SG11201400331WA - Novel betulinic acid derivatives with antiviral activity - Google Patents
Novel betulinic acid derivatives with antiviral activityInfo
- Publication number
- SG11201400331WA SG11201400331WA SG11201400331WA SG11201400331WA SG11201400331WA SG 11201400331W A SG11201400331W A SG 11201400331WA SG 11201400331W A SG11201400331W A SG 11201400331WA SG 11201400331W A SG11201400331W A SG 11201400331WA SG 11201400331W A SG11201400331W A SG 11201400331WA
- Authority
- SG
- Singapore
- Prior art keywords
- acid derivatives
- antiviral activity
- betulinic acid
- novel betulinic
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161537099P | 2011-09-21 | 2011-09-21 | |
PCT/US2012/056186 WO2013043778A1 (en) | 2011-09-21 | 2012-09-20 | Novel betulinic acid derivatives with antiviral activity |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201400331WA true SG11201400331WA (en) | 2014-08-28 |
Family
ID=46964090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201400331WA SG11201400331WA (en) | 2011-09-21 | 2012-09-20 | Novel betulinic acid derivatives with antiviral activity |
Country Status (15)
Country | Link |
---|---|
US (1) | US8754069B2 (en) |
EP (1) | EP2758419B8 (en) |
JP (1) | JP6100786B2 (en) |
KR (1) | KR20140069167A (en) |
CN (1) | CN103814042B (en) |
AU (1) | AU2012312485B2 (en) |
BR (1) | BR112014006559A2 (en) |
CA (1) | CA2849475A1 (en) |
EA (1) | EA023463B1 (en) |
ES (1) | ES2611727T3 (en) |
IL (1) | IL231421A (en) |
MX (1) | MX2014002936A (en) |
SG (1) | SG11201400331WA (en) |
TW (1) | TW201317255A (en) |
WO (1) | WO2013043778A1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
CA2981056A1 (en) * | 2015-04-14 | 2016-10-20 | ViiV Healthcare UK (No.4) Limited | Methods of producing an hiv maturation inhibitor |
US20180194799A1 (en) | 2015-07-28 | 2018-07-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Betuin derivatives for preventing or treating hiv infections |
KR20180028534A (en) | 2015-07-28 | 2018-03-16 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | Betuin derivatives for preventing or treating HIV infection |
AU2016327169A1 (en) | 2015-09-24 | 2018-04-12 | Glaxosmithkline Intellectual Property (No.2) Limited | Compounds with hiv maturation inhibitory activity |
US20190023733A1 (en) | 2016-01-20 | 2019-01-24 | Glaxosmithkline Intellectual Property (No.2) Limited | Amine derivatives of lupanes with hiv maturation inhibitory activity |
WO2018002847A1 (en) * | 2016-06-30 | 2018-01-04 | VIIV Healthcare UK (No.5) Limited | Aza-substituted inhibitors of human immunodeficiency virus replication |
PT3784349T (en) | 2018-04-24 | 2024-01-22 | Viiv Healthcare Uk No 5 Ltd | Compounds with hiv maturation inhibitory activity |
NZ769842A (en) * | 2018-06-29 | 2023-01-27 | Dfh Therapeutics | Triterpene amine derivatives |
MX2021009584A (en) * | 2019-02-11 | 2021-09-23 | Hetero Labs Ltd | Novel triterpene derivatives as hiv inhibitors. |
US20230174570A1 (en) * | 2020-02-11 | 2023-06-08 | Hetero Labs Limited | Novel triterpene derivatives as hiv inhibitors |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
US5869535A (en) | 1995-03-21 | 1999-02-09 | The Board Of Trustees Of The University Of Illinois | Method and composition for selectively inhibiting melanoma |
US5962527A (en) | 1995-03-21 | 1999-10-05 | The Board Of Trustees Of The University Of Illinois | Method and composition for treating cancers |
US5679828A (en) | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
WO2004089357A2 (en) | 2003-04-02 | 2004-10-21 | Regents Of The University Of Minnesota | Anti-fungal formulation of triterpene and essential oil |
US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
EP1730163A4 (en) | 2004-03-17 | 2009-12-30 | Panacos Pharmaceuticals Inc | Pharmaceuticals salts of 3-o-(3,3-dimethylsuccinyl) betulinic acid |
TW200628161A (en) | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
WO2008127364A2 (en) * | 2006-10-13 | 2008-10-23 | Myriad Genetics, Inc. | Antiviral compounds and use thereof |
US20110144069A1 (en) | 2006-10-16 | 2011-06-16 | Myriad Genetics, Incorporated | Compounds for treating viral infections |
EP2257567A1 (en) * | 2008-02-14 | 2010-12-08 | Virochem Pharma Inc. | Novel 17 beta lupane derivatives |
US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
CN103038245B (en) | 2010-06-04 | 2015-03-25 | 百时美施贵宝公司 | Modified c-3 betulinic acid derivatives as HIV maturation inhibitors |
DK2576586T3 (en) | 2010-06-04 | 2015-11-23 | Bristol Myers Squibb Co | C-28 AMINES OF MODIFIED C-3-BETULIN ACID DERIVATIVES AS ANTI-HUMIDITY INHIBITORS |
HUE026371T2 (en) | 2011-01-31 | 2016-05-30 | Bristol Myers Squibb Co | C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors |
PT2670765T (en) | 2011-01-31 | 2018-01-08 | Viiv Healthcare Uk No 4 Ltd | C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity |
-
2012
- 2012-09-20 JP JP2014531936A patent/JP6100786B2/en not_active Expired - Fee Related
- 2012-09-20 WO PCT/US2012/056186 patent/WO2013043778A1/en active Application Filing
- 2012-09-20 TW TW101134558A patent/TW201317255A/en unknown
- 2012-09-20 CN CN201280046037.7A patent/CN103814042B/en not_active Expired - Fee Related
- 2012-09-20 MX MX2014002936A patent/MX2014002936A/en unknown
- 2012-09-20 CA CA2849475A patent/CA2849475A1/en not_active Abandoned
- 2012-09-20 EP EP12766825.9A patent/EP2758419B8/en not_active Not-in-force
- 2012-09-20 BR BR112014006559A patent/BR112014006559A2/en not_active IP Right Cessation
- 2012-09-20 ES ES12766825.9T patent/ES2611727T3/en active Active
- 2012-09-20 KR KR1020147010087A patent/KR20140069167A/en not_active Application Discontinuation
- 2012-09-20 US US13/623,165 patent/US8754069B2/en not_active Expired - Fee Related
- 2012-09-20 EA EA201490643A patent/EA023463B1/en not_active IP Right Cessation
- 2012-09-20 AU AU2012312485A patent/AU2012312485B2/en not_active Ceased
- 2012-09-20 SG SG11201400331WA patent/SG11201400331WA/en unknown
-
2014
- 2014-03-09 IL IL231421A patent/IL231421A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20130072465A1 (en) | 2013-03-21 |
IL231421A (en) | 2015-11-30 |
AU2012312485A1 (en) | 2014-05-08 |
EP2758419A1 (en) | 2014-07-30 |
MX2014002936A (en) | 2014-04-25 |
EP2758419B1 (en) | 2016-10-19 |
CN103814042A (en) | 2014-05-21 |
US8754069B2 (en) | 2014-06-17 |
ES2611727T3 (en) | 2017-05-10 |
JP2014526554A (en) | 2014-10-06 |
TW201317255A (en) | 2013-05-01 |
CA2849475A1 (en) | 2013-03-28 |
KR20140069167A (en) | 2014-06-09 |
CN103814042B (en) | 2015-08-19 |
AU2012312485B2 (en) | 2016-09-01 |
EA201490643A1 (en) | 2014-06-30 |
EA023463B1 (en) | 2016-06-30 |
WO2013043778A1 (en) | 2013-03-28 |
JP6100786B2 (en) | 2017-03-22 |
BR112014006559A2 (en) | 2017-03-28 |
EP2758419B8 (en) | 2017-04-19 |
IL231421A0 (en) | 2014-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL252345A0 (en) | Antiviral compounds | |
IL231421A0 (en) | Novel betulinic acid derivatives with antiviral activity | |
EP2715539A4 (en) | Distributed computing framework | |
IL250370A0 (en) | 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | |
IL249825A0 (en) | Substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals | |
HK1199454A1 (en) | Antiviral compounds | |
EP2664621A4 (en) | Antiviral agent | |
EP2699241A4 (en) | Antiviral compounds | |
EP2691106A4 (en) | Antiviral composition | |
HK1193407A1 (en) | Pyrrolidine-3-ylacetic acid derivative -3- | |
EP2782902A4 (en) | Derivatives of phenoxyisobutyric acid | |
ZA201306909B (en) | Antiviral composition | |
EP2799424A4 (en) | 2-fluorophenylpropionic acid derivative | |
GB201121309D0 (en) | Antiviral | |
ZA201402374B (en) | Antiviral compounds | |
GB201121968D0 (en) | Antiviral drug derivatives | |
GB201121966D0 (en) | Antiviral drug derivatives | |
PL394696A1 (en) | Antiviral drug derivative |