JP5891334B2 - ソリフェナシン又はその塩の製造方法及びここに用いられる新規な中間体 - Google Patents

ソリフェナシン又はその塩の製造方法及びここに用いられる新規な中間体 Download PDF

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Publication number
JP5891334B2
JP5891334B2 JP2015501582A JP2015501582A JP5891334B2 JP 5891334 B2 JP5891334 B2 JP 5891334B2 JP 2015501582 A JP2015501582 A JP 2015501582A JP 2015501582 A JP2015501582 A JP 2015501582A JP 5891334 B2 JP5891334 B2 JP 5891334B2
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Prior art keywords
solifenacin
general formula
reaction
salt
producing
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Japanese (ja)
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JP2015510927A (ja
Inventor
ソク イ、ビョン
ソク イ、ビョン
フン シン、サン
フン シン、サン
ヨン イ、キ
ヨン イ、キ
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Kyung Dong Pharmaceutical Co Ltd
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Kyung Dong Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2015501582A 2012-03-28 2013-03-21 ソリフェナシン又はその塩の製造方法及びここに用いられる新規な中間体 Active JP5891334B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20120031492A KR101365849B1 (ko) 2012-03-28 2012-03-28 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체
KR10-2012-0031492 2012-03-28
PCT/KR2013/002358 WO2013147458A1 (en) 2012-03-28 2013-03-21 Process of preparing solifenacin or salt thereof, and novel intermediate used in the process

Publications (2)

Publication Number Publication Date
JP2015510927A JP2015510927A (ja) 2015-04-13
JP5891334B2 true JP5891334B2 (ja) 2016-03-22

Family

ID=49260649

Family Applications (1)

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JP2015501582A Active JP5891334B2 (ja) 2012-03-28 2013-03-21 ソリフェナシン又はその塩の製造方法及びここに用いられる新規な中間体

Country Status (9)

Country Link
US (1) US9018379B1 (https=)
EP (1) EP2831070A4 (https=)
JP (1) JP5891334B2 (https=)
KR (1) KR101365849B1 (https=)
CN (1) CN104169280A (https=)
AU (1) AU2013240842B2 (https=)
BR (1) BR112014021223A2 (https=)
IN (1) IN2014DN07762A (https=)
WO (1) WO2013147458A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116986986A (zh) * 2023-07-19 2023-11-03 杭州国瑞生物科技有限公司 一种3-氧代-1-环丁烷羧酸中间体的合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2005012I1 (no) 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
EP0888543A4 (en) * 1996-03-20 2004-04-07 Scripps Research Inst CHANNEL ESTIMATION DEVICE
KR100669823B1 (ko) 2001-02-20 2007-01-17 경동제약 주식회사 2-(4-클로로벤조일아미노)-3-[2(1ｈ)-퀴놀리논-4-일]프로피온산의 제조방법 및 그 중간체
US20040157804A1 (en) * 2002-10-16 2004-08-12 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
GB0312426D0 (en) * 2003-05-30 2003-07-09 Albachem Ltd Purification means
CA2558877A1 (en) 2004-02-09 2005-08-18 Astellas Pharma Inc. Solifenacin succinate-containing composition
JPWO2005087231A1 (ja) 2004-03-16 2008-01-24 アステラス製薬株式会社 ソリフェナシン含有組成物
EP1742642B1 (en) * 2004-04-14 2008-10-15 Gilead Sciences, Inc. Phosphonate analogs of hiv integrase inhibitor compounds
JP4803352B2 (ja) * 2005-07-13 2011-10-26 Ｊｓｒ株式会社 アミノ酸−ｎ−カルボキシ無水物の製造方法
CA2630846A1 (en) 2005-12-21 2007-07-05 Teva Pharmaceutical Industries Ltd. Intermediates for preparing solifenacin
EP2102200A2 (en) 2006-11-22 2009-09-23 Medichem, S.A. An improved process for the synthesis of solifenacin
CN101711248A (zh) * 2007-03-30 2010-05-19 医药化学公司 一种改进的素非那新合成工艺
JP2009538362A (ja) * 2007-07-13 2009-11-05 テバ ファーマシューティカル インダストリーズ リミティド ソリフェナシンの調製方法
HRP20161040T1 (hr) * 2008-04-29 2016-12-16 Ascendis Pharma Growth Disorders Division A/S Pegilirani rekombinantni spojevi ljudskog hormona rasta
PL2406257T3 (pl) * 2009-03-09 2020-01-31 Megafine Pharma (P) Ltd. Nowy sposób wytwarzania solifenacyny i jej nowy produkt pośredni
US8178700B2 (en) * 2009-05-04 2012-05-15 International Business Machines Corporation Method of preparing cyclic carbonates, cyclic carbamates, cyclic ureas, cyclic thiocarbonates, cyclic thiocarbamates, and cyclic dithiocarbonates
WO2011030139A1 (en) * 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators

Also Published As

Publication number Publication date
JP2015510927A (ja) 2015-04-13
US20150112072A1 (en) 2015-04-23
US9018379B1 (en) 2015-04-28
EP2831070A1 (en) 2015-02-04
AU2013240842A1 (en) 2014-08-28
WO2013147458A1 (en) 2013-10-03
KR20130109609A (ko) 2013-10-08
KR101365849B1 (ko) 2014-02-24
EP2831070A4 (en) 2015-08-19
CN104169280A (zh) 2014-11-26
AU2013240842B2 (en) 2015-09-03
IN2014DN07762A (https=) 2015-05-15
BR112014021223A2 (pt) 2020-10-27

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