
バシニウム属の植物からの組成物は、ミルチリン、ケルセチン、又はコーヒー酸誘導体(例えば、クロロゲン酸)を含むことができる。バシニウム・アウグスチホリウム及び/又はバシニウム・コリムボサムの抽出物においては、カフェオイルキナ酸の含有率は、20%の範囲にあり得る。
組成物は水性組成物であり得る。
選択された植物の抽出物は、植物抽出物を調製するために、当業界において知られており、そして使用される方法に従って調製され得る。前記方法は、抽出物から抽出物への再現性及びコンシステンシーを改良するために標準化され得る。前記方法は、成熟果実、新鮮又は凍結果実、又は特定される場合、植物のハルバにより開始することができる。抽出は、有機酸又は鉱酸の存在下でエタノールにおいて、又は亜硫酸水素イオンの存在下で水により果実を抽出することにより進行することができる。J. B. Hrborne, The Flavonoids, Chapman & Hall ED. London p227を参照のこと。亜硫酸水素イオンは、当業界において知られている方法により(例えば、二酸化硫黄の添加により、又は単純にメタ亜硫酸水素ナトリウムの添加により)、調製され得る。
アントシアニン類は、糖フリーアントシアニジンアグリコン及びアントシアニングリコシドに細分され、そして本発明の方法の組成物はいずれかのタイプ又は両タイプのアントシアニン類を包含することができる。
本発明の組成物における個々のアントシアニン又は特定のアントシアニン又は他の活性化合物の治療的含有量は、約0.01mg/kg体重から約1g/kg体重に変化することができる。
15gのアントシアニジン類を含むアリストテリア・キレンシスの凍結果実(1kg)を、5×1Lのエタノール/水(50%v/v)により抽出し;個々の抽出は4時間、実施された。第1及び第2抽出の両者に関して、7.5gの亜硫酸水素ナトリウムを、エタノール/水溶媒に溶解した。抽出された液体を、エタノールを排除するために、30℃の温度で真空下で2Lの体積に濃縮した。その濃縮物を、25〜60メッシュの粒子サイズを有する非極性ポリスチレン樹脂2.5Lのカラム上に負荷した。カラムを、10Lの水により洗浄し、そして次に、3Lのエタノール(95%)により洗浄した。そのエタノール溶液を、撹拌下で0.5L(実質的にエタノールを除去する)に濃縮し、そしてその濃縮された溶液を、NaOH溶液中に泡立てることにより、窒素流下でpH1に酸性化し、SO2を除去した。次に、暗赤色の溶液を真空下で注意して濃縮乾燥した。約30%のアントシアニジン含有率の抽出物150gを得た。
アントシアニジン類及びポリフェノール類の両者を含むアリストテリア・キレンシス抽出物を、例1の方法に実質的に従って調製した。但しエタノール溶液を1Lに濃縮し、そして酸性化の後、水により2.5Lに希釈し、そして例1に記載されるような2Lのポリスチレンカラム上に負荷した。カラムを記載されるように、エタノールにより溶出した。この工程により、抽出物の収量は約135gであり、そして約41%のアントシアニジンを含んだ。
15gのアントラアニジン類を含むアリストテリア・キレンシスの凍結果実(1kg)を、5×1Lのエタノール/水(50%v/v)により抽出した。個々の抽出は4時間、実施された。第1及び第2抽出の両者に関して、7.5gの亜硫酸水素ナトリウムを、エタノール/水溶媒に溶解した。抽出された液体を、エタノールを排除するために、30℃の温度で真空下で2Lの体積に濃縮した。その混合物を、NaOHの10%溶液の添加によりpH5.5にアルカリ化し、そして2Lの非極性ポリスチレン樹脂を含むカラム上に負荷した。カラムを2Lの水により溶出した。
アンドログラフィス・パニキュラタの乾燥された葉(1kg)を、60℃で4時間、5Lのエタノール/水(50%v/v)により抽出した。3種の追加の抽出を、3Lの同じ溶媒混合物を用いて実施し、そして組合された抽出物を、アルコールが排除されるまで、45℃の温度で真空下で濃縮した。水性抽出物を遠心分離し、ポリマー性凝集物及び濁りを排除し、そして透明な溶液を、3Lの非極性ポリスチレン樹脂に通した。カラムを2Lの水により溶出した。吸収された材料を、アルコール溶出物が無色になるまで、樹脂のエタノール洗浄により除去した。アルコール性溶液を濃縮乾燥し、約35%の合計アンドログラホリド類(10%のアンドログラホリド、3%のデオキシアンドログラホリド及び1%のネオアンドログラホリド)を含む抽出物120gを得た。
バシニウム・アングスチホリウムの乾燥された葉(1kg)を、60℃で4時間、5Lのエタノール/水(50%v/v)により抽出した。3種の追加の抽出を、3Lの同じ溶媒混合物を用いて実施し、そして組合された抽出物を、アルコールが排除されるまで、45℃の温度で真空下で濃縮した。水性抽出物を遠心分離し、ポリマー性凝集物及び濁りを排除し、そして透明な溶液を、3Lの非極性ポリスチレン樹脂に通した。カラムを2Lの水により溶出した。吸収された材料を、アルコール溶出物が無色になるまで、樹脂のエタノール洗浄により除去した。アルコール性溶液を濃縮乾燥し、約35%のカフェオイルキナ酸類、10%のプロシアニジン類、及び3%のトリテルペン酸を含む抽出物120gを得た。
我々は、Jurkat T細胞における細胞内カルシウム放出に対するデルフィニジンの効果を評価した。抽出物は、例1の方法に従って調製された。
我々は、次にJurkat T細胞における細胞内カルシウム侵入及び放出に対するデルフィニジンの効果の機構を調べた。
4×106個のFURA 2−AM−負荷されたJurkat T細胞を、HBSSカルシウムフリー媒体においてインキュベートした。次に、その細胞を、50μMのデルフィニジンにおいてインキュベートし、そしてCa2+の流れを、分光計(LS55, PerkinELmer)において37℃で、340及び380nmでの励起及び509nmでの発光の比として測定した。
我々は、例7に記載される方法に実質的に従って、貯蔵操作されたカルシウム流に対するデルフィニジンの効果を評価した。
我々は、選択的ホスホリパーゼCインヒビターU73122を用いて、デルフィニジン誘発されたカルシウム放出におけるホスホリパーゼC(PLC)の役割を評価した。
我々は、Jurkat T細胞におけるインターロイキン-2(IL-2)生成に対するデルフィニジン及びシアニジンの効果を調べた。
我々は、Jurkat T細胞におけるインターフェロン−γ(INF-γ)生成に対するデルフィニジン及びシアニジンの効果を調べた。RPMI培地における2×106個のJurkat T細胞を、5%CO2において37℃で48時間インキュベートした。サンプルを、ビークル対照溶液;又はT細胞活性化因子、ホルボール12−ミリステート13−アセテート/イオノマイシン(PMA/Io 2ng/ml 1μM);50μMのデルフィニジン;50μMのデルフィニジン+PMA/Io;50μMのシアニジン;又は50μMのシアニジン+PMA/Ioの存在下でインキュベートした。次に、上清液を集め、そしてINF-γ生成を、市販のキット(Becton Dickinson, USA)を用いて、その供給者の説明書に従って、ELISAにより分析した。
IL-2及びINF-γ生成に対するデルフィニジンの効果をまた、新しく単離されたヒトT細胞に対してアッセイした。ヒトT細胞を、Lymphoprep試薬を用いて、健康なボランティアの血液から単離した。RMPI培地におけるT細胞(1×106)を、ビークル対照溶液;50μMのデルフィニジン;50μMのデルフィニジン+1μMのBTP-2;50μMのデルフィニジン+5μMのBTP-2;50μMのデルフィニジン+10μMのBTP-2;1μMのBTP-2;5μMのBTP-2;又は10μMのBTP-2の存在下で、5%CO2下で37℃で48時間インキュベートした。次に、上清液を集め、そしてIL-2及びINF-γを測定するために、市販のELISAキット(Becton Dickinson, USA)を用いて、その供給者の説明書に従って分析した。
一緒にすると、表7及び8に示されるデータは、デルフィニジン−誘発されたIL-2−及びINF−γ生成がSOCE−依存性機能を通してヒトT細胞において介在されることを示唆する。
次に、我々は、デルフィニジンが活性化されたT細胞の核因子(NFAT)活性化を通してIL-2生成を誘発したかどうかを調べた。RPMI培地における2×106個のJurkat T細胞を、ビークル対照溶液;50μMのデルフィニジン;50μMのデルフィニジン+シクロスポリンA(CsA, NFAT経路のカルシネウリンインヒビター);又はCsAのみの存在下で、5%CO2において37℃で48時間インキュベートした。次に、上清液を集め、そしてIL-2生成を測定するために、市販のELISAキット(Becton Dickinson, USA)を用いて、その供給者の説明書に従って分析した。
我々は、新たに収穫されたヒトT細胞及びJurkat細胞系の両者におけるIL-2生成に対するデルフィニジン及びアンドログラホリドの組合せの効果を評価した。アンドログラホリドを、例4に記載される方法に従って調製した。ヒトT細胞を、Lymphoprep試薬を用いて、健康なボランティアの血液から単離した。RMPI培地におけるT細胞(1×106)を、ビークル対照溶液;5nMのアンドログラホリド;50μMのデルフィニジン;又は5nMのアンドログラホリド+50μMのデルフィニジンの存在下で、5%CO2において37℃で48時間インキュベートした。次に、上清液を集め、そして市販のELISAキット(Becton Dickinson, USA)を用いて、その供給者の説明書に従って分析し、IL-2生成を測定した。
我々は、HL-60細胞(ヒト前骨髄細胞白血病細胞)においてルシフェラーゼレポーターアッセイを用いて、NF-κB活性化に対するアントシアニジンの効果を試験した。IMDM培地におけるHL-60細胞を、ルシフェラーゼプロモーターに位置するNF−κBコンセンサス配列を有するレポーターベクターにより、37℃で24時間トランスフェクトし、次に1:500000、1:50000及び1:5000に希釈されたデルフィニジンに富んでいるアントシアニジン類と共にインキュベートした。PMAが陽性対照として使用された。ルシフェラーゼ活性を、二重ルシフェラーゼアッセイキット(Promega)により、その供給者の説明書に従って測定した。レニラルシフェラーゼを構成的に発現したベクターを用いて、アッセイを標準化した。
デルフィニジン類に富んでいるアントシアニジン類を含んで成る組成物を、本発明に従って調製した。
我々は、シクロオキシゲナーゼ2(COX-2)、すなわち炎症工程を介在する酵素の発現に対するアントシアニジン、及びアンドログラホリドにより組合されたアントシアニジンの効果を分析した。Caco-2細胞(COX-2を構成的に発現する結腸癌の腫瘍系)を、5%CO2下で37℃でMEM培地において培養し、そして1.75μg/mlのデルフィニジンに富んでいるアントシアニジンと共に24、48又は72時間インキュベートした。COX-2 mRNAのレベルを、SYBRGreen試薬(Stratagene)を用いて、COX-2特異的プライマーを用いる即時RT_PCRにより分析し;βアクチンは内部対照として作用した。COX-2タンパク質のレベルを、特異的COX-2抗体(Cayman)を用いてのイムノブロットによりアッセイし、発現を比較し;βアクチンは標準化された対照として使用された。
PPar-γ(ペルオキシゾーム増殖体−活性化受容体、すなわちインスリンに対する感作に包含される受容体)の活性化を通して糖血レベルを調節する、チアゾリデンジオン(ロシグリタゾン及びピオグリタゾン)由来の薬物群の能力は知られている。アジポキン、前炎症タンパク質及び脂質の発現レベルの変更の他に、PPar-γの活性化はまた、成熟脂肪細胞の脂肪生成の上昇を伴わないで(Sugiiなど.,2009)、インスリンに対する感作を生成する。従って、PPar-γの活性化は、タイプII糖尿病の進行を妨げ、そしてインスリンに対する応答を改善することができる。
我々は、糖尿病性ラットモデルにおけるデルフィニジンに富んでいるアントシアニジン類の効果を評価した。糖尿病を、ストレプトゾトシンの静脈内注射によりラットにおいて誘発した。7日後、動物の代謝プロフィールを分析し、ラットが高血糖症であるかどうかを決定した。
単位組成物内に次の成分を含む:
アントシアニジン類を含んで成る組成物(41%のアントシアニジン類、このアントシアニジン類の35%がデルフィニジンである)・・・・・・400mg
微晶性セルロース・・・・・・・・・・・・・・・・400mg
ラクトース・・・・・・・・・・・・・・・・・・・95mg
二酸化珪素・・・・・・・・・・・・・・・・・・・10mg
単位組成物内に次の成分を含む:
アンドログラホリド類を含んで成る組成物(35%の合計アンドログラホリド類)・・・・・・・・・・・・・・・・・・・・・・・・・・・300mg
アントシアニジン類を含んで成る組成物(41%のアントシアニジン類、このアントシアニジン類の35%がデルフィニジンである)・・・・・100mg
グリセリルモノステアレート・・・・・・・・・・30mg
大豆レシチン・・・・・・・・・・・・・・・・・20mg
十分な量のメマツヨイグサ油・・・・・・・・・・700mg
単位組成物内に次の成分を含む:
アンドログラホリド類を含んで成る組成物(35%の合計アンドログラホリド類)・・・・・・・・・・・・・・・・・・・・・・・・・・300mg
アントシアニジン類を含んで成る組成物(41%のアントシアニジン類、このアントシアニジン類の35%がデルフィニジンである)・・・・100mg
微晶性セルロース・・・・・・・・・・・・・・400mg
ラクトース・・・・・・・・・・・・・・・・・95mg
二酸化珪素・・・・・・・・・・・・・・・・・10mg
単位組成物内に次の成分を含む:
アントシアニジン類を含んで成る組成物(41%のアントシアニジン類、このアントシアニジン類の35%がデルフィニジンである)・・・・200mg
微晶性セルロース・・・・・・・・・・・・・・400mg
ポビドン・・・・・・・・・・・・・・・・・・15mg
ナトリウムカルボキシメチルセルロース・・・・10mg
単位組成物内に次の成分を含む:
カフェオイルキナ酸を含んで成る組成物
(20%のカフェオイルキナ酸)・・・・・・・・・200mg
アントシアニジン類を含んで成る組成物(41%のアントシアニジン類、このアントシアニジン類の35%がデルフィニジンである)・・・・200mg
微晶性セルロース・・・・・・・・・・・・・・400mg
ラクトース・・・・・・・・・・・・・・・・・95mg
二酸化珪素・・・・・・・・・・・・・・・・・10mg
デルフィニジンに富んでいるアントシアニジン類を含んで成る組成物のクロマトグラフィー分析を実施した。
我々は、糖尿病性ラットモデルにおけるマキ抽出物のみ、及びバシニウム又はA. パニキュラタからの抽出物と共に組合されたマキ抽出物の経口投与の効果を比較した。ラットを、60mg/kgでストレプトゾトシンにより処理し、糖尿病を誘発した。ストレプトゾトシン投与の1週間後、動物を、次の処理をそれぞれ受けた5つのグループに分けた:
2)グループ2(n=4)、マキ(20mg/kg);
3)グループ(n=5)、マキ(200mg/kg);
4)グループ4(n=4)、マキ(20mg/kg)+バシニウム(100mg/kg);
5)グループ5(n=5)、マキ(20mg/kg)+A.パニキュラタ(100mg/kg)。
処理の4日後、血液サンプルを採取し、そして血液グルコースレベルを、ACCU-CHEK(商標)キット(Roche)を用いて、その供給者の説明書に従って測定した。
Claims (13)
- アントシアニン及び/又はアントシアニジンを含んでなるアントシアニジン組成物において、
(a)当該組成物の少なくとも又は約35重量%がアントシアニン又はアントシアニジンであり、
(b)当該アントシアニン又はアントシアニジンの少なくとも約15重量%が糖を含まないか又は糖を含むデルフィニジンであり、
(c)当該組成物は、アリストテリア・キレンシス(Aristotelia chilensis)植物から得られる抽出物として形成されており、そして
(d)当該組成物は、下記の量のアントシアニジン:
6,38重量%のデルフィニジン−3−O−サムブビオシド−5−O−グルコシド;
13.64重量%のデルフィニジン−3,5−O−ジグルコシド;
3.36重量%のシアニジン−3−O−サムブビオシド−5−O−グルコシド;
1.58重量%のシアニジン−3,5−O−ジグルコシド;
1.67重量%のデルフィニジン−3−O−サムブビオシド;
6.95重量%のデルフィニジン−3−O−グルコシド;
0.79重量%のシアニジン−3−O−サムブビオシド;及び
1.05重量%のシアニジン−3−O−グルコシド;
を含んで成る、前記組成物。 - アンドログラホリドをさらに含んで成り、好ましくは、前記アンドログラホリドは、前記組成物の少なくとも又は約10重量%を構成し、或いは当該アンドログラホリドは、アンドログラホリド、デオキシ−アンドログラホリド、ネオアンドログラホリド、又はそれらの混合物であり、或いは前記アンドログラホリドは、アンドログラフィス(Andrographis)属の植物の抽出物内に含まれ、或いはアントシアニン及び/又はアントシアニジン:アンドログラホリドの比が、約1.0:0.5(w:w)〜約1.0:2.5(w:w)である、請求項1に記載の組成物。
- (a)前記アントシアニン及び/又はアントシアニジンがミルチリン、ケルセチン又はシアニジンを含んで成り、又は(b)前記組成物がさらに、ミルチリン、ケルセチン及び/又はシアニジンに富んでいる組成物を含んで成り、好ましくはミルチリン、ケルセチン及び/又はシアニジンに富んでいる前記組成物が、少なくとも15%のミルチリン、ケルセチン及び/又はシアニジンを含んで成る、請求項1記載の組成物。
- 前記組成物が、経口消化又は経口投与のために製剤化されている、請求項1〜3のいずれか1項に記載のデルフィニジンに富むアントシアニジン組成物。
- 対象における免疫機能を維持するための方法において使用するための、請求項1〜4のいずれか1項記載の組成物、ここで、当該対象は、免疫系を無防備状態にすることが知られている明確な状態を有さず、そして当該組成物は、免疫機能を維持するのに十分な量及び十分な時間投与される。
- 前記対象がヒトであるか、又はペット若しくは家畜として飼育される動物である、請求項5記載の組成物。
- 免疫系が有害的に抑制される条件を有する患者の処理方法において使用するための、請求項1〜4のいずれか1項記載の組成物、ここで、当該組成物は、当該患者の免疫系を刺激するのに十分な量及び十分な時間、前記患者に投与され、好ましくは、当該患者はヒトであり、あるいは当該条件は、癌又は後天性免疫欠損症候群である。
- 対象における炎症を処理するための方法において使用するための請求項1〜4のいずれか1項記載の組成物、ここで、当該組成物は、対象における炎症の徴候又は症状を低めるか又は改善するのに十分な量及び十分な時間、対象に投与され、好ましくは、前記患者はヒトであり、或いは、前記炎症は、熱傷又は他の外傷性損傷、化学的刺激物又は毒素、感染、又は自己免疫疾患により引起され、好ましくは、前記感染は、細菌性又はウィルス性感染である。
- 患者における代謝症候群の処理方法において使用するための請求項1〜4のいずれか1項記載の組成物、ここで、当該組成物は、患者における代謝症候群の徴候又は症状を低めるか又は改善するのに十分な量及び十分な時間、患者に投与され、好ましくは、前記患者はヒトであり、又は前記代謝症候群が糖尿病に関連している。
- (a)キャリヤーを含んで成る第1組成物、及び(b)100mg〜400mgの第2組成物を含んで成る医薬組成物:ここで、
(1)当該第2組成物の少なくとも又は約35重量%がアントシアニン又はアントシアニジンであり、
(2)当該アントシアニン又はアントシアニジンの少なくとも約15重量%が糖を含まないか又は糖を含むデルフィニジンであり、
(3)当該第2組成物は、アリストテリア・キレンシス(Aristotelia chilensis)植物から得られる抽出物として形成されており、そして
(4)当該第2組成物は、下記の量のアントシアニジン:
6,38重量%のデルフィニジン−3−O−サムブビオシド−5−O−グルコシド;
13.64重量%のデルフィニジン−3,5−O−ジグルコシド;
3.36重量%のシアニジン−3−O−サムブビオシド−5−O−グルコシド;
1.58重量%のシアニジン−3,5−O−ジグルコシド;
1.67重量%のデルフィニジン−3−O−サムブビオシド;
6.95重量%のデルフィニジン−3−O−グルコシド;
0.79重量%のシアニジン−3−O−サムブビオシド;及び
1.05重量%のシアニジン−3−O−グルコシド;
を含んで成る。 - アンドログラホリドを含んで成る第3組成物をさらに含んで成る、請求項10に記載の医薬組成物、好ましくは、前記第3組成物の約30〜40%がアンドログラホリドである。
- (c)カフェオイルキナ酸を含んで成る第3組成物を含んで成る請求項10に記載の医薬組成物。
- 請求項1に記載の組成物の製造方法において、
(a)アントシアニン類及び/又はアントシアニジン類を含んで成るアリストテリア・キレンシス(Aristotelia chilensis)植物を供給し;
(b)前記植物の統合性を破壊し;
(c)前記破壊された植物から化学物質を抽出し、抽出液体を生成し;
(d)前記抽出液体を濃縮し、抽出混合物を生成し;
(e)前記抽出混合物をアルカリ化し;
(f)前記抽出混合物における少なくとも1つの成分を、前記抽出混合物における他の成分から分離し;そして
(g)前記分離された成分の少なくとも1つを集め、そして乾燥する;
ことを含んで成る方法。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25383509P | 2009-10-21 | 2009-10-21 | |
US61/253,835 | 2009-10-21 | ||
US27954109P | 2009-10-22 | 2009-10-22 | |
US61/279,541 | 2009-10-22 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012534790A Division JP2013508347A (ja) | 2009-10-21 | 2010-10-21 | アントシアニジンを含む組成物及び使用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015232038A JP2015232038A (ja) | 2015-12-24 |
JP6141929B2 true JP6141929B2 (ja) | 2017-06-07 |
Family
ID=43709162
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012534790A Withdrawn JP2013508347A (ja) | 2009-10-21 | 2010-10-21 | アントシアニジンを含む組成物及び使用方法 |
JP2015182146A Active JP6141929B2 (ja) | 2009-10-21 | 2015-09-15 | アントシアニジンを含む組成物及び使用方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012534790A Withdrawn JP2013508347A (ja) | 2009-10-21 | 2010-10-21 | アントシアニジンを含む組成物及び使用方法 |
Country Status (7)
Country | Link |
---|---|
US (3) | US10786522B2 (ja) |
EP (1) | EP2344154B1 (ja) |
JP (2) | JP2013508347A (ja) |
KR (1) | KR101625882B1 (ja) |
CA (1) | CA2735343A1 (ja) |
ES (1) | ES2618952T3 (ja) |
WO (1) | WO2011048479A2 (ja) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5968610B2 (ja) * | 2011-10-24 | 2016-08-10 | 株式会社ファイン | マクイベリー含有抗酸化組成物 |
US20140295482A1 (en) * | 2011-11-02 | 2014-10-02 | Texas Tech University System | Media Compositions for Promoting Bacterial and Fungal Growth |
US11753617B2 (en) | 2011-11-02 | 2023-09-12 | Texas Tech University System | Media compositions for promoting bacterial and fungal growth |
US9969707B2 (en) | 2011-12-16 | 2018-05-15 | CENTRE DE RECHERCHE INDUSTRIELLE DU QUéBEC | Method for extracting anthocyanin derivatives from a plant source |
JP6193970B2 (ja) * | 2012-03-30 | 2017-09-06 | ザピオテック・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングSAPIOTEC GmbH | 黄色ブドウ球菌(Staphylococcusaureus)に対するデルフィニジンの使用 |
JP2013234140A (ja) * | 2012-05-08 | 2013-11-21 | Oriza Yuka Kk | 発毛促進剤 |
CN102716122B (zh) * | 2012-07-03 | 2014-06-25 | 郑州大学 | 15-苄亚基-14-脱氧-11,12-脱氢穿心莲内酯衍生物在制备治疗糖尿病药物中的应用 |
EP2682005A1 (en) | 2012-07-05 | 2014-01-08 | Symrise AG | A dietary supplement composition |
CN102786507B (zh) * | 2012-08-27 | 2014-12-10 | 袁乃坤 | 从紫色马铃薯中快速提取食品级花青素的简便方法 |
US20140128333A1 (en) * | 2012-11-02 | 2014-05-08 | Maqui New Life S.A. | Compounds, Compositions, and Methods for Decreasing Intestinal Glucose Uptake and Inducing Incretin Release |
KR102147084B1 (ko) | 2012-11-15 | 2020-08-24 | 자피오텍 게엠베하 | 소염성 활성 물질 또는 면역 억제성 활성물질로서 델피니딘 복합제 |
EP2931287B1 (de) | 2012-12-11 | 2017-10-04 | Sapiotec GmbH | Delphinidin zur bekämpfung von melanomzellen |
BR112015014459A2 (ja) | 2012-12-18 | 2019-12-31 | Univ Keio | Dry eye prevention / medical treatment agent |
US10398664B2 (en) | 2013-05-01 | 2019-09-03 | Lanny Leo Johnson | Methods of diagnosing and treating infected implants |
US10016380B2 (en) | 2013-05-01 | 2018-07-10 | Lanny Leo Johnson | Antimicrobials and methods of use thereof |
US9498413B2 (en) | 2013-05-01 | 2016-11-22 | Lanny Leo Johnson | Antimicrobials and methods of use thereof for wound healing |
JP6144536B2 (ja) * | 2013-05-14 | 2017-06-07 | オリザ油化株式会社 | 美白剤 |
WO2014186369A1 (en) * | 2013-05-15 | 2014-11-20 | Abbott Laboratories | Nutritional composition comprising anthocyanidin(s) and related methods |
CN103766901A (zh) * | 2014-01-08 | 2014-05-07 | 浙江大学 | 一种穿心莲丙素在制备减肥食品或药品中的应用 |
JP2015182955A (ja) * | 2014-03-20 | 2015-10-22 | 学校法人中部大学 | Glp−1分泌促進剤 |
JP6742575B2 (ja) * | 2015-07-02 | 2020-08-19 | 株式会社東洋新薬 | 関節機能改善組成物 |
CN105017202A (zh) * | 2015-08-11 | 2015-11-04 | 贵州北极熊实业有限公司 | 一种从黑莓果渣中提取花青素的方法 |
ITUA20161822A1 (it) * | 2016-03-18 | 2017-09-18 | Indena Spa | Composizioni utili nella prevenzione e/o nel trattamento di patologie del cavo orale, delle prime vie aeree e dell’esofago |
IT201700040937A1 (it) * | 2017-04-12 | 2018-10-12 | Giannamaria Annunziato | Antocianidine per il trattamento e la prevenzione di malattie infiammatorie e metaboliche |
KR102032621B1 (ko) | 2017-12-01 | 2019-10-15 | 숙명여자대학교산학협력단 | 마키베리 추출물 또는 이의 효소 가수분해물을 유효성분으로 함유하는 갱년기 증상 예방 또는 치료용 약학적 조성물 |
CN108853026A (zh) * | 2018-08-21 | 2018-11-23 | 无锡正大生物股份有限公司 | 一种兽用穿心莲内酯散 |
MX2018011698A (es) * | 2018-09-26 | 2019-08-27 | Instituto Nac De Enfermedades Respiratorias Ismael Cosio Villegas | Uso de inhibidores enzimaticos de cd38 en pacientes vih positivos. |
EP3701960A1 (en) * | 2019-02-27 | 2020-09-02 | Anklam Extrakt GmbH | Maqui berry extracts for use in the treatment or prevention of bone disorders |
WO2020219686A1 (en) * | 2019-04-23 | 2020-10-29 | Mann Francis Michelle | Anthocyanin extraction methods |
EP3733194A1 (en) * | 2019-05-03 | 2020-11-04 | Anklam Extrakt GmbH | Maqui berry extracts for treatment of skin diseases |
KR102153250B1 (ko) * | 2020-01-10 | 2020-09-07 | 건국대학교 글로컬산학협력단 | 클로로겐산을 표준물질로 함유하는 블루베리의 항염증 조성물 |
AU2021330526A1 (en) * | 2020-08-24 | 2023-03-23 | Neuroscience Pharma Spa | Fruit extracts for use in the treatment of neurodegenerative diseases |
CN112220704B (zh) * | 2020-09-29 | 2023-01-31 | 四川大学华西医院 | 一种天然高spf防晒剂及其制备方法和在彩妆中的应用 |
KR102575617B1 (ko) * | 2020-12-22 | 2023-09-06 | 안동대학교 산학협력단 | 상동나무 추출물을 유효성분으로 포함하는 면역증진용 조성물 |
US20220257692A1 (en) * | 2021-02-17 | 2022-08-18 | Plexus Worldwide, Llc | Compositions and methods for supporting immune health |
KR20220122877A (ko) * | 2021-02-26 | 2022-09-05 | 유한회사 한터 | 블랙커런트 열수 추출물을 포함하는 비알코올성 지방간 질환의 예방, 개선 또는 치료용 조성물 |
US20240269219A1 (en) * | 2021-04-02 | 2024-08-15 | Aronpharma Sp. Z O.O. | Pharmaceutical composition and its antiviral use |
RS20210431A1 (sr) | 2021-04-07 | 2022-10-31 | Phytonet Doo | Ekstrakti aristotelia chilensis u tretmanu gljivičnih infekcija |
WO2023150072A1 (en) | 2022-02-01 | 2023-08-10 | Sinclair David A | Compositions and methods for the preservation of plant matter |
WO2024148202A1 (en) * | 2023-01-04 | 2024-07-11 | Nse Products, Inc. | Metabolic health promoting compositions |
KR102598567B1 (ko) * | 2023-02-24 | 2023-11-07 | 재단법인 전남바이오진흥원 | 가시모밀 추출물을 유효성분으로 포함하는 면역증강용 건강기능식품 조성물 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6277328A (ja) * | 1985-09-30 | 1987-04-09 | Shiseido Co Ltd | 循環改善剤 |
AU2578997A (en) | 1996-04-17 | 1997-11-19 | Unifob | Use of anthocyanidin and anthocyanidin derivatives |
JP2000212092A (ja) * | 1999-01-27 | 2000-08-02 | Yanai Yoshiaki | 抗ウイルス・抗菌剤 |
EP1074254A3 (en) * | 1999-07-20 | 2002-09-11 | MEDIS S.r.l. Medical Infusion Systems | Use of plant polyphenols with vitamines for treating iron overload |
CN1384713A (zh) * | 1999-08-27 | 2002-12-11 | 密执安州大学 | 包含天然的环加氧酶抑制剂的保健食品添加剂 |
ITGE20020026A1 (it) * | 2002-03-25 | 2003-09-25 | Segre Silvia Perella | Composto da impiegare nel trattamento scleroterapico,nell'insufficienza venosa e nelle alterazioni del microcircolo. |
US20070060533A1 (en) * | 2003-10-24 | 2007-03-15 | Meiji Seika Kaisha Ltd. | Novel inhibitor of the formation of advanced glycation end product and aldose reductase inhibitor |
WO2007038421A2 (en) * | 2005-09-27 | 2007-04-05 | University Of Kentucky Research Foundation | Berry preparations and extracts |
EP1882473A1 (en) * | 2006-07-28 | 2008-01-30 | Indena S.P.A. | Use of anthocyanosides to prepare formulations for the treatment of mucositis induced by antitumoral drugs |
US8846757B2 (en) * | 2006-07-31 | 2014-09-30 | The Trustees Of Columbia University In The City Of New York | Bioactive depside and anthocyanin compounds, compositions, and methods of use |
JP5201662B2 (ja) * | 2007-02-28 | 2013-06-05 | キッコーマン株式会社 | 血流改善組成物 |
KR100832240B1 (ko) * | 2007-04-11 | 2008-05-28 | 경상대학교산학협력단 | 검정콩 껍질로부터 추출한 안토시아닌을 함유하는 창상치료용 의약 조성물 |
CN100584841C (zh) * | 2007-08-08 | 2010-01-27 | 暨南大学 | 穿心莲内酯衍生物及其在制药中的应用 |
WO2009059218A1 (en) * | 2007-10-31 | 2009-05-07 | Phytomedics, Inc. | Berry preparations for treatment of diabetes and metabolic syndrome |
GB0908397D0 (en) * | 2009-05-15 | 2009-06-24 | Univ Leeds | Natural hair dyes |
-
2010
- 2010-10-21 KR KR1020127013111A patent/KR101625882B1/ko active IP Right Grant
- 2010-10-21 ES ES10784340.1T patent/ES2618952T3/es active Active
- 2010-10-21 EP EP10784340.1A patent/EP2344154B1/en active Active
- 2010-10-21 CA CA2735343A patent/CA2735343A1/en not_active Abandoned
- 2010-10-21 JP JP2012534790A patent/JP2013508347A/ja not_active Withdrawn
- 2010-10-21 WO PCT/IB2010/002698 patent/WO2011048479A2/en active Application Filing
-
2011
- 2011-03-30 US US13/076,117 patent/US10786522B2/en active Active
-
2014
- 2014-12-31 US US14/587,070 patent/US20150164932A1/en not_active Abandoned
-
2015
- 2015-09-15 JP JP2015182146A patent/JP6141929B2/ja active Active
-
2019
- 2019-01-24 US US16/256,384 patent/US20190151342A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ES2618952T3 (es) | 2017-06-22 |
JP2015232038A (ja) | 2015-12-24 |
CA2735343A1 (en) | 2011-04-21 |
EP2344154B1 (en) | 2016-12-07 |
KR101625882B1 (ko) | 2016-05-31 |
WO2011048479A3 (en) | 2011-08-11 |
EP2344154A1 (en) | 2011-07-20 |
US10786522B2 (en) | 2020-09-29 |
KR20120090089A (ko) | 2012-08-16 |
US20190151342A1 (en) | 2019-05-23 |
US20150164932A1 (en) | 2015-06-18 |
JP2013508347A (ja) | 2013-03-07 |
US20110268825A1 (en) | 2011-11-03 |
WO2011048479A2 (en) | 2011-04-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6141929B2 (ja) | アントシアニジンを含む組成物及び使用方法 | |
JP6415394B2 (ja) | 安定化されたアントシアニン組成物 | |
US20130108706A1 (en) | Dietary formulations | |
US8679550B2 (en) | Morinda citrifolia juice formulations comprising iridoids | |
US20150086655A1 (en) | Morinda Citrifolia Juice Formulations Comprising Iridoids | |
JP2016520540A (ja) | 脳内におけるカロテノイドの神経保護作用 | |
JPWO2017135466A1 (ja) | キサントフィルとヒシ属植物の加工物を含有する組成物 | |
WO2021255464A1 (en) | Nutraceutical composition | |
Mahomoodally et al. | Nutritional, medicinal and functional properties of different parts of the date palm and its fruit (Phoenix dactylifera L.)–A systematic review | |
US20080254143A1 (en) | Composition for improving immune system health | |
US9034399B2 (en) | Dietary compositions for promoting brain health | |
JP5071618B2 (ja) | 外分泌腺の機能障害改善剤及び機能障害改善用飲食物 | |
KR20080088925A (ko) | 시력 보호용 조성물 | |
CN110691590A (zh) | 用于预防和/或改善脑功能障碍的含有叶黄素类或其盐和菱属植物的加工产物的组合物 | |
US20080268039A1 (en) | Loquat compositions | |
EP2476425B1 (en) | Composition comprising OPC and Omega-3 for preventing and/or inhibiting the development of diabetic retinopathy | |
KR20070033236A (ko) | 엘라그산, 엘라지탄닌과 이를 포함하는 천연식물 추출물을유효성분으로 함유하는 간기능 보호제 | |
KR102395338B1 (ko) | 추위 민감증을 포함하는 전신 증상을 개선하기 위한 경구 조성물 | |
US20230241149A1 (en) | Transthyretin tetramer stabilizing agent, and preventing agent or progression suppressing agent for transthyretin amyloidosis | |
US20230241022A1 (en) | Transthyretin tetramer stabilizing agent, and preventing agent or progression suppressing agent for transthyretin amyloidosis | |
EP1677628B1 (en) | Composition for the activation of the immune system | |
CA3215039A1 (en) | Aristotelia chilensis extracts for treating fungal infections | |
Fruit | AmericanHerbal Pharmacopoeia | |
EP1570751A1 (en) | Composition for the activation of the immune system | |
US20140370131A1 (en) | Pharmaceutical Composition for Protecting Brain Neurons Comprising Plumula Nelumbinis Extract as Active Ingredient |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150929 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150929 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160719 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20161019 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161031 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20161206 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170111 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170228 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170307 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170404 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170508 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6141929 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |