JP6076742B2 - 高繰返周波数の超高速パルスレーザ溶発による、有機化合物のナノ粒子の液中生成方法 - Google Patents
高繰返周波数の超高速パルスレーザ溶発による、有機化合物のナノ粒子の液中生成方法 Download PDFInfo
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- JP6076742B2 JP6076742B2 JP2012552906A JP2012552906A JP6076742B2 JP 6076742 B2 JP6076742 B2 JP 6076742B2 JP 2012552906 A JP2012552906 A JP 2012552906A JP 2012552906 A JP2012552906 A JP 2012552906A JP 6076742 B2 JP6076742 B2 JP 6076742B2
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- A61K9/00—Medicinal preparations characterised by special physical form
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/0086—Preparation of sols by physical processes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/02—Positioning or observing the workpiece, e.g. with respect to the point of impact; Aligning, aiming or focusing the laser beam
- B23K26/06—Shaping the laser beam, e.g. by masks or multi-focusing
- B23K26/062—Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam
- B23K26/0622—Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses
- B23K26/0624—Shaping the laser beam, e.g. by masks or multi-focusing by direct control of the laser beam by shaping pulses using ultrashort pulses, i.e. pulses of 1ns or less
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/14—Working by laser beam, e.g. welding, cutting or boring using a fluid stream, e.g. a jet of gas, in conjunction with the laser beam; Nozzles therefor
- B23K26/144—Working by laser beam, e.g. welding, cutting or boring using a fluid stream, e.g. a jet of gas, in conjunction with the laser beam; Nozzles therefor the fluid stream containing particles, e.g. powder
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/14—Working by laser beam, e.g. welding, cutting or boring using a fluid stream, e.g. a jet of gas, in conjunction with the laser beam; Nozzles therefor
- B23K26/146—Working by laser beam, e.g. welding, cutting or boring using a fluid stream, e.g. a jet of gas, in conjunction with the laser beam; Nozzles therefor the fluid stream containing a liquid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Physical Or Chemical Processes And Apparatus (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30298410P | 2010-02-10 | 2010-02-10 | |
| US61/302,984 | 2010-02-10 | ||
| US12/951,496 | 2010-11-22 | ||
| US12/951,496 US8992815B2 (en) | 2010-02-10 | 2010-11-22 | Production of organic compound nanoparticles with high repetition rate ultrafast pulsed laser ablation in liquids |
| PCT/US2011/023530 WO2011100154A1 (en) | 2010-02-10 | 2011-02-03 | Production of organic compound nanoparticles with high repetition rate ultrafast pulsed laser ablation in liquids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519671A JP2013519671A (ja) | 2013-05-30 |
| JP2013519671A5 JP2013519671A5 (enExample) | 2015-08-20 |
| JP6076742B2 true JP6076742B2 (ja) | 2017-02-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2012552906A Expired - Fee Related JP6076742B2 (ja) | 2010-02-10 | 2011-02-03 | 高繰返周波数の超高速パルスレーザ溶発による、有機化合物のナノ粒子の液中生成方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8992815B2 (enExample) |
| JP (1) | JP6076742B2 (enExample) |
| CN (1) | CN102802934A (enExample) |
| DE (1) | DE112011100502T5 (enExample) |
| WO (1) | WO2011100154A1 (enExample) |
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| US8540173B2 (en) * | 2010-02-10 | 2013-09-24 | Imra America, Inc. | Production of fine particles of functional ceramic by using pulsed laser |
| US20110192450A1 (en) * | 2010-02-10 | 2011-08-11 | Bing Liu | Method for producing nanoparticle solutions based on pulsed laser ablation for fabrication of thin film solar cells |
| US8685293B1 (en) * | 2010-03-19 | 2014-04-01 | Nicholas V. Coppa | Control of particle formation at the nanoscale |
| US8802234B2 (en) | 2011-01-03 | 2014-08-12 | Imra America, Inc. | Composite nanoparticles and methods for making the same |
| JP5671724B2 (ja) * | 2011-02-21 | 2015-02-18 | 株式会社奈良機械製作所 | 液相レーザーアブレーション方法及び装置 |
| US9849512B2 (en) | 2011-07-01 | 2017-12-26 | Attostat, Inc. | Method and apparatus for production of uniformly sized nanoparticles |
| JP2015506986A (ja) * | 2012-02-13 | 2015-03-05 | イムラ アメリカ インコーポレイテッド | 液中パルスレーザーアブレーションによって製造された非晶質医薬微粒子およびその製造方法 |
| CN102701270B (zh) * | 2012-06-12 | 2014-05-14 | 天津大学 | 胶体硫化锡空心纳米颗粒的制备方法 |
| US9646729B2 (en) * | 2013-01-18 | 2017-05-09 | Westinghouse Electric Company Llc | Laser sintering systems and methods for remote manufacture of high density pellets containing highly radioactive elements |
| WO2015077867A1 (en) * | 2013-11-26 | 2015-06-04 | National Research Council Of Canada | Method and apparatus for fast quantitative analysis of a material by laser induced breakdown spectroscopy (libs) |
| US20160236296A1 (en) * | 2015-02-13 | 2016-08-18 | Gold Nanotech Inc | Nanoparticle Manufacturing System |
| WO2016161348A1 (en) | 2015-04-01 | 2016-10-06 | Attostat, Inc. | Nanoparticle compositions and methods for treating or preventing tissue infections and diseases |
| US11473202B2 (en) | 2015-04-13 | 2022-10-18 | Attostat, Inc. | Anti-corrosion nanoparticle compositions |
| US10774429B2 (en) | 2015-04-13 | 2020-09-15 | Attostat, Inc. | Anti-corrosion nanoparticle compositions |
| DE102015211280B4 (de) * | 2015-06-18 | 2018-01-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Dispergierung von agglomerierten Nanopartikeln |
| US10201571B2 (en) | 2016-01-25 | 2019-02-12 | Attostat, Inc. | Nanoparticle compositions and methods for treating onychomychosis |
| TWI593134B (zh) * | 2016-05-19 | 2017-07-21 | Method and structure for manufacturing graphene quantum dot on light-emitting diode | |
| CN106496605B (zh) * | 2016-12-23 | 2019-10-11 | 广东工业大学 | 一种制备高分子磁性微球的装置与方法 |
| US11018376B2 (en) | 2017-11-28 | 2021-05-25 | Attostat, Inc. | Nanoparticle compositions and methods for enhancing lead-acid batteries |
| US11646453B2 (en) | 2017-11-28 | 2023-05-09 | Attostat, Inc. | Nanoparticle compositions and methods for enhancing lead-acid batteries |
| CN108875264B (zh) * | 2018-07-06 | 2021-06-15 | 厦门大学 | 一种用于飞秒激光烧蚀仿真的激光源模型的建立方法 |
| DE102018216824A1 (de) * | 2018-10-01 | 2020-04-02 | Universität Duisburg-Essen | Kompakte Vorrichtung und Verfahren zur Herstellung von Nanopartikeln in Suspension |
| WO2020165220A1 (de) * | 2019-02-12 | 2020-08-20 | Trumpf Laser- Und Systemtechnik Gmbh | Verfahren und vorrichtung zum bearbeiten von partikeln sowie nanopartikel eines pharmazeutischen wirkstoffs |
| CN109868462A (zh) * | 2019-03-28 | 2019-06-11 | 北京理工大学 | 一种实现在纳米尺度下激光辅助金离子化学还原的方法 |
| US12115250B2 (en) | 2019-07-12 | 2024-10-15 | Evoq Nano, Inc. | Use of nanoparticles for treating respiratory infections associated with cystic fibrosis |
| EP4221929B1 (en) * | 2020-10-01 | 2025-09-17 | University of South Africa | Method of producing a nanofluid using laser ablation, and laser ablation system for manufacturing nanofluids |
| US12456759B2 (en) | 2021-03-30 | 2025-10-28 | Evoq Nano, Inc. | Nanoparticle-enhanced lead-acid electrode paste and improved lead-acid batteries made therefrom |
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| US5390864A (en) * | 1990-03-13 | 1995-02-21 | The Board Of Regents Of The University Of Nebraska | Apparatus for forming fine particles |
| US5585020A (en) * | 1994-11-03 | 1996-12-17 | Becker; Michael F. | Process for the production of nanoparticles |
| US6653226B1 (en) | 2001-01-09 | 2003-11-25 | Novellus Systems, Inc. | Method for electrochemical planarization of metal surfaces |
| FR2802308B1 (fr) | 1999-12-09 | 2002-03-08 | Gc Comm | Procede et dispositif d'usinage par laser de guides de lumiere, guides de lumiere obtenus et ecrans retro-elaires incorporant ces guides |
| NZ522896A (en) * | 2000-05-10 | 2004-05-28 | Skyepharma Canada Inc | Media milling |
| US6741345B2 (en) | 2001-02-08 | 2004-05-25 | National Research Council Of Canada | Method and apparatus for in-process liquid analysis by laser induced plasma spectroscopy |
| JP2003306319A (ja) * | 2002-04-10 | 2003-10-28 | Japan Atom Energy Res Inst | 金属酸化物ナノ微粒子の製造方法 |
| JP4116404B2 (ja) | 2002-11-18 | 2008-07-09 | 浜松ホトニクス株式会社 | ナノ粒子化処理に用いるレーザ光照射条件の決定方法及び決定装置並びにナノ粒子の製造方法 |
| JP4398182B2 (ja) | 2003-06-16 | 2010-01-13 | 浜松ホトニクス株式会社 | 微粒子の製造方法、並びに注射剤の製造方法 |
| JP4344153B2 (ja) | 2003-03-07 | 2009-10-14 | 浜松ホトニクス株式会社 | 微粒子の製造方法及び製造装置、並びに注射剤の製造方法 |
| JP4643155B2 (ja) | 2004-02-24 | 2011-03-02 | 株式会社ABsize | 薬効成分の超微粒子の製造方法 |
| US7529011B2 (en) * | 2004-04-12 | 2009-05-05 | Ricoh Company, Ltd. | Deflector mirror with regions of different flexural rigidity |
| US7133182B2 (en) | 2004-06-07 | 2006-11-07 | Electro Scientific Industries, Inc. | AOM frequency and amplitude modulation techniques for facilitating full beam extinction in laser systems |
| US7527824B2 (en) * | 2004-06-25 | 2009-05-05 | Becker Michael F | Methods for producing coated nanoparticles from microparticles |
| US8512436B2 (en) | 2004-09-15 | 2013-08-20 | Kyoto University | Metal fine particles and manufacturing method therefor |
| JP2006152032A (ja) * | 2004-11-25 | 2006-06-15 | Matsushita Electric Works Ltd | 蛍光体ナノ粒子の製造方法 |
| CN100467118C (zh) * | 2005-08-08 | 2009-03-11 | 鸿富锦精密工业(深圳)有限公司 | 纳米粒子制备装置 |
| US7718432B2 (en) * | 2006-03-22 | 2010-05-18 | The University Of Southern Mississippi | Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof |
| JP2007306950A (ja) * | 2006-05-15 | 2007-11-29 | Osaka Univ | 薬効成分ナノ粒子分散液の製造方法 |
| JP2007301534A (ja) | 2006-05-15 | 2007-11-22 | Ebara Corp | 微細化装置 |
| US20080006524A1 (en) | 2006-07-05 | 2008-01-10 | Imra America, Inc. | Method for producing and depositing nanoparticles |
| GB0712287D0 (en) * | 2007-06-22 | 2007-08-01 | Ucl Business Plc | Antimicrobial Conjugates |
| US7729031B2 (en) | 2006-09-07 | 2010-06-01 | Ricoh Company, Ltd. | Light-source device, optical scanning device, and image forming apparatus |
| AU2007333528B2 (en) * | 2006-10-05 | 2013-10-17 | The Johns Hopkins University | Water-dispersible oral, parenteral, and topical formulations for poorly water soluble drugs using smart polymeric nanoparticles |
| CN102006964B (zh) * | 2008-03-21 | 2016-05-25 | Imra美国公司 | 基于激光的材料加工方法和系统 |
| US20090246530A1 (en) | 2008-03-27 | 2009-10-01 | Imra America, Inc. | Method For Fabricating Thin Films |
| JP5589168B2 (ja) * | 2008-06-11 | 2014-09-17 | 独立行政法人産業技術総合研究所 | 金ナノ粒子およびその分散液、金ナノ粒子の製造方法、ナノ粒子製造システム |
| US20110190399A1 (en) * | 2008-07-31 | 2011-08-04 | Santosh Kumar Kar | Curcumin nanoparticles and methods of producing the same |
| US8246714B2 (en) * | 2009-01-30 | 2012-08-21 | Imra America, Inc. | Production of metal and metal-alloy nanoparticles with high repetition rate ultrafast pulsed laser ablation in liquids |
-
2010
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-
2011
- 2011-02-03 CN CN2011800089575A patent/CN102802934A/zh active Pending
- 2011-02-03 DE DE112011100502T patent/DE112011100502T5/de not_active Ceased
- 2011-02-03 JP JP2012552906A patent/JP6076742B2/ja not_active Expired - Fee Related
- 2011-02-03 WO PCT/US2011/023530 patent/WO2011100154A1/en not_active Ceased
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2015
- 2015-02-24 US US14/629,617 patent/US20150258631A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN102802934A (zh) | 2012-11-28 |
| US8992815B2 (en) | 2015-03-31 |
| WO2011100154A1 (en) | 2011-08-18 |
| DE112011100502T5 (de) | 2013-03-28 |
| US20110196044A1 (en) | 2011-08-11 |
| JP2013519671A (ja) | 2013-05-30 |
| US20150258631A1 (en) | 2015-09-17 |
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