AR085806A1 - Inhibidores triciclicos de girasa - Google Patents
Inhibidores triciclicos de girasaInfo
- Publication number
- AR085806A1 AR085806A1 ARP120100830A ARP120100830A AR085806A1 AR 085806 A1 AR085806 A1 AR 085806A1 AR P120100830 A ARP120100830 A AR P120100830A AR P120100830 A ARP120100830 A AR P120100830A AR 085806 A1 AR085806 A1 AR 085806A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituent
- optionally substituted
- carbon
- length
- interacting
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procesos de obtención, composiciones farmacéuticas y compuestos intermediarios.Reivindicación 1: Un compuesto que tiene la estructura de fórmula (1) o sales farmacéuticamente aceptables, ésteres, y prodrogas del mismo, donde L es O ó S; R8 es H o un sustituyente interactuante con una longitud de aproximadamente 1 - 5 Å desde el punto de unión de carbono en el Anillo A hasta el átomo terminal en R8 y un ancho de aproximadamente 3,3 Å o menor; X, Y y Z se seleccionan en forma independiente entre el grupo que consiste en N, CRX, CRY, y CRZ, con la condición de que no más que dos de X, Y y Z son N, donde RX es H o un sustituyente interactuante con una longitud de aproximadamente 1 - 2 Å desde el carbono en CRX hasta el átomo terminal en RX; donde RY es H o un sustituyente interactuante con una longitud de aproximadamente 1 - 3 Å desde el carbono en CRY hasta el átomo terminal en RY; donde RZ es H o un sustituyente interactuante con una longitud de aproximadamente 1 - 2 Å desde el carbono en CRZ hasta el átomo terminal en RZ; R2 es un anillo arilo o heteroarilo de 6 miembros que contiene 0 - 3 heteroátomos O, S, o N, opcionalmente sustituido con 0 - 3 sustituyentes no interferentes, donde 2 sustituyentes no interferentes adyacentes sobre R2 pueden formar uno o más anillos fusionados con el anillo arilo o heteroarilo de 6 miembros; donde el anillo arilo o heteroarilo de 6 miembros de R2 tiene un CH en la posición inmediatamente adyacente a la posición donde R2 se une a L; R4 es: H; un ORa opcionalmente sustituido; una amina secundaria o terciaria opcionalmente sustituida unida al anillo C a través del N de la amina secundaria o terciaria; o un residuo cíclico o heterocíclico insaturado de 5 - 10 miembros opcionalmente sustituido que contiene 0 - 3 heteroátomos N, O ó S; donde el sustituyente opcional es 0 - 3 sustituyentes no interferentes; donde Ra es un arilo o heteroarilo de 5 - 6 miembros que contiene 0 - 3 heteroátomos O, S, o N opcionalmente sustituido con 0 - 3 sustituyentes no interferentes; donde el sustituyente R4 no se proyecta más que 3 Å por debajo del plano de los anillos A, B y C hacia el piso del bolsillo de unión de GyrB/ParE en el estado unido; y donde R4 no interfiere estéricamente con R2 o Z cuando el compuesto se encuentra en el estado unido.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161453011P | 2011-03-15 | 2011-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR085806A1 true AR085806A1 (es) | 2013-10-30 |
Family
ID=45879060
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120100830A AR085806A1 (es) | 2011-03-15 | 2012-03-14 | Inhibidores triciclicos de girasa |
Country Status (15)
Country | Link |
---|---|
US (2) | US9732083B2 (es) |
EP (1) | EP2686320B1 (es) |
JP (1) | JP6140083B2 (es) |
KR (2) | KR102132574B1 (es) |
CN (1) | CN103562208B (es) |
AR (1) | AR085806A1 (es) |
AU (1) | AU2012229997B2 (es) |
BR (1) | BR112013023266B8 (es) |
CA (1) | CA2829939C (es) |
IL (1) | IL228220A (es) |
MX (1) | MX345780B (es) |
RU (1) | RU2626979C2 (es) |
TW (1) | TWI527818B (es) |
WO (1) | WO2012125746A1 (es) |
ZA (1) | ZA201307583B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2829939C (en) | 2011-03-15 | 2020-10-13 | Trius Therapeutics, Inc. | Tricyclic gyrase inhibitors |
NZ627188A (en) * | 2012-01-27 | 2015-12-24 | Univ Montreal | Pyrimido[4,5-b]indole derivatives and use thereof in the expansion of hematopoietic stem cells |
CN105189505B (zh) * | 2012-09-12 | 2019-03-22 | 默克夏普&多梅有限公司 | 用作抗菌剂的三环促旋酶抑制剂 |
CN103304488B (zh) * | 2013-06-13 | 2015-12-09 | 暨明医药科技(苏州)有限公司 | 光学纯2-(1-羟基乙基)-5-羟基嘧啶的制备方法 |
RU2680138C2 (ru) * | 2013-09-11 | 2019-02-18 | Мерк Шарп И Доум Корп. | Трициклические ингибиторы гиразы |
BR112016018048A2 (pt) | 2014-02-03 | 2017-08-08 | Spero Gyrase Inc | Método para o tratamento ou prevenção de uma infecção bacteriana, uso de um inibidor de topoisomerase tipo ii bacteriana em combinação com uma polimixina ou derivado de polimixina no tratamento ou prevenção de uma infecção bacteriana, uso de um inibidor de topoisomerase tipo ii bacteriana em combinação com uma polimixina ou derivado de polimixina na preparação de um medicamento para o tratamento ou prevenção de uma infecção bacteriana, método para melhorar a atividade antibacteriana de um inibidor de topoisomerase tipo ii bacteriana, método para melhorar a eficácia bactericida de um inibidor de topoisomerase tipo ii bacteriana, composição, agente antibacteriano, processo, e, composto |
WO2015150337A1 (en) * | 2014-04-01 | 2015-10-08 | Amakem Nv | Lim kinase inhibitors |
RU2019133662A (ru) | 2017-03-24 | 2021-04-26 | Тайсо Фармасьютикал Ко., Лтд. | Производное 2(1h)-хинолинона |
JP7344125B2 (ja) * | 2017-03-30 | 2023-09-13 | エフ. ホフマン-ラ ロシュ アーゲー | 細菌感染の治療及び予防のための新規ピリド[2,3-b]インドール化合物 |
CN108504647B (zh) * | 2018-03-09 | 2021-11-05 | 中山大学 | 一种dna促旋酶的药物结合口袋及其应用 |
WO2019228940A1 (en) | 2018-05-28 | 2019-12-05 | F. Hoffmann-La Roche Ag | Novel oxoquinolizine compounds for the treatment and prophylaxis of bacterial infection |
CN112752762A (zh) * | 2018-09-26 | 2021-05-04 | 豪夫迈·罗氏有限公司 | 用于治疗和预防细菌感染的取代的吡啶并吲哚 |
CN113166145A (zh) | 2018-11-27 | 2021-07-23 | 豪夫迈·罗氏有限公司 | 用于治疗和预防细菌感染的三环化合物 |
EP3887371B1 (en) | 2018-11-27 | 2023-02-22 | F. Hoffmann-La Roche AG | Aryl compounds for the treatment and prophylaxis of bacterial infection |
CN113195503A (zh) | 2018-12-20 | 2021-07-30 | 豪夫迈·罗氏有限公司 | 用于治疗和预防细菌感染的氧代吡啶并[1,2-a]嘧啶化合物 |
CN114763357B (zh) * | 2021-01-15 | 2024-06-18 | 中国科学院上海药物研究所 | 吲哚并嘧啶三环类化合物及其制备方法和用途 |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN157280B (es) | 1983-07-15 | 1986-02-22 | Hoechst India | |
CA1336090C (en) | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
DE4030059A1 (de) | 1990-09-22 | 1992-03-26 | Bayer Ag | Verfahren zur herstellung von 5-hydroxy-3,4,5,6-tetrahydro-pyrimidin-derivaten |
DE4032560A1 (de) | 1990-10-13 | 1992-04-16 | Bayer Ag | 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate |
ATE197051T1 (de) | 1992-04-03 | 2000-11-15 | Upjohn Co | Pharmazeutisch wirksame bicyclisch heterocyclische amine |
US5279359A (en) | 1992-06-26 | 1994-01-18 | Erickson Donald C | Rotary trisorption heat pump |
US5350791A (en) | 1992-07-02 | 1994-09-27 | Henkel Corporation | Hydrophilicizing treatment for metal objects |
US5527910A (en) | 1992-12-30 | 1996-06-18 | Cheil Foods & Chemicals, Inc. | Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
RU2158127C2 (ru) * | 1994-12-23 | 2000-10-27 | Варнер-Ламберт Компани | Способы ингибирования тирозинкиназы рецептора эпидермального фактора роста, азотсодержащие трициклические соединения, фармацевтическая композиция, предназначенная для введения ингибитора тирозинкиназы рецептора эпидермального фактора роста, например, erb-b2, erb-b3 или erb-b4, и противозачаточная композиция |
JPH11501623A (ja) | 1995-03-02 | 1999-02-09 | ファルマシア・アンド・アップジョン・カンパニー | ピリミド[4,5−b]インドール |
SK398A3 (en) * | 1995-07-06 | 1998-07-08 | Novartis Ag | Pyrrolopyrimidines and processes for the preparation thereof |
WO1998029397A1 (fr) | 1996-12-27 | 1998-07-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Composes pyrimidine a anneaux condenses et leur utilisation medicinale |
PT964865E (pt) | 1997-01-08 | 2003-06-30 | Upjohn Co | Aminas triciclicas farmaceuticamente activas |
ES2219895T3 (es) | 1997-07-29 | 2004-12-01 | PHARMACIA & UPJOHN COMPANY | Formulacion autoemulsionante para compuestos lipofilos. |
WO1999051598A1 (en) | 1998-04-02 | 1999-10-14 | Neurogen Corporation | SUBSTITUTED 9H-PYRIDINO[2,3-b]INDOLE AND 9H-PYRIMIDINO[4,5-b]INDOLE DERIVATIVES: SELECTIVE NEUROPEPTIDE y RECEPTOR LIGANDS |
EP1068207A1 (en) | 1998-04-02 | 2001-01-17 | Neurogen Corporation | AMINOALKYL SUBSTITUTED 9H-PYRIDINO 2,3-b]INDOLE AND 9H-PYRIMIDINO 4,5-b]INDOLE DERIVATIVES |
US6147085A (en) | 1999-04-01 | 2000-11-14 | Neurogen Corporation | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives |
JP2000038350A (ja) | 1998-05-18 | 2000-02-08 | Yoshitomi Pharmaceut Ind Ltd | 糖尿病治療薬 |
CA2371271A1 (en) | 1999-04-30 | 2000-11-09 | Neurogen Corporation | 9h-pyrimido[4,5-b]indole derivatives: crf1 specific ligands |
OA12316A (en) | 2000-01-24 | 2006-05-15 | Warner Lambert Co | 3-Aminoquinazolin-2,4-dione antibacterial agents. |
FR2816509B1 (fr) | 2000-11-15 | 2004-02-06 | Sod Conseils Rech Applic | Association d'inhibiteurs de calpaine et de piegeurs des formes reactives de l'oxygene |
CA2464934A1 (en) | 2001-10-31 | 2003-05-08 | Bayer Healthcare Ag | Pyrimido [4,5-b] indole derivatives |
JP2005515263A (ja) * | 2001-11-08 | 2005-05-26 | アンテックスファーマ・インコーポレーテッド | 新規な置換アルカン化合物及びその使用法 |
WO2003057149A2 (en) | 2001-12-28 | 2003-07-17 | Bayer Corporation | 4-substituted fused heteropyrimidines and fused hetero-4-pyrimidones |
AR042667A1 (es) | 2002-12-26 | 2005-06-29 | Taisho Pharmaceutical Co Ltd | Derivados de pirrolopirimidina y pirrolopiridina sustituidos con un grupo amino ciclico |
WO2004058764A1 (en) * | 2002-12-27 | 2004-07-15 | Bayer Healthcare Ag | 4-phenyl-pyrimido [4,5-b] indole derivatives |
US20080051414A1 (en) | 2003-10-14 | 2008-02-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
US20090099165A1 (en) | 2003-10-14 | 2009-04-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
US20090143399A1 (en) * | 2003-10-14 | 2009-06-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Protein Kinase Inhibitors |
DE602004022318D1 (de) | 2003-10-14 | 2009-09-10 | Supergen Inc | Proteinkinaseinhibitoren |
JP2007161585A (ja) | 2004-06-25 | 2007-06-28 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
JP2006036762A (ja) | 2004-06-25 | 2006-02-09 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
WO2008007113A2 (en) | 2006-07-14 | 2008-01-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
WO2006116733A2 (en) | 2005-04-28 | 2006-11-02 | Supergen, Inc. | Protein kinase inhibitors |
DE602005010421D1 (de) * | 2005-08-05 | 2008-11-27 | Hybrigenics Sa | Neue Cysteine Protease Hemmers und ihre therapeutische Anwendungen |
US20070049591A1 (en) | 2005-08-25 | 2007-03-01 | Kalypsys, Inc. | Inhibitors of MAPK/Erk Kinase |
JP2007169216A (ja) | 2005-12-22 | 2007-07-05 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
WO2008055233A1 (en) | 2006-10-31 | 2008-05-08 | Supergen, Inc. | Protein kinase inhibitors |
WO2009004329A1 (en) | 2007-07-02 | 2009-01-08 | Cancer Research Technology Limited | 9h-pyrimido[4,5-b]indoles, 9h-pyrido[4',3':4,5]pyrrolo[2,3-d]pyridines, and 9h-1,3,6,9-tetraaza-fluorenes as chk1 kinase function inhibitors |
US7960400B2 (en) * | 2007-08-27 | 2011-06-14 | Duquesne University Of The Holy Ghost | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof |
US7982035B2 (en) * | 2007-08-27 | 2011-07-19 | Duquesne University Of The Holy Spirit | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof |
US20110021524A1 (en) | 2008-01-14 | 2011-01-27 | Irm Llc | Compositions and methods for treating cancers |
WO2010017105A1 (en) * | 2008-08-02 | 2010-02-11 | Janssen Pharmaceutica N.V. | Urotensin ii receptor antagonists |
WO2011056739A1 (en) | 2009-11-03 | 2011-05-12 | Glaxosmithkline Llc | Compounds and methods |
CA2829939C (en) | 2011-03-15 | 2020-10-13 | Trius Therapeutics, Inc. | Tricyclic gyrase inhibitors |
CN105189505B (zh) * | 2012-09-12 | 2019-03-22 | 默克夏普&多梅有限公司 | 用作抗菌剂的三环促旋酶抑制剂 |
RU2680138C2 (ru) * | 2013-09-11 | 2019-02-18 | Мерк Шарп И Доум Корп. | Трициклические ингибиторы гиразы |
WO2016067009A1 (en) * | 2014-10-28 | 2016-05-06 | Redx Pharma Plc | Compounds with activity against bacteria and mycobacteria |
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2012
- 2012-03-14 CA CA2829939A patent/CA2829939C/en active Active
- 2012-03-14 TW TW101108646A patent/TWI527818B/zh active
- 2012-03-14 JP JP2013558143A patent/JP6140083B2/ja active Active
- 2012-03-14 KR KR1020197025342A patent/KR102132574B1/ko active IP Right Grant
- 2012-03-14 WO PCT/US2012/029104 patent/WO2012125746A1/en active Application Filing
- 2012-03-14 MX MX2013010511A patent/MX345780B/es active IP Right Grant
- 2012-03-14 AU AU2012229997A patent/AU2012229997B2/en active Active
- 2012-03-14 US US13/496,188 patent/US9732083B2/en active Active
- 2012-03-14 BR BR112013023266A patent/BR112013023266B8/pt active IP Right Grant
- 2012-03-14 EP EP12710633.4A patent/EP2686320B1/en active Active
- 2012-03-14 AR ARP120100830A patent/AR085806A1/es active IP Right Grant
- 2012-03-14 RU RU2013140798A patent/RU2626979C2/ru active
- 2012-03-14 CN CN201280020849.4A patent/CN103562208B/zh active Active
- 2012-03-14 KR KR1020137026970A patent/KR20140059164A/ko not_active Application Discontinuation
-
2013
- 2013-09-01 IL IL228220A patent/IL228220A/en active IP Right Grant
- 2013-10-11 ZA ZA2013/07583A patent/ZA201307583B/en unknown
-
2017
- 2017-07-07 US US15/643,760 patent/US10858360B2/en active Active
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