KR20140059164A - 트라이사이클릭 자이라제 억제제 - Google Patents

트라이사이클릭 자이라제 억제제 Download PDF

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Publication number
KR20140059164A
KR20140059164A KR1020137026970A KR20137026970A KR20140059164A KR 20140059164 A KR20140059164 A KR 20140059164A KR 1020137026970 A KR1020137026970 A KR 1020137026970A KR 20137026970 A KR20137026970 A KR 20137026970A KR 20140059164 A KR20140059164 A KR 20140059164A
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South Korea
Prior art keywords
compound
optionally substituted
ring
mmol
group
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Ceased
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KR1020137026970A
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English (en)
Korean (ko)
Inventor
대니얼 벤슨
존 핀
석중 이
쯔용 첸
탄 토 램
시아오밍 리
마이클 튀조스
마이클 정
또안 비. 응유옌
펠리체 라이트스톤
레슬리 윌리엄 타리
준후 장
폴 아리스토프
더글라스 떠블류. 필립슨
세르지오 이. 옹
Original Assignee
트라이우스 테라퓨틱스, 아이엔씨.
로렌스 리버모어 내쇼날 시큐리티, 엘엘시
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Application filed by 트라이우스 테라퓨틱스, 아이엔씨., 로렌스 리버모어 내쇼날 시큐리티, 엘엘시 filed Critical 트라이우스 테라퓨틱스, 아이엔씨.
Publication of KR20140059164A publication Critical patent/KR20140059164A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020137026970A 2011-03-15 2012-03-14 트라이사이클릭 자이라제 억제제 Ceased KR20140059164A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161453011P 2011-03-15 2011-03-15
US61/453,011 2011-03-15
PCT/US2012/029104 WO2012125746A1 (en) 2011-03-15 2012-03-14 Tricyclic gyrase inhibitors

Related Child Applications (1)

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KR1020197025342A Division KR102132574B1 (ko) 2011-03-15 2012-03-14 트라이사이클릭 자이라제 억제제

Publications (1)

Publication Number Publication Date
KR20140059164A true KR20140059164A (ko) 2014-05-15

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KR1020137026970A Ceased KR20140059164A (ko) 2011-03-15 2012-03-14 트라이사이클릭 자이라제 억제제
KR1020197025342A Active KR102132574B1 (ko) 2011-03-15 2012-03-14 트라이사이클릭 자이라제 억제제

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Country Link
US (2) US9732083B2 (https=)
EP (1) EP2686320B1 (https=)
JP (1) JP6140083B2 (https=)
KR (2) KR20140059164A (https=)
CN (1) CN103562208B (https=)
AR (1) AR085806A1 (https=)
AU (1) AU2012229997B2 (https=)
BR (1) BR112013023266B8 (https=)
CA (1) CA2829939C (https=)
IL (1) IL228220A (https=)
MX (1) MX345780B (https=)
PH (1) PH12013501800A1 (https=)
RU (1) RU2626979C2 (https=)
TW (1) TWI527818B (https=)
WO (1) WO2012125746A1 (https=)
ZA (1) ZA201307583B (https=)

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EP2686320B1 (en) * 2011-03-15 2016-05-18 Merck Sharp & Dohme Corp. Tricyclic gyrase inhibitors
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CN103304488B (zh) * 2013-06-13 2015-12-09 暨明医药科技（苏州）有限公司 光学纯2-（1-羟基乙基）-5-羟基嘧啶的制备方法
CN105899511B (zh) * 2013-09-11 2019-06-07 默沙东公司 三环促旋酶抑制剂
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CN110475777B (zh) * 2017-03-30 2022-04-15 豪夫迈·罗氏有限公司 用于治疗和预防细菌感染的新吡啶并[2,3-b]吲哚化合物
CN108504647B (zh) * 2018-03-09 2021-11-05 中山大学 一种dna促旋酶的药物结合口袋及其应用
JP7296992B2 (ja) * 2018-05-28 2023-06-23 エフ． ホフマン－ラ ロシュ アーゲー 細菌感染症の処置および予防のための新規オキソキノリジン化合物
WO2020064661A1 (en) * 2018-09-26 2020-04-02 F. Hoffmann-La Roche Ag Substituted pyridoindoles for the treatment and prophylaxis of bacterial infection
EP3887370B1 (en) * 2018-11-27 2023-01-18 F. Hoffmann-La Roche AG Tricyclic compounds for the treatment and prophylaxis of bacterial infection
WO2020109191A1 (en) 2018-11-27 2020-06-04 F. Hoffmann-La Roche Ag Aryl compounds for the treatment and prophylaxis of bacterial infection
WO2020127624A1 (en) 2018-12-20 2020-06-25 F. Hoffmann-La Roche Ag Oxopyrido[1,2-a]pyrimidine compounds for the treatment and prophylaxis of bacterial infection
CN114763357B (zh) * 2021-01-15 2024-06-18 中国科学院上海药物研究所 吲哚并嘧啶三环类化合物及其制备方法和用途

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Also Published As

Publication number Publication date
WO2012125746A1 (en) 2012-09-20
IL228220A0 (en) 2013-11-25
BR112013023266A8 (pt) 2018-06-12
MX2013010511A (es) 2014-03-27
RU2013140798A (ru) 2015-04-20
IL228220A (en) 2017-04-30
CN103562208B (zh) 2016-08-31
CN103562208A (zh) 2014-02-05
AU2012229997A1 (en) 2013-09-19
EP2686320A1 (en) 2014-01-22
AU2012229997B2 (en) 2016-04-14
MX345780B (es) 2017-02-15
KR102132574B1 (ko) 2020-07-09
EP2686320B1 (en) 2016-05-18
BR112013023266B8 (pt) 2021-04-06
CA2829939C (en) 2020-10-13
NZ614983A (en) 2016-07-29
US10858360B2 (en) 2020-12-08
PH12013501800A1 (en) 2013-10-14
TWI527818B (zh) 2016-04-01
ZA201307583B (en) 2014-08-27
JP2014508173A (ja) 2014-04-03
BR112013023266B1 (pt) 2020-12-29
RU2626979C2 (ru) 2017-08-02
US20120238751A1 (en) 2012-09-20
AR085806A1 (es) 2013-10-30
WO2012125746A9 (en) 2013-10-24
BR112013023266A2 (https=) 2017-09-12
TW201245200A (en) 2012-11-16
JP6140083B2 (ja) 2017-05-31
CA2829939A1 (en) 2012-09-20
KR20190104632A (ko) 2019-09-10
US20170369498A1 (en) 2017-12-28
US9732083B2 (en) 2017-08-15

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