JP2017061523A5 - - Google Patents
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- Publication number
- JP2017061523A5 JP2017061523A5 JP2016223583A JP2016223583A JP2017061523A5 JP 2017061523 A5 JP2017061523 A5 JP 2017061523A5 JP 2016223583 A JP2016223583 A JP 2016223583A JP 2016223583 A JP2016223583 A JP 2016223583A JP 2017061523 A5 JP2017061523 A5 JP 2017061523A5
- Authority
- JP
- Japan
- Prior art keywords
- purification method
- stationary phase
- alkyl
- group
- prostaglandin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(CCC*)C=CCC(C(*C(C(*)(*)CC*)=*)C(C)(*)C1)C1(*)I Chemical compound CC(CCC*)C=CCC(C(*C(C(*)(*)CC*)=*)C(C)(*)C1)C1(*)I 0.000 description 9
- FQAZZZLOHWFVAY-BPMJKKHOSA-N CC([C@@H](/C=C/[C@H]([C@@H]1[C@H](C2)OC(CCCCC(O)=O)C1)[C@@H]2O)O)C=C Chemical compound CC([C@@H](/C=C/[C@H]([C@@H]1[C@H](C2)OC(CCCCC(O)=O)C1)[C@@H]2O)O)C=C FQAZZZLOHWFVAY-BPMJKKHOSA-N 0.000 description 1
- ZQHQVOVYNUJIEO-FPGKPGRWSA-N CC1C=CC(OC[C@@H](CS[C@H]([C@@H](C/C=C\CCCC(O)=O)[C@H](C2)O)[C@@H]2O)O)=CC1Cl Chemical compound CC1C=CC(OC[C@@H](CS[C@H]([C@@H](C/C=C\CCCC(O)=O)[C@H](C2)O)[C@@H]2O)O)=CC1Cl ZQHQVOVYNUJIEO-FPGKPGRWSA-N 0.000 description 1
- BTBZHGONRBKZOT-NNXOMEEOSA-N CCCC/C=C(/C=C/[C@H]([C@@H](C/C=C\CCCC(O)O)[C@H](C1)O)[C@@H]1O)\O Chemical compound CCCC/C=C(/C=C/[C@H]([C@@H](C/C=C\CCCC(O)O)[C@H](C1)O)[C@@H]1O)\O BTBZHGONRBKZOT-NNXOMEEOSA-N 0.000 description 1
- DBVFKLAGQHYVGQ-BFYDXBDKSA-N CCCCC(C(CC[C@H]([C@@H](CCCCCCC(O)=O)C(C1)=O)[C@@H]1O)=O)(F)F Chemical compound CCCCC(C(CC[C@H]([C@@H](CCCCCCC(O)=O)C(C1)=O)[C@@H]1O)=O)(F)F DBVFKLAGQHYVGQ-BFYDXBDKSA-N 0.000 description 1
- KWHKHPVLVAXNPX-NIZQAJIFSA-N CCCCC[C@@H](CC(C)(C1)C1([C@@H](CCCCCCC(O)=O)C(C1)=O)[C@@H]1O)O Chemical compound CCCCC[C@@H](CC(C)(C1)C1([C@@H](CCCCCCC(O)=O)C(C1)=O)[C@@H]1O)O KWHKHPVLVAXNPX-NIZQAJIFSA-N 0.000 description 1
- BRDDWYHEBLQFFN-HSOILSAZSA-N C[C@H](CCC1C=CCCC1C)O Chemical compound C[C@H](CCC1C=CCCC1C)O BRDDWYHEBLQFFN-HSOILSAZSA-N 0.000 description 1
- KFUDFIMHDRJVLV-MSKGSUGCSA-N O[C@@H](COc1cc(Cl)ccc1)CS[C@H]([C@@H](C/C=C\CCCC(O)=O)[C@H](C1)O)[C@@H]1O Chemical compound O[C@@H](COc1cc(Cl)ccc1)CS[C@H]([C@@H](C/C=C\CCCC(O)=O)[C@H](C1)O)[C@@H]1O KFUDFIMHDRJVLV-MSKGSUGCSA-N 0.000 description 1
- PSEYFXDAFMEEQR-WLVFYWOSSA-N O[C@@H](C[C@H]1O)[C@H](CC#CCCCC=O)[C@H]1/C=C/CCOc1cccc(C(F)(F)F)c1 Chemical compound O[C@@H](C[C@H]1O)[C@H](CC#CCCCC=O)[C@H]1/C=C/CCOc1cccc(C(F)(F)F)c1 PSEYFXDAFMEEQR-WLVFYWOSSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21916609P | 2009-06-22 | 2009-06-22 | |
| US61/219,166 | 2009-06-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517644A Division JP6087147B2 (ja) | 2009-06-22 | 2010-06-22 | プロスタグランジンの精製方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018006190A Division JP2018104435A (ja) | 2009-06-22 | 2018-01-18 | プロスタグランジンの精製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017061523A JP2017061523A (ja) | 2017-03-30 |
| JP2017061523A5 true JP2017061523A5 (https=) | 2018-03-15 |
| JP6633497B2 JP6633497B2 (ja) | 2020-01-22 |
Family
ID=43126874
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517644A Expired - Fee Related JP6087147B2 (ja) | 2009-06-22 | 2010-06-22 | プロスタグランジンの精製方法 |
| JP2016223583A Expired - Fee Related JP6633497B2 (ja) | 2009-06-22 | 2016-11-16 | プロスタグランジンの精製方法 |
| JP2018006190A Pending JP2018104435A (ja) | 2009-06-22 | 2018-01-18 | プロスタグランジンの精製方法 |
| JP2019235482A Pending JP2020090500A (ja) | 2009-06-22 | 2019-12-26 | プロスタグランジンの精製方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517644A Expired - Fee Related JP6087147B2 (ja) | 2009-06-22 | 2010-06-22 | プロスタグランジンの精製方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018006190A Pending JP2018104435A (ja) | 2009-06-22 | 2018-01-18 | プロスタグランジンの精製方法 |
| JP2019235482A Pending JP2020090500A (ja) | 2009-06-22 | 2019-12-26 | プロスタグランジンの精製方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (3) | US8519178B2 (https=) |
| JP (4) | JP6087147B2 (https=) |
| WO (1) | WO2011005505A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6087147B2 (ja) * | 2009-06-22 | 2017-03-01 | ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ | プロスタグランジンの精製方法 |
| US9238621B2 (en) * | 2011-06-02 | 2016-01-19 | Chinoin Zrt | Processes for the preparation of prostaglandin amides |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| US9115109B2 (en) | 2013-08-15 | 2015-08-25 | Chirogate International Inc. | Processes and intermediates for the preparations of isomer free prostaglandins |
| LT3060041T (lt) | 2013-10-25 | 2021-03-25 | Insmed Incorporated | Prostaciklino junginiai |
| EP3063260B1 (en) * | 2013-10-28 | 2019-01-09 | Totally Natural Solutions Ltd | Fractionation of hop oils using liquid and supercritical carbon dioxide |
| HU231214B1 (hu) | 2014-03-13 | 2021-11-29 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás nagytisztaságú prosztaglandinok előállítására |
| JP6866043B2 (ja) | 2014-11-18 | 2021-04-28 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグおよびトレプロスチニル誘導体プロドラッグの製造方法 |
| JP6786761B2 (ja) * | 2015-05-26 | 2020-11-18 | ディーエスエム アイピー アセッツ ビー．ブイ．Ｄｓｍ Ｉｐ Ａｓｓｅｔｓ Ｂ．Ｖ． | Ｓｆｃによるキラル異性体の分離 |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| CN106467465A (zh) * | 2015-08-17 | 2017-03-01 | 上海天伟生物制药有限公司 | 一种高纯度拉坦前列素及其制备方法和用途 |
| US11458041B2 (en) | 2015-10-08 | 2022-10-04 | Ocular Therapeutix, Inc. | Punctal plug and bioadhesives |
| CN106902543B (zh) * | 2017-03-17 | 2019-04-23 | 万华化学集团股份有限公司 | 超临界二氧化碳萃取分离醇盐混合物的方法 |
| HU231185B1 (hu) | 2017-07-11 | 2021-07-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Eljárás Misoprostol előállítására és tisztítására |
| CN111351869B (zh) * | 2018-12-24 | 2022-07-05 | 南京正大天晴制药有限公司 | 一种测定鲁比前列酮供试品有关物质的分析方法 |
| JP7455144B2 (ja) | 2019-04-29 | 2024-03-25 | インスメッド インコーポレイテッド | トレプロスチニルプロドラッグの乾燥粉末組成物およびその使用方法 |
| CA3166738A1 (en) | 2020-02-06 | 2021-08-12 | Charles D. Blizzard | Travoprost compositions and methods for treating ocular diseases |
| WO2021222117A1 (en) | 2020-04-27 | 2021-11-04 | Ocular Therapeutix, Inc. | Methods of treating allergic conjunctivitis |
| CN116583500B (zh) * | 2020-12-23 | 2025-11-18 | 协和医药化工股份有限公司 | 几何异构体的分离方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04112866A (ja) * | 1990-09-03 | 1992-04-14 | Lion Corp | プロスタグランジンの精製法 |
| DE59610489D1 (de) * | 1995-08-17 | 2003-07-10 | Hoffmann La Roche | Chromatographie-Verfahren |
| EP0969001A3 (de) | 1998-06-23 | 2005-09-14 | DSM IP Assets B.V. | Verfahren zur Herstellung von Vitamin D3 oder Prävitamin D3 |
| US7166730B2 (en) * | 2000-01-27 | 2007-01-23 | Fine Tech Laboratories, Ltd | Process for the preparation of prostaglandin derivatives |
| IL134241A (en) * | 2000-01-27 | 2006-06-11 | Finetech Pharmaceutical Ltd | Process for the preparation of latanoprost |
| GB0112699D0 (en) | 2001-05-24 | 2001-07-18 | Resolution Chemicals Ltd | Process for the preparation of prostglandins and analogues thereof |
| GB0329635D0 (en) | 2003-12-23 | 2004-01-28 | Johnson Matthey Plc | Process for purifying trans-tetrahydrocannabinol |
| AU2006257646A1 (en) * | 2005-06-16 | 2006-12-21 | Pfizer Inc. | N-(pyridin-2-YL)-sulfonamide derivatives |
| AR076731A1 (es) * | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
| JP6087147B2 (ja) * | 2009-06-22 | 2017-03-01 | ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ | プロスタグランジンの精製方法 |
| JP6564740B2 (ja) * | 2016-07-04 | 2019-08-21 | 信越化学工業株式会社 | 負極活物質、負極、リチウムイオン二次電池、リチウムイオン二次電池の使用方法、負極活物質の製造方法及びリチウムイオン二次電池の製造方法 |
-
2010
- 2010-06-22 JP JP2012517644A patent/JP6087147B2/ja not_active Expired - Fee Related
- 2010-06-22 US US12/820,610 patent/US8519178B2/en not_active Expired - Fee Related
- 2010-06-22 WO PCT/US2010/039457 patent/WO2011005505A2/en not_active Ceased
-
2013
- 2013-07-29 US US13/953,236 patent/US8957240B2/en active Active
-
2015
- 2015-01-12 US US14/594,668 patent/US9353055B2/en active Active
-
2016
- 2016-11-16 JP JP2016223583A patent/JP6633497B2/ja not_active Expired - Fee Related
-
2018
- 2018-01-18 JP JP2018006190A patent/JP2018104435A/ja active Pending
-
2019
- 2019-12-26 JP JP2019235482A patent/JP2020090500A/ja active Pending
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