JP6027547B2 - ホスホジエステラーゼの阻害薬としての（１，２，４）トリアゾロ［４，３−ａ］キノキサリン誘導体 - Google Patents

ホスホジエステラーゼの阻害薬としての（１，２，４）トリアゾロ［４，３−ａ］キノキサリン誘導体 Download PDF

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JP6027547B2
JP6027547B2 JP2013550908A JP2013550908A JP6027547B2 JP 6027547 B2 JP6027547 B2 JP 6027547B2 JP 2013550908 A JP2013550908 A JP 2013550908A JP 2013550908 A JP2013550908 A JP 2013550908A JP 6027547 B2 JP6027547 B2 JP 6027547B2
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methyl
triazolo
quinoxaline
phenyl
chloro
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JP2014503576A (ja
JP2014503576A5 (enExample
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ハンス ヨアヒム ランカウ
ハンス ヨアヒム ランカウ
バーバラ ランゲン
バーバラ ランゲン
クリスティアン グルンワルト
クリスティアン グルンワルト
ノルベルト ヘフゲン
ノルベルト ヘフゲン
ハンス シュタンゲ
ハンス シュタンゲ
リタ ドスト
リタ ドスト
ウテ エガーランド
ウテ エガーランド
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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JP2013550908A 2011-01-31 2012-01-31 ホスホジエステラーゼの阻害薬としての（１，２，４）トリアゾロ［４，３−ａ］キノキサリン誘導体 Active JP6027547B2 (ja)

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US201161437848P 2011-01-31 2011-01-31
US61/437,848 2011-01-31
PCT/EP2012/051546 WO2012104293A1 (en) 2011-01-31 2012-01-31 (1,2,4)triazolo[4,3-a]quinoxaline derivatives as inhibitors of phosphodiesterases

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JP2014503576A JP2014503576A (ja) 2014-02-13
JP2014503576A5 JP2014503576A5 (enExample) 2015-03-19
JP6027547B2 true JP6027547B2 (ja) 2016-11-16

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US (1) US9540379B2 (enExample)
EP (1) EP2670754B1 (enExample)
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KR (1) KR20140019342A (enExample)
CN (1) CN103459395A (enExample)
AR (1) AR085099A1 (enExample)
AU (1) AU2012213471B2 (enExample)
BR (1) BR112013019354A2 (enExample)
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UA111963C2 (uk) 2016-07-11
ECSP13012824A (es) 2013-10-31
KR20140019342A (ko) 2014-02-14
TN2013000325A1 (en) 2015-01-20
AU2012213471A1 (en) 2013-07-04
MA34844B1 (fr) 2014-01-02
PH12013501355A1 (en) 2013-09-02
AU2012213471B2 (en) 2016-07-14
UY33888A (es) 2012-08-31
EA201300871A1 (ru) 2014-01-30
BR112013019354A2 (pt) 2019-09-24
US9540379B2 (en) 2017-01-10
EP2670754B1 (en) 2017-05-24
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SG192210A1 (en) 2013-09-30
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CL2013002003A1 (es) 2013-12-06
GEP20156333B (en) 2015-07-27
AR085099A1 (es) 2013-09-11
EA023792B1 (ru) 2016-07-29
CA2824929A1 (en) 2012-08-09
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EP2670754A1 (en) 2013-12-11
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