JP5905184B2 - 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物 - Google Patents

自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物 Download PDF

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JP5905184B2
JP5905184B2 JP2008535568A JP2008535568A JP5905184B2 JP 5905184 B2 JP5905184 B2 JP 5905184B2 JP 2008535568 A JP2008535568 A JP 2008535568A JP 2008535568 A JP2008535568 A JP 2008535568A JP 5905184 B2 JP5905184 B2 JP 5905184B2
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neutrokine
alpha
patient
antibody
antagonist
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JP2009521398A (ja
JP2009521398A5 (enExample
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マーク シェブリアー，
マーク シェブリアー，
ウィリアム フリームス，
ウィリアム フリームス，
チェンシャオ チョン，
チェンシャオ チョン，
ダニエル オーデンハイマー，
ダニエル オーデンハイマー，
メリッサ ディー． パーキンス，
メリッサ ディー． パーキンス，
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Human Genome Sciences Inc
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Human Genome Sciences Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
JP2008535568A 2005-10-13 2006-10-05 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物 Active JP5905184B2 (ja)

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US72562505P 2005-10-13 2005-10-13
US72562705P 2005-10-13 2005-10-13
US72562905P 2005-10-13 2005-10-13
US72562605P 2005-10-13 2005-10-13
US72562805P 2005-10-13 2005-10-13
US60/725,628 2005-10-13
US60/725,629 2005-10-13
US60/725,627 2005-10-13
US60/725,626 2005-10-13
US60/725,625 2005-10-13
US73596705P 2005-11-14 2005-11-14
US73596405P 2005-11-14 2005-11-14
US73598805P 2005-11-14 2005-11-14
US73598705P 2005-11-14 2005-11-14
US73596305P 2005-11-14 2005-11-14
US60/735,963 2005-11-14
US60/735,988 2005-11-14
US60/735,987 2005-11-14
US60/735,967 2005-11-14
US60/735,964 2005-11-14
US77666006P 2006-02-27 2006-02-27
US77666506P 2006-02-27 2006-02-27
US77665806P 2006-02-27 2006-02-27
US77666406P 2006-02-27 2006-02-27
US77665906P 2006-02-27 2006-02-27
US60/776,664 2006-02-27
US60/776,658 2006-02-27
US60/776,660 2006-02-27
US60/776,665 2006-02-27
US60/776,659 2006-02-27
US78138706P 2006-03-13 2006-03-13
US60/781,387 2006-03-13
US78755706P 2006-03-31 2006-03-31
US60/787,557 2006-03-31
US79735106P 2006-05-04 2006-05-04
US79736006P 2006-05-04 2006-05-04
US60/797,360 2006-05-04
US60/797,351 2006-05-04
US81486906P 2006-06-20 2006-06-20
US81487006P 2006-06-20 2006-06-20
US60/814,870 2006-06-20
US60/814,869 2006-06-20
US81555806P 2006-06-22 2006-06-22
US81555906P 2006-06-22 2006-06-22
US60/815,558 2006-06-22
US60/815,559 2006-06-22
US81582706P 2006-06-23 2006-06-23
US60/815,827 2006-06-23
US83415006P 2006-07-31 2006-07-31
US83415206P 2006-07-31 2006-07-31
US60/834,152 2006-07-31
US60/834,150 2006-07-31
PCT/US2006/038756 WO2007142667A2 (en) 2005-10-13 2006-10-05 Treatment of patients with autoantibody positive disease

Related Child Applications (2)

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JP2012253135A Division JP5936994B2 (ja) 2005-10-13 2012-11-19 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物
JP2012253134A Division JP2013040207A (ja) 2005-10-13 2012-11-19 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物

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JP2009521398A JP2009521398A (ja) 2009-06-04
JP2009521398A5 JP2009521398A5 (enExample) 2009-11-26
JP5905184B2 true JP5905184B2 (ja) 2016-04-20

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JP2008535568A Active JP5905184B2 (ja) 2005-10-13 2006-10-05 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物
JP2012253134A Pending JP2013040207A (ja) 2005-10-13 2012-11-19 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物
JP2012253135A Active JP5936994B2 (ja) 2005-10-13 2012-11-19 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物

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JP2012253134A Pending JP2013040207A (ja) 2005-10-13 2012-11-19 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物
JP2012253135A Active JP5936994B2 (ja) 2005-10-13 2012-11-19 自己抗体陽性疾患を有する患者の処置に使用するための方法および組成物

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US (3) US20070086979A1 (enExample)
EP (2) EP1933873A4 (enExample)
JP (3) JP5905184B2 (enExample)
KR (2) KR20080074120A (enExample)
AU (1) AU2006344395B2 (enExample)
CA (1) CA2626082C (enExample)
EA (1) EA015860B1 (enExample)
HK (1) HK1222681A1 (enExample)
IL (2) IL190733A0 (enExample)
NO (1) NO20081842L (enExample)
NZ (2) NZ568204A (enExample)
WO (1) WO2007142667A2 (enExample)

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US20090081231A1 (en) 2009-03-26
JP2009521398A (ja) 2009-06-04
JP5936994B2 (ja) 2016-06-22
KR20140077946A (ko) 2014-06-24
JP2013032402A (ja) 2013-02-14
HK1222681A1 (en) 2017-07-07
AU2006344395B2 (en) 2013-05-02
EP3037544A1 (en) 2016-06-29

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