JP5872573B2 - ポリエチレングリコール含有製剤 - Google Patents

ポリエチレングリコール含有製剤 Download PDF

Info

Publication number
JP5872573B2
JP5872573B2 JP2013537196A JP2013537196A JP5872573B2 JP 5872573 B2 JP5872573 B2 JP 5872573B2 JP 2013537196 A JP2013537196 A JP 2013537196A JP 2013537196 A JP2013537196 A JP 2013537196A JP 5872573 B2 JP5872573 B2 JP 5872573B2
Authority
JP
Japan
Prior art keywords
peg
solid
mannitol
present
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013537196A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014500246A (ja
JP2014500246A5 (enExample
Inventor
シュタイン，ペーター
コックス，イアン
スミス，サミュエル
ジョーンズ，レイトン
プレッスル，ヨルグ
Original Assignee
ノージン ビーブイ
ノージン ビーブイ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1018647.6A external-priority patent/GB201018647D0/en
Priority claimed from GBGB1104049.0A external-priority patent/GB201104049D0/en
Priority claimed from GBGB1107626.2A external-priority patent/GB201107626D0/en
Application filed by ノージン ビーブイ, ノージン ビーブイ filed Critical ノージン ビーブイ
Publication of JP2014500246A publication Critical patent/JP2014500246A/ja
Publication of JP2014500246A5 publication Critical patent/JP2014500246A5/ja
Application granted granted Critical
Publication of JP5872573B2 publication Critical patent/JP5872573B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2013537196A 2010-11-04 2011-11-04 ポリエチレングリコール含有製剤 Active JP5872573B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB1018647.6 2010-11-04
GBGB1018647.6A GB201018647D0 (en) 2010-11-04 2010-11-04 Formulations
US41210910P 2010-11-10 2010-11-10
US61/412,109 2010-11-10
GBGB1104049.0A GB201104049D0 (en) 2011-03-09 2011-03-09 Formulations
GB1104049.0 2011-03-09
GBGB1107626.2A GB201107626D0 (en) 2011-05-06 2011-05-06 Formulations
GB1107626.2 2011-05-06
PCT/GB2011/001560 WO2012059724A1 (en) 2010-11-04 2011-11-04 Formulations comprising polyethylene glycol

Publications (3)

Publication Number Publication Date
JP2014500246A JP2014500246A (ja) 2014-01-09
JP2014500246A5 JP2014500246A5 (enExample) 2014-12-11
JP5872573B2 true JP5872573B2 (ja) 2016-03-01

Family

ID=44999794

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013537196A Active JP5872573B2 (ja) 2010-11-04 2011-11-04 ポリエチレングリコール含有製剤

Country Status (20)

Country Link
US (3) US20130225692A1 (enExample)
EP (1) EP2635264B8 (enExample)
JP (1) JP5872573B2 (enExample)
KR (1) KR20130101102A (enExample)
CN (1) CN103384516B (enExample)
AR (1) AR083769A1 (enExample)
AU (1) AU2011324995B2 (enExample)
BE (1) BE1019493A3 (enExample)
BR (1) BR112013010884A2 (enExample)
CA (1) CA2816835A1 (enExample)
EA (1) EA024566B1 (enExample)
ES (1) ES2405531B1 (enExample)
IL (1) IL225892A0 (enExample)
MX (1) MX342181B (enExample)
MY (1) MY164204A (enExample)
NL (1) NL2007716C2 (enExample)
NZ (1) NZ611148A (enExample)
SG (1) SG190018A1 (enExample)
TW (1) TWI520730B (enExample)
WO (1) WO2012059724A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI535461B (zh) 2011-03-11 2016-06-01 諾金私人有限公司 結腸清潔溶液、用於製備該溶液之組成物、包含該組成物或溶液之套組、與製備該溶液之方法
US20130209522A1 (en) * 2012-02-06 2013-08-15 University Of Utah Research Foundation Drug Release from a Polymer-Controlled Local Antibiotic Delivery System Using a Degradable Bone Graft
BR112015005270B1 (pt) 2012-09-11 2022-11-01 Norgine Bv Composição para mistura com água, solução de limpeza de cólon, seus usos e seu kit
WO2014123978A2 (en) 2013-02-05 2014-08-14 University Of Utah Research Foundation Implantable devices for bone or joint defects
EA034234B1 (ru) 2013-03-15 2020-01-20 Брейнтри Лабораторис, Инк. Пероральные фармацевтические таблетированные композиции двойного применения, содержащие сульфат натрия или его комбинацию с другими сульфатными солями, и способы их получения и применения
EP3137167A4 (en) * 2014-04-29 2017-12-20 Colonaryconcepts LLC Foods, systems, methods, and kits for providing electrolyte replacement
EP3344238A4 (en) * 2015-09-01 2019-04-24 Colonaryconcepts LLC DEFLECTIVE FORMULATIONS AND MANUFACTURE
US10859512B2 (en) 2016-06-15 2020-12-08 Shimadzu Corporation X-ray phase contrast imaging apparatus
FR3056109B1 (fr) 2016-09-21 2019-10-11 Pierre Fabre Medicament Utilisation de formulations solides de polyethylene glycol dans le traitement de la constipation
CN112386577B (zh) * 2019-08-16 2024-01-23 北京天衡药物研究院有限公司 一种治疗便秘的组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710183A (en) * 1995-07-14 1998-01-20 Halow; George M. Laxative/antidiarrheal composition comprising polyethylene glycol and fiber bulking agent
CA2516291C (en) * 2003-02-28 2012-02-14 Alk-Abello A/S Dosage form having a saccharide matrix
GB0409104D0 (en) * 2004-04-23 2004-05-26 Norgine Europe Bv Compressed pharmaceutical compositions
AU2006244112B2 (en) * 2005-05-06 2011-02-17 Salix Pharmaceuticals, Inc. Polyethylene glycol colonic purgative composition
CO5790164A1 (es) * 2006-08-10 2007-08-31 Procaps S A Composicion farmaceutica solida que incluye en combinacion un agente regulador de la motilidad intestinal y un agente antiflatulento

Also Published As

Publication number Publication date
EA024566B1 (ru) 2016-09-30
WO2012059724A1 (en) 2012-05-10
US20160193245A1 (en) 2016-07-07
MX2013004972A (es) 2013-08-27
JP2014500246A (ja) 2014-01-09
BE1019493A3 (fr) 2012-07-03
AR083769A1 (es) 2013-03-20
EP2635264B1 (en) 2018-05-30
EP2635264A1 (en) 2013-09-11
TWI520730B (zh) 2016-02-11
NL2007716A (en) 2012-05-07
KR20130101102A (ko) 2013-09-12
MY164204A (en) 2017-11-30
EP2635264B8 (en) 2018-07-18
ES2405531B1 (es) 2014-06-11
CN103384516A (zh) 2013-11-06
WO2012059724A8 (en) 2013-06-06
US20170296575A1 (en) 2017-10-19
EA201300539A1 (ru) 2013-09-30
NZ611148A (en) 2015-09-25
AU2011324995A1 (en) 2013-05-02
CN103384516B (zh) 2017-02-15
SG190018A1 (en) 2013-06-28
MX342181B (es) 2016-09-20
ES2405531A2 (es) 2013-05-31
NL2007716C2 (en) 2012-11-13
CA2816835A1 (en) 2012-05-10
IL225892A0 (en) 2013-06-27
TW201223522A (en) 2012-06-16
US20130225692A1 (en) 2013-08-29
BR112013010884A2 (pt) 2016-08-02
ES2405531R1 (es) 2013-06-07
AU2011324995B2 (en) 2015-12-24

Similar Documents

Publication Publication Date Title
JP2014500246A (ja) ポリエチレングリコール含有製剤
RS61332B1 (sr) Preparat za kolonoskopiju
US20130189377A1 (en) Compositions
EP2635289B1 (en) Peg or peg block copolymers for treating colorectal cancer
JP2014500246A5 (enExample)
JP2013540726A (ja) 便秘薬
JP2005272401A (ja) チュアブル錠
FR2967069A3 (fr) Formulations
AU2011100528A4 (en) Formulations
UA108135C2 (uk) Тверда композиція для прийому всередину (варіанти), спосіб профілактики шлунково-кишкових розладів або підтримання здорового стану шлунково-кишкового тракту за її допомогою (варіанти) та упаковка, що її містить
IE20110480U1 (en) A solid formulation for oral administration comprising polyethylene glycol and mannitol
IES86031Y1 (en) A solid formulation for oral administration comprising polyethylene glycol and mannitol
IL225891A (en) Peg or block peg copolymers for the treatment of colorectal cancer

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20141014

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141015

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20141015

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150821

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150826

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151125

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20151224

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160113

R150 Certificate of patent or registration of utility model

Ref document number: 5872573

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250