JP6100786B2 - 抗ウイルス活性を有する新規ベツリン酸誘導体 - Google Patents

抗ウイルス活性を有する新規ベツリン酸誘導体 Download PDF

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Publication number
JP6100786B2
JP6100786B2 JP2014531936A JP2014531936A JP6100786B2 JP 6100786 B2 JP6100786 B2 JP 6100786B2 JP 2014531936 A JP2014531936 A JP 2014531936A JP 2014531936 A JP2014531936 A JP 2014531936A JP 6100786 B2 JP6100786 B2 JP 6100786B2
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Japan
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group
hiv
acid
alkyl
compounds
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Japanese (ja)
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JP2014526554A5 (enExample
JP2014526554A (ja
Inventor
チェン・リウ
ニコラス・エイ・ミーンウェル
アリシア・レゲイロ−レン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014531936A 2011-09-21 2012-09-20 抗ウイルス活性を有する新規ベツリン酸誘導体 Expired - Fee Related JP6100786B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161537099P 2011-09-21 2011-09-21
US61/537,099 2011-09-21
PCT/US2012/056186 WO2013043778A1 (en) 2011-09-21 2012-09-20 Novel betulinic acid derivatives with antiviral activity

Publications (3)

Publication Number Publication Date
JP2014526554A JP2014526554A (ja) 2014-10-06
JP2014526554A5 JP2014526554A5 (enExample) 2015-11-05
JP6100786B2 true JP6100786B2 (ja) 2017-03-22

Family

ID=46964090

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014531936A Expired - Fee Related JP6100786B2 (ja) 2011-09-21 2012-09-20 抗ウイルス活性を有する新規ベツリン酸誘導体

Country Status (15)

Country Link
US (1) US8754069B2 (enExample)
EP (1) EP2758419B8 (enExample)
JP (1) JP6100786B2 (enExample)
KR (1) KR20140069167A (enExample)
CN (1) CN103814042B (enExample)
AU (1) AU2012312485B2 (enExample)
BR (1) BR112014006559A2 (enExample)
CA (1) CA2849475A1 (enExample)
EA (1) EA023463B1 (enExample)
ES (1) ES2611727T3 (enExample)
IL (1) IL231421A (enExample)
MX (1) MX2014002936A (enExample)
SG (1) SG11201400331WA (enExample)
TW (1) TW201317255A (enExample)
WO (1) WO2013043778A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
KR20170135970A (ko) * 2015-04-14 2017-12-08 비브 헬스케어 유케이 (넘버4) 리미티드 Hiv 성숙화 억제제를 생산하는 방법
KR20180028534A (ko) 2015-07-28 2018-03-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체
RU2018105352A (ru) 2015-07-28 2019-08-29 ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед Производные бетулина для предупреждения или лечения ВИЧ-инфекций
CN108368071A (zh) 2015-09-24 2018-08-03 葛兰素史克知识产权第二有限公司 具有hiv成熟抑制活性的化合物
CN108699103A (zh) 2016-01-20 2018-10-23 葛兰素史克知识产权第二有限公司 具有hiv成熟抑制活性的羽扇烷类的胺衍生物
EP3478661A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Aza-substituted inhibitors of human immunodeficiency virus replication
WO2019207460A1 (en) 2018-04-24 2019-10-31 VIIV Healthcare UK (No.5) Limited Compounds with hiv maturation inhibitory activity
NZ769842A (en) * 2018-06-29 2023-01-27 Dfh Therapeutics Triterpene amine derivatives
MX2021009584A (es) * 2019-02-11 2021-09-23 Hetero Labs Ltd Nuevos derivados de triterpeno como inhibidores del virus de la inmunodeficiencia humana (vih).
CN115380040A (zh) * 2020-02-11 2022-11-22 熙德隆制药有限公司 作为hiv抑制剂的新型三萜衍生物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5962527A (en) 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7365221B2 (en) 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
JP2007529544A (ja) 2004-03-17 2007-10-25 パナコス ファーマシューティカルズ， インコーポレイテッド ３−ｏ−（３’，３’−ジメチルスクシニル）ベツリン酸の製薬的な塩
TW200628161A (en) * 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
WO2008127364A2 (en) 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
US20110144069A1 (en) 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
CA2714049A1 (en) * 2008-02-14 2009-08-20 Virochem Pharma Inc. Novel 17.beta. lupane derivatives
US9067966B2 (en) * 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
ES2612452T3 (es) 2010-06-04 2017-05-17 VIIV Healthcare UK (No.5) Limited Derivados de ácido betulínico C-3 modificados como inhibidores de la maduración del VIH
EP2576586B1 (en) 2010-06-04 2015-08-12 Bristol-Myers Squibb Company C-28 amides of modified c-3 betulinic acid derivatives as hiv maturation inhibitors
ES2653847T3 (es) 2011-01-31 2018-02-09 Viiv Healthcare Uk (No. 4) Limited Triterpenoides C-17 y C-3 modificados con actividad inhibitoria contra maduración del VIH
CN103339141B (zh) 2011-01-31 2016-08-24 百时美施贵宝公司 作为hiv成熟抑制剂的c-3修饰的桦木酸衍生物的c-28胺

Also Published As

Publication number Publication date
SG11201400331WA (en) 2014-08-28
IL231421A (en) 2015-11-30
KR20140069167A (ko) 2014-06-09
CA2849475A1 (en) 2013-03-28
JP2014526554A (ja) 2014-10-06
US8754069B2 (en) 2014-06-17
AU2012312485B2 (en) 2016-09-01
US20130072465A1 (en) 2013-03-21
EA201490643A1 (ru) 2014-06-30
EP2758419B8 (en) 2017-04-19
EP2758419A1 (en) 2014-07-30
MX2014002936A (es) 2014-04-25
AU2012312485A1 (en) 2014-05-08
BR112014006559A2 (pt) 2017-03-28
WO2013043778A1 (en) 2013-03-28
CN103814042A (zh) 2014-05-21
EA023463B1 (ru) 2016-06-30
IL231421A0 (en) 2014-04-30
CN103814042B (zh) 2015-08-19
EP2758419B1 (en) 2016-10-19
ES2611727T3 (es) 2017-05-10
TW201317255A (zh) 2013-05-01

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