JP5937007B2 - 発泡性エアゾール組成物 - Google Patents
発泡性エアゾール組成物 Download PDFInfo
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- JP5937007B2 JP5937007B2 JP2012533043A JP2012533043A JP5937007B2 JP 5937007 B2 JP5937007 B2 JP 5937007B2 JP 2012533043 A JP2012533043 A JP 2012533043A JP 2012533043 A JP2012533043 A JP 2012533043A JP 5937007 B2 JP5937007 B2 JP 5937007B2
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- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 229940119676 diethoxyethyl succinate Drugs 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- GMSCBRSQMRDRCD-UHFFFAOYSA-N dodecyl 2-methylprop-2-enoate Chemical compound CCCCCCCCCCCCOC(=O)C(C)=C GMSCBRSQMRDRCD-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229940108623 eicosenoic acid Drugs 0.000 description 1
- BITHHVVYSMSWAG-UHFFFAOYSA-N eicosenoic acid Natural products CCCCCCCCC=CCCCCCCCCCC(O)=O BITHHVVYSMSWAG-UHFFFAOYSA-N 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 229960000192 felbinac Drugs 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 125000002350 geranyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 229960002389 glycol salicylate Drugs 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- OIKBVOIOVNEVJR-UHFFFAOYSA-N hexadecyl 6-methylheptanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCC(C)C OIKBVOIOVNEVJR-UHFFFAOYSA-N 0.000 description 1
- OGEMCJNRDGZFQF-UHFFFAOYSA-N hexyl 2-benzoyl-4-(diethylamino)-3-hydroxybenzoate Chemical compound CCCCCCOC(=O)C1=CC=C(N(CC)CC)C(O)=C1C(=O)C1=CC=CC=C1 OGEMCJNRDGZFQF-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229910052919 magnesium silicate Inorganic materials 0.000 description 1
- 235000019792 magnesium silicate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 235000006109 methionine Nutrition 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 229960005040 miconazole nitrate Drugs 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 229960001173 oxybenzone Drugs 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 229920000223 polyglycerol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229940068984 polyvinyl alcohol Drugs 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229940093625 propylene glycol monostearate Drugs 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229940071139 pyrrolidone carboxylate Drugs 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011863 silicon-based powder Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940035044 sorbitan monolaurate Drugs 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 229960004718 sulconazole nitrate Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
乳化するまでに上下に振った回数を測定した。
◎:10回以内に乳化した。
○:11〜20回で乳化した。
△:21〜30回で乳化した。
×:30回で乳化しなかった。
乳化させた後に容器を室温で静置し、分離し始める時間を測定した。
◎:30日以上分離しなかった。
○:15日で分離し始めた。
△:7日以内に分離し始めた。
×:1日以内に分離した。
容器を25℃の恒温水槽中に1時間保持し、エアゾール組成物0.5gを腕に吐出して塗り拡げたときの状態を評価した。
◎:パチパチと大きな破泡音を発し、液垂れせずに均等に塗り拡げることができた。
○:パチパチと破泡音を発し、液垂れせずに均等に塗り拡げることができた。
△:小さな破泡音を発した。塗り伸ばしているときに一部が液垂れした。
×1:パチパチと破泡音を発せず、また伸ばしているときに液垂れが生じた。
×2:発泡せずに飛び散った。
容器を25℃の恒温水槽中に1時間保持し、エアゾール組成物0.5gを腕に吐出して塗り拡げたときの冷却感を評価した。
◎:非常に心地よい冷却効果が得られた。
○:冷却効果が得られた。
×:冷却効果は得られなかった。
―:適切に塗布できなかったため評価せず。
表1に示す原液を調製し、該原液20g(40重量%)を透明なポリエチレンテレフタレート製耐圧容器に充填してエアゾールバルブを固着した。次いで液化ガスとして液化石油ガス(*1)を30g(60重量%)充填し、容器を上下に振って原液と液化ガスとを乳化させ、消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表2に示す。
*2:NIKKOL TL−10(商品名)、HLB:16.9、日光ケミカルズ株式会社
*3:NIKKOL GO−460V(商品名)、HLB:14.0、日光ケミカルズ株式会社
*4:NIKKOL HCO−40(商品名)、HLB:12.5、日光ケミカルズ株式会社
*5:NIKKOL BL−2(商品名)、HLB:9.5、日光ケミカルズ株式会社
*6:NIKKOL BC−20TX(商品名)、HLB:17.0、日光ケミカルズ株式会社
*7:HEC−SE850(商品名)、新田ゼラチン株式会社
*8:サイロスフェアC−1504(商品名)、富士シリシア化学株式会社
液化石油ガス(*1) 60.0
合計 100.0重量%
実施例3の原液25g(50重量%)、液化ガスとして液化石油ガス(*1)を25g(50重量%)用いたこと以外は実施例1と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表2に示す。
実施例3の原液30g(60重量%)、液化ガスとして液化石油ガス(*1)を20g(40重量%)用いたこと以外は実施例1と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表2に示す。
実施例3の原液10g(20重量%)、液化ガスとして液化石油ガス(*1)を40g(80重量%)用いたこと以外は実施例1と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表2に示す。
表3に示す原液を用いたこと以外は、実施例1と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表4に示す。
*10:NIKKOL HCO−10(商品名)、HLB:6.5、日光ケミカルズ株式会社
*11:NIKKOL BC−40(商品名)、HLB20.0、日光ケミカルズ株式会社
*12:NIKKOL BO−2(商品名)、HLB:7.5、日光ケミカルズ株式会社
*13:NIKKOL PBC−44(商品名)、HLB:12.5、日光ケミカルズ株式会社
実施例3の原液2.5g(5重量%)、液化ガスとして液化石油ガス(*1)を47.5g(95重量%)用いたこと以外は実施例1と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表4に示す。
実施例3の原液35g(70重量%)、液化ガスとして液化石油ガス(*1)を15g(30重量%)用いたこと以外は実施例1と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表4に示す。
表5に示す原液を調製し、該原液20g(40重量%)を透明なポリエチレンテレフタレート製耐圧容器に充填してエアゾールバルブを固着した。次いで液化ガスとして液化石油ガス(*1)を30g(60重量%)充填し、容器を上下に振って原液と液化ガスとを乳化させ、害虫忌避用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表6に示す。
表7に示す原液を調製し、該原液20g(40重量%)を透明なポリエチレンテレフタレート製耐圧容器に充填してエアゾールバルブを固着した。次いで液化ガスとして液化石油ガス(*1)を30g(60重量%)充填し、容器を上下に振って原液と液化ガスとを乳化させ、日焼け止め用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表8に示す。
表9に示す原液を調製し、該原液25g(50重量%)を透明なポリエチレンテレフタレート製耐圧容器に充填してエアゾールバルブを固着した。次いで液化ガスとして液化石油ガス(*1)を25g(50重量%)充填し、容器を上下に振って原液と液化ガスとを乳化させ、消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表10に示す。
液化ガスとして液化石油ガス(*15)を使用したこと以外は実施例22と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表10に示す。
*15:20℃での蒸気圧が0.30MPa、20℃における水への溶解度が1重量%以下、プロパン、ノルマルブタン、イソブタンの混合物
液化ガスとして液化石油ガス(*1)とジメチルエーテルの混合ガス(*16)を使用したこと以外は実施例22と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表10に示す。
*16:液化石油ガス/ジメチルエーテル=70/30、20℃での蒸気圧が0.29MPa、20℃における水への溶解度が3.3重量%
液化ガスとしてジメチルエーテル(*17)を使用したこと以外は実施例22と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表10に示す。
*17:20℃での蒸気圧が0.42MPa、20℃における水への溶解度が33重量%
表11に示す原液を調製し、該原液20g(40重量%)を透明なポリエチレンテレフタレート製耐圧容器に充填してエアゾールバルブを固着した。次いで液化ガスとして液化石油ガス(*1)を30g(60重量%)充填し、容器を上下に振って原液と液化ガスとを乳化させ、消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表12に示す。
実施例22と同じ原液10g(20重量%)を透明なポリエチレンテレフタレート製耐圧容器に充填してエアゾールバルブを固着した。次いで液化ガスとしてトランス−1,3,3,3,−テトラフルオロプロパ−1−エン(*20)を40g(80重量%)充填し、容器を上下に振って原液と液化ガスとを乳化させ、消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表13に示す。
*20:20℃での蒸気圧が0.42MPa、20℃における水への溶解度が1重量%以下
実施例22と同じ原液15g(30重量%)、液化ガスとしてトランス−1,3,3,3,−テトラフルオロプロパ−1−エン(*20)を35g(70重量%)充填したこと以外は実施例25と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表13に示す。
実施例22と同じ原液35g(70重量%)、液化ガスとしてトランス−1,3,3,3,−テトラフルオロプロパ−1−エン(*20)を15g(30重量%)充填したこと以外は実施例25と同様にして消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表13に示す。
表14に示す原液を調製し、該原液20g(40重量%)を透明なポリエチレンテレフタレート製耐圧容器に充填してエアゾールバルブを固着した。次いで液化ガスとして液化石油ガス(*1)を30g(60重量%)充填し、容器を上下に振って原液と液化ガスとを乳化させ、消炎鎮痛用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表15に示す。
表16に示す原液を調製し、該原液20g(40重量%)を透明なポリエチレンテレフタレート製耐圧容器に充填してエアゾールバルブを固着した。次いで液化ガスとして液化石油ガス(*1)を30g(60重量%)充填し、容器を上下に振って原液と液化ガスとを乳化させ、清涼用エアゾール組成物が充填されたエアゾール製品を調製した。得られたエアゾール製品について、乳化のしやすさ、乳化安定性、使用感および冷却感を評価した。結果を表17に示す。
Claims (7)
- 原液と液化ガスとからなる発泡性エアゾール組成物であって、
前記原液が有効成分、界面活性剤、炭素数が2〜3の1価アルコールおよび水を配合してなり、
前記有効成分が、25℃における水への溶解度が10重量%未満である難水溶性有効成分であり、
前記難水溶性有効成分は、消炎鎮痛剤、清涼化剤、紫外線吸収剤、害虫忌避剤、酸化防止剤、ビタミン類、抗炎症剤、抗真菌剤、消臭成分および香料からなる群から選ばれる少なくとも1つであり、
前記炭素数が2〜3の1価アルコールの配合量が原液中5〜35重量%であり、
前記水の配合量が原液中50〜80重量%であり、
前記難水溶性有効成分の配合量が原液中10〜30重量%であり、
前記界面活性剤がポリオキシエチレン付加型の脂肪酸エステルおよびHLBが8〜19である非イオン界面活性剤を含有し、
前記液化ガスが、20℃における水への溶解度が5重量%未満である難水溶性液化ガスであり、
前記原液と前記液化ガスとの配合比が60/40〜10/90(重量比)であり、
前記原液と前記液化ガスとが乳化している発泡性エアゾール組成物。 - 前記ポリオキシエチレン付加型の脂肪酸エステルがポリオキシエチレンソルビタン脂肪酸エステルである請求項1記載の発泡性エアゾール組成物。
- 前記非イオン界面活性剤がポリオキシエチレン硬化ヒマシ油および/またはエーテル系界面活性剤である請求項1または2記載の発泡性エアゾール組成物。
- 前記難水溶性有効成分が紫外線吸収剤である請求項1〜3のいずれか1項に記載の発泡性エアゾール組成物。
- 前記難水溶性有効成分が消炎鎮痛剤である請求項1〜3のいずれか1項に記載の発泡性エアゾール組成物。
- 前記液化ガスの20℃における水への溶解度は、3.3重量%以下である、請求項1〜5記載の発泡性エアゾール組成物。
- 前記液化ガス中に脂肪族炭化水素が含まれ、
前記脂肪族炭化水素の配合量は、液化ガス中に60重量%以上である、請求項1〜6記載の発泡性エアゾール組成物。
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