JP5976100B2 - 神経精神障害の処置のための化合物 - Google Patents

神経精神障害の処置のための化合物 Download PDF

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JP5976100B2
JP5976100B2 JP2014506582A JP2014506582A JP5976100B2 JP 5976100 B2 JP5976100 B2 JP 5976100B2 JP 2014506582 A JP2014506582 A JP 2014506582A JP 2014506582 A JP2014506582 A JP 2014506582A JP 5976100 B2 JP5976100 B2 JP 5976100B2
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enzyme
symptoms
pharmaceutical composition
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disorder
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JP2014512390A5 (enExample
JP2014512390A (ja
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ジョーン エム． ファロン
ジョーン エム． ファロン
マシュー ハイル
マシュー ハイル
ジェイムズ エフ． シゲティ
ジェイムズ エフ． シゲティ
ジェイムズ ジェイ． ファロン
ジェイムズ ジェイ． ファロン
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キュアマーク リミテッド ライアビリティ カンパニー
キュアマーク リミテッド ライアビリティ カンパニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2014506582A 2011-04-21 2012-04-20 神経精神障害の処置のための化合物 Active JP5976100B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477988P 2011-04-21 2011-04-21
US61/477,988 2011-04-21
PCT/US2012/034489 WO2012145651A2 (en) 2011-04-21 2012-04-20 Compounds for the treatment of neuropsychiatric disorders

Related Child Applications (1)

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JP2016141004A Division JP6404278B2 (ja) 2011-04-21 2016-07-19 神経精神障害の処置のための化合物

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JP2014512390A JP2014512390A (ja) 2014-05-22
JP2014512390A5 JP2014512390A5 (enExample) 2015-05-07
JP5976100B2 true JP5976100B2 (ja) 2016-08-23

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JP2016141004A Expired - Fee Related JP6404278B2 (ja) 2011-04-21 2016-07-19 神経精神障害の処置のための化合物

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US (6) US8980252B2 (enExample)
EP (2) EP3305317B1 (enExample)
JP (2) JP5976100B2 (enExample)
CN (2) CN103619348B (enExample)
AU (2) AU2012245287B2 (enExample)
BR (1) BR112013027034A8 (enExample)
CA (1) CA2837134C (enExample)
DK (2) DK3305317T3 (enExample)
ES (2) ES2726978T3 (enExample)
GB (1) GB2503852B (enExample)
HU (1) HUE050873T2 (enExample)
MX (2) MX362974B (enExample)
WO (1) WO2012145651A2 (enExample)

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US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US11016104B2 (en) 2008-07-01 2021-05-25 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
US20100092447A1 (en) 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
EP3064217B1 (en) 2009-01-06 2018-04-18 Galenagen, LLC Compositions comprising protease, amylase and lipase for use in the treatment of staphylococcus aureus infections
GB2480773B (en) 2009-01-06 2013-12-11 Curelon Llc Compositions for the treatment of diarrhea caused by virulent E. coli infections
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
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EP3305317B1 (en) * 2011-04-21 2020-06-24 Curemark, LLC Compounds for the treatment of neuropsychiatric disorders
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
WO2018191233A1 (en) * 2017-04-10 2018-10-18 Curemark, Llc Compositions for treating addiction
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
WO2025188992A1 (en) * 2024-03-06 2025-09-12 Neurelis, Inc. Oral film for rapid active delivery

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BR112013027034A2 (pt) 2016-09-06
EP2701733A4 (en) 2014-12-31
US20140127184A1 (en) 2014-05-08
CN103619348A (zh) 2014-03-05
CN106310242A (zh) 2017-01-11
JP2014512390A (ja) 2014-05-22
MX347770B (es) 2017-05-12
JP2016216494A (ja) 2016-12-22
US20240156924A1 (en) 2024-05-16
MX362974B (es) 2019-02-28
EP3305317B1 (en) 2020-06-24
JP6404278B2 (ja) 2018-10-10
DK3305317T3 (da) 2020-07-20
ES2804223T3 (es) 2021-02-04
AU2012245287A1 (en) 2013-11-07
US10279016B2 (en) 2019-05-07
US10940187B2 (en) 2021-03-09
DK2701733T3 (da) 2019-05-27
EP2701733B1 (en) 2019-04-03
ES2726978T3 (es) 2019-10-11
AU2012245287B2 (en) 2017-04-13
CN106310242B (zh) 2020-02-28
AU2017203919A1 (en) 2017-06-29
AU2017203919C1 (en) 2020-05-28
GB2503852B (en) 2018-12-12
US20150147308A1 (en) 2015-05-28
US20190183990A1 (en) 2019-06-20
HK1250640A1 (en) 2019-01-11
US20170189501A1 (en) 2017-07-06
CA2837134A1 (en) 2012-10-26
US20210145947A1 (en) 2021-05-20
US8980252B2 (en) 2015-03-17
BR112013027034A8 (pt) 2018-01-02
AU2017203919B2 (en) 2019-08-29
CN103619348B (zh) 2016-10-26
WO2012145651A3 (en) 2013-01-17
EP2701733A2 (en) 2014-03-05
MX2013012130A (es) 2014-02-27

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