IL231421A - Lupane and its similar compounds are preserved in position 3ß by carboxy-alkyl-carbonyl-oxy and position 17- by (alkyl-conserved) amino, and also anti-HIV drug preparations containing them - Google Patents
Lupane and its similar compounds are preserved in position 3ß by carboxy-alkyl-carbonyl-oxy and position 17- by (alkyl-conserved) amino, and also anti-HIV drug preparations containing themInfo
- Publication number
- IL231421A IL231421A IL231421A IL23142114A IL231421A IL 231421 A IL231421 A IL 231421A IL 231421 A IL231421 A IL 231421A IL 23142114 A IL23142114 A IL 23142114A IL 231421 A IL231421 A IL 231421A
- Authority
- IL
- Israel
- Prior art keywords
- substituted
- carboxyalkylcarbonyloxy
- lupane
- amino
- well
- Prior art date
Links
- 230000036436 anti-hiv Effects 0.000 title 1
- NKMDIWKRKQFYPH-VIUFNMEASA-N lupane Chemical compound C1CCC(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C(C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C NKMDIWKRKQFYPH-VIUFNMEASA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title 1
- 125000000547 substituted alkyl group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161537099P | 2011-09-21 | 2011-09-21 | |
| PCT/US2012/056186 WO2013043778A1 (en) | 2011-09-21 | 2012-09-20 | Novel betulinic acid derivatives with antiviral activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL231421A0 IL231421A0 (en) | 2014-04-30 |
| IL231421A true IL231421A (en) | 2015-11-30 |
Family
ID=46964090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL231421A IL231421A (en) | 2011-09-21 | 2014-03-09 | Lupane and its similar compounds are preserved in position 3ß by carboxy-alkyl-carbonyl-oxy and position 17- by (alkyl-conserved) amino, and also anti-HIV drug preparations containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8754069B2 (enExample) |
| EP (1) | EP2758419B8 (enExample) |
| JP (1) | JP6100786B2 (enExample) |
| KR (1) | KR20140069167A (enExample) |
| CN (1) | CN103814042B (enExample) |
| AU (1) | AU2012312485B2 (enExample) |
| BR (1) | BR112014006559A2 (enExample) |
| CA (1) | CA2849475A1 (enExample) |
| EA (1) | EA023463B1 (enExample) |
| ES (1) | ES2611727T3 (enExample) |
| IL (1) | IL231421A (enExample) |
| MX (1) | MX2014002936A (enExample) |
| SG (1) | SG11201400331WA (enExample) |
| TW (1) | TW201317255A (enExample) |
| WO (1) | WO2013043778A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8906889B2 (en) | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
| US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
| JP2018512433A (ja) * | 2015-04-14 | 2018-05-17 | ヴィーブ ヘルスケア ユーケー（ナンバー４）リミテッド | Ｈｉｖ成熟阻害剤の製造方法 |
| RU2018105352A (ru) | 2015-07-28 | 2019-08-29 | ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед | Производные бетулина для предупреждения или лечения ВИЧ-инфекций |
| KR20180028534A (ko) | 2015-07-28 | 2018-03-16 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체 |
| RU2018112958A (ru) | 2015-09-24 | 2019-10-28 | ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед | Соединения с ингибирующей созревание ВИЧ активностью |
| CN108699103A (zh) | 2016-01-20 | 2018-10-23 | 葛兰素史克知识产权第二有限公司 | 具有hiv成熟抑制活性的羽扇烷类的胺衍生物 |
| WO2018002847A1 (en) * | 2016-06-30 | 2018-01-04 | VIIV Healthcare UK (No.5) Limited | Aza-substituted inhibitors of human immunodeficiency virus replication |
| JP7436385B2 (ja) | 2018-04-24 | 2024-02-21 | ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド | Ｈｉｖ成熟阻害活性を有する化合物 |
| WO2020006510A1 (en) * | 2018-06-29 | 2020-01-02 | Dfh Therapeutics | Triterpene amine derivatives |
| JP7648531B2 (ja) | 2019-02-11 | 2025-03-18 | ヘテロ ラボズ リミテッド | Ｈｉｖ阻害剤としての新規トリテルペン誘導体 |
| WO2021161206A1 (en) * | 2020-02-11 | 2021-08-19 | Hetero Labs Limited | Novel triterpene derivatives as hiv inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| US5869535A (en) | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
| US5962527A (en) | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
| US5679828A (en) | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| US20050014730A1 (en) | 2003-04-02 | 2005-01-20 | Carlson Robert M. | Anti-fungal formulation of triterpene and essential oil |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| EP1730163A4 (en) | 2004-03-17 | 2009-12-30 | Panacos Pharmaceuticals Inc | Pharmaceutical salts of 3-O- (3,3-dimethylsuccinyl) betulinic acid |
| TW200628161A (en) * | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| WO2008127364A2 (en) * | 2006-10-13 | 2008-10-23 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
| WO2008115281A2 (en) | 2006-10-16 | 2008-09-25 | Myriad Genetics, Inc. | Compounds for treating viral infections |
| WO2012106190A1 (en) | 2011-01-31 | 2012-08-09 | Bristol-Myers Squibb Company | C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity |
| JP2011511812A (ja) * | 2008-02-14 | 2011-04-14 | バイロケム ファーマ インコーポレイテッド | 新規１７βルパン誘導体 |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| BR112012030810A2 (pt) | 2010-06-04 | 2019-09-24 | Bristol-Myers Squibb Company | "c-28 amidas de derivados de ácido c-3 betulínico modificados como inibidores de maturação de hiv" |
| CA2801487C (en) | 2010-06-04 | 2017-12-05 | Bristol-Myers Squibb Company | Modified c-3 betulinic acid derivatives as hiv maturation inhibitors |
| HRP20151212T1 (hr) | 2011-01-31 | 2015-12-04 | Bristol-Myers Squibb Company | C-28 AMINI C-3 MODIFICIRANIH DERIVATA BETULINSKE KISELINE KAO INHIBITORI SAZRIJEVANJA HIV-a P |
-
2012
- 2012-09-20 EP EP12766825.9A patent/EP2758419B8/en not_active Not-in-force
- 2012-09-20 WO PCT/US2012/056186 patent/WO2013043778A1/en not_active Ceased
- 2012-09-20 CA CA2849475A patent/CA2849475A1/en not_active Abandoned
- 2012-09-20 AU AU2012312485A patent/AU2012312485B2/en not_active Ceased
- 2012-09-20 KR KR1020147010087A patent/KR20140069167A/ko not_active Ceased
- 2012-09-20 EA EA201490643A patent/EA023463B1/ru not_active IP Right Cessation
- 2012-09-20 JP JP2014531936A patent/JP6100786B2/ja not_active Expired - Fee Related
- 2012-09-20 TW TW101134558A patent/TW201317255A/zh unknown
- 2012-09-20 US US13/623,165 patent/US8754069B2/en not_active Expired - Fee Related
- 2012-09-20 BR BR112014006559A patent/BR112014006559A2/pt not_active IP Right Cessation
- 2012-09-20 ES ES12766825.9T patent/ES2611727T3/es active Active
- 2012-09-20 MX MX2014002936A patent/MX2014002936A/es unknown
- 2012-09-20 CN CN201280046037.7A patent/CN103814042B/zh not_active Expired - Fee Related
- 2012-09-20 SG SG11201400331WA patent/SG11201400331WA/en unknown
-
2014
- 2014-03-09 IL IL231421A patent/IL231421A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN103814042B (zh) | 2015-08-19 |
| US8754069B2 (en) | 2014-06-17 |
| IL231421A0 (en) | 2014-04-30 |
| CN103814042A (zh) | 2014-05-21 |
| BR112014006559A2 (pt) | 2017-03-28 |
| US20130072465A1 (en) | 2013-03-21 |
| MX2014002936A (es) | 2014-04-25 |
| JP6100786B2 (ja) | 2017-03-22 |
| EP2758419A1 (en) | 2014-07-30 |
| EA201490643A1 (ru) | 2014-06-30 |
| KR20140069167A (ko) | 2014-06-09 |
| AU2012312485A1 (en) | 2014-05-08 |
| EP2758419B8 (en) | 2017-04-19 |
| TW201317255A (zh) | 2013-05-01 |
| AU2012312485B2 (en) | 2016-09-01 |
| JP2014526554A (ja) | 2014-10-06 |
| SG11201400331WA (en) | 2014-08-28 |
| EA023463B1 (ru) | 2016-06-30 |
| WO2013043778A1 (en) | 2013-03-28 |
| ES2611727T3 (es) | 2017-05-10 |
| EP2758419B1 (en) | 2016-10-19 |
| CA2849475A1 (en) | 2013-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |