MX2013010511A - Inhibidores triciclicos de girasa. - Google Patents

Inhibidores triciclicos de girasa.

Info

Publication number
MX2013010511A
MX2013010511A MX2013010511A MX2013010511A MX2013010511A MX 2013010511 A MX2013010511 A MX 2013010511A MX 2013010511 A MX2013010511 A MX 2013010511A MX 2013010511 A MX2013010511 A MX 2013010511A MX 2013010511 A MX2013010511 A MX 2013010511A
Authority
MX
Mexico
Prior art keywords
gyrase inhibitors
tricyclic gyrase
compounds
tricyclic
inhibitors
Prior art date
Application number
MX2013010511A
Other languages
English (en)
Other versions
MX345780B (es
Inventor
John Finn
Junhu Zhang
Michael Jung
Douglas Phillipson
Daniel Bensen
Suk Joong Lee
Zhiyong Chen
Thanh To Lam
Xiaoming Li
Michael Trzoss
Toan B Nguyen
Felice Lightstone
Leslie William Tari
Paul Aristoff
Sergio E Wong
Original Assignee
Trius Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trius Therapeutics Inc filed Critical Trius Therapeutics Inc
Publication of MX2013010511A publication Critical patent/MX2013010511A/es
Publication of MX345780B publication Critical patent/MX345780B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se divulgan compuestos con la estructura de la Fórmula I y sales, ésteres, y profármacos de los mismos, farmacéuticamente adecuados que son útiles como inhibidores tricíclicos de girasa eficaces contra las bacterias. También se contemplan composiciones, usos y métodos farmacéuticamente relacionados para obtener los compuestos.
MX2013010511A 2011-03-15 2012-03-14 Inhibidores triciclicos de girasa. MX345780B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161453011P 2011-03-15 2011-03-15
PCT/US2012/029104 WO2012125746A1 (en) 2011-03-15 2012-03-14 Tricyclic gyrase inhibitors

Publications (2)

Publication Number Publication Date
MX2013010511A true MX2013010511A (es) 2014-03-27
MX345780B MX345780B (es) 2017-02-15

Family

ID=45879060

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013010511A MX345780B (es) 2011-03-15 2012-03-14 Inhibidores triciclicos de girasa.

Country Status (15)

Country Link
US (2) US9732083B2 (es)
EP (1) EP2686320B1 (es)
JP (1) JP6140083B2 (es)
KR (2) KR102132574B1 (es)
CN (1) CN103562208B (es)
AR (1) AR085806A1 (es)
AU (1) AU2012229997B2 (es)
BR (1) BR112013023266B8 (es)
CA (1) CA2829939C (es)
IL (1) IL228220A (es)
MX (1) MX345780B (es)
RU (1) RU2626979C2 (es)
TW (1) TWI527818B (es)
WO (1) WO2012125746A1 (es)
ZA (1) ZA201307583B (es)

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CN103562208B (zh) * 2011-03-15 2016-08-31 默沙东公司 三环促旋酶抑制剂
BR112014018524B1 (pt) * 2012-01-27 2023-03-28 Universite De Montreal Derivados de pirimido [4,5-b]indol, seu usos, composição farmaceutica, e método in vivo ou ex vivo para aumen-tar as células estaminais e/ou progenitoras
US10865216B2 (en) * 2012-09-12 2020-12-15 Merck Sharp & Dohme Corp. Tricyclic Gyrase inhibitors
CN103304488B (zh) * 2013-06-13 2015-12-09 暨明医药科技（苏州）有限公司 光学纯2-（1-羟基乙基）-5-羟基嘧啶的制备方法
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EP3601282B1 (en) * 2017-03-30 2021-07-21 F. Hoffmann-La Roche AG Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
CN108504647B (zh) * 2018-03-09 2021-11-05 中山大学 一种dna促旋酶的药物结合口袋及其应用
WO2019228940A1 (en) 2018-05-28 2019-12-05 F. Hoffmann-La Roche Ag Novel oxoquinolizine compounds for the treatment and prophylaxis of bacterial infection
CN112752762A (zh) * 2018-09-26 2021-05-04 豪夫迈·罗氏有限公司 用于治疗和预防细菌感染的取代的吡啶并吲哚
CN113166144A (zh) * 2018-11-27 2021-07-23 豪夫迈·罗氏有限公司 用于治疗和预防细菌感染的芳基化合物
EP3887370B1 (en) * 2018-11-27 2023-01-18 F. Hoffmann-La Roche AG Tricyclic compounds for the treatment and prophylaxis of bacterial infection
JP7531492B2 (ja) 2018-12-20 2024-08-09 エフ． ホフマン－ラ ロシュ アーゲー 細菌感染症の処置および予防のためのオキソピリド［１，２－ａ］ピリミジン化合物
CN114763357B (zh) * 2021-01-15 2024-06-18 中国科学院上海药物研究所 吲哚并嘧啶三环类化合物及其制备方法和用途

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Also Published As

Publication number Publication date
EP2686320A1 (en) 2014-01-22
NZ614983A (en) 2016-07-29
RU2626979C2 (ru) 2017-08-02
TW201245200A (en) 2012-11-16
WO2012125746A1 (en) 2012-09-20
AR085806A1 (es) 2013-10-30
KR102132574B1 (ko) 2020-07-09
BR112013023266B8 (pt) 2021-04-06
US20120238751A1 (en) 2012-09-20
AU2012229997A1 (en) 2013-09-19
CA2829939A1 (en) 2012-09-20
AU2012229997B2 (en) 2016-04-14
KR20140059164A (ko) 2014-05-15
US10858360B2 (en) 2020-12-08
WO2012125746A9 (en) 2013-10-24
KR20190104632A (ko) 2019-09-10
CN103562208A (zh) 2014-02-05
BR112013023266A8 (pt) 2018-06-12
CA2829939C (en) 2020-10-13
BR112013023266A2 (es) 2017-09-12
CN103562208B (zh) 2016-08-31
BR112013023266B1 (pt) 2020-12-29
IL228220A0 (en) 2013-11-25
JP2014508173A (ja) 2014-04-03
MX345780B (es) 2017-02-15
ZA201307583B (en) 2014-08-27
RU2013140798A (ru) 2015-04-20
TWI527818B (zh) 2016-04-01
JP6140083B2 (ja) 2017-05-31
US20170369498A1 (en) 2017-12-28
IL228220A (en) 2017-04-30
EP2686320B1 (en) 2016-05-18
US9732083B2 (en) 2017-08-15

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