JP5979726B2 - 食用エマルション - Google Patents
食用エマルション Download PDFInfo
- Publication number
- JP5979726B2 JP5979726B2 JP2013527701A JP2013527701A JP5979726B2 JP 5979726 B2 JP5979726 B2 JP 5979726B2 JP 2013527701 A JP2013527701 A JP 2013527701A JP 2013527701 A JP2013527701 A JP 2013527701A JP 5979726 B2 JP5979726 B2 JP 5979726B2
- Authority
- JP
- Japan
- Prior art keywords
- emulsion
- polyethylene glycol
- tocopherol
- weight
- emulsifier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000839 emulsion Substances 0.000 title claims description 183
- 239000003995 emulsifying agent Substances 0.000 claims description 83
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 78
- 238000000034 method Methods 0.000 claims description 78
- 239000002202 Polyethylene glycol Substances 0.000 claims description 69
- 229920001223 polyethylene glycol Polymers 0.000 claims description 69
- 239000000203 mixture Substances 0.000 claims description 64
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 54
- 229930003799 tocopherol Natural products 0.000 claims description 53
- 239000011732 tocopherol Substances 0.000 claims description 53
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 52
- 235000010384 tocopherol Nutrition 0.000 claims description 51
- 229960001295 tocopherol Drugs 0.000 claims description 51
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims description 43
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 29
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical group CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 25
- 239000006184 cosolvent Substances 0.000 claims description 25
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 24
- 150000002016 disaccharides Chemical class 0.000 claims description 22
- 238000002835 absorbance Methods 0.000 claims description 20
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 19
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 15
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 14
- AOBORMOPSGHCAX-UHFFFAOYSA-N Tocophersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-UHFFFAOYSA-N 0.000 claims description 13
- 229930003427 Vitamin E Natural products 0.000 claims description 13
- 150000002772 monosaccharides Chemical class 0.000 claims description 13
- 235000019165 vitamin E Nutrition 0.000 claims description 13
- 239000011709 vitamin E Substances 0.000 claims description 13
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- -1 sterol esters Chemical class 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 10
- 238000000265 homogenisation Methods 0.000 claims description 9
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims description 8
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 8
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 claims description 8
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims description 7
- 125000005907 alkyl ester group Chemical group 0.000 claims description 6
- 125000005456 glyceride group Chemical group 0.000 claims description 6
- 229930006000 Sucrose Natural products 0.000 claims description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 5
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 5
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 5
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims description 5
- 150000004676 glycans Chemical class 0.000 claims description 5
- 229920001282 polysaccharide Polymers 0.000 claims description 5
- 239000005017 polysaccharide Substances 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 5
- ADHNUPOJJCKWRT-JLXBFWJWSA-N (2e,4e)-octadeca-2,4-dienoic acid Chemical compound CCCCCCCCCCCCC\C=C\C=C\C(O)=O ADHNUPOJJCKWRT-JLXBFWJWSA-N 0.000 claims description 4
- ZUUFLXSNVWQOJW-MBIXAETLSA-N (2e,4e,6e)-octadeca-2,4,6-trienoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C(O)=O ZUUFLXSNVWQOJW-MBIXAETLSA-N 0.000 claims description 4
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims description 4
- XVOUMQNXTGKGMA-OWOJBTEDSA-N (E)-glutaconic acid Chemical compound OC(=O)C\C=C\C(O)=O XVOUMQNXTGKGMA-OWOJBTEDSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 4
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims description 4
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims description 4
- JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical compound OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 claims description 4
- LVHBHZANLOWSRM-UHFFFAOYSA-N itaconic acid Chemical compound OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 4
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 4
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 4
- 229940116351 sebacate Drugs 0.000 claims description 4
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 claims description 4
- BGMFJTUTJOZHHZ-ARJAWSKDSA-N (z)-4-methoxy-3-methyl-4-oxobut-2-enoic acid Chemical compound COC(=O)C(\C)=C/C(O)=O BGMFJTUTJOZHHZ-ARJAWSKDSA-N 0.000 claims description 3
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims description 3
- 229930182558 Sterol Natural products 0.000 claims description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 3
- HNEGQIOMVPPMNR-IHWYPQMZSA-N citraconic acid Chemical compound OC(=O)C(/C)=C\C(O)=O HNEGQIOMVPPMNR-IHWYPQMZSA-N 0.000 claims description 3
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 150000002334 glycols Chemical class 0.000 claims description 3
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 claims description 3
- 235000003702 sterols Nutrition 0.000 claims description 3
- TYFQFVWCELRYAO-UHFFFAOYSA-L suberate(2-) Chemical compound [O-]C(=O)CCCCCCC([O-])=O TYFQFVWCELRYAO-UHFFFAOYSA-L 0.000 claims description 3
- 125000002640 tocopherol group Chemical group 0.000 claims description 3
- 235000019155 vitamin A Nutrition 0.000 claims description 3
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- 235000005282 vitamin D3 Nutrition 0.000 claims 4
- 239000011647 vitamin D3 Substances 0.000 claims 4
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 4
- 229940021056 vitamin d3 Drugs 0.000 claims 4
- UOELMDIOCSFSEN-FVZZCGLESA-N 7-Dehydrositosterol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)C=C[C@H](C)C(C)C)=CC=C1C[C@@H](O)CCC1=C.C1[C@@H](O)CCC2(C)C(CC[C@@]3([C@@H]([C@H](C)C=C[C@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 UOELMDIOCSFSEN-FVZZCGLESA-N 0.000 claims 2
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims 2
- DIPPFEXMRDPFBK-UHFFFAOYSA-N Vitamin D4 Natural products C1CCC2(C)C(C(C)CCC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C DIPPFEXMRDPFBK-UHFFFAOYSA-N 0.000 claims 2
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- 235000001892 vitamin D2 Nutrition 0.000 claims 2
- 239000011653 vitamin D2 Substances 0.000 claims 2
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 2
- DIPPFEXMRDPFBK-JPWDPSJFSA-N vitamin D4 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CC[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C DIPPFEXMRDPFBK-JPWDPSJFSA-N 0.000 claims 2
- RMDJVOZETBHEAR-GHTRHTQZSA-N vitamin d5 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CC[C@H](CC)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C RMDJVOZETBHEAR-GHTRHTQZSA-N 0.000 claims 2
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
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- 229940033080 omega-6 fatty acid Drugs 0.000 description 1
- 239000010661 oregano oil Substances 0.000 description 1
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- 230000001590 oxidative effect Effects 0.000 description 1
- 229940023569 palmate Drugs 0.000 description 1
- 238000010951 particle size reduction Methods 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
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- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
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- 235000010378 sodium ascorbate Nutrition 0.000 description 1
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- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
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- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/005—Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
- A23D7/0053—Compositions other than spreads
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/01—Other fatty acid esters, e.g. phosphatides
- A23D7/011—Compositions other than spreads
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS OR COOKING OILS
- A23D7/00—Edible oil or fat compositions containing an aqueous phase, e.g. margarines
- A23D7/015—Reducing calorie content; Reducing fat content, e.g. "halvarines"
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L35/00—Foods or foodstuffs not provided for in groups A23L5/00 - A23L33/00; Preparation or treatment thereof
- A23L35/10—Emulsified foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Mycology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Colloid Chemistry (AREA)
- General Preparation And Processing Of Foods (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38057710P | 2010-09-07 | 2010-09-07 | |
| US61/380,577 | 2010-09-07 | ||
| PCT/IB2011/002743 WO2012032416A2 (en) | 2010-09-07 | 2011-09-07 | Comestible emulsions |
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|---|---|
| JP2013538817A JP2013538817A (ja) | 2013-10-17 |
| JP2013538817A5 JP2013538817A5 (enExample) | 2014-10-09 |
| JP5979726B2 true JP5979726B2 (ja) | 2016-08-31 |
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| Country | Link |
|---|---|
| US (1) | US8722131B2 (enExample) |
| EP (1) | EP2613652B1 (enExample) |
| JP (1) | JP5979726B2 (enExample) |
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| BR (1) | BR112013005517B1 (enExample) |
| CA (1) | CA2810474C (enExample) |
| ES (1) | ES2610907T3 (enExample) |
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| RU (1) | RU2580470C2 (enExample) |
| WO (1) | WO2012032416A2 (enExample) |
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| BR112015023714A2 (pt) * | 2013-03-15 | 2017-07-18 | Virun Inc | formulações de derivados solúveis em água de vitamina e e composições contendo a mesma |
| PL227367B1 (pl) * | 2013-07-13 | 2017-11-30 | Univ Jagiellonski | Spozywcza mikroemulsja stanowiaca nosnik oleju rybiego |
| WO2015186040A1 (en) * | 2014-06-02 | 2015-12-10 | Sun Pharmaceutical Industries Limited | Stable nanoemulsion composition |
| CN107645910A (zh) * | 2015-05-25 | 2018-01-30 | 麦赛尔科技有限责任公司 | ω‑3脂肪酸乳液的单和二甘油酯 |
| CN105410566A (zh) * | 2015-11-30 | 2016-03-23 | 杭州鑫伟低碳技术研发有限公司 | 一种利用多糖及其聚合物制造食用油饮料的方法 |
| JP6961339B2 (ja) * | 2015-12-18 | 2021-11-05 | アサヒ飲料株式会社 | 微生物菌体含有飲料 |
| AR105674A1 (es) | 2016-08-11 | 2017-10-25 | Consejo Nac De Investigaciones Científicas Y Técnicas (Conicet) | Una nanoemulsión comestible de aceite de chía |
| WO2018174938A1 (en) | 2017-03-23 | 2018-09-27 | Virun, Inc. | Stable dry powders and emulsions containing probiotics and mucoadhesive protein |
| CA3114898A1 (en) * | 2018-10-30 | 2020-05-07 | Kapil DESHPANDE | A method of dispersing fine particles in an aqueous or polar solvent |
| EP4025533A4 (en) * | 2019-09-06 | 2023-08-30 | Quicksilver Scientific, Inc. | MICROEMULSION DELIVERY SYSTEMS FOR ALCOHOL-SOLUBLE SPECIES INCLUDING NON-DERIVATIZED HORMONES |
| CA3162536A1 (en) * | 2019-12-18 | 2021-06-24 | Anja VOGT | Emulsions of bioactive lipophilic compounds including oils |
| CN119655408B (zh) * | 2024-12-16 | 2025-10-28 | 深圳大学 | 改善针对吞咽困难的三文鱼乳液凝胶的制备及检验方法 |
Family Cites Families (57)
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| US2167144A (en) * | 1937-03-24 | 1939-07-25 | Mead Johnson & Co | Composition of matter |
| US2680749A (en) | 1951-12-01 | 1954-06-08 | Eastman Kodak Co | Water-soluble tocopherol derivatives |
| US3102078A (en) | 1961-01-13 | 1963-08-27 | Eastman Kodak Co | Water-dispersible vitamin preparations |
| US4005196A (en) | 1976-02-12 | 1977-01-25 | The Procter & Gamble Company | Vitaminized compositions for treating hypercholesterolemia |
| US4146652A (en) * | 1977-01-28 | 1979-03-27 | Rich Products Corporation | Intermediate moisture, ready-to-use frozen whippable foods |
| US4963380A (en) | 1987-11-30 | 1990-10-16 | General Mills, Inc. | Beverages containing fish oils stabilized with fructose |
| CA2063791C (en) | 1989-08-17 | 2000-12-19 | Michael John Story | Hard gelatine capsule containing fat-soluble nutrients. |
| US5532002A (en) | 1989-08-17 | 1996-07-02 | Cortecs Limited | Gelatin pharmaceutical formulations |
| CA2082418A1 (en) | 1990-05-07 | 1991-12-28 | Barry I. Bockow | Methods and preparations of stable, deodorized oils and pharmaceutical compositions thereof |
| IT1274734B (it) | 1994-08-25 | 1997-07-24 | Prospa Bv | Composizioni farmaceutiche contenenti acidi grassi poliinsaturi, loro esteri o sali, unitamente a vitamine o provitamine antiossidanti |
| HU215966B (hu) | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
| FR2730932B1 (fr) | 1995-02-27 | 1997-04-04 | Oreal | Nanoemulsion transparente a base de lipides amphiphiles non-ioniques fluides et utilisation en cosmetique ou en dermopharmacie |
| DK0782827T3 (da) | 1995-07-04 | 2004-02-09 | Suntory Ltd | Anvendelse af et afbalanceringsmiddel til omega-6- og omega-3-umættede fedtsyrer |
| JP3177947B2 (ja) | 1996-07-30 | 2001-06-18 | 株式会社ジャニフ・テック | Ｄｈａ入り豆腐、飲用豆乳およびそれらの乾燥粉末の製造方法 |
| US5798333A (en) | 1996-09-17 | 1998-08-25 | Sherman; Bernard C. | Water-soluble concentrates containing cyclosporins |
| FR2755854B1 (fr) | 1996-11-15 | 1998-12-24 | Oreal | Nanoemulsion a base de lipides amphiphiles non-ioniques et cationiques et utilisations |
| US6235331B1 (en) | 1999-07-29 | 2001-05-22 | Nisshin Flour Milling Co Ltd | Modified fish oil type material containing highly unsaturated fatty acid and/or esters thereof, and a composition containing said material |
| DE60136093D1 (de) | 2000-11-13 | 2008-11-20 | Nippon Suisan Kaisha Ltd | Epa- und/oder dha-haltige saure milchen |
| US7431986B2 (en) | 2002-07-24 | 2008-10-07 | General Mills, Inc. | Encapsulation of sensitive components using pre-emulsification |
| CA2498032C (en) * | 2002-09-10 | 2011-10-11 | Pepsico, Inc. | Use of surfactants to solubilize water-insoluble solids in beverages |
| AU2003296923B2 (en) | 2002-11-01 | 2010-03-04 | Biodelivery Sciences International, Inc. | Geodate delivery vehicles |
| AU2003284617A1 (en) | 2002-11-22 | 2004-06-18 | Nippon Suisan Kaisha, Ltd. | Composition containing organic substance having double bond with improved oxidation stability |
| NO317310B1 (no) | 2003-02-28 | 2004-10-04 | Bioli Innovation As | Olje-i-vann emulsjonskonsentrat for ernaeringsformal, samt anvendelse derav. |
| US20040219274A1 (en) | 2003-04-29 | 2004-11-04 | Cook Phillip Michael | Beverages containing water-soluble vitamin E |
| AU2004247108A1 (en) | 2003-06-11 | 2004-12-23 | Novacea, Inc | Treatment of immune-mediated disorders with active vitamin D compounds alone or in combination with other therapeutic agents |
| US20070098787A1 (en) | 2003-06-20 | 2007-05-03 | Mochida Pharmaceutical Co., Ltd. | Composition for preventing and treating varicose veins of lower extremities |
| AU2004316985A1 (en) | 2004-02-23 | 2005-09-15 | The Texas A & M University System | Antioxidant compositions and methods of use thereof |
| US20070189977A1 (en) | 2004-06-07 | 2007-08-16 | Jie Zhang | Spray-on formulations and methods for dermal delivery of drugs |
| WO2006009825A1 (en) | 2004-06-17 | 2006-01-26 | Virun, Inc. | Compositions comprising a mucoadhesive protein and an active principle for mucosal delivery of said agents |
| EP1616486A1 (en) | 2004-07-13 | 2006-01-18 | Friesland Brands B.V. | Powdered compositions containing an edible oil and their use in food products |
| WO2006056293A1 (en) | 2004-11-29 | 2006-06-01 | Unilever Plc | Oral composition for enhancing skin properties |
| AU2006240567B2 (en) | 2005-04-26 | 2010-08-26 | Massey University | Lipid encapsulation |
| JP5368793B2 (ja) | 2005-07-18 | 2013-12-18 | ユニバーシティ オブ マサチューセッツ ロウエル | ナノエマルジョンを製造および使用するための組成物および方法 |
| EP1909760A1 (en) | 2005-08-03 | 2008-04-16 | Eastman Chemical Company | Tocopheryl polyethylene glycol succinate powder and process for preparing same |
| AU2006294649A1 (en) | 2005-09-28 | 2007-04-05 | University Of Massachusetts | Stable acidic beverage emulsions and methods of preparation |
| US7803413B2 (en) | 2005-10-31 | 2010-09-28 | General Mills Ip Holdings Ii, Llc. | Encapsulation of readily oxidizable components |
| ATE484409T1 (de) | 2006-02-08 | 2010-10-15 | Webasto Ag | Windabweiser im kraftfahrzeugbereich |
| US20070298083A1 (en) | 2006-06-23 | 2007-12-27 | Haile Mehansho | Concentrated omega-3 fatty acids and mixtures containing them |
| US20090018186A1 (en) | 2006-09-06 | 2009-01-15 | The Coca-Cola Company | Stable beverage products comprising polyunsaturated fatty acid emulsions |
| US20100098821A1 (en) | 2006-09-25 | 2010-04-22 | Bob Comstock | Process for Solubilization of Flavor Oils |
| US20100323066A1 (en) | 2006-09-25 | 2010-12-23 | Robert Lawrence Comstock | Process for Solubilization of Flavor Oils |
| GB2444896B (en) | 2006-12-18 | 2010-05-19 | Nutraceuticals Ltd | Compositions comprising polyunsaturated fatty acids |
| US20080199589A1 (en) * | 2007-02-20 | 2008-08-21 | Cargill, Incorporated | Lipid Microemulsions |
| US8075054B2 (en) | 2007-06-27 | 2011-12-13 | Laura Lisa Smith | Ampere modular tandem seating system |
| US9186640B2 (en) | 2007-08-28 | 2015-11-17 | Pepsico, Inc. | Delivery and controlled release of encapsulated lipophilic nutrients |
| DE102007057258B4 (de) | 2007-11-27 | 2010-09-23 | Optisens Gmbh | Öl-in-Wasser-Emulsion für Bio-Lebensmittel sowie deren Herstellung und Verwendung |
| WO2009078245A1 (ja) | 2007-12-19 | 2009-06-25 | Foodtech Trading Co., Ltd. | 透明乳化組成物およびそれを含有する化粧品、食品 |
| WO2009117152A1 (en) * | 2008-03-20 | 2009-09-24 | Virun, Inc. | Emulsions including a peg-derivative of tocopherol |
| BRPI0909185A2 (pt) | 2008-03-20 | 2015-08-25 | Virun Inc | Derivado de vitamina e e seus usos |
| CN101259102B (zh) | 2008-04-17 | 2011-05-25 | 湖北福星生物科技有限公司 | 一种微米级二十二碳六烯酸乳状液及其制备方法 |
| CN101259101B (zh) | 2008-04-17 | 2010-06-02 | 湖北福星生物科技有限公司 | 微米级花生四烯酸和二十二碳六烯酸乳状液及其制备方法 |
| AU2009271437A1 (en) * | 2008-07-15 | 2010-01-21 | Comstock, Robert Lawrence Mr | Improved emulsifying system for nutraceutical composition |
| WO2010035704A1 (ja) | 2008-09-24 | 2010-04-01 | 江崎グリコ株式会社 | 乳化状態の遊離長鎖脂肪酸を含有する飲食品 |
| EP2448421B1 (en) | 2009-02-11 | 2017-12-13 | DSM IP Assets B.V. | High concentrated pufa emulsions |
| WO2011060084A1 (en) | 2009-11-10 | 2011-05-19 | MyCell Holdings Limited | Stabilized formulations of fatty acids |
| EP2359698B1 (en) | 2010-01-22 | 2013-12-04 | Symrise AG | Compositions with a surfactant system comprising saponins, and lecithin |
| CA2792330C (en) | 2010-03-23 | 2017-01-03 | Virun, Inc | Nanoemulsion including a peg-derivative of vitamin e and a sucrose fatty acid ester |
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- 2011-09-07 BR BR112013005517-0A patent/BR112013005517B1/pt active IP Right Grant
- 2011-09-07 EP EP11823131.5A patent/EP2613652B1/en active Active
- 2011-09-07 CN CN201180053438.0A patent/CN103429100B/zh active Active
- 2011-09-07 RU RU2013115296/13A patent/RU2580470C2/ru active
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| AU2011300428B2 (en) | 2016-03-24 |
| BR112013005517B1 (pt) | 2018-08-14 |
| AU2011300428A1 (en) | 2013-03-21 |
| WO2012032416A2 (en) | 2012-03-15 |
| US8722131B2 (en) | 2014-05-13 |
| ES2610907T3 (es) | 2017-05-04 |
| CA2810474A1 (en) | 2012-03-15 |
| JP2013538817A (ja) | 2013-10-17 |
| WO2012032416A3 (en) | 2012-05-03 |
| BR112013005517A2 (pt) | 2016-05-03 |
| EP2613652A4 (en) | 2014-05-07 |
| EP2613652A2 (en) | 2013-07-17 |
| CN103429100A (zh) | 2013-12-04 |
| CA2810474C (en) | 2020-01-07 |
| CN103429100B (zh) | 2015-09-02 |
| MX2013002644A (es) | 2013-06-28 |
| EP2613652B1 (en) | 2016-10-26 |
| US20120058241A1 (en) | 2012-03-08 |
| RU2013115296A (ru) | 2014-10-20 |
| RU2580470C2 (ru) | 2016-04-10 |
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