CN104169280A - 制备索利那辛或其盐的方法和用于该方法的新型中间体 - Google Patents

制备索利那辛或其盐的方法和用于该方法的新型中间体 Download PDF

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Publication number
CN104169280A
CN104169280A CN201380016063.XA CN201380016063A CN104169280A CN 104169280 A CN104169280 A CN 104169280A CN 201380016063 A CN201380016063 A CN 201380016063A CN 104169280 A CN104169280 A CN 104169280A
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CN
China
Prior art keywords
reaction solution
reaction
solifenacin
formula
following formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380016063.XA
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English (en)
Chinese (zh)
Inventor
李炳硕
申尚勋
李基荣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyung Dong Pharmaceutical Co Ltd
Original Assignee
Kyung Dong Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyung Dong Pharmaceutical Co Ltd filed Critical Kyung Dong Pharmaceutical Co Ltd
Publication of CN104169280A publication Critical patent/CN104169280A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201380016063.XA 2012-03-28 2013-03-21 制备索利那辛或其盐的方法和用于该方法的新型中间体 Pending CN104169280A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20120031492A KR101365849B1 (ko) 2012-03-28 2012-03-28 솔리페나신 또는 그의 염의 제조방법 및 이에 사용되는 신규 중간체
KR10-2012-0031492 2012-03-28
PCT/KR2013/002358 WO2013147458A1 (en) 2012-03-28 2013-03-21 Process of preparing solifenacin or salt thereof, and novel intermediate used in the process

Publications (1)

Publication Number Publication Date
CN104169280A true CN104169280A (zh) 2014-11-26

Family

ID=49260649

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201380016063.XA Pending CN104169280A (zh) 2012-03-28 2013-03-21 制备索利那辛或其盐的方法和用于该方法的新型中间体

Country Status (9)

Country Link
US (1) US9018379B1 (https=)
EP (1) EP2831070A4 (https=)
JP (1) JP5891334B2 (https=)
KR (1) KR101365849B1 (https=)
CN (1) CN104169280A (https=)
AU (1) AU2013240842B2 (https=)
BR (1) BR112014021223A2 (https=)
IN (1) IN2014DN07762A (https=)
WO (1) WO2013147458A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116986986A (zh) * 2023-07-19 2023-11-03 杭州国瑞生物科技有限公司 一种3-氧代-1-环丁烷羧酸中间体的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070010673A1 (en) * 2003-05-30 2007-01-11 Css-Albachem Limited Purification means
US20070173528A1 (en) * 2005-12-21 2007-07-26 Nurit Perlman Process for preparing solifenacin
CN101711248A (zh) * 2007-03-30 2010-05-19 医药化学公司 一种改进的素非那新合成工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO2005012I1 (no) 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
EP0888543A4 (en) * 1996-03-20 2004-04-07 Scripps Research Inst CHANNEL ESTIMATION DEVICE
KR100669823B1 (ko) 2001-02-20 2007-01-17 경동제약 주식회사 2-(4-클로로벤조일아미노)-3-[2(1ｈ)-퀴놀리논-4-일]프로피온산의 제조방법 및 그 중간체
US20040157804A1 (en) * 2002-10-16 2004-08-12 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
CA2558877A1 (en) 2004-02-09 2005-08-18 Astellas Pharma Inc. Solifenacin succinate-containing composition
JPWO2005087231A1 (ja) 2004-03-16 2008-01-24 アステラス製薬株式会社 ソリフェナシン含有組成物
EP1742642B1 (en) * 2004-04-14 2008-10-15 Gilead Sciences, Inc. Phosphonate analogs of hiv integrase inhibitor compounds
JP4803352B2 (ja) * 2005-07-13 2011-10-26 Ｊｓｒ株式会社 アミノ酸−ｎ−カルボキシ無水物の製造方法
EP2102200A2 (en) 2006-11-22 2009-09-23 Medichem, S.A. An improved process for the synthesis of solifenacin
JP2009538362A (ja) * 2007-07-13 2009-11-05 テバ ファーマシューティカル インダストリーズ リミティド ソリフェナシンの調製方法
HRP20161040T1 (hr) * 2008-04-29 2016-12-16 Ascendis Pharma Growth Disorders Division A/S Pegilirani rekombinantni spojevi ljudskog hormona rasta
PL2406257T3 (pl) * 2009-03-09 2020-01-31 Megafine Pharma (P) Ltd. Nowy sposób wytwarzania solifenacyny i jej nowy produkt pośredni
US8178700B2 (en) * 2009-05-04 2012-05-15 International Business Machines Corporation Method of preparing cyclic carbonates, cyclic carbamates, cyclic ureas, cyclic thiocarbonates, cyclic thiocarbamates, and cyclic dithiocarbonates
WO2011030139A1 (en) * 2009-09-11 2011-03-17 Astrazeneca Ab 4- (pyrimidin-2-yl) -piperazine and 4- (pyrimidin-2-yl) -piperidine derivatives as gpr119 modulators

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070010673A1 (en) * 2003-05-30 2007-01-11 Css-Albachem Limited Purification means
US20070173528A1 (en) * 2005-12-21 2007-07-26 Nurit Perlman Process for preparing solifenacin
CN101711248A (zh) * 2007-03-30 2010-05-19 医药化学公司 一种改进的素非那新合成工艺

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116986986A (zh) * 2023-07-19 2023-11-03 杭州国瑞生物科技有限公司 一种3-氧代-1-环丁烷羧酸中间体的合成方法

Also Published As

Publication number Publication date
JP5891334B2 (ja) 2016-03-22
JP2015510927A (ja) 2015-04-13
US20150112072A1 (en) 2015-04-23
US9018379B1 (en) 2015-04-28
EP2831070A1 (en) 2015-02-04
AU2013240842A1 (en) 2014-08-28
WO2013147458A1 (en) 2013-10-03
KR20130109609A (ko) 2013-10-08
KR101365849B1 (ko) 2014-02-24
EP2831070A4 (en) 2015-08-19
AU2013240842B2 (en) 2015-09-03
IN2014DN07762A (https=) 2015-05-15
BR112014021223A2 (pt) 2020-10-27

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Application publication date: 20141126