JP6050230B2 - Ｈｌａ遺伝子座の修飾のための方法及び組成物 - Google Patents

Ｈｌａ遺伝子座の修飾のための方法及び組成物 Download PDF

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JP6050230B2
JP6050230B2 JP2013520872A JP2013520872A JP6050230B2 JP 6050230 B2 JP6050230 B2 JP 6050230B2 JP 2013520872 A JP2013520872 A JP 2013520872A JP 2013520872 A JP2013520872 A JP 2013520872A JP 6050230 B2 JP6050230 B2 JP 6050230B2
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seq
hla
gene
cells
cell
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JP2013538562A (ja
JP2013538562A5 (enExample
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コリンウッド トレバー
コリンウッド トレバー
ジェイ．エヌ．クーパー ローレンス
ジェイ．エヌ．クーパー ローレンス
ディー．グレゴリー フィリップ
ディー．グレゴリー フィリップ
シー．ホームズ マイケル
シー．ホームズ マイケル
シー．ミラー ジェフリー
シー．ミラー ジェフリー
ジェイ．レバー エドワード
ジェイ．レバー エドワード
レイク アンドレアズ
レイク アンドレアズ
ウルノブ フョードル
ウルノブ フョードル
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Sangamo Therapeutics Inc
University of Texas System
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Sangamo Therapeutics Inc
University of Texas System
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C07K2319/81—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor containing a Zn-finger domain for DNA binding
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    • C12N2800/00—Nucleic acids vectors
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JP2013520872A 2010-07-21 2011-07-21 Ｈｌａ遺伝子座の修飾のための方法及び組成物 Expired - Fee Related JP6050230B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40000910P 2010-07-21 2010-07-21
US61/400,009 2010-07-21
US40468510P 2010-10-06 2010-10-06
US61/404,685 2010-10-06
PCT/US2011/044902 WO2012012667A2 (en) 2010-07-21 2011-07-21 Methods and compositions for modification of a hla locus

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JP2013538562A JP2013538562A (ja) 2013-10-17
JP2013538562A5 JP2013538562A5 (enExample) 2016-11-10
JP6050230B2 true JP6050230B2 (ja) 2016-12-21

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US (4) US8945868B2 (enExample)
EP (1) EP2596011B1 (enExample)
JP (1) JP6050230B2 (enExample)
AU (1) AU2011281062B2 (enExample)
CA (3) CA2805442C (enExample)
WO (1) WO2012012667A2 (enExample)

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US20210054046A1 (en) 2021-02-25
US20150252094A1 (en) 2015-09-10
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US10858416B2 (en) 2020-12-08
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