AU2009236306B2 - Stimulation of an immune response by enantiomers of cationic lipids - Google Patents

Stimulation of an immune response by enantiomers of cationic lipids Download PDF

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Publication number
AU2009236306B2
AU2009236306B2 AU2009236306A AU2009236306A AU2009236306B2 AU 2009236306 B2 AU2009236306 B2 AU 2009236306B2 AU 2009236306 A AU2009236306 A AU 2009236306A AU 2009236306 A AU2009236306 A AU 2009236306A AU 2009236306 B2 AU2009236306 B2 AU 2009236306B2
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Prior art keywords
enantiomer
dotap
patient
antigen
cationic lipid
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AU2009236306A1 (en
Inventor
Frank Bedu-Addo
Weihsu Chen
Gregory Conn
Leaf Huang
Kenya Toney
Elizabeth Ann Vasievich
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PDS Biotechnology Corp
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PDS Biotechnology Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2009236306A 2008-04-17 2009-04-14 Stimulation of an immune response by enantiomers of cationic lipids Active AU2009236306B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4583708P 2008-04-17 2008-04-17
US61/045,837 2008-04-17
PCT/US2009/040500 WO2009129227A1 (en) 2008-04-17 2009-04-14 Stimulation of an immune response by enantiomers of cationic lipids

Publications (2)

Publication Number Publication Date
AU2009236306A1 AU2009236306A1 (en) 2009-10-22
AU2009236306B2 true AU2009236306B2 (en) 2015-04-02

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AU2009236306A Active AU2009236306B2 (en) 2008-04-17 2009-04-14 Stimulation of an immune response by enantiomers of cationic lipids

Country Status (13)

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US (4) US9789129B2 (OSRAM)
EP (1) EP2276495B1 (OSRAM)
JP (1) JP5971945B2 (OSRAM)
CN (2) CN110075113A (OSRAM)
AU (1) AU2009236306B2 (OSRAM)
BR (1) BRPI0910464B1 (OSRAM)
CA (1) CA2721366C (OSRAM)
ES (1) ES2712505T3 (OSRAM)
IL (1) IL208713A (OSRAM)
PL (1) PL2276495T3 (OSRAM)
RU (1) RU2530555C2 (OSRAM)
TW (1) TWI449534B (OSRAM)
WO (1) WO2009129227A1 (OSRAM)

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US20190321321A1 (en) * 2017-12-05 2019-10-24 Pds Biotechnology Coporation Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes
US20230076515A1 (en) * 2019-11-18 2023-03-09 Children's Medical Center Corporation Stimuli that hyperactivate resident dendritic cells for cancer immunotherapy
JP2023551444A (ja) * 2020-11-20 2023-12-08 ピーディーエス バイオテクノロジー コーポレイション 腫瘍内直接注射による免疫療法のための、方法及び陽イオン性脂質を含む組成物
EP4604990A2 (en) * 2022-10-19 2025-08-27 PDS Biotechnology Corporation Novel t cell activating immunotherapeutic for treatment of mucin 1 protein expressing human cancers

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