JP6087147B2 - プロスタグランジンの精製方法 - Google Patents

プロスタグランジンの精製方法 Download PDF

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Publication number
JP6087147B2
JP6087147B2 JP2012517644A JP2012517644A JP6087147B2 JP 6087147 B2 JP6087147 B2 JP 6087147B2 JP 2012517644 A JP2012517644 A JP 2012517644A JP 2012517644 A JP2012517644 A JP 2012517644A JP 6087147 B2 JP6087147 B2 JP 6087147B2
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Prior art keywords
alkyl
prostaglandin
latanoprost
group
column
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Expired - Fee Related
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JP2012517644A
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Japanese (ja)
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JP2012530783A (ja
Inventor
ロバート、アール．ホーガン
ロナルド、ロッシ
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Johnson Matthey PLC
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Johnson Matthey PLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
JP2012517644A 2009-06-22 2010-06-22 プロスタグランジンの精製方法 Expired - Fee Related JP6087147B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21916609P 2009-06-22 2009-06-22
US61/219,166 2009-06-22
PCT/US2010/039457 WO2011005505A2 (en) 2009-06-22 2010-06-22 Method for the purification of prostaglandins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016223583A Division JP6633497B2 (ja) 2009-06-22 2016-11-16 プロスタグランジンの精製方法

Publications (2)

Publication Number Publication Date
JP2012530783A JP2012530783A (ja) 2012-12-06
JP6087147B2 true JP6087147B2 (ja) 2017-03-01

Family

ID=43126874

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2012517644A Expired - Fee Related JP6087147B2 (ja) 2009-06-22 2010-06-22 プロスタグランジンの精製方法
JP2016223583A Expired - Fee Related JP6633497B2 (ja) 2009-06-22 2016-11-16 プロスタグランジンの精製方法
JP2018006190A Pending JP2018104435A (ja) 2009-06-22 2018-01-18 プロスタグランジンの精製方法
JP2019235482A Pending JP2020090500A (ja) 2009-06-22 2019-12-26 プロスタグランジンの精製方法

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Application Number Title Priority Date Filing Date
JP2016223583A Expired - Fee Related JP6633497B2 (ja) 2009-06-22 2016-11-16 プロスタグランジンの精製方法
JP2018006190A Pending JP2018104435A (ja) 2009-06-22 2018-01-18 プロスタグランジンの精製方法
JP2019235482A Pending JP2020090500A (ja) 2009-06-22 2019-12-26 プロスタグランジンの精製方法

Country Status (3)

Country Link
US (3) US8519178B2 (https=)
JP (4) JP6087147B2 (https=)
WO (1) WO2011005505A2 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6087147B2 (ja) * 2009-06-22 2017-03-01 ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ プロスタグランジンの精製方法
US9238621B2 (en) * 2011-06-02 2016-01-19 Chinoin Zrt Processes for the preparation of prostaglandin amides
EP3712142B1 (en) 2013-01-11 2022-07-06 Corsair Pharma, Inc. Prodrugs of treprostinil
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9115109B2 (en) 2013-08-15 2015-08-25 Chirogate International Inc. Processes and intermediates for the preparations of isomer free prostaglandins
LT3060041T (lt) 2013-10-25 2021-03-25 Insmed Incorporated Prostaciklino junginiai
EP3063260B1 (en) * 2013-10-28 2019-01-09 Totally Natural Solutions Ltd Fractionation of hop oils using liquid and supercritical carbon dioxide
HU231214B1 (hu) 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
JP6866043B2 (ja) 2014-11-18 2021-04-28 インスメッド インコーポレイテッド トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法
JP6786761B2 (ja) * 2015-05-26 2020-11-18 ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． Ｓｆｃによるキラル異性体の分離
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
CN106467465A (zh) * 2015-08-17 2017-03-01 上海天伟生物制药有限公司 一种高纯度拉坦前列素及其制备方法和用途
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
CN106902543B (zh) * 2017-03-17 2019-04-23 万华化学集团股份有限公司 超临界二氧化碳萃取分离醇盐混合物的方法
HU231185B1 (hu) 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás Misoprostol előállítására és tisztítására
CN111351869B (zh) * 2018-12-24 2022-07-05 南京正大天晴制药有限公司 一种测定鲁比前列酮供试品有关物质的分析方法
JP7455144B2 (ja) 2019-04-29 2024-03-25 インスメッド インコーポレイテッド トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法
CA3166738A1 (en) 2020-02-06 2021-08-12 Charles D. Blizzard Travoprost compositions and methods for treating ocular diseases
WO2021222117A1 (en) 2020-04-27 2021-11-04 Ocular Therapeutix, Inc. Methods of treating allergic conjunctivitis
CN116583500B (zh) * 2020-12-23 2025-11-18 协和医药化工股份有限公司 几何异构体的分离方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04112866A (ja) * 1990-09-03 1992-04-14 Lion Corp プロスタグランジンの精製法
DE59610489D1 (de) * 1995-08-17 2003-07-10 Hoffmann La Roche Chromatographie-Verfahren
EP0969001A3 (de) 1998-06-23 2005-09-14 DSM IP Assets B.V. Verfahren zur Herstellung von Vitamin D3 oder Prävitamin D3
US7166730B2 (en) * 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
IL134241A (en) * 2000-01-27 2006-06-11 Finetech Pharmaceutical Ltd Process for the preparation of latanoprost
GB0112699D0 (en) 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
GB0329635D0 (en) 2003-12-23 2004-01-28 Johnson Matthey Plc Process for purifying trans-tetrahydrocannabinol
AU2006257646A1 (en) * 2005-06-16 2006-12-21 Pfizer Inc. N-(pyridin-2-YL)-sulfonamide derivatives
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
JP6087147B2 (ja) * 2009-06-22 2017-03-01 ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ プロスタグランジンの精製方法
JP6564740B2 (ja) * 2016-07-04 2019-08-21 信越化学工業株式会社 負極活物質、負極、リチウムイオン二次電池、リチウムイオン二次電池の使用方法、負極活物質の製造方法及びリチウムイオン二次電池の製造方法

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Publication number Publication date
JP2020090500A (ja) 2020-06-11
JP2012530783A (ja) 2012-12-06
US9353055B2 (en) 2016-05-31
US20100324313A1 (en) 2010-12-23
JP2017061523A (ja) 2017-03-30
WO2011005505A3 (en) 2011-07-14
US8957240B2 (en) 2015-02-17
US20150126764A1 (en) 2015-05-07
US8519178B2 (en) 2013-08-27
WO2011005505A2 (en) 2011-01-13
JP2018104435A (ja) 2018-07-05
JP6633497B2 (ja) 2020-01-22
US20130317249A1 (en) 2013-11-28

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