SG11201400331WA - Novel betulinic acid derivatives with antiviral activity - Google Patents

Novel betulinic acid derivatives with antiviral activity

Info

Publication number
SG11201400331WA
SG11201400331WA SG11201400331WA SG11201400331WA SG11201400331WA SG 11201400331W A SG11201400331W A SG 11201400331WA SG 11201400331W A SG11201400331W A SG 11201400331WA SG 11201400331W A SG11201400331W A SG 11201400331WA SG 11201400331W A SG11201400331W A SG 11201400331WA
Authority
SG
Singapore
Prior art keywords
acid derivatives
antiviral activity
betulinic acid
novel betulinic
novel
Prior art date
Application number
SG11201400331WA
Inventor
Zheng Liu
Nicholas A Meanwell
Alicia Regueiro-Ren
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG11201400331WA publication Critical patent/SG11201400331WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J63/00Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008Expansion of ring D by one atom, e.g. D homo steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
SG11201400331WA 2011-09-21 2012-09-20 Novel betulinic acid derivatives with antiviral activity SG11201400331WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161537099P 2011-09-21 2011-09-21
PCT/US2012/056186 WO2013043778A1 (en) 2011-09-21 2012-09-20 Novel betulinic acid derivatives with antiviral activity

Publications (1)

Publication Number Publication Date
SG11201400331WA true SG11201400331WA (en) 2014-08-28

Family

ID=46964090

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201400331WA SG11201400331WA (en) 2011-09-21 2012-09-20 Novel betulinic acid derivatives with antiviral activity

Country Status (15)

Country Link
US (1) US8754069B2 (en)
EP (1) EP2758419B8 (en)
JP (1) JP6100786B2 (en)
KR (1) KR20140069167A (en)
CN (1) CN103814042B (en)
AU (1) AU2012312485B2 (en)
BR (1) BR112014006559A2 (en)
CA (1) CA2849475A1 (en)
EA (1) EA023463B1 (en)
ES (1) ES2611727T3 (en)
IL (1) IL231421A (en)
MX (1) MX2014002936A (en)
SG (1) SG11201400331WA (en)
TW (1) TW201317255A (en)
WO (1) WO2013043778A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
CA2981056A1 (en) * 2015-04-14 2016-10-20 ViiV Healthcare UK (No.4) Limited Methods of producing an hiv maturation inhibitor
US20180194799A1 (en) 2015-07-28 2018-07-12 Glaxosmithkline Intellectual Property (No.2) Limited Betuin derivatives for preventing or treating hiv infections
KR20180028534A (en) 2015-07-28 2018-03-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Betuin derivatives for preventing or treating HIV infection
AU2016327169A1 (en) 2015-09-24 2018-04-12 Glaxosmithkline Intellectual Property (No.2) Limited Compounds with hiv maturation inhibitory activity
US20190023733A1 (en) 2016-01-20 2019-01-24 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
WO2018002847A1 (en) * 2016-06-30 2018-01-04 VIIV Healthcare UK (No.5) Limited Aza-substituted inhibitors of human immunodeficiency virus replication
PT3784349T (en) 2018-04-24 2024-01-22 Viiv Healthcare Uk No 5 Ltd Compounds with hiv maturation inhibitory activity
NZ769842A (en) * 2018-06-29 2023-01-27 Dfh Therapeutics Triterpene amine derivatives
MX2021009584A (en) * 2019-02-11 2021-09-23 Hetero Labs Ltd Novel triterpene derivatives as hiv inhibitors.
US20230174570A1 (en) * 2020-02-11 2023-06-08 Hetero Labs Limited Novel triterpene derivatives as hiv inhibitors

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5413999A (en) 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
US5962527A (en) 1995-03-21 1999-10-05 The Board Of Trustees Of The University Of Illinois Method and composition for treating cancers
US5679828A (en) 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US20040110785A1 (en) 2001-02-02 2004-06-10 Tao Wang Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
US7365221B2 (en) 2002-09-26 2008-04-29 Panacos Pharmaceuticals, Inc. Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
WO2004089357A2 (en) 2003-04-02 2004-10-21 Regents Of The University Of Minnesota Anti-fungal formulation of triterpene and essential oil
US7745625B2 (en) 2004-03-15 2010-06-29 Bristol-Myers Squibb Company Prodrugs of piperazine and substituted piperidine antiviral agents
EP1730163A4 (en) 2004-03-17 2009-12-30 Panacos Pharmaceuticals Inc Pharmaceuticals salts of 3-o-(3,3-dimethylsuccinyl) betulinic acid
TW200628161A (en) 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof
WO2008127364A2 (en) * 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
US20110144069A1 (en) 2006-10-16 2011-06-16 Myriad Genetics, Incorporated Compounds for treating viral infections
EP2257567A1 (en) * 2008-02-14 2010-12-08 Virochem Pharma Inc. Novel 17 beta lupane derivatives
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
CN103038245B (en) 2010-06-04 2015-03-25 百时美施贵宝公司 Modified c-3 betulinic acid derivatives as HIV maturation inhibitors
DK2576586T3 (en) 2010-06-04 2015-11-23 Bristol Myers Squibb Co C-28 AMINES OF MODIFIED C-3-BETULIN ACID DERIVATIVES AS ANTI-HUMIDITY INHIBITORS
HUE026371T2 (en) 2011-01-31 2016-05-30 Bristol Myers Squibb Co C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors
PT2670765T (en) 2011-01-31 2018-01-08 Viiv Healthcare Uk No 4 Ltd C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity

Also Published As

Publication number Publication date
US20130072465A1 (en) 2013-03-21
IL231421A (en) 2015-11-30
AU2012312485A1 (en) 2014-05-08
EP2758419A1 (en) 2014-07-30
MX2014002936A (en) 2014-04-25
EP2758419B1 (en) 2016-10-19
CN103814042A (en) 2014-05-21
US8754069B2 (en) 2014-06-17
ES2611727T3 (en) 2017-05-10
JP2014526554A (en) 2014-10-06
TW201317255A (en) 2013-05-01
CA2849475A1 (en) 2013-03-28
KR20140069167A (en) 2014-06-09
CN103814042B (en) 2015-08-19
AU2012312485B2 (en) 2016-09-01
EA201490643A1 (en) 2014-06-30
EA023463B1 (en) 2016-06-30
WO2013043778A1 (en) 2013-03-28
JP6100786B2 (en) 2017-03-22
BR112014006559A2 (en) 2017-03-28
EP2758419B8 (en) 2017-04-19
IL231421A0 (en) 2014-04-30

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