JP6140083B2 - 三環式ジャイレース阻害薬 - Google Patents

三環式ジャイレース阻害薬 Download PDF

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Publication number
JP6140083B2
JP6140083B2 JP2013558143A JP2013558143A JP6140083B2 JP 6140083 B2 JP6140083 B2 JP 6140083B2 JP 2013558143 A JP2013558143 A JP 2013558143A JP 2013558143 A JP2013558143 A JP 2013558143A JP 6140083 B2 JP6140083 B2 JP 6140083B2
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Japanese (ja)
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JP2014508173A (ja
Inventor
ベンセン，ダニエル
フィン，ジョン
リー，ソク，ジュン
チェン，ジヨン
ラム，タン，ト
リー，シャオミン
トルゾス，ミヒャエル
ジュン，マイケル
ニューエン，トーン，ビー．
ライトストーン，フェリス
タリ，レスリー，ウィリアム
チャン，ジュンホー
アリストフ，ポール
フィリップソン，ダグラス，ダブリュー．
ウォン，セルジオ，イー．
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Merck Sharp and Dohme LLC
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Merck Sharp and Dohme LLC
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Publication of JP2014508173A publication Critical patent/JP2014508173A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013558143A 2011-03-15 2012-03-14 三環式ジャイレース阻害薬 Active JP6140083B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161453011P 2011-03-15 2011-03-15
US61/453,011 2011-03-15
PCT/US2012/029104 WO2012125746A1 (en) 2011-03-15 2012-03-14 Tricyclic gyrase inhibitors

Publications (2)

Publication Number Publication Date
JP2014508173A JP2014508173A (ja) 2014-04-03
JP6140083B2 true JP6140083B2 (ja) 2017-05-31

Family

ID=45879060

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013558143A Active JP6140083B2 (ja) 2011-03-15 2012-03-14 三環式ジャイレース阻害薬

Country Status (16)

Country Link
US (2) US9732083B2 (https=)
EP (1) EP2686320B1 (https=)
JP (1) JP6140083B2 (https=)
KR (2) KR20140059164A (https=)
CN (1) CN103562208B (https=)
AR (1) AR085806A1 (https=)
AU (1) AU2012229997B2 (https=)
BR (1) BR112013023266B8 (https=)
CA (1) CA2829939C (https=)
IL (1) IL228220A (https=)
MX (1) MX345780B (https=)
PH (1) PH12013501800A1 (https=)
RU (1) RU2626979C2 (https=)
TW (1) TWI527818B (https=)
WO (1) WO2012125746A1 (https=)
ZA (1) ZA201307583B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015528502A (ja) * 2012-09-12 2015-09-28 トリウス セラピューティクス，インコーポレイテッド 抗菌剤として使用するための三環式ジャイレース阻害剤

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EP2686320B1 (en) * 2011-03-15 2016-05-18 Merck Sharp & Dohme Corp. Tricyclic gyrase inhibitors
EP2807165B1 (en) * 2012-01-27 2019-05-15 Université de Montréal Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells
CN103304488B (zh) * 2013-06-13 2015-12-09 暨明医药科技（苏州）有限公司 光学纯2-（1-羟基乙基）-5-羟基嘧啶的制备方法
CN105899511B (zh) * 2013-09-11 2019-06-07 默沙东公司 三环促旋酶抑制剂
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CA3057431A1 (en) 2017-03-24 2018-09-27 Taisho Pharmaceutical Co., Ltd. 2(1h)-quinolinone derivative
CN110475777B (zh) * 2017-03-30 2022-04-15 豪夫迈·罗氏有限公司 用于治疗和预防细菌感染的新吡啶并[2,3-b]吲哚化合物
CN108504647B (zh) * 2018-03-09 2021-11-05 中山大学 一种dna促旋酶的药物结合口袋及其应用
JP7296992B2 (ja) * 2018-05-28 2023-06-23 エフ． ホフマン－ラ ロシュ アーゲー 細菌感染症の処置および予防のための新規オキソキノリジン化合物
WO2020064661A1 (en) * 2018-09-26 2020-04-02 F. Hoffmann-La Roche Ag Substituted pyridoindoles for the treatment and prophylaxis of bacterial infection
EP3887370B1 (en) * 2018-11-27 2023-01-18 F. Hoffmann-La Roche AG Tricyclic compounds for the treatment and prophylaxis of bacterial infection
WO2020109191A1 (en) 2018-11-27 2020-06-04 F. Hoffmann-La Roche Ag Aryl compounds for the treatment and prophylaxis of bacterial infection
WO2020127624A1 (en) 2018-12-20 2020-06-25 F. Hoffmann-La Roche Ag Oxopyrido[1,2-a]pyrimidine compounds for the treatment and prophylaxis of bacterial infection
CN114763357B (zh) * 2021-01-15 2024-06-18 中国科学院上海药物研究所 吲哚并嘧啶三环类化合物及其制备方法和用途

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015528502A (ja) * 2012-09-12 2015-09-28 トリウス セラピューティクス，インコーポレイテッド 抗菌剤として使用するための三環式ジャイレース阻害剤

Also Published As

Publication number Publication date
WO2012125746A1 (en) 2012-09-20
IL228220A0 (en) 2013-11-25
BR112013023266A8 (pt) 2018-06-12
MX2013010511A (es) 2014-03-27
RU2013140798A (ru) 2015-04-20
IL228220A (en) 2017-04-30
CN103562208B (zh) 2016-08-31
CN103562208A (zh) 2014-02-05
AU2012229997A1 (en) 2013-09-19
EP2686320A1 (en) 2014-01-22
AU2012229997B2 (en) 2016-04-14
MX345780B (es) 2017-02-15
KR102132574B1 (ko) 2020-07-09
EP2686320B1 (en) 2016-05-18
BR112013023266B8 (pt) 2021-04-06
CA2829939C (en) 2020-10-13
NZ614983A (en) 2016-07-29
US10858360B2 (en) 2020-12-08
PH12013501800A1 (en) 2013-10-14
KR20140059164A (ko) 2014-05-15
TWI527818B (zh) 2016-04-01
ZA201307583B (en) 2014-08-27
JP2014508173A (ja) 2014-04-03
BR112013023266B1 (pt) 2020-12-29
RU2626979C2 (ru) 2017-08-02
US20120238751A1 (en) 2012-09-20
AR085806A1 (es) 2013-10-30
WO2012125746A9 (en) 2013-10-24
BR112013023266A2 (https=) 2017-09-12
TW201245200A (en) 2012-11-16
CA2829939A1 (en) 2012-09-20
KR20190104632A (ko) 2019-09-10
US20170369498A1 (en) 2017-12-28
US9732083B2 (en) 2017-08-15

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