JP6033783B2 - Pan−her抗体組成物 - Google Patents

Pan−her抗体組成物 Download PDF

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Publication number
JP6033783B2
JP6033783B2 JP2013535577A JP2013535577A JP6033783B2 JP 6033783 B2 JP6033783 B2 JP 6033783B2 JP 2013535577 A JP2013535577 A JP 2013535577A JP 2013535577 A JP2013535577 A JP 2013535577A JP 6033783 B2 JP6033783 B2 JP 6033783B2
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antibody
seq
amino acid
acid sequence
light chain
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Expired - Fee Related
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JP2014503188A (ja
JP2014503188A5 (enExample
Inventor
ミッケル・ワンダール・ペダーセン
イーダ・コー・クリステンセン
ヨハン・ラント
ヘレ・ヤコブセン
ミカエル・クラウ
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Symphogen AS
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Symphogen AS
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2013535577A 2010-11-01 2011-10-31 Pan−her抗体組成物 Expired - Fee Related JP6033783B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40878210P 2010-11-01 2010-11-01
US61/408,782 2010-11-01
DKPA201000988 2010-11-01
DKPA201000988 2010-11-01
DKPA201100672 2011-09-05
DKPA201100672 2011-09-05
US201161531407P 2011-09-06 2011-09-06
US61/531,407 2011-09-06
PCT/IB2011/054834 WO2012059857A2 (en) 2010-11-01 2011-10-31 Pan-her antibody composition

Publications (3)

Publication Number Publication Date
JP2014503188A JP2014503188A (ja) 2014-02-13
JP2014503188A5 JP2014503188A5 (enExample) 2014-12-18
JP6033783B2 true JP6033783B2 (ja) 2016-11-30

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013535577A Expired - Fee Related JP6033783B2 (ja) 2010-11-01 2011-10-31 Pan−her抗体組成物
JP2013535578A Expired - Fee Related JP6186277B2 (ja) 2010-11-01 2011-10-31 抗her3抗体および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013535578A Expired - Fee Related JP6186277B2 (ja) 2010-11-01 2011-10-31 抗her3抗体および組成物

Country Status (13)

Country Link
US (1) US9217039B2 (enExample)
EP (3) EP3156421B1 (enExample)
JP (2) JP6033783B2 (enExample)
KR (2) KR101862832B1 (enExample)
AU (2) AU2011324871B2 (enExample)
CA (2) CA2816519C (enExample)
DK (1) DK2635604T3 (enExample)
ES (2) ES2616961T3 (enExample)
IL (2) IL225954B (enExample)
MX (2) MX347981B (enExample)
PL (1) PL2635604T3 (enExample)
TW (1) TW201231066A (enExample)
WO (2) WO2012059858A1 (enExample)

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EP2337800B1 (en) 2008-09-15 2013-10-02 Yeda Research and Development Co. Ltd. Antibody combinations and use of same for treating cancer
JP5680671B2 (ja) 2009-12-22 2015-03-04 ロシュ グリクアート アーゲー 抗her3抗体及びその使用
JP6033783B2 (ja) 2010-11-01 2016-11-30 シムフォゲン・アクティーゼルスカブSymphogen A/S Pan−her抗体組成物
US9155802B2 (en) 2010-11-01 2015-10-13 Symphogen A/S Pan-HER antibody composition
EA201301025A1 (ru) * 2011-03-15 2014-01-30 Мерримак Фармасьютикалс, Инк. Преодоление устойчивости к ингибиторам пути erbb
WO2012156975A1 (en) * 2011-05-16 2012-11-22 Yeda Research And Development Co. Ltd. COMBINATIONS OF ANTI ErbB ANTIBODIES FOR THE TREATMENT OF CANCER
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MX350957B (es) 2011-11-23 2017-09-27 Medimmune Llc Moleculas de union especificas para her3 y usos de las mismas.
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US10745490B2 (en) 2014-04-11 2020-08-18 Celldex Therapeutics, Inc. Anti-ErbB antibodies and methods of use thereof
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JP7301002B2 (ja) 2017-05-30 2023-06-30 ブリストル-マイヤーズ スクイブ カンパニー 抗lag-3抗体または抗lag-3抗体および抗pd-1もしくは抗pd-l1抗体を含む組成物
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JP2021514656A (ja) 2018-03-02 2021-06-17 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. Il−6抗体ならびにその融合構築物およびコンジュゲート
WO2020051333A1 (en) * 2018-09-07 2020-03-12 Pfizer Inc. Anti-avb8 antibodies and compositions and uses thereof
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Publication number Publication date
EP2635605A1 (en) 2013-09-11
JP2014503188A (ja) 2014-02-13
MX348637B (es) 2017-06-22
PL2635604T3 (pl) 2017-09-29
CA2816520C (en) 2017-11-21
IL225954B (en) 2018-05-31
IL225954A0 (en) 2013-07-31
WO2012059857A3 (en) 2012-07-19
JP2014503189A (ja) 2014-02-13
KR101862832B1 (ko) 2018-05-30
MX2013004899A (es) 2013-07-15
WO2012059857A2 (en) 2012-05-10
ES2616961T3 (es) 2017-06-14
CA2816520A1 (en) 2012-05-10
DK2635604T3 (en) 2017-02-27
EP3156421A1 (en) 2017-04-19
TW201231066A (en) 2012-08-01
EP2635604A2 (en) 2013-09-11
AU2011324870A1 (en) 2013-01-31
EP2635605A4 (en) 2014-10-22
KR101773120B1 (ko) 2017-08-30
US20130287684A1 (en) 2013-10-31
CA2816519C (en) 2019-01-15
US9217039B2 (en) 2015-12-22
ES2692379T3 (es) 2018-12-03
KR20140026336A (ko) 2014-03-05
MX2013004897A (es) 2013-07-15
EP2635605B1 (en) 2018-07-25
JP6186277B2 (ja) 2017-08-23
MX347981B (es) 2017-05-22
IL225953A0 (en) 2013-07-31
AU2011324870B2 (en) 2015-01-29
EP2635604B1 (en) 2016-11-30
AU2011324871B2 (en) 2016-05-19
AU2011324871A1 (en) 2013-05-09
KR20140026337A (ko) 2014-03-05
EP3156421B1 (en) 2018-06-06
CA2816519A1 (en) 2012-05-10
WO2012059858A1 (en) 2012-05-10

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