JP5971945B2 - カチオン性脂質の鏡像異性体による免疫応答の刺激 - Google Patents
カチオン性脂質の鏡像異性体による免疫応答の刺激 Download PDFInfo
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- JP5971945B2 JP5971945B2 JP2011505132A JP2011505132A JP5971945B2 JP 5971945 B2 JP5971945 B2 JP 5971945B2 JP 2011505132 A JP2011505132 A JP 2011505132A JP 2011505132 A JP2011505132 A JP 2011505132A JP 5971945 B2 JP5971945 B2 JP 5971945B2
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- Prior art keywords
- dotap
- antigen
- ccl
- cationic lipid
- antigens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4583708P | 2008-04-17 | 2008-04-17 | |
| US61/045,837 | 2008-04-17 | ||
| PCT/US2009/040500 WO2009129227A1 (en) | 2008-04-17 | 2009-04-14 | Stimulation of an immune response by enantiomers of cationic lipids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011518170A JP2011518170A (ja) | 2011-06-23 |
| JP2011518170A5 JP2011518170A5 (OSRAM) | 2013-05-23 |
| JP5971945B2 true JP5971945B2 (ja) | 2016-08-17 |
Family
ID=41199446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011505132A Active JP5971945B2 (ja) | 2008-04-17 | 2009-04-14 | カチオン性脂質の鏡像異性体による免疫応答の刺激 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US9789129B2 (OSRAM) |
| EP (1) | EP2276495B1 (OSRAM) |
| JP (1) | JP5971945B2 (OSRAM) |
| CN (2) | CN102137675A (OSRAM) |
| AU (1) | AU2009236306B2 (OSRAM) |
| BR (1) | BRPI0910464B1 (OSRAM) |
| CA (1) | CA2721366C (OSRAM) |
| ES (1) | ES2712505T3 (OSRAM) |
| IL (1) | IL208713A (OSRAM) |
| PL (1) | PL2276495T3 (OSRAM) |
| RU (1) | RU2530555C2 (OSRAM) |
| TW (1) | TWI449534B (OSRAM) |
| WO (1) | WO2009129227A1 (OSRAM) |
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| US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| BRPI0910464B1 (pt) | 2008-04-17 | 2021-08-10 | Pds Biotechnology Corporation | Uso de uso de um lipídio catiônico quiral consistindo de r-dotap a preparação de composição farmacêutica |
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| JP2011184344A (ja) * | 2010-03-08 | 2011-09-22 | Kao Corp | p21発現促進剤 |
| RU2625546C2 (ru) | 2010-07-06 | 2017-07-14 | Новартис Аг | Катионные эмульсии "масло-в-воде" |
| HRP20230443T1 (hr) | 2011-05-24 | 2023-09-15 | BioNTech SE | Individualizirana cjepiva protiv raka |
| AU2012280901B2 (en) | 2011-07-06 | 2016-11-10 | Glaxosmithkline Biologicals S.A. | Oil-in-water emulsions that contain nucleic acids |
| RU2649133C2 (ru) | 2011-07-06 | 2018-03-29 | Новартис Аг | Катионные эмульсии масло-в-воде |
| US20150110823A1 (en) * | 2011-09-12 | 2015-04-23 | Pds Biotechnology Corporation | Particulate vaccine formulations |
| WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| RU2649365C2 (ru) * | 2012-06-15 | 2018-04-02 | ПиДиЭс БАЙОТЕКНОЛОДЖИ КОРПОРЭЙШН | Вакцинные композиции с катионными липидами и способы применения |
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| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| JP2017501172A (ja) * | 2013-12-16 | 2017-01-12 | メルク パテント ゲーエムベーハー | サバイビン指向性癌ワクチン治療 |
| WO2016045732A1 (en) | 2014-09-25 | 2016-03-31 | Biontech Rna Pharmaceuticals Gmbh | Stable formulations of lipids and liposomes |
| WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| WO2017059902A1 (en) | 2015-10-07 | 2017-04-13 | Biontech Rna Pharmaceuticals Gmbh | 3' utr sequences for stabilization of rna |
| EP3374496A4 (en) * | 2015-11-13 | 2019-07-10 | PDS Biotechnology Corporation | LIPIDES AS SYNTHETIC VECTORS FOR IMPROVING ANTIGEN PROCESSING AND PRESENTATION EX-VIVO IN DENDRITIC CELL THERAPY |
| JP2019500021A (ja) * | 2015-11-13 | 2019-01-10 | ピーディーエス バイオテクノロジー コーポレイションPds Biotechnology Corporation | 樹状細胞療法においてex vivoでの抗原のプロセシングと提示を亢進させるための合成ベクターとしての脂質 |
| US20180221475A1 (en) * | 2016-10-05 | 2018-08-09 | Pds Biotechnology Corporation | Methods to alter the tumor microenvironment for effective cancer immunotherapy |
| JP6963019B2 (ja) * | 2016-10-31 | 2021-11-05 | アイジーン インコーポレイテッドEyegene Inc. | 免疫調節剤及び陽イオン性リポソームを含む免疫増強用組成物及びその用途 |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| TW201924722A (zh) * | 2017-12-05 | 2019-07-01 | 美商Pds生技公司 | 用於刺激第i型干擾素基因之方法及包含陽離子脂質的組合物 |
| KR20220114556A (ko) * | 2019-11-18 | 2022-08-17 | 칠드런'즈 메디컬 센터 코포레이션 | 암 면역요법을 위한 상주 수지상 세포를 과다활성화시키는 자극제 |
| CA3198708A1 (en) * | 2020-11-20 | 2022-05-27 | Frank Bedu-Addo | Methods and compositions comprising cationic lipids for immunotherapy by direct tumor injection |
| JP2025535364A (ja) * | 2022-10-19 | 2025-10-24 | ピーディーエス バイオテクノロジー コーポレイション | ムチン1タンパク質を発現するヒトがんを治療するための新規のt細胞活性化免疫療法剤 |
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| US20210308157A1 (en) | 2021-10-07 |
| US20180015114A1 (en) | 2018-01-18 |
| BRPI0910464B1 (pt) | 2021-08-10 |
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