KR101365849B1 - 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체 - Google Patents

솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체 Download PDF

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Publication number
KR101365849B1
KR101365849B1 KR20120031492A KR20120031492A KR101365849B1 KR 101365849 B1 KR101365849 B1 KR 101365849B1 KR 20120031492 A KR20120031492 A KR 20120031492A KR 20120031492 A KR20120031492 A KR 20120031492A KR 101365849 B1 KR101365849 B1 KR 101365849B1
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KR
South Korea
Prior art keywords
formula
solifenacin
reaction
toluene
added
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KR20120031492A
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English (en)
Korean (ko)
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KR20130109609A (ko
Inventor
이병석
신상훈
이기영
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경동제약 주식회사
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Priority to KR20120031492A priority Critical patent/KR101365849B1/ko
Application filed by 경동제약 주식회사 filed Critical 경동제약 주식회사
Priority to EP13768214.2A priority patent/EP2831070A4/en
Priority to IN7762DEN2014 priority patent/IN2014DN07762A/en
Priority to AU2013240842A priority patent/AU2013240842B2/en
Priority to JP2015501582A priority patent/JP5891334B2/ja
Priority to CN201380016063.XA priority patent/CN104169280A/zh
Priority to US14/382,529 priority patent/US9018379B1/en
Priority to PCT/KR2013/002358 priority patent/WO2013147458A1/en
Priority to BR112014021223-6A priority patent/BR112014021223A2/pt
Publication of KR20130109609A publication Critical patent/KR20130109609A/ko
Application granted granted Critical
Publication of KR101365849B1 publication Critical patent/KR101365849B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR20120031492A 2012-03-28 2012-03-28 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체 Active KR101365849B1 (ko)

Priority Applications (9)

Application Number Priority Date Filing Date Title
KR20120031492A KR101365849B1 (ko) 2012-03-28 2012-03-28 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체
IN7762DEN2014 IN2014DN07762A (https=) 2012-03-28 2013-03-21
AU2013240842A AU2013240842B2 (en) 2012-03-28 2013-03-21 Process of preparing solifenacin or salt thereof, and novel intermediate used in the process
JP2015501582A JP5891334B2 (ja) 2012-03-28 2013-03-21 ソリフェナシン又はその塩の製造方法及びここに用いられる新規な中間体
EP13768214.2A EP2831070A4 (en) 2012-03-28 2013-03-21 METHOD FOR THE PRODUCTION OF SOLIFENACIN OR A SALT THEREOF AND NOVEL INTERMEDIATE PRODUCT USED IN THE PROCESS
CN201380016063.XA CN104169280A (zh) 2012-03-28 2013-03-21 制备索利那辛或其盐的方法和用于该方法的新型中间体
US14/382,529 US9018379B1 (en) 2012-03-28 2013-03-21 Process of preparing solifenacin or salt thereof, and novel intermediate used in the process
PCT/KR2013/002358 WO2013147458A1 (en) 2012-03-28 2013-03-21 Process of preparing solifenacin or salt thereof, and novel intermediate used in the process
BR112014021223-6A BR112014021223A2 (pt) 2012-03-28 2013-03-21 processo de preparar solifenacina ou sal deste, e intermediário inédito usado no processo

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20120031492A KR101365849B1 (ko) 2012-03-28 2012-03-28 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체

Publications (2)

Publication Number Publication Date
KR20130109609A KR20130109609A (ko) 2013-10-08
KR101365849B1 true KR101365849B1 (ko) 2014-02-24

Family

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KR20120031492A Active KR101365849B1 (ko) 2012-03-28 2012-03-28 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체

Country Status (9)

Country Link
US (1) US9018379B1 (https=)
EP (1) EP2831070A4 (https=)
JP (1) JP5891334B2 (https=)
KR (1) KR101365849B1 (https=)
CN (1) CN104169280A (https=)
AU (1) AU2013240842B2 (https=)
BR (1) BR112014021223A2 (https=)
IN (1) IN2014DN07762A (https=)
WO (1) WO2013147458A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116986986A (zh) * 2023-07-19 2023-11-03 杭州国瑞生物科技有限公司 一种3-氧代-1-环丁烷羧酸中间体的合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005075474A1 (ja) 2004-02-09 2005-08-18 Astellas Pharma Inc. コハク酸ソリフェナシン含有組成物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2005012I1 (no) 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
EP0888543A4 (en) * 1996-03-20 2004-04-07 Scripps Research Inst CHANNEL ESTIMATION DEVICE
KR100669823B1 (ko) 2001-02-20 2007-01-17 경동제약 주식회사 2-(4-클로로벤조일아미노)-3-[2(1ｈ)-퀴놀리논-4-일]프로피온산의 제조방법 및 그 중간체
US20040157804A1 (en) * 2002-10-16 2004-08-12 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
GB0312426D0 (en) * 2003-05-30 2003-07-09 Albachem Ltd Purification means
JPWO2005087231A1 (ja) 2004-03-16 2008-01-24 アステラス製薬株式会社 ソリフェナシン含有組成物
EP1742642B1 (en) * 2004-04-14 2008-10-15 Gilead Sciences, Inc. Phosphonate analogs of hiv integrase inhibitor compounds
JP4803352B2 (ja) * 2005-07-13 2011-10-26 Ｊｓｒ株式会社 アミノ酸−ｎ−カルボキシ無水物の製造方法
CA2630846A1 (en) 2005-12-21 2007-07-05 Teva Pharmaceutical Industries Ltd. Intermediates for preparing solifenacin
EP2102200A2 (en) 2006-11-22 2009-09-23 Medichem, S.A. An improved process for the synthesis of solifenacin
CN101711248A (zh) * 2007-03-30 2010-05-19 医药化学公司 一种改进的素非那新合成工艺
JP2009538362A (ja) * 2007-07-13 2009-11-05 テバ ファーマシューティカル インダストリーズ リミティド ソリフェナシンの調製方法
HRP20161040T1 (hr) * 2008-04-29 2016-12-16 Ascendis Pharma Growth Disorders Division A/S Pegilirani rekombinantni spojevi ljudskog hormona rasta
PL2406257T3 (pl) * 2009-03-09 2020-01-31 Megafine Pharma (P) Ltd. Nowy sposób wytwarzania solifenacyny i jej nowy produkt pośredni
US8178700B2 (en) * 2009-05-04 2012-05-15 International Business Machines Corporation Method of preparing cyclic carbonates, cyclic carbamates, cyclic ureas, cyclic thiocarbonates, cyclic thiocarbamates, and cyclic dithiocarbonates
WO2011030139A1 (en) * 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005075474A1 (ja) 2004-02-09 2005-08-18 Astellas Pharma Inc. コハク酸ソリフェナシン含有組成物

Also Published As

Publication number Publication date
JP5891334B2 (ja) 2016-03-22
JP2015510927A (ja) 2015-04-13
US20150112072A1 (en) 2015-04-23
US9018379B1 (en) 2015-04-28
EP2831070A1 (en) 2015-02-04
AU2013240842A1 (en) 2014-08-28
WO2013147458A1 (en) 2013-10-03
KR20130109609A (ko) 2013-10-08
EP2831070A4 (en) 2015-08-19
CN104169280A (zh) 2014-11-26
AU2013240842B2 (en) 2015-09-03
IN2014DN07762A (https=) 2015-05-15
BR112014021223A2 (pt) 2020-10-27

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